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Protein

Mitochondrial 10-formyltetrahydrofolate dehydrogenase

Gene

Aldh1l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

The phosphoserine observed at Ser-375 in PubMed:21183079 may result from secondary neutral loss of pantetheine from the phosphodiester linked cofactor.Curated

Catalytic activityi

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128Proton donorPROSITE-ProRule annotation1
Sitei164Essential for catalytic activityBy similarity1
Active sitei694By similarity1
Active sitei728By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processOne-carbon metabolism
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-196757 Metabolism of folate and pterines

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (EC:1.5.1.6)
Short name:
Mitochondrial 10-FTHFDH
Short name:
mtFDH
Alternative name(s):
Aldehyde dehydrogenase family 1 member L2
Gene namesi
Name:Aldh1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2444680 Aldh1l2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003160021 – 923Mitochondrial 10-formyltetrahydrofolate dehydrogenaseAdd BLAST923
Transit peptidei1 – 19Mitochondrion; not cleavedBy similarityAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei60N6-succinyllysineBy similarity1
Modified residuei375O-(pantetheine 4'-phosphoryl)serine; alternatePROSITE-ProRule annotationCurated1
Modified residuei375Phosphoserine; alternateCombined sources1
Modified residuei650PhosphoserineBy similarity1
Modified residuei681N6-succinyllysineCombined sources1
Modified residuei903N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiQ8K009
PaxDbiQ8K009
PeptideAtlasiQ8K009
PRIDEiQ8K009

PTM databases

iPTMnetiQ8K009
PhosphoSitePlusiQ8K009
SwissPalmiQ8K009

Expressioni

Gene expression databases

BgeeiENSMUSG00000020256
CleanExiMM_ALDH1L2
ExpressionAtlasiQ8K009 baseline and differential
GenevisibleiQ8K009 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020497

Structurei

3D structure databases

ProteinModelPortaliQ8K009
SMRiQ8K009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 416CarrierPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 225GARTAdd BLAST203
Regioni438 – 923Aldehyde dehydrogenaseAdd BLAST486

Sequence similaritiesi

In the N-terminal section; belongs to the GART family.Curated
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00760000118999
HOGENOMiHOG000006902
HOVERGENiHBG051668
InParanoidiQ8K009
KOiK00289
OMAiMMLAWKS
OrthoDBiEOG091G05E8
TreeFamiTF354242

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.25.10, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR011407 10_FTHF_DH
IPR036736 ACP-like_sf
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
PF00550 PP-binding, 1 hit
PIRSFiPIRSF036489 10-FTHFDH, 1 hit
SUPFAMiSSF47336 SSF47336, 1 hit
SSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
SSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
PS50075 CARRIER, 1 hit
PS00373 GART, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWRGSQALR HFSTSRVYFK NKLKLALIGQ SLFGQEVYSQ LLKEGHRVVG
60 70 80 90 100
VFTVPDKDGK ADPLALAAEK DGTPVFKFPR WRLKGKTIKE VAEAYQSVGA
110 120 130 140 150
ELNVLPFCTQ FIPMDVIDSP KHGSIIYHPS LLPRHRGASA INWTLIMGDK
160 170 180 190 200
KAGFSVFWAD DGLDTGPILL QRSCDVKPND TVDSLYNRFL FPEGIKAMVE
210 220 230 240 250
AVQLIADGKA PRTPQPEEGA TYEGIQKKEN AEVSWDQPAE GLHNWIRGHD
260 270 280 290 300
KVPGAWAEIN GQMVTFYGSS LLTSSVPSGE PLDIRGAKKP GLVTKNGLVL
310 320 330 340 350
FGNDGKALMV RNLQFEDGKM IPASQYFSAG ETSVVELTAE ELKVAETIKV
360 370 380 390 400
IWARILSNTP VIEDSTDFFK SGASSMDVVR LVEEIRQSCG GLQLQNEDVY
410 420 430 440 450
MATKFGDFIQ KVVRRLRGED EEAEMVVDYV SKEVNGMTVK IPYQCFINGQ
460 470 480 490 500
FVDAEDGETY ATVNPTDGTT ICRVSYASLA DVDRAVAAAK DAFENGEWGR
510 520 530 540 550
MNARDRGRLM YRLADLMEEN QEELATIEAL DSGAVYTLAL KTHIGMSVQT
560 570 580 590 600
FRYFAGWCDK IQGSTIPINQ ARPNYNLTFT KKEPLGACAI IIPWNYPLMM
610 620 630 640 650
LAWKSAACLA AGNTLVLKPA QVTPLTALKF AELTVKAGFP KGVINIIPGS
660 670 680 690 700
GGVAGQRLSQ HPDIRKLGFT GSTSVGKQIM KSCAVSNLKK VSLELGGKSP
710 720 730 740 750
LIIFSDCDLE KAVRMGMGAV FFNKGENCIA AGRLFVEEAI HDEFVTRVVE
760 770 780 790 800
EIKKMKIGDP LDRSTDHGPQ NHRAHLEKLL QYCETGVQEG ATLVYGGRQV
810 820 830 840 850
QRPGFFMEPT VFTGVEDHMY LAKEESFGPI MVISKFQNGD IDGVLQRANN
860 870 880 890 900
TEYGLASGVF TRDINKAMYV SDKLEAGTVF INTYNKTDVA APFGGMKQSG
910 920
FGKDLGEEAL NEYLKIKTVT LEY
Length:923
Mass (Da):101,590
Last modified:July 27, 2011 - v2
Checksum:i57CB83C38FAFB0D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti476Y → H in AAH34531 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113014 Genomic DNA No translation available.
BC034531 mRNA Translation: AAH34531.1
CCDSiCCDS24077.1
RefSeqiNP_705771.2, NM_153543.2
UniGeneiMm.263138

Genome annotation databases

EnsembliENSMUST00000020497; ENSMUSP00000020497; ENSMUSG00000020256
GeneIDi216188
KEGGimmu:216188
UCSCiuc007gkh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAL1L2_MOUSE
AccessioniPrimary (citable) accession number: Q8K009
Secondary accession number(s): E9QLV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health