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Reviewed, UniProtKB/Swiss-Prot Q8K009 (AL1L2_MOUSE)

Last modified November 3, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2
    EC=1.5.1.6
Alternative name(s):
    Aldehyde dehydrogenase family 1 member L2
Gene names
Name: Aldh1l2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length923 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

Sequence similarities

In the N-terminal section; belongs to the GART family.

In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.

Contains 1 acyl carrier domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 923923Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2
PRO_0000316002

Regions

Domain344 – 41370Acyl carrier
Region23 – 225203GART
Region438 – 923486Aldehyde dehydrogenase

Sites

Active site1281Proton donor By similarity
Active site6941 By similarity
Active site7281 By similarity
Site1641Essential for catalytic activity By similarity

Amino acid modifications

Modified residue3751O-(pantetheine 4'-phosphoryl)serine By similarity
Modified residue9031N6-acetyllysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q8K009-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 441D57CAF3D11303

FASTA923101,564
        10         20         30         40         50         60 
MLWRGSQALR HFSTSRVYFK NKLKLALIGQ SLFGQEVYSQ LLKEGHRVVG VFTVPDKDGK 

        70         80         90        100        110        120 
ADPLALAAEK DGTPVFKFPR WRLKGKTIKE VAEAYQSVGA ELNVLPFCTQ FIPMDVIDSP 

       130        140        150        160        170        180 
KHGSIIYHPS LLPRHRGASA INWTLIMGDK KAGFSVFWAD DGLDTGPILL QRSCDVKPND 

       190        200        210        220        230        240 
TVDSLYNRFL FPEGIKAMVE AVQLIADGKA PRTPQPEEGA TYEGIQKKEN AEVSWDQPAE 

       250        260        270        280        290        300 
GLHNWIRGHD KVPGAWAEIN GQMVTFYGSS LLTSSVPSGE PLDIRGAKKP GLVTKNGLVL 

       310        320        330        340        350        360 
FGNDGKALMV RNLQFEDGKM IPASQYFSAG ETSVVELTAE ELKVAETIKV IWARILSNTP 

       370        380        390        400        410        420 
VIEDSTDFFK SGASSMDVVR LVEEIRQSCG GLQLQNEDVY MATKFGDFIQ KVVRRLRGED 

       430        440        450        460        470        480 
EEAEMVVDYV SKEVNGMTVK IPYQCFINGQ FVDAEDGETY ATVNPTDGTT ICRVSHASLA 

       490        500        510        520        530        540 
DVDRAVAAAK DAFENGEWGR MNARDRGRLM YRLADLMEEN QEELATIEAL DSGAVYTLAL 

       550        560        570        580        590        600 
KTHIGMSVQT FRYFAGWCDK IQGSTIPINQ ARPNYNLTFT KKEPLGACAI IIPWNYPLMM 

       610        620        630        640        650        660 
LAWKSAACLA AGNTLVLKPA QVTPLTALKF AELTVKAGFP KGVINIIPGS GGVAGQRLSQ 

       670        680        690        700        710        720 
HPDIRKLGFT GSTSVGKQIM KSCAVSNLKK VSLELGGKSP LIIFSDCDLE KAVRMGMGAV 

       730        740        750        760        770        780 
FFNKGENCIA AGRLFVEEAI HDEFVTRVVE EIKKMKIGDP LDRSTDHGPQ NHRAHLEKLL 

       790        800        810        820        830        840 
QYCETGVQEG ATLVYGGRQV QRPGFFMEPT VFTGVEDHMY LAKEESFGPI MVISKFQNGD 

       850        860        870        880        890        900 
IDGVLQRANN TEYGLASGVF TRDINKAMYV SDKLEAGTVF INTYNKTDVA APFGGMKQSG 

       910        920 
FGKDLGEEAL NEYLKIKTVT LEY

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.

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Cross-references

Sequence databases

BC034531 mRNA. Translation: AAH34531.1.
IPIIPI00169472.
RefSeqNP_705771.1.
UniGeneMm.263138

3D structure databases

HSSPHSSP built from PDB template 1S3I based on UniProtKB P28037.
SMRQ8K009. Positions 426-923.
ModBaseSearch...

Proteomic databases

PRIDEQ8K009.

Genome annotation databases

EnsemblENSMUST00000020497; ENSMUSP00000020497; ENSMUSG00000020256; Mus musculus. [Genome view]
GeneID216188.
KEGGmmu:216188.
UCSCuc007gkh.1. mouse.

Organism-specific databases

CTD216188.
MGIMGI:2444680. Aldh1l2.

Phylogenomic databases

HOGENOMQ8K009.
HOVERGENQ8K009.

Enzyme and pathway databases

BRENDA1.5.1.6. 244.

Gene expression databases

ArrayExpressQ8K009.
BgeeQ8K009.
CleanExMM_ALDH1L2.
GenevestigatorQ8K009.

Family and domain databases

InterProIPR011407. 10_FTHF_DH.
IPR009081. Acyl_carrier_prot-like.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR001555. GART_AS.
IPR006162. PPantetheine_attach_site.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
G3DSA:3.10.25.10. Formyl_trans_C. 1 hit.
G3DSA:3.40.50.170. Formyl_transf_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
PIRSFPIRSF036489. 10-FTHFDH. 1 hit.
PROSITEPS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio375062.
SOURCESearch...

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Entry information

Entry nameAL1L2_MOUSE
AccessionPrimary (citable) accession number: Q8K009
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents