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Protein

Mitochondrial ribonuclease P protein 3

Gene

Kiaa0391

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ribonuclease P protein 3
Short name:
Mitochondrial RNase P protein 3
Gene namesi
Name:Kiaa0391
Synonyms:Mrpp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913382. 1110008L16Rik.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial nucleoid Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343MitochondrionSequence analysisAdd
BLAST
Chaini44 – 584541Mitochondrial ribonuclease P protein 3PRO_0000360397Add
BLAST

Proteomic databases

EPDiQ8JZY4.
MaxQBiQ8JZY4.
PaxDbiQ8JZY4.
PeptideAtlasiQ8JZY4.
PRIDEiQ8JZY4.

PTM databases

PhosphoSiteiQ8JZY4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021023.
ExpressionAtlasiQ8JZY4. baseline and differential.
GenevisibleiQ8JZY4. MM.

Interactioni

Subunit structurei

Interacts with MRPP1/TRMT10C and MRPP2/HSD17B10.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021411.

Structurei

3D structure databases

ProteinModelPortaliQ8JZY4.
SMRiQ8JZY4. Positions 153-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IE4T. Eukaryota.
ENOG4111GT9. LUCA.
GeneTreeiENSGT00390000002201.
HOGENOMiHOG000294131.
HOVERGENiHBG099441.
InParanoidiQ8JZY4.
KOiK17655.
OMAiCVIDGLN.
OrthoDBiEOG091G0JTR.
PhylomeDBiQ8JZY4.
TreeFamiTF324726.

Family and domain databases

InterProiIPR033495. MRPP3.
IPR031595. PRORP_C.
[Graphical view]
PANTHERiPTHR13547:SF1. PTHR13547:SF1. 1 hit.
PfamiPF16953. PRORP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFYLSGFRS IPKLWKSNPY FELGPATSST PFFLCAIGNQ QRWFSVKPTT
60 70 80 90 100
PPNSKALNLL DTKARTHRKG NDNNGQVSSD PHYFAAGAAK KRSHIGANPQ
110 120 130 140 150
NQGHALPVRS SVQLPTKPLN SAEWDKLKED FKGKASFEDF IISQMARNCC
160 170 180 190 200
SVDVAKSLLA WVAAKNNGIV GYNLLVKYLY LCVFHKQTSE VIDVYEIMKA
210 220 230 240 250
KYKSLESGGY TLLIRGLIHS DRWRESLLLL EDIKKVMVPS KKNYGDCIQG
260 270 280 290 300
ALLHQDVNTA WNLYQELIGH NLIPPLETLK AFFDYGKDIN DDHYSDKLLD
310 320 330 340 350
ILLYLRNNQL YPGESFAHSI KTWFESIPGR QWKGQFTTIQ KSