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Q8K007

- SULF1_MOUSE

UniProt

Q8K007 - SULF1_MOUSE

Protein

Extracellular sulfatase Sulf-1

Gene

Sulf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation By similarity.By similarity

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi51 – 511CalciumBy similarity
    Metal bindingi52 – 521CalciumBy similarity
    Metal bindingi87 – 871Calcium; via 3-oxoalanineBy similarity
    Metal bindingi316 – 3161CalciumBy similarity
    Metal bindingi317 – 3171CalciumBy similarity

    GO - Molecular functioni

    1. arylsulfatase activity Source: UniProtKB
    2. calcium ion binding Source: InterPro
    3. N-acetylglucosamine-6-sulfatase activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. bone development Source: BHF-UCL
    3. cartilage condensation Source: UniProtKB
    4. cartilage development Source: UniProtKB
    5. cell adhesion Source: UniProtKB
    6. chondrocyte development Source: UniProtKB
    7. embryonic skeletal system development Source: UniProtKB
    8. esophagus smooth muscle contraction Source: UniProtKB
    9. glial cell-derived neurotrophic factor receptor signaling pathway Source: UniProtKB
    10. glomerular basement membrane development Source: UniProtKB
    11. glomerular filtration Source: UniProtKB
    12. heparan sulfate proteoglycan metabolic process Source: UniProtKB
    13. innervation Source: UniProtKB
    14. kidney development Source: BHF-UCL
    15. limb joint morphogenesis Source: UniProtKB
    16. negative regulation of angiogenesis Source: UniProtKB
    17. negative regulation of cell migration Source: UniProtKB
    18. negative regulation of endothelial cell proliferation Source: UniProtKB
    19. negative regulation of fibroblast growth factor receptor signaling pathway Source: UniProtKB
    20. negative regulation of prostatic bud formation Source: UniProtKB
    21. positive regulation of BMP signaling pathway Source: UniProtKB
    22. positive regulation of smooth muscle cell proliferation Source: UniProtKB
    23. positive regulation of Wnt signaling pathway Source: UniProtKB
    24. positive regulation vascular endothelial growth factor production Source: UniProtKB
    25. sulfur compound metabolic process Source: MGI
    26. vascular endothelial growth factor receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Extracellular sulfatase Sulf-1 (EC:3.1.6.-)
    Short name:
    mSulf-1
    Gene namesi
    Name:Sulf1
    Synonyms:Kiaa1077
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2138563. Sulf1.

    Subcellular locationi

    Endoplasmic reticulum By similarity. Golgi apparatusGolgi stack By similarity. Cell surface By similarity
    Note: Also localized on the cell surface.By similarity

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. endoplasmic reticulum Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. Golgi apparatus Source: UniProtKB
    5. Golgi stack Source: UniProtKB-SubCell
    6. membrane raft Source: UniProtKB
    7. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 870848Extracellular sulfatase Sulf-1PRO_0000033435Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Modified residuei87 – 8713-oxoalanine (Cys)By similarity
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi772 – 7721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi782 – 7821N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8K007.
    PRIDEiQ8K007.

    PTM databases

    PhosphoSiteiQ8K007.

    Expressioni

    Gene expression databases

    BgeeiQ8K007.
    CleanExiMM_SULF1.
    GenevestigatoriQ8K007.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K007.
    SMRiQ8K007. Positions 34-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sulfatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3119.
    GeneTreeiENSGT00400000022041.
    HOGENOMiHOG000290161.
    HOVERGENiHBG056431.
    KOiK14607.
    OMAiKPDECDC.
    OrthoDBiEOG7FR7H6.
    PhylomeDBiQ8K007.
    TreeFamiTF313545.

    Family and domain databases

    Gene3Di3.40.720.10. 3 hits.
    InterProiIPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR014615. Extracellular_sulfatase.
    IPR024609. Extracellular_sulfatase_C.
    IPR000917. Sulfatase.
    IPR024607. Sulfatase_CS.
    [Graphical view]
    PfamiPF12548. DUF3740. 1 hit.
    PF00884. Sulfatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036665. Sulf1. 1 hit.
    SUPFAMiSSF53649. SSF53649. 3 hits.
    PROSITEiPS00523. SULFATASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K007-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYSLWALLL AVLGTQLLGS LCSTVRSQRF RGRIQQERKN IRPNIILVLT    50
    DDQDVELGSL QVMNKTRKIM EQGGATFTNA FVTTPMCCPS RSSMLTGKYV 100
    HNHNVYTNNE NCSSPSWQAM HEPRTFAVYL NNTGYRTAFF GKYLNEYNGS 150
    YIPPGWREWL GLIKNSRFYN YTVCRNGIKE KHGFDYAKDY FTDLITNESI 200
    NYFKMSKRMY PHRPIMMVIS HAAPHGPEDS APQFSKLYPN ASQHITPSYN 250
    YAPNMDKHWI MQYTGPMLPI HMEFTNVLQR KRLQTLMSVD DSVERLYNML 300
    VESGELDNTY IIYTADHGYH IGQFGLVKGK SMPYDFDIRV PFFIRGPSIE 350
    PGSIVPQIVL NIDLAPTILD IAGLDSPSDV DGKSVLKLLD LEKPGNRFRT 400
    NKKAKIWRDT FLVERGKFLR KKEESGKNIQ QSNHLPKYER VKELCQQARY 450
    QTACEQPGQN WQCIEDTSGK LRIHKCKGPS DLLTVRQNAR NLYSRGLHDK 500
    DKECHCRDSG YRSSRSQRKN QRQFLRNKGT PKYKPRFVHT RQTRSLSVEF 550
    EGEIYDINLE EEELQVLPPR SIAKRHDEGH QGFIGHQAAA GDIRNEMLAD 600
    SNNAVGLPAT VRVTHKCFIL PNDTIHCERE LYQSARAWKD HKAYIDKEIE 650
    VLQDKIKNLR EVRGHLKKRK PEECGCGDQS YYNKEKGVKR QEKLKSHLHP 700
    FKEAAAQEVD SKLQLFKEHR RRKKERKEKK RQRKGEECSL PGLTCFTHDN 750
    NHWQTAPFWN LGSFCACTSS NNNTYWCLRT VNETHNFLFC EFATGFLEYF 800
    DMNTDPYQLT NTVHTVERSI LNQLHIQLME LRSCQGYKQC NPRPKSLDIG 850
    AKEGGNYDPH RGQLWDGWEG 870
    Length:870
    Mass (Da):100,923
    Last modified:October 1, 2002 - v1
    Checksum:i4A9BE710D7CF4F9D
    GO

