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Q8K010

- OPLA_MOUSE

UniProt

Q8K010 - OPLA_MOUSE

Protein

5-oxoprolinase

Gene

Oplah

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.By similarity

    Catalytic activityi

    ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

    GO - Molecular functioni

    1. 5-oxoprolinase (ATP-hydrolyzing) activity Source: MGI
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. glutathione metabolic process Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_210980. Glutathione synthesis and recycling.
    SABIO-RKQ8K010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-oxoprolinase (EC:3.5.2.9)
    Alternative name(s):
    5-oxo-L-prolinase
    Short name:
    5-OPase
    Pyroglutamase
    Gene namesi
    Name:Oplah
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1922725. Oplah.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 128812885-oxoprolinasePRO_0000208578Add
    BLAST

    Proteomic databases

    MaxQBiQ8K010.
    PaxDbiQ8K010.
    PRIDEiQ8K010.

    PTM databases

    PhosphoSiteiQ8K010.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K010.
    BgeeiQ8K010.
    CleanExiMM_OPLAH.
    GenevestigatoriQ8K010.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ8K010. 1 interaction.
    MINTiMINT-1855298.
    STRINGi10090.ENSMUSP00000023222.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the oxoprolinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0146.
    GeneTreeiENSGT00390000013463.
    HOGENOMiHOG000047200.
    HOVERGENiHBG007870.
    InParanoidiQ8K010.
    KOiK01469.
    OMAiVEAYMGH.
    OrthoDBiEOG78M013.
    PhylomeDBiQ8K010.
    TreeFamiTF300520.

    Family and domain databases

    InterProiIPR008040. Hydant_A_N.
    IPR002821. Hydantoinase_A.
    IPR003692. Hydantoinase_B.
    [Graphical view]
    PfamiPF05378. Hydant_A_N. 1 hit.
    PF01968. Hydantoinase_A. 1 hit.
    PF02538. Hydantoinase_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K010-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSPEERFHF AIDRGGTFTD VFAQCPGGHV RVLKLLSEDP ANYADAPTEG     50
    IRRILEQERG VLLPRGRPLD TSHIASIRMG TTVATNALLE RQGERVALLV 100
    TRGFRDLLHI GTQARPDLFD LAVPMPEVLY EEVVEVDERV LLYRGEPGAG 150
    SPVKGCTGDL LEIQQPVDLA ALRGKLEGLL TRGIHSLAVV LMHSYTWAQH 200
    EQQVGTLARE LGFTHVSLSS EVMPMVRIVP RGHTACADAY LTPTIQRYVQ 250
    GFRRGFQGQL KNVQVLFMRS DGGLAPMDAF SGSRAVLSGP AGGVVGYSTT 300
    TYQLEGGQPV IGFDMGGTST DVSRYAGEFE HVFEASTAGV TLQAPQLDIN 350
    TVAAGGGSRL FFRSGLFVVG PESAGAHPGP ACYRKGGPVT VTDANLVLGR 400
    LLPASFPCIF GPGEDQPLSP EASRKALEAV AMEVNSFLAS GPCPASQLSL 450
    EEVAMGFVRV ANEAMCRPIR ALTQARGHDP SAHVLACFGG AGGQHACAIA 500
    RALGMDTVHI HRHSGLLSAL GLALADVVHE AQEPCSLSYT PETFAQLDQR 550
    LSRLEEQCVD ALQAQGFSRS QISTESFLHL RYQGTDCALM VSANQHPATT 600
    CSPRAGDFGA AFVERYMREF GFIIPERSVV VDDVRVRGTG RSGLQLEETS 650
    KIQSGPPHVE KVTQCYFEGG YQETPVYLLG ELGYGHQLQG PCLIIDNNST 700
    ILVEPGCQAE VIETGDIRIS VGAEAPSMID TKLDPIQLSI FSHRFMSIAE 750
    QMGRILQRTA ISTNIKERLD FSCALFGPDG GLVSNAPHIP VHLGAMQETV 800
    QFQIQHLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW PGQSRPVFYV 850
    ASRGHHADIG GITPGSMPPH STTLQQEGAV FLSFKLVQGG VFQEEAVTEA 900
    LQAPGKISGC SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ 950
    AYMGHIQANA ELAVRDMLRA FGTSRQARGL PLEVSAKDHM DDGSPICLHV 1000
    QINLNQGSAV FDFSGSGSEV FGNLNAPRAI TLSALIYCLR CLVGRDIPLN 1050
    QGCLAPVQVI IPKGSILDPS PEAAVVGGNV LTSQRVVDVI LGAFGACAAS 1100
    QGCMNNVTLG NARMGYYETV AGGAGAGPGW HGRSGVHSHM TNTRITDPEI 1150
    LESRYPVILR RFELRPGSGG RGRFRGGDGV VRELVFREEA LLSVLTERRA 1200
    FQPYGLHGGE PGTRGLNLLI RKDGRTVNLG GKTSVTVYPG DAFCLHTPGG 1250
    GGYGDPEDPA PPPGSPPLYP AFPERGSVYE YRRAQEAV 1288
    Length:1,288
    Mass (Da):137,611
    Last modified:October 1, 2002 - v1
    Checksum:iDD6DDF24DF5AC390
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti902 – 9021Q → R in AAH25120. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC025120 mRNA. Translation: AAH25120.1.
    BC034522 mRNA. Translation: AAH34522.1.
    CCDSiCCDS27565.1.
    RefSeqiNP_694762.1. NM_153122.2.
    XP_006521572.1. XM_006521509.1.
    UniGeneiMm.322738.

    Genome annotation databases

    EnsembliENSMUST00000023222; ENSMUSP00000023222; ENSMUSG00000022562.
    ENSMUST00000171340; ENSMUSP00000129100; ENSMUSG00000022562.
    GeneIDi75475.
    KEGGimmu:75475.
    UCSCiuc007wjo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC025120 mRNA. Translation: AAH25120.1 .
    BC034522 mRNA. Translation: AAH34522.1 .
    CCDSi CCDS27565.1.
    RefSeqi NP_694762.1. NM_153122.2.
    XP_006521572.1. XM_006521509.1.
    UniGenei Mm.322738.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K010. 1 interaction.
    MINTi MINT-1855298.
    STRINGi 10090.ENSMUSP00000023222.

    PTM databases

    PhosphoSitei Q8K010.

    Proteomic databases

    MaxQBi Q8K010.
    PaxDbi Q8K010.
    PRIDEi Q8K010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023222 ; ENSMUSP00000023222 ; ENSMUSG00000022562 .
    ENSMUST00000171340 ; ENSMUSP00000129100 ; ENSMUSG00000022562 .
    GeneIDi 75475.
    KEGGi mmu:75475.
    UCSCi uc007wjo.1. mouse.

    Organism-specific databases

    CTDi 26873.
    MGIi MGI:1922725. Oplah.

    Phylogenomic databases

    eggNOGi COG0146.
    GeneTreei ENSGT00390000013463.
    HOGENOMi HOG000047200.
    HOVERGENi HBG007870.
    InParanoidi Q8K010.
    KOi K01469.
    OMAi VEAYMGH.
    OrthoDBi EOG78M013.
    PhylomeDBi Q8K010.
    TreeFami TF300520.

    Enzyme and pathway databases

    Reactomei REACT_210980. Glutathione synthesis and recycling.
    SABIO-RK Q8K010.

    Miscellaneous databases

    ChiTaRSi OPLAH. mouse.
    NextBioi 343114.
    PROi Q8K010.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K010.
    Bgeei Q8K010.
    CleanExi MM_OPLAH.
    Genevestigatori Q8K010.

    Family and domain databases

    InterProi IPR008040. Hydant_A_N.
    IPR002821. Hydantoinase_A.
    IPR003692. Hydantoinase_B.
    [Graphical view ]
    Pfami PF05378. Hydant_A_N. 1 hit.
    PF01968. Hydantoinase_A. 1 hit.
    PF02538. Hydantoinase_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiOPLA_MOUSE
    AccessioniPrimary (citable) accession number: Q8K010
    Secondary accession number(s): Q8R3K2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3