Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8K009

- AL1L2_MOUSE

UniProt

Q8K009 - AL1L2_MOUSE

Protein

Mitochondrial 10-formyltetrahydrofolate dehydrogenase

Gene

Aldh1l2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281Proton donorPROSITE-ProRule annotation
    Sitei164 – 1641Essential for catalytic activityBy similarity
    Active sitei694 – 6941By similarity
    Active sitei728 – 7281By similarity

    GO - Molecular functioni

    1. formyltetrahydrofolate dehydrogenase activity Source: UniProtKB-EC
    2. hydroxymethyl-, formyl- and related transferase activity Source: InterPro
    3. methyltransferase activity Source: InterPro
    4. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. 10-formyltetrahydrofolate catabolic process Source: InterPro
    2. biosynthetic process Source: InterPro
    3. one-carbon metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial 10-formyltetrahydrofolate dehydrogenase (EC:1.5.1.6)
    Short name:
    Mitochondrial 10-FTHFDH
    Short name:
    mtFDH
    Alternative name(s):
    Aldehyde dehydrogenase family 1 member L2
    Gene namesi
    Name:Aldh1l2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2444680. Aldh1l2.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 923923Mitochondrial 10-formyltetrahydrofolate dehydrogenasePRO_0000316002Add
    BLAST
    Transit peptidei1 – 1919Mitochondrion; not cleavedBy similarityAdd
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei375 – 3751O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
    Modified residuei681 – 6811N6-succinyllysine1 Publication
    Modified residuei903 – 9031N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphopantetheine, Phosphoprotein

    Proteomic databases

    MaxQBiQ8K009.
    PaxDbiQ8K009.
    PRIDEiQ8K009.

    PTM databases

    PhosphoSiteiQ8K009.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K009.
    BgeeiQ8K009.
    CleanExiMM_ALDH1L2.
    GenevestigatoriQ8K009.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000020497.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K009.
    SMRiQ8K009. Positions 23-923.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini344 – 41370Acyl carrierPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 225203GARTAdd
    BLAST
    Regioni438 – 923486Aldehyde dehydrogenaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the GART family.Curated
    In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.Curated
    Contains 1 acyl carrier domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00740000115528.
    HOGENOMiHOG000006902.
    HOVERGENiHBG051668.
    InParanoidiQ8K009.
    KOiK00289.
    OMAiHIGMSVQ.
    OrthoDBiEOG7MSMN7.
    TreeFamiTF354242.

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    3.10.25.10. 1 hit.
    3.40.309.10. 1 hit.
    3.40.50.170. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR011407. 10_FTHF_DH.
    IPR009081. Acyl_carrier_prot-like.
    IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR001555. GART_AS.
    IPR006162. PPantetheine_attach_site.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036489. 10-FTHFDH. 1 hit.
    SUPFAMiSSF47336. SSF47336. 1 hit.
    SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    SSF53720. SSF53720. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    PS00373. GART. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K009-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWRGSQALR HFSTSRVYFK NKLKLALIGQ SLFGQEVYSQ LLKEGHRVVG    50
    VFTVPDKDGK ADPLALAAEK DGTPVFKFPR WRLKGKTIKE VAEAYQSVGA 100
    ELNVLPFCTQ FIPMDVIDSP KHGSIIYHPS LLPRHRGASA INWTLIMGDK 150
    KAGFSVFWAD DGLDTGPILL QRSCDVKPND TVDSLYNRFL FPEGIKAMVE 200
    AVQLIADGKA PRTPQPEEGA TYEGIQKKEN AEVSWDQPAE GLHNWIRGHD 250
    KVPGAWAEIN GQMVTFYGSS LLTSSVPSGE PLDIRGAKKP GLVTKNGLVL 300
    FGNDGKALMV RNLQFEDGKM IPASQYFSAG ETSVVELTAE ELKVAETIKV 350
    IWARILSNTP VIEDSTDFFK SGASSMDVVR LVEEIRQSCG GLQLQNEDVY 400
    MATKFGDFIQ KVVRRLRGED EEAEMVVDYV SKEVNGMTVK IPYQCFINGQ 450
    FVDAEDGETY ATVNPTDGTT ICRVSYASLA DVDRAVAAAK DAFENGEWGR 500
    MNARDRGRLM YRLADLMEEN QEELATIEAL DSGAVYTLAL KTHIGMSVQT 550
    FRYFAGWCDK IQGSTIPINQ ARPNYNLTFT KKEPLGACAI IIPWNYPLMM 600
    LAWKSAACLA AGNTLVLKPA QVTPLTALKF AELTVKAGFP KGVINIIPGS 650
    GGVAGQRLSQ HPDIRKLGFT GSTSVGKQIM KSCAVSNLKK VSLELGGKSP 700
    LIIFSDCDLE KAVRMGMGAV FFNKGENCIA AGRLFVEEAI HDEFVTRVVE 750
    EIKKMKIGDP LDRSTDHGPQ NHRAHLEKLL QYCETGVQEG ATLVYGGRQV 800
    QRPGFFMEPT VFTGVEDHMY LAKEESFGPI MVISKFQNGD IDGVLQRANN 850
    TEYGLASGVF TRDINKAMYV SDKLEAGTVF INTYNKTDVA APFGGMKQSG 900
    FGKDLGEEAL NEYLKIKTVT LEY 923
    Length:923
    Mass (Da):101,590
    Last modified:July 27, 2011 - v2
    Checksum:i57CB83C38FAFB0D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti476 – 4761Y → H in AAH34531. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC113014 Genomic DNA. No translation available.
    BC034531 mRNA. Translation: AAH34531.1.
    CCDSiCCDS24077.1.
    RefSeqiNP_705771.2. NM_153543.2.
    UniGeneiMm.263138.

    Genome annotation databases

    EnsembliENSMUST00000020497; ENSMUSP00000020497; ENSMUSG00000020256.
    GeneIDi216188.
    KEGGimmu:216188.
    UCSCiuc007gkh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC113014 Genomic DNA. No translation available.
    BC034531 mRNA. Translation: AAH34531.1 .
    CCDSi CCDS24077.1.
    RefSeqi NP_705771.2. NM_153543.2.
    UniGenei Mm.263138.

    3D structure databases

    ProteinModelPortali Q8K009.
    SMRi Q8K009. Positions 23-923.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000020497.

    PTM databases

    PhosphoSitei Q8K009.

    Proteomic databases

    MaxQBi Q8K009.
    PaxDbi Q8K009.
    PRIDEi Q8K009.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020497 ; ENSMUSP00000020497 ; ENSMUSG00000020256 .
    GeneIDi 216188.
    KEGGi mmu:216188.
    UCSCi uc007gkh.2. mouse.

    Organism-specific databases

    CTDi 160428.
    MGIi MGI:2444680. Aldh1l2.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00740000115528.
    HOGENOMi HOG000006902.
    HOVERGENi HBG051668.
    InParanoidi Q8K009.
    KOi K00289.
    OMAi HIGMSVQ.
    OrthoDBi EOG7MSMN7.
    TreeFami TF354242.

    Miscellaneous databases

    NextBioi 375062.
    PROi Q8K009.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K009.
    Bgeei Q8K009.
    CleanExi MM_ALDH1L2.
    Genevestigatori Q8K009.

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    3.10.25.10. 1 hit.
    3.40.309.10. 1 hit.
    3.40.50.170. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR011407. 10_FTHF_DH.
    IPR009081. Acyl_carrier_prot-like.
    IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR001555. GART_AS.
    IPR006162. PPantetheine_attach_site.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036489. 10-FTHFDH. 1 hit.
    SUPFAMi SSF47336. SSF47336. 1 hit.
    SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    SSF53720. SSF53720. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    PS00373. GART. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-681, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiAL1L2_MOUSE
    AccessioniPrimary (citable) accession number: Q8K009
    Secondary accession number(s): E9QLV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3