ID   AL1L2_MOUSE             Reviewed;         923 AA.
AC   Q8K009;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 52.
DE   RecName: Full=Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2;
DE            EC=1.5.1.6;
DE   AltName: Full=Aldehyde dehydrogenase family 1 member L2;
GN   Name=Aldh1l2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Salivary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + NADP(+) + H(2)O =
CC       tetrahydrofolate + CO(2) + NADPH.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the GART family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the aldehyde
CC       dehydrogenase family. ALDH1L subfamily.
CC   -!- SIMILARITY: Contains 1 acyl carrier domain.
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DR   EMBL; BC034531; AAH34531.1; -; mRNA.
DR   IPI; IPI00169472; -.
DR   RefSeq; NP_705771.1; -.
DR   UniGene; Mm.263138; -.
DR   HSSP; P28037; 1S3I.
DR   SMR; Q8K009; 426-923.
DR   PRIDE; Q8K009; -.
DR   Ensembl; ENSMUSG00000020256; Mus musculus.
DR   GeneID; 216188; -.
DR   KEGG; mmu:216188; -.
DR   MGI; MGI:2444680; Aldh1l2.
DR   HOGENOM; Q8K009; -.
DR   HOVERGEN; Q8K009; -.
DR   BRENDA; 1.5.1.6; 244.
DR   NextBio; 375062; -.
DR   ArrayExpress; Q8K009; -.
DR   Bgee; Q8K009; -.
DR   CleanEx; MM_ALDH1L2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:InterPro.
DR   GO; GO:0016155; F:formyltetrahydrofolate dehydrogenase activity; IEA:EC.
DR   GO; GO:0016742; F:hydroxymethyl-, formyl- and related transfe...; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0009258; P:10-formyltetrahydrofolate catabolic process; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR011407; 10_FTHF_DH.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR005793; Formyl_trans_C.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR001555; GART_AS.
DR   InterPro; IPR006162; Ppantne_S.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   Gene3D; G3DSA:3.10.25.10; Formyl_trans_C; 1.
DR   Gene3D; G3DSA:3.40.50.170; Formyl_transf_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   Pfam; PF02911; Formyl_trans_C; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   PIRSF; PIRSF036489; 10-FTHFDH; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
DR   PROSITE; PS00373; GART; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   2: Evidence at transcript level;
KW   NADP; One-carbon metabolism; Oxidoreductase; Phosphopantetheine.
FT   CHAIN         1    923       Probable 10-formyltetrahydrofolate
FT                                dehydrogenase ALDH1L2.
FT                                /FTId=PRO_0000316002.
FT   DOMAIN      344    413       Acyl carrier.
FT   REGION       23    225       GART.
FT   REGION      438    923       Aldehyde dehydrogenase.
FT   ACT_SITE    128    128       Proton donor (By similarity).
FT   ACT_SITE    694    694       By similarity.
FT   ACT_SITE    728    728       By similarity.
FT   SITE        164    164       Essential for catalytic activity (By
FT                                similarity).
FT   MOD_RES     375    375       O-(pantetheine 4'-phosphoryl)serine (By
FT                                similarity).
SQ   SEQUENCE   923 AA;  101564 MW;  441D57CAF3D11303 CRC64;
     MLWRGSQALR HFSTSRVYFK NKLKLALIGQ SLFGQEVYSQ LLKEGHRVVG VFTVPDKDGK
     ADPLALAAEK DGTPVFKFPR WRLKGKTIKE VAEAYQSVGA ELNVLPFCTQ FIPMDVIDSP
     KHGSIIYHPS LLPRHRGASA INWTLIMGDK KAGFSVFWAD DGLDTGPILL QRSCDVKPND
     TVDSLYNRFL FPEGIKAMVE AVQLIADGKA PRTPQPEEGA TYEGIQKKEN AEVSWDQPAE
     GLHNWIRGHD KVPGAWAEIN GQMVTFYGSS LLTSSVPSGE PLDIRGAKKP GLVTKNGLVL
     FGNDGKALMV RNLQFEDGKM IPASQYFSAG ETSVVELTAE ELKVAETIKV IWARILSNTP
     VIEDSTDFFK SGASSMDVVR LVEEIRQSCG GLQLQNEDVY MATKFGDFIQ KVVRRLRGED
     EEAEMVVDYV SKEVNGMTVK IPYQCFINGQ FVDAEDGETY ATVNPTDGTT ICRVSHASLA
     DVDRAVAAAK DAFENGEWGR MNARDRGRLM YRLADLMEEN QEELATIEAL DSGAVYTLAL
     KTHIGMSVQT FRYFAGWCDK IQGSTIPINQ ARPNYNLTFT KKEPLGACAI IIPWNYPLMM
     LAWKSAACLA AGNTLVLKPA QVTPLTALKF AELTVKAGFP KGVINIIPGS GGVAGQRLSQ
     HPDIRKLGFT GSTSVGKQIM KSCAVSNLKK VSLELGGKSP LIIFSDCDLE KAVRMGMGAV
     FFNKGENCIA AGRLFVEEAI HDEFVTRVVE EIKKMKIGDP LDRSTDHGPQ NHRAHLEKLL
     QYCETGVQEG ATLVYGGRQV QRPGFFMEPT VFTGVEDHMY LAKEESFGPI MVISKFQNGD
     IDGVLQRANN TEYGLASGVF TRDINKAMYV SDKLEAGTVF INTYNKTDVA APFGGMKQSG
     FGKDLGEEAL NEYLKIKTVT LEY
//