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Q8K009

- AL1L2_MOUSE

UniProt

Q8K009 - AL1L2_MOUSE

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Protein

Mitochondrial 10-formyltetrahydrofolate dehydrogenase

Gene

Aldh1l2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281Proton donorPROSITE-ProRule annotation
Sitei164 – 1641Essential for catalytic activityBy similarity
Active sitei694 – 6941By similarity
Active sitei728 – 7281By similarity

GO - Molecular functioni

  1. formyltetrahydrofolate dehydrogenase activity Source: UniProtKB-EC
  2. hydroxymethyl-, formyl- and related transferase activity Source: InterPro
  3. methyltransferase activity Source: InterPro
  4. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro

GO - Biological processi

  1. 10-formyltetrahydrofolate catabolic process Source: InterPro
  2. biosynthetic process Source: InterPro
  3. one-carbon metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (EC:1.5.1.6)
Short name:
Mitochondrial 10-FTHFDH
Short name:
mtFDH
Alternative name(s):
Aldehyde dehydrogenase family 1 member L2
Gene namesi
Name:Aldh1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2444680. Aldh1l2.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 923923Mitochondrial 10-formyltetrahydrofolate dehydrogenasePRO_0000316002Add
BLAST
Transit peptidei1 – 1919Mitochondrion; not cleavedBy similarityAdd
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei375 – 3751O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei681 – 6811N6-succinyllysine1 Publication
Modified residuei903 – 9031N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiQ8K009.
PaxDbiQ8K009.
PRIDEiQ8K009.

PTM databases

PhosphoSiteiQ8K009.

Expressioni

Gene expression databases

BgeeiQ8K009.
CleanExiMM_ALDH1L2.
ExpressionAtlasiQ8K009. baseline and differential.
GenevestigatoriQ8K009.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020497.

Structurei

3D structure databases

ProteinModelPortaliQ8K009.
SMRiQ8K009. Positions 23-923.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini344 – 41370Acyl carrierPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 225203GARTAdd
BLAST
Regioni438 – 923486Aldehyde dehydrogenaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the GART family.Curated
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.Curated
Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000006902.
HOVERGENiHBG051668.
InParanoidiQ8K009.
KOiK00289.
OMAiHIGMSVQ.
OrthoDBiEOG7MSMN7.
TreeFamiTF354242.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.10.25.10. 1 hit.
3.40.309.10. 1 hit.
3.40.50.170. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR011407. 10_FTHF_DH.
IPR009081. Acyl_carrier_prot-like.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR006162. PPantetheine_attach_site.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF036489. 10-FTHFDH. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF53720. SSF53720. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K009-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWRGSQALR HFSTSRVYFK NKLKLALIGQ SLFGQEVYSQ LLKEGHRVVG
60 70 80 90 100
VFTVPDKDGK ADPLALAAEK DGTPVFKFPR WRLKGKTIKE VAEAYQSVGA
110 120 130 140 150
ELNVLPFCTQ FIPMDVIDSP KHGSIIYHPS LLPRHRGASA INWTLIMGDK
160 170 180 190 200
KAGFSVFWAD DGLDTGPILL QRSCDVKPND TVDSLYNRFL FPEGIKAMVE
210 220 230 240 250
AVQLIADGKA PRTPQPEEGA TYEGIQKKEN AEVSWDQPAE GLHNWIRGHD
260 270 280 290 300
KVPGAWAEIN GQMVTFYGSS LLTSSVPSGE PLDIRGAKKP GLVTKNGLVL
310 320 330 340 350
FGNDGKALMV RNLQFEDGKM IPASQYFSAG ETSVVELTAE ELKVAETIKV
360 370 380 390 400
IWARILSNTP VIEDSTDFFK SGASSMDVVR LVEEIRQSCG GLQLQNEDVY
410 420 430 440 450
MATKFGDFIQ KVVRRLRGED EEAEMVVDYV SKEVNGMTVK IPYQCFINGQ
460 470 480 490 500
FVDAEDGETY ATVNPTDGTT ICRVSYASLA DVDRAVAAAK DAFENGEWGR
510 520 530 540 550
MNARDRGRLM YRLADLMEEN QEELATIEAL DSGAVYTLAL KTHIGMSVQT
560 570 580 590 600
FRYFAGWCDK IQGSTIPINQ ARPNYNLTFT KKEPLGACAI IIPWNYPLMM
610 620 630 640 650
LAWKSAACLA AGNTLVLKPA QVTPLTALKF AELTVKAGFP KGVINIIPGS
660 670 680 690 700
GGVAGQRLSQ HPDIRKLGFT GSTSVGKQIM KSCAVSNLKK VSLELGGKSP
710 720 730 740 750
LIIFSDCDLE KAVRMGMGAV FFNKGENCIA AGRLFVEEAI HDEFVTRVVE
760 770 780 790 800
EIKKMKIGDP LDRSTDHGPQ NHRAHLEKLL QYCETGVQEG ATLVYGGRQV
810 820 830 840 850
QRPGFFMEPT VFTGVEDHMY LAKEESFGPI MVISKFQNGD IDGVLQRANN
860 870 880 890 900
TEYGLASGVF TRDINKAMYV SDKLEAGTVF INTYNKTDVA APFGGMKQSG
910 920
FGKDLGEEAL NEYLKIKTVT LEY
Length:923
Mass (Da):101,590
Last modified:July 27, 2011 - v2
Checksum:i57CB83C38FAFB0D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti476 – 4761Y → H in AAH34531. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113014 Genomic DNA. No translation available.
BC034531 mRNA. Translation: AAH34531.1.
CCDSiCCDS24077.1.
RefSeqiNP_705771.2. NM_153543.2.
UniGeneiMm.263138.

Genome annotation databases

EnsembliENSMUST00000020497; ENSMUSP00000020497; ENSMUSG00000020256.
GeneIDi216188.
KEGGimmu:216188.
UCSCiuc007gkh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113014 Genomic DNA. No translation available.
BC034531 mRNA. Translation: AAH34531.1 .
CCDSi CCDS24077.1.
RefSeqi NP_705771.2. NM_153543.2.
UniGenei Mm.263138.

3D structure databases

ProteinModelPortali Q8K009.
SMRi Q8K009. Positions 23-923.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000020497.

PTM databases

PhosphoSitei Q8K009.

Proteomic databases

MaxQBi Q8K009.
PaxDbi Q8K009.
PRIDEi Q8K009.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020497 ; ENSMUSP00000020497 ; ENSMUSG00000020256 .
GeneIDi 216188.
KEGGi mmu:216188.
UCSCi uc007gkh.2. mouse.

Organism-specific databases

CTDi 160428.
MGIi MGI:2444680. Aldh1l2.

Phylogenomic databases

eggNOGi COG1012.
GeneTreei ENSGT00760000118999.
HOGENOMi HOG000006902.
HOVERGENi HBG051668.
InParanoidi Q8K009.
KOi K00289.
OMAi HIGMSVQ.
OrthoDBi EOG7MSMN7.
TreeFami TF354242.

Miscellaneous databases

ChiTaRSi Aldh1l2. mouse.
NextBioi 375062.
PROi Q8K009.
SOURCEi Search...

Gene expression databases

Bgeei Q8K009.
CleanExi MM_ALDH1L2.
ExpressionAtlasi Q8K009. baseline and differential.
Genevestigatori Q8K009.

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.10.25.10. 1 hit.
3.40.309.10. 1 hit.
3.40.50.170. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR011407. 10_FTHF_DH.
IPR009081. Acyl_carrier_prot-like.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR006162. PPantetheine_attach_site.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF036489. 10-FTHFDH. 1 hit.
SUPFAMi SSF47336. SSF47336. 1 hit.
SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF53720. SSF53720. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-681, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiAL1L2_MOUSE
AccessioniPrimary (citable) accession number: Q8K009
Secondary accession number(s): E9QLV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3