    Sequence cautioni

    The sequence BAC32179.1 differs from that shown. Reason: Intron retention.
    The sequence BAC98088.1 differs from that shown. Reason: Intron retention. The sequence is a pre-RNA and intronic sequences remain.
    The sequence BAC98088.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti486 – 4861R → H in BAC25858. (PubMed:14621295)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY101178 mRNA. Translation: AAM76863.1.
    AK129278 Transcribed RNA. Translation: BAC98088.1. Sequence problems.
    AK028285 mRNA. Translation: BAC25858.1.
    AK045002 mRNA. Translation: BAC32179.1. Sequence problems.
    BC034547 mRNA. Translation: AAH34547.1.
    BC049276 mRNA. Translation: AAH49276.1.
    CCDSiCCDS14820.1.
    RefSeqiNP_001185494.1. NM_001198565.1.
    NP_001185495.1. NM_001198566.1.
    NP_758498.1. NM_172294.1.
    UniGeneiMm.45563.

    Genome annotation databases

    EnsembliENSMUST00000088585; ENSMUSP00000085949; ENSMUSG00000016918.
    ENSMUST00000177608; ENSMUSP00000137523; ENSMUSG00000016918.
    ENSMUST00000180062; ENSMUSP00000136014; ENSMUSG00000016918.
    GeneIDi240725.
    KEGGimmu:240725.
    UCSCiuc007aia.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY101178 mRNA. Translation: AAM76863.1 .
    AK129278 Transcribed RNA. Translation: BAC98088.1 . Sequence problems.
    AK028285 mRNA. Translation: BAC25858.1 .
    AK045002 mRNA. Translation: BAC32179.1 . Sequence problems.
    BC034547 mRNA. Translation: AAH34547.1 .
    BC049276 mRNA. Translation: AAH49276.1 .
    CCDSi CCDS14820.1.
    RefSeqi NP_001185494.1. NM_001198565.1.
    NP_001185495.1. NM_001198566.1.
    NP_758498.1. NM_172294.1.
    UniGenei Mm.45563.

    3D structure databases

    ProteinModelPortali Q8K007.
    SMRi Q8K007. Positions 34-411.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K007.

    Proteomic databases

    PaxDbi Q8K007.
    PRIDEi Q8K007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000088585 ; ENSMUSP00000085949 ; ENSMUSG00000016918 .
    ENSMUST00000177608 ; ENSMUSP00000137523 ; ENSMUSG00000016918 .
    ENSMUST00000180062 ; ENSMUSP00000136014 ; ENSMUSG00000016918 .
    GeneIDi 240725.
    KEGGi mmu:240725.
    UCSCi uc007aia.2. mouse.

    Organism-specific databases

    CTDi 23213.
    MGIi MGI:2138563. Sulf1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG3119.
    GeneTreei ENSGT00400000022041.
    HOGENOMi HOG000290161.
    HOVERGENi HBG056431.
    KOi K14607.
    OMAi KPDECDC.
    OrthoDBi EOG7FR7H6.
    PhylomeDBi Q8K007.
    TreeFami TF313545.

    Miscellaneous databases

    ChiTaRSi SULF1. mouse.
    NextBioi 384701.
    PROi Q8K007.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K007.
    CleanExi MM_SULF1.
    Genevestigatori Q8K007.

    Family and domain databases

    Gene3Di 3.40.720.10. 3 hits.
    InterProi IPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR014615. Extracellular_sulfatase.
    IPR024609. Extracellular_sulfatase_C.
    IPR000917. Sulfatase.
    IPR024607. Sulfatase_CS.
    [Graphical view ]
    Pfami PF12548. DUF3740. 1 hit.
    PF00884. Sulfatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036665. Sulf1. 1 hit.
    SUPFAMi SSF53649. SSF53649. 3 hits.
    PROSITEi PS00523. SULFATASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans."
      Morimoto-Tomita M., Uchimura K., Werb Z., Hemmerich S., Rosen S.D.
      J. Biol. Chem. 277:49175-49185(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryonic tail.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Head.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo, Eye and Retina.

    Entry informationi

    Entry nameiSULF1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K007
    Secondary accession number(s): Q6ZPZ0, Q8BLJ0, Q8C1D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3