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Q8JZZ0

- UD3A2_MOUSE

UniProt

Q8JZZ0 - UD3A2_MOUSE

Protein

UDP-glucuronosyltransferase 3A2

Gene

Ugt3a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.By similarity

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC
    2. UDP-glycosyltransferase activity Source: MGI

    GO - Biological processi

    1. cellular response to genistein Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 3A2 (EC:2.4.1.17)
    Short name:
    UDPGT 3A2
    Gene namesi
    Name:Ugt3a2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2145969. Ugt3a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 523501UDP-glucuronosyltransferase 3A2PRO_0000299154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8JZZ0.
    PaxDbiQ8JZZ0.
    PRIDEiQ8JZZ0.

    PTM databases

    PhosphoSiteiQ8JZZ0.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney, while it is expressed at low levels in liver. Not detected in other tissues examined.1 Publication

    Gene expression databases

    BgeeiQ8JZZ0.
    CleanExiMM_UGT3A2.
    GenevestigatoriQ8JZZ0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8JZZ0. 2 interactions.
    MINTiMINT-4116696.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JZZ0.
    SMRiQ8JZZ0. Positions 230-462.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 487465ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini509 – 52315CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei488 – 50821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    GeneTreeiENSGT00560000076760.
    HOGENOMiHOG000220831.
    HOVERGENiHBG106370.
    InParanoidiQ8JZZ0.
    OMAiYESANIP.
    OrthoDBiEOG7GBFWS.
    PhylomeDBiQ8JZZ0.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8JZZ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAHRRWLLM SFLFLEVILL EAAKILTIST LSASHYIVIS RVSQVLHEGG    50
    HNVTKLLYES ANIPDFRKEK PSYQVINWRP PEDQEKKFAD LRHRLTEEIT 100
    YGRSKHHTLL KIHQYFGDLC SQLLSRKDIM DFLKNENFDL VLLDSMDLCS 150
    LLIVEKLGKR FVSFLPFQFS YMDFGLPSAP LSYAPVYGSG LTDQMDFWGR 200
    VKNFLMFLDF SMKQREILSQ YDSTIQEHFV EGSQPVLSDL LLKAELWFVN 250
    SDFALDFARP LFPNTVYVGG LLDKPVQPIP QDLENFISQF GDSGFVLVAL 300
    GSIVSMIQSK EIIKEMNSAF AHLPQGVLWT CKTSHWPKDV SLAPNVKIMD 350
    WLPQTDLLAH PSIRLFVTHG GMNSVMEAVH HGVPMVGIPF FFDQPENMVR 400
    VEAKNLGVSI QLQTLKAESF ALTMKKIIED KRYKSAAMAS KIIRHSHPLT 450
    PAQRLLGWID HILQTGGAAH LKPYAFQQPW HEQYMLDVFL FLLGLMLGTL 500
    WLSVKVLVAV TRYLSIATKV KEA 523
    Length:523
    Mass (Da):59,673
    Last modified:August 21, 2007 - v2
    Checksum:iBC7BD6ADF197ADD9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti121 – 1211S → G in BAE25548. (PubMed:16141072)Curated
    Sequence conflicti344 – 3441P → S in AAH34837. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050128 mRNA. Translation: BAC34080.1.
    AK143815 mRNA. Translation: BAE25548.1.
    BC022134 mRNA. Translation: AAH22134.1.
    BC024453 mRNA. Translation: AAH24453.1.
    BC034837 mRNA. Translation: AAH34837.1.
    CCDSiCCDS27375.1.
    RefSeqiNP_659094.1. NM_144845.3.
    UniGeneiMm.422853.

    Genome annotation databases

    EnsembliENSMUST00000072403; ENSMUSP00000072236; ENSMUSG00000049152.
    GeneIDi223337.
    KEGGimmu:223337.
    UCSCiuc007vfl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050128 mRNA. Translation: BAC34080.1 .
    AK143815 mRNA. Translation: BAE25548.1 .
    BC022134 mRNA. Translation: AAH22134.1 .
    BC024453 mRNA. Translation: AAH24453.1 .
    BC034837 mRNA. Translation: AAH34837.1 .
    CCDSi CCDS27375.1.
    RefSeqi NP_659094.1. NM_144845.3.
    UniGenei Mm.422853.

    3D structure databases

    ProteinModelPortali Q8JZZ0.
    SMRi Q8JZZ0. Positions 230-462.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8JZZ0. 2 interactions.
    MINTi MINT-4116696.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei Q8JZZ0.

    Proteomic databases

    MaxQBi Q8JZZ0.
    PaxDbi Q8JZZ0.
    PRIDEi Q8JZZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072403 ; ENSMUSP00000072236 ; ENSMUSG00000049152 .
    GeneIDi 223337.
    KEGGi mmu:223337.
    UCSCi uc007vfl.1. mouse.

    Organism-specific databases

    CTDi 167127.
    MGIi MGI:2145969. Ugt3a2.

    Phylogenomic databases

    eggNOGi COG1819.
    GeneTreei ENSGT00560000076760.
    HOGENOMi HOG000220831.
    HOVERGENi HBG106370.
    InParanoidi Q8JZZ0.
    OMAi YESANIP.
    OrthoDBi EOG7GBFWS.
    PhylomeDBi Q8JZZ0.
    TreeFami TF315472.

    Miscellaneous databases

    NextBioi 376697.
    PROi Q8JZZ0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8JZZ0.
    CleanExi MM_UGT3A2.
    Genevestigatori Q8JZZ0.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver and Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney and Liver.
    3. "Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice."
      Buckley D.B., Klaassen C.D.
      Drug Metab. Dispos. 35:121-127(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiUD3A2_MOUSE
    AccessioniPrimary (citable) accession number: Q8JZZ0
    Secondary accession number(s): A1A4B4, Q3UP49, Q8VC11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3