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Q8JZZ0

- UD3A2_MOUSE

UniProt

Q8JZZ0 - UD3A2_MOUSE

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Protein
UDP-glucuronosyltransferase 3A2
Gene
Ugt3a2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds By similarity.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. UDP-glycosyltransferase activity Source: MGI
  2. glucuronosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular response to genistein Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A2 (EC:2.4.1.17)
Short name:
UDPGT 3A2
Gene namesi
Name:Ugt3a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2145969. Ugt3a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 487465Extracellular Reviewed prediction
Add
BLAST
Transmembranei488 – 50821Helical; Reviewed prediction
Add
BLAST
Topological domaini509 – 52315Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 523501UDP-glucuronosyltransferase 3A2
PRO_0000299154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8JZZ0.
PaxDbiQ8JZZ0.
PRIDEiQ8JZZ0.

PTM databases

PhosphoSiteiQ8JZZ0.

Expressioni

Tissue specificityi

Highly expressed in kidney, while it is expressed at low levels in liver. Not detected in other tissues examined.1 Publication

Gene expression databases

BgeeiQ8JZZ0.
CleanExiMM_UGT3A2.
GenevestigatoriQ8JZZ0.

Interactioni

Protein-protein interaction databases

IntActiQ8JZZ0. 2 interactions.
MINTiMINT-4116696.

Structurei

3D structure databases

ProteinModelPortaliQ8JZZ0.
SMRiQ8JZZ0. Positions 230-462.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00560000076760.
HOGENOMiHOG000220831.
HOVERGENiHBG106370.
InParanoidiQ8JZZ0.
OMAiYESANIP.
OrthoDBiEOG7GBFWS.
PhylomeDBiQ8JZZ0.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZZ0-1 [UniParc]FASTAAdd to Basket

« Hide

MAAHRRWLLM SFLFLEVILL EAAKILTIST LSASHYIVIS RVSQVLHEGG    50
HNVTKLLYES ANIPDFRKEK PSYQVINWRP PEDQEKKFAD LRHRLTEEIT 100
YGRSKHHTLL KIHQYFGDLC SQLLSRKDIM DFLKNENFDL VLLDSMDLCS 150
LLIVEKLGKR FVSFLPFQFS YMDFGLPSAP LSYAPVYGSG LTDQMDFWGR 200
VKNFLMFLDF SMKQREILSQ YDSTIQEHFV EGSQPVLSDL LLKAELWFVN 250
SDFALDFARP LFPNTVYVGG LLDKPVQPIP QDLENFISQF GDSGFVLVAL 300
GSIVSMIQSK EIIKEMNSAF AHLPQGVLWT CKTSHWPKDV SLAPNVKIMD 350
WLPQTDLLAH PSIRLFVTHG GMNSVMEAVH HGVPMVGIPF FFDQPENMVR 400
VEAKNLGVSI QLQTLKAESF ALTMKKIIED KRYKSAAMAS KIIRHSHPLT 450
PAQRLLGWID HILQTGGAAH LKPYAFQQPW HEQYMLDVFL FLLGLMLGTL 500
WLSVKVLVAV TRYLSIATKV KEA 523
Length:523
Mass (Da):59,673
Last modified:August 21, 2007 - v2
Checksum:iBC7BD6ADF197ADD9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211S → G in BAE25548. 1 Publication
Sequence conflicti344 – 3441P → S in AAH34837. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050128 mRNA. Translation: BAC34080.1.
AK143815 mRNA. Translation: BAE25548.1.
BC022134 mRNA. Translation: AAH22134.1.
BC024453 mRNA. Translation: AAH24453.1.
BC034837 mRNA. Translation: AAH34837.1.
CCDSiCCDS27375.1.
RefSeqiNP_659094.1. NM_144845.3.
UniGeneiMm.422853.

Genome annotation databases

EnsembliENSMUST00000072403; ENSMUSP00000072236; ENSMUSG00000049152.
GeneIDi223337.
KEGGimmu:223337.
UCSCiuc007vfl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050128 mRNA. Translation: BAC34080.1 .
AK143815 mRNA. Translation: BAE25548.1 .
BC022134 mRNA. Translation: AAH22134.1 .
BC024453 mRNA. Translation: AAH24453.1 .
BC034837 mRNA. Translation: AAH34837.1 .
CCDSi CCDS27375.1.
RefSeqi NP_659094.1. NM_144845.3.
UniGenei Mm.422853.

3D structure databases

ProteinModelPortali Q8JZZ0.
SMRi Q8JZZ0. Positions 230-462.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8JZZ0. 2 interactions.
MINTi MINT-4116696.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei Q8JZZ0.

Proteomic databases

MaxQBi Q8JZZ0.
PaxDbi Q8JZZ0.
PRIDEi Q8JZZ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072403 ; ENSMUSP00000072236 ; ENSMUSG00000049152 .
GeneIDi 223337.
KEGGi mmu:223337.
UCSCi uc007vfl.1. mouse.

Organism-specific databases

CTDi 167127.
MGIi MGI:2145969. Ugt3a2.

Phylogenomic databases

eggNOGi COG1819.
GeneTreei ENSGT00560000076760.
HOGENOMi HOG000220831.
HOVERGENi HBG106370.
InParanoidi Q8JZZ0.
OMAi YESANIP.
OrthoDBi EOG7GBFWS.
PhylomeDBi Q8JZZ0.
TreeFami TF315472.

Miscellaneous databases

NextBioi 376697.
PROi Q8JZZ0.
SOURCEi Search...

Gene expression databases

Bgeei Q8JZZ0.
CleanExi MM_UGT3A2.
Genevestigatori Q8JZZ0.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver and Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney and Liver.
  3. "Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice."
    Buckley D.B., Klaassen C.D.
    Drug Metab. Dispos. 35:121-127(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiUD3A2_MOUSE
AccessioniPrimary (citable) accession number: Q8JZZ0
Secondary accession number(s): A1A4B4, Q3UP49, Q8VC11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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