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Q8K010 (OPLA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-oxoprolinase

EC=3.5.2.9
Alternative name(s):
5-oxo-L-prolinase
Short name=5-OPase
Pyroglutamase
Gene names
Name:Oplah
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1288 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate By similarity.

Catalytic activity

ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the oxoprolinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 128812885-oxoprolinase
PRO_0000208578

Experimental info

Sequence conflict9021Q → R in AAH25120. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K010 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: DD6DDF24DF5AC390

FASTA1,288137,611
        10         20         30         40         50         60 
MGSPEERFHF AIDRGGTFTD VFAQCPGGHV RVLKLLSEDP ANYADAPTEG IRRILEQERG 

        70         80         90        100        110        120 
VLLPRGRPLD TSHIASIRMG TTVATNALLE RQGERVALLV TRGFRDLLHI GTQARPDLFD 

       130        140        150        160        170        180 
LAVPMPEVLY EEVVEVDERV LLYRGEPGAG SPVKGCTGDL LEIQQPVDLA ALRGKLEGLL 

       190        200        210        220        230        240 
TRGIHSLAVV LMHSYTWAQH EQQVGTLARE LGFTHVSLSS EVMPMVRIVP RGHTACADAY 

       250        260        270        280        290        300 
LTPTIQRYVQ GFRRGFQGQL KNVQVLFMRS DGGLAPMDAF SGSRAVLSGP AGGVVGYSTT 

       310        320        330        340        350        360 
TYQLEGGQPV IGFDMGGTST DVSRYAGEFE HVFEASTAGV TLQAPQLDIN TVAAGGGSRL 

       370        380        390        400        410        420 
FFRSGLFVVG PESAGAHPGP ACYRKGGPVT VTDANLVLGR LLPASFPCIF GPGEDQPLSP 

       430        440        450        460        470        480 
EASRKALEAV AMEVNSFLAS GPCPASQLSL EEVAMGFVRV ANEAMCRPIR ALTQARGHDP 

       490        500        510        520        530        540 
SAHVLACFGG AGGQHACAIA RALGMDTVHI HRHSGLLSAL GLALADVVHE AQEPCSLSYT 

       550        560        570        580        590        600 
PETFAQLDQR LSRLEEQCVD ALQAQGFSRS QISTESFLHL RYQGTDCALM VSANQHPATT 

       610        620        630        640        650        660 
CSPRAGDFGA AFVERYMREF GFIIPERSVV VDDVRVRGTG RSGLQLEETS KIQSGPPHVE 

       670        680        690        700        710        720 
KVTQCYFEGG YQETPVYLLG ELGYGHQLQG PCLIIDNNST ILVEPGCQAE VIETGDIRIS 

       730        740        750        760        770        780 
VGAEAPSMID TKLDPIQLSI FSHRFMSIAE QMGRILQRTA ISTNIKERLD FSCALFGPDG 

       790        800        810        820        830        840 
GLVSNAPHIP VHLGAMQETV QFQIQHLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW 

       850        860        870        880        890        900 
PGQSRPVFYV ASRGHHADIG GITPGSMPPH STTLQQEGAV FLSFKLVQGG VFQEEAVTEA 

       910        920        930        940        950        960 
LQAPGKISGC SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ AYMGHIQANA 

       970        980        990       1000       1010       1020 
ELAVRDMLRA FGTSRQARGL PLEVSAKDHM DDGSPICLHV QINLNQGSAV FDFSGSGSEV 

      1030       1040       1050       1060       1070       1080 
FGNLNAPRAI TLSALIYCLR CLVGRDIPLN QGCLAPVQVI IPKGSILDPS PEAAVVGGNV 

      1090       1100       1110       1120       1130       1140 
LTSQRVVDVI LGAFGACAAS QGCMNNVTLG NARMGYYETV AGGAGAGPGW HGRSGVHSHM 

      1150       1160       1170       1180       1190       1200 
TNTRITDPEI LESRYPVILR RFELRPGSGG RGRFRGGDGV VRELVFREEA LLSVLTERRA 

      1210       1220       1230       1240       1250       1260 
FQPYGLHGGE PGTRGLNLLI RKDGRTVNLG GKTSVTVYPG DAFCLHTPGG GGYGDPEDPA 

      1270       1280 
PPPGSPPLYP AFPERGSVYE YRRAQEAV 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC025120 mRNA. Translation: AAH25120.1.
BC034522 mRNA. Translation: AAH34522.1.
CCDSCCDS27565.1.
RefSeqNP_694762.1. NM_153122.2.
XP_006521572.1. XM_006521509.1.
UniGeneMm.322738.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8K010. 1 interaction.
MINTMINT-1855298.
STRING10090.ENSMUSP00000023222.

PTM databases

PhosphoSiteQ8K010.

Proteomic databases

MaxQBQ8K010.
PaxDbQ8K010.
PRIDEQ8K010.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023222; ENSMUSP00000023222; ENSMUSG00000022562.
ENSMUST00000171340; ENSMUSP00000129100; ENSMUSG00000022562.
GeneID75475.
KEGGmmu:75475.
UCSCuc007wjo.1. mouse.

Organism-specific databases

CTD26873.
MGIMGI:1922725. Oplah.

Phylogenomic databases

eggNOGCOG0146.
GeneTreeENSGT00390000013463.
HOGENOMHOG000047200.
HOVERGENHBG007870.
InParanoidQ8K010.
KOK01469.
OMAVEAYMGH.
OrthoDBEOG78M013.
PhylomeDBQ8K010.
TreeFamTF300520.

Enzyme and pathway databases

SABIO-RKQ8K010.

Gene expression databases

ArrayExpressQ8K010.
BgeeQ8K010.
CleanExMM_OPLAH.
GenevestigatorQ8K010.

Family and domain databases

InterProIPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view]
PfamPF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSOPLAH. mouse.
NextBio343114.
PROQ8K010.
SOURCESearch...

Entry information

Entry nameOPLA_MOUSE
AccessionPrimary (citable) accession number: Q8K010
Secondary accession number(s): Q8R3K2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot