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Protein

Mitochondrial 10-formyltetrahydrofolate dehydrogenase

Gene

Aldh1l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128Proton donorPROSITE-ProRule annotation1
Sitei164Essential for catalytic activityBy similarity1
Active sitei694By similarity1
Active sitei728By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-MMU-196757. Metabolism of folate and pterines.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (EC:1.5.1.6)
Short name:
Mitochondrial 10-FTHFDH
Short name:
mtFDH
Alternative name(s):
Aldehyde dehydrogenase family 1 member L2
Gene namesi
Name:Aldh1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2444680. Aldh1l2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003160021 – 923Mitochondrial 10-formyltetrahydrofolate dehydrogenaseAdd BLAST923
Transit peptidei1 – 19Mitochondrion; not cleavedBy similarityAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei375O-(pantetheine 4'-phosphoryl)serine; alternatePROSITE-ProRule annotation1
Modified residuei375Phosphoserine; alternateCombined sources1
Modified residuei681N6-succinyllysineCombined sources1
Modified residuei903N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiQ8K009.
PaxDbiQ8K009.
PeptideAtlasiQ8K009.
PRIDEiQ8K009.

PTM databases

iPTMnetiQ8K009.
PhosphoSitePlusiQ8K009.
SwissPalmiQ8K009.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020256.
CleanExiMM_ALDH1L2.
ExpressionAtlasiQ8K009. baseline and differential.
GenevisibleiQ8K009. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020497.

Structurei

3D structure databases

ProteinModelPortaliQ8K009.
SMRiQ8K009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini344 – 413Acyl carrierPROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 225GARTAdd BLAST203
Regioni438 – 923Aldehyde dehydrogenaseAdd BLAST486

Sequence similaritiesi

In the N-terminal section; belongs to the GART family.Curated
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.Curated
Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000006902.
HOVERGENiHBG051668.
InParanoidiQ8K009.
KOiK00289.
OMAiPNHNLTF.
OrthoDBiEOG091G05E8.
TreeFamiTF354242.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.10.25.10. 1 hit.
3.40.309.10. 1 hit.
3.40.50.170. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR011407. 10_FTHF_DH.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF036489. 10-FTHFDH. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF53720. SSF53720. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWRGSQALR HFSTSRVYFK NKLKLALIGQ SLFGQEVYSQ LLKEGHRVVG
60 70 80 90 100
VFTVPDKDGK ADPLALAAEK DGTPVFKFPR WRLKGKTIKE VAEAYQSVGA
110 120 130 140 150
ELNVLPFCTQ FIPMDVIDSP KHGSIIYHPS LLPRHRGASA INWTLIMGDK
160 170 180 190 200
KAGFSVFWAD DGLDTGPILL QRSCDVKPND TVDSLYNRFL FPEGIKAMVE
210 220 230 240 250
AVQLIADGKA PRTPQPEEGA TYEGIQKKEN AEVSWDQPAE GLHNWIRGHD
260 270 280 290 300
KVPGAWAEIN GQMVTFYGSS LLTSSVPSGE PLDIRGAKKP GLVTKNGLVL
310 320 330 340 350
FGNDGKALMV RNLQFEDGKM IPASQYFSAG ETSVVELTAE ELKVAETIKV
360 370 380 390 400
IWARILSNTP VIEDSTDFFK SGASSMDVVR LVEEIRQSCG GLQLQNEDVY
410 420 430 440 450
MATKFGDFIQ KVVRRLRGED EEAEMVVDYV SKEVNGMTVK IPYQCFINGQ
460 470 480 490 500
FVDAEDGETY ATVNPTDGTT ICRVSYASLA DVDRAVAAAK DAFENGEWGR
510 520 530 540 550
MNARDRGRLM YRLADLMEEN QEELATIEAL DSGAVYTLAL KTHIGMSVQT
560 570 580 590 600
FRYFAGWCDK IQGSTIPINQ ARPNYNLTFT KKEPLGACAI IIPWNYPLMM
610 620 630 640 650
LAWKSAACLA AGNTLVLKPA QVTPLTALKF AELTVKAGFP KGVINIIPGS
660 670 680 690 700
GGVAGQRLSQ HPDIRKLGFT GSTSVGKQIM KSCAVSNLKK VSLELGGKSP
710 720 730 740 750
LIIFSDCDLE KAVRMGMGAV FFNKGENCIA AGRLFVEEAI HDEFVTRVVE
760 770 780 790 800
EIKKMKIGDP LDRSTDHGPQ NHRAHLEKLL QYCETGVQEG ATLVYGGRQV
810 820 830 840 850
QRPGFFMEPT VFTGVEDHMY LAKEESFGPI MVISKFQNGD IDGVLQRANN
860 870 880 890 900
TEYGLASGVF TRDINKAMYV SDKLEAGTVF INTYNKTDVA APFGGMKQSG
910 920
FGKDLGEEAL NEYLKIKTVT LEY
Length:923
Mass (Da):101,590
Last modified:July 27, 2011 - v2
Checksum:i57CB83C38FAFB0D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti476Y → H in AAH34531 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113014 Genomic DNA. No translation available.
BC034531 mRNA. Translation: AAH34531.1.
CCDSiCCDS24077.1.
RefSeqiNP_705771.2. NM_153543.2.
UniGeneiMm.263138.

Genome annotation databases

EnsembliENSMUST00000020497; ENSMUSP00000020497; ENSMUSG00000020256.
GeneIDi216188.
KEGGimmu:216188.
UCSCiuc007gkh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113014 Genomic DNA. No translation available.
BC034531 mRNA. Translation: AAH34531.1.
CCDSiCCDS24077.1.
RefSeqiNP_705771.2. NM_153543.2.
UniGeneiMm.263138.

3D structure databases

ProteinModelPortaliQ8K009.
SMRiQ8K009.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020497.

PTM databases

iPTMnetiQ8K009.
PhosphoSitePlusiQ8K009.
SwissPalmiQ8K009.

Proteomic databases

MaxQBiQ8K009.
PaxDbiQ8K009.
PeptideAtlasiQ8K009.
PRIDEiQ8K009.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020497; ENSMUSP00000020497; ENSMUSG00000020256.
GeneIDi216188.
KEGGimmu:216188.
UCSCiuc007gkh.2. mouse.

Organism-specific databases

CTDi160428.
MGIiMGI:2444680. Aldh1l2.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000006902.
HOVERGENiHBG051668.
InParanoidiQ8K009.
KOiK00289.
OMAiPNHNLTF.
OrthoDBiEOG091G05E8.
TreeFamiTF354242.

Enzyme and pathway databases

ReactomeiR-MMU-196757. Metabolism of folate and pterines.

Miscellaneous databases

ChiTaRSiAldh1l2. mouse.
PROiQ8K009.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020256.
CleanExiMM_ALDH1L2.
ExpressionAtlasiQ8K009. baseline and differential.
GenevisibleiQ8K009. MM.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.10.25.10. 1 hit.
3.40.309.10. 1 hit.
3.40.50.170. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR011407. 10_FTHF_DH.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF036489. 10-FTHFDH. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
SSF53720. SSF53720. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL1L2_MOUSE
AccessioniPrimary (citable) accession number: Q8K009
Secondary accession number(s): E9QLV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.