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Protein

GTP-binding protein 10

Gene

Gtpbp10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the ribosome maturation process.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi155 – 1628GTPPROSITE-ProRule annotation
Nucleotide bindingi202 – 2065GTPPROSITE-ProRule annotation
Nucleotide bindingi278 – 2814GTPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 10
Gene namesi
Name:Gtpbp10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2385599. Gtpbp10.

Subcellular locationi

  • Nucleusnucleolus

  • Note: Found in the dense fibrillar compartment region of the nucleolus.By similarity

GO - Cellular componenti

  • mitochondrion Source: MGI
  • nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366GTP-binding protein 10PRO_0000312631Add
BLAST

Proteomic databases

EPDiQ8K013.
MaxQBiQ8K013.
PaxDbiQ8K013.
PRIDEiQ8K013.

PTM databases

iPTMnetiQ8K013.
PhosphoSiteiQ8K013.

Expressioni

Gene expression databases

BgeeiQ8K013.
CleanExiMM_GTPBP10.
ExpressionAtlasiQ8K013. baseline and differential.
GenevisibleiQ8K013. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111101.

Structurei

3D structure databases

ProteinModelPortaliQ8K013.
SMRiQ8K013. Positions 15-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 344196OBG-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1489. Eukaryota.
COG0536. LUCA.
GeneTreeiENSGT00530000063429.
HOGENOMiHOG000019084.
HOVERGENiHBG104309.
InParanoidiQ8K013.
OMAiNLWISDT.
OrthoDBiEOG7DJSMM.
PhylomeDBiQ8K013.
TreeFamiTF314774.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRCGCALLR KYGNFIDNLR IFTKGGSGGM GYPRLGGEGG RGGDVWVVAH
60 70 80 90 100
KNMTLKQLKN KYPQKRFVAG GGANSRVSAL QGSKGKDCEV PAPVGISVTD
110 120 130 140 150
ENGQVLGELN KEEDRVLVAK GGLGGKLHTN FLPLKGQKRI VHLDLKVIAD
160 170 180 190 200
VGLVGFPNAG KSSLLSRVSH ATPVIADYAF TTLRPELGKI MYNDFKQISV
210 220 230 240 250
ADLPGLIEGA HMNKGMGHKF LKHLERTRQL LFVVDISGFQ LSSVTPYRTA
260 270 280 290 300
FETIILLTKE LELYKEELQT KPALLAINKM DLPDAQVKLQ ELMKQLLSPE
310 320 330 340 350
DFLHLFETKM IPEKALEFQH IVPISTVTGE GIAELKSCIR KALDEQDGKE
360
SDAHRSKQLL NLQSSS
Length:366
Mass (Da):40,142
Last modified:October 1, 2002 - v1
Checksum:i0A08069F9C3FECF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK139595 mRNA. Translation: BAE24078.1.
BC034507 mRNA. Translation: AAH34507.1.
CCDSiCCDS39006.1.
RefSeqiNP_694756.1. NM_153116.1.
UniGeneiMm.323984.

Genome annotation databases

EnsembliENSMUST00000115441; ENSMUSP00000111101; ENSMUSG00000040464.
GeneIDi207704.
KEGGimmu:207704.
UCSCiuc008wis.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK139595 mRNA. Translation: BAE24078.1.
BC034507 mRNA. Translation: AAH34507.1.
CCDSiCCDS39006.1.
RefSeqiNP_694756.1. NM_153116.1.
UniGeneiMm.323984.

3D structure databases

ProteinModelPortaliQ8K013.
SMRiQ8K013. Positions 15-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111101.

PTM databases

iPTMnetiQ8K013.
PhosphoSiteiQ8K013.

Proteomic databases

EPDiQ8K013.
MaxQBiQ8K013.
PaxDbiQ8K013.
PRIDEiQ8K013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115441; ENSMUSP00000111101; ENSMUSG00000040464.
GeneIDi207704.
KEGGimmu:207704.
UCSCiuc008wis.1. mouse.

Organism-specific databases

CTDi85865.
MGIiMGI:2385599. Gtpbp10.

Phylogenomic databases

eggNOGiKOG1489. Eukaryota.
COG0536. LUCA.
GeneTreeiENSGT00530000063429.
HOGENOMiHOG000019084.
HOVERGENiHBG104309.
InParanoidiQ8K013.
OMAiNLWISDT.
OrthoDBiEOG7DJSMM.
PhylomeDBiQ8K013.
TreeFamiTF314774.

Miscellaneous databases

ChiTaRSiGtpbp10. mouse.
NextBioi372009.
PROiQ8K013.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K013.
CleanExiMM_GTPBP10.
ExpressionAtlasiQ8K013. baseline and differential.
GenevisibleiQ8K013. MM.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 1 hit.
PfamiPF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF002401. GTP_bd_Obg/CgtA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiGTPBA_MOUSE
AccessioniPrimary (citable) accession number: Q8K013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.