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Q8K010

- OPLA_MOUSE

UniProt

Q8K010 - OPLA_MOUSE

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Protein

5-oxoprolinase

Gene
Oplah
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate By similarity.

Catalytic activityi

ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

GO - Molecular functioni

  1. 5-oxoprolinase (ATP-hydrolyzing) activity Source: MGI
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. glutathione metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_210980. Glutathione synthesis and recycling.
SABIO-RKQ8K010.

Names & Taxonomyi

Protein namesi
Recommended name:
5-oxoprolinase (EC:3.5.2.9)
Alternative name(s):
5-oxo-L-prolinase
Short name:
5-OPase
Pyroglutamase
Gene namesi
Name:Oplah
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1922725. Oplah.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128812885-oxoprolinasePRO_0000208578Add
BLAST

Proteomic databases

MaxQBiQ8K010.
PaxDbiQ8K010.
PRIDEiQ8K010.

PTM databases

PhosphoSiteiQ8K010.

Expressioni

Gene expression databases

ArrayExpressiQ8K010.
BgeeiQ8K010.
CleanExiMM_OPLAH.
GenevestigatoriQ8K010.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ8K010. 1 interaction.
MINTiMINT-1855298.
STRINGi10090.ENSMUSP00000023222.

Family & Domainsi

Sequence similaritiesi

Belongs to the oxoprolinase family.

Phylogenomic databases

eggNOGiCOG0146.
GeneTreeiENSGT00390000013463.
HOGENOMiHOG000047200.
HOVERGENiHBG007870.
InParanoidiQ8K010.
KOiK01469.
OMAiVEAYMGH.
OrthoDBiEOG78M013.
PhylomeDBiQ8K010.
TreeFamiTF300520.

Family and domain databases

InterProiIPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view]
PfamiPF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K010-1 [UniParc]FASTAAdd to Basket

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MGSPEERFHF AIDRGGTFTD VFAQCPGGHV RVLKLLSEDP ANYADAPTEG     50
IRRILEQERG VLLPRGRPLD TSHIASIRMG TTVATNALLE RQGERVALLV 100
TRGFRDLLHI GTQARPDLFD LAVPMPEVLY EEVVEVDERV LLYRGEPGAG 150
SPVKGCTGDL LEIQQPVDLA ALRGKLEGLL TRGIHSLAVV LMHSYTWAQH 200
EQQVGTLARE LGFTHVSLSS EVMPMVRIVP RGHTACADAY LTPTIQRYVQ 250
GFRRGFQGQL KNVQVLFMRS DGGLAPMDAF SGSRAVLSGP AGGVVGYSTT 300
TYQLEGGQPV IGFDMGGTST DVSRYAGEFE HVFEASTAGV TLQAPQLDIN 350
TVAAGGGSRL FFRSGLFVVG PESAGAHPGP ACYRKGGPVT VTDANLVLGR 400
LLPASFPCIF GPGEDQPLSP EASRKALEAV AMEVNSFLAS GPCPASQLSL 450
EEVAMGFVRV ANEAMCRPIR ALTQARGHDP SAHVLACFGG AGGQHACAIA 500
RALGMDTVHI HRHSGLLSAL GLALADVVHE AQEPCSLSYT PETFAQLDQR 550
LSRLEEQCVD ALQAQGFSRS QISTESFLHL RYQGTDCALM VSANQHPATT 600
CSPRAGDFGA AFVERYMREF GFIIPERSVV VDDVRVRGTG RSGLQLEETS 650
KIQSGPPHVE KVTQCYFEGG YQETPVYLLG ELGYGHQLQG PCLIIDNNST 700
ILVEPGCQAE VIETGDIRIS VGAEAPSMID TKLDPIQLSI FSHRFMSIAE 750
QMGRILQRTA ISTNIKERLD FSCALFGPDG GLVSNAPHIP VHLGAMQETV 800
QFQIQHLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW PGQSRPVFYV 850
ASRGHHADIG GITPGSMPPH STTLQQEGAV FLSFKLVQGG VFQEEAVTEA 900
LQAPGKISGC SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ 950
AYMGHIQANA ELAVRDMLRA FGTSRQARGL PLEVSAKDHM DDGSPICLHV 1000
QINLNQGSAV FDFSGSGSEV FGNLNAPRAI TLSALIYCLR CLVGRDIPLN 1050
QGCLAPVQVI IPKGSILDPS PEAAVVGGNV LTSQRVVDVI LGAFGACAAS 1100
QGCMNNVTLG NARMGYYETV AGGAGAGPGW HGRSGVHSHM TNTRITDPEI 1150
LESRYPVILR RFELRPGSGG RGRFRGGDGV VRELVFREEA LLSVLTERRA 1200
FQPYGLHGGE PGTRGLNLLI RKDGRTVNLG GKTSVTVYPG DAFCLHTPGG 1250
GGYGDPEDPA PPPGSPPLYP AFPERGSVYE YRRAQEAV 1288
Length:1,288
Mass (Da):137,611
Last modified:October 1, 2002 - v1
Checksum:iDD6DDF24DF5AC390
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti902 – 9021Q → R in AAH25120. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC025120 mRNA. Translation: AAH25120.1.
BC034522 mRNA. Translation: AAH34522.1.
CCDSiCCDS27565.1.
RefSeqiNP_694762.1. NM_153122.2.
XP_006521572.1. XM_006521509.1.
UniGeneiMm.322738.

Genome annotation databases

EnsembliENSMUST00000023222; ENSMUSP00000023222; ENSMUSG00000022562.
ENSMUST00000171340; ENSMUSP00000129100; ENSMUSG00000022562.
GeneIDi75475.
KEGGimmu:75475.
UCSCiuc007wjo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC025120 mRNA. Translation: AAH25120.1 .
BC034522 mRNA. Translation: AAH34522.1 .
CCDSi CCDS27565.1.
RefSeqi NP_694762.1. NM_153122.2.
XP_006521572.1. XM_006521509.1.
UniGenei Mm.322738.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K010. 1 interaction.
MINTi MINT-1855298.
STRINGi 10090.ENSMUSP00000023222.

PTM databases

PhosphoSitei Q8K010.

Proteomic databases

MaxQBi Q8K010.
PaxDbi Q8K010.
PRIDEi Q8K010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023222 ; ENSMUSP00000023222 ; ENSMUSG00000022562 .
ENSMUST00000171340 ; ENSMUSP00000129100 ; ENSMUSG00000022562 .
GeneIDi 75475.
KEGGi mmu:75475.
UCSCi uc007wjo.1. mouse.

Organism-specific databases

CTDi 26873.
MGIi MGI:1922725. Oplah.

Phylogenomic databases

eggNOGi COG0146.
GeneTreei ENSGT00390000013463.
HOGENOMi HOG000047200.
HOVERGENi HBG007870.
InParanoidi Q8K010.
KOi K01469.
OMAi VEAYMGH.
OrthoDBi EOG78M013.
PhylomeDBi Q8K010.
TreeFami TF300520.

Enzyme and pathway databases

Reactomei REACT_210980. Glutathione synthesis and recycling.
SABIO-RK Q8K010.

Miscellaneous databases

ChiTaRSi OPLAH. mouse.
NextBioi 343114.
PROi Q8K010.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K010.
Bgeei Q8K010.
CleanExi MM_OPLAH.
Genevestigatori Q8K010.

Family and domain databases

InterProi IPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view ]
Pfami PF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiOPLA_MOUSE
AccessioniPrimary (citable) accession number: Q8K010
Secondary accession number(s): Q8R3K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi