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Protein

UDP-glucuronosyltransferase 3A2

Gene

Ugt3a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: GO_Central
  • UDP-glycosyltransferase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156588 Glucuronidation

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A2 (EC:2.4.1.17)
Short name:
UDPGT 3A2
Gene namesi
Name:Ugt3a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2145969 Ugt3a2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 487ExtracellularSequence analysisAdd BLAST465
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 523CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029915423 – 523UDP-glucuronosyltransferase 3A2Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8JZZ0
PaxDbiQ8JZZ0
PeptideAtlasiQ8JZZ0
PRIDEiQ8JZZ0

PTM databases

iPTMnetiQ8JZZ0
PhosphoSitePlusiQ8JZZ0

Expressioni

Tissue specificityi

Highly expressed in kidney, while it is expressed at low levels in liver. Not detected in other tissues examined.1 Publication

Gene expression databases

BgeeiENSMUSG00000049152
CleanExiMM_UGT3A2
GenevisibleiQ8JZZ0 MM

Interactioni

Protein-protein interaction databases

IntActiQ8JZZ0, 2 interactors
MINTiQ8JZZ0
STRINGi10090.ENSMUSP00000072236

Structurei

3D structure databases

ProteinModelPortaliQ8JZZ0
SMRiQ8JZZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG106370
InParanoidiQ8JZZ0
OMAiWHEQYLI
OrthoDBiEOG091G06JC
PhylomeDBiQ8JZZ0
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHRRWLLM SFLFLEVILL EAAKILTIST LSASHYIVIS RVSQVLHEGG
60 70 80 90 100
HNVTKLLYES ANIPDFRKEK PSYQVINWRP PEDQEKKFAD LRHRLTEEIT
110 120 130 140 150
YGRSKHHTLL KIHQYFGDLC SQLLSRKDIM DFLKNENFDL VLLDSMDLCS
160 170 180 190 200
LLIVEKLGKR FVSFLPFQFS YMDFGLPSAP LSYAPVYGSG LTDQMDFWGR
210 220 230 240 250
VKNFLMFLDF SMKQREILSQ YDSTIQEHFV EGSQPVLSDL LLKAELWFVN
260 270 280 290 300
SDFALDFARP LFPNTVYVGG LLDKPVQPIP QDLENFISQF GDSGFVLVAL
310 320 330 340 350
GSIVSMIQSK EIIKEMNSAF AHLPQGVLWT CKTSHWPKDV SLAPNVKIMD
360 370 380 390 400
WLPQTDLLAH PSIRLFVTHG GMNSVMEAVH HGVPMVGIPF FFDQPENMVR
410 420 430 440 450
VEAKNLGVSI QLQTLKAESF ALTMKKIIED KRYKSAAMAS KIIRHSHPLT
460 470 480 490 500
PAQRLLGWID HILQTGGAAH LKPYAFQQPW HEQYMLDVFL FLLGLMLGTL
510 520
WLSVKVLVAV TRYLSIATKV KEA
Length:523
Mass (Da):59,673
Last modified:August 21, 2007 - v2
Checksum:iBC7BD6ADF197ADD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121S → G in BAE25548 (PubMed:16141072).Curated1
Sequence conflicti344P → S in AAH34837 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050128 mRNA Translation: BAC34080.1
AK143815 mRNA Translation: BAE25548.1
BC022134 mRNA Translation: AAH22134.1
BC024453 mRNA Translation: AAH24453.1
BC034837 mRNA Translation: AAH34837.1
CCDSiCCDS27375.1
RefSeqiNP_659094.1, NM_144845.3
UniGeneiMm.422853

Genome annotation databases

EnsembliENSMUST00000072403; ENSMUSP00000072236; ENSMUSG00000049152
GeneIDi223337
KEGGimmu:223337
UCSCiuc007vfl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiUD3A2_MOUSE
AccessioniPrimary (citable) accession number: Q8JZZ0
Secondary accession number(s): A1A4B4, Q3UP49, Q8VC11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 20, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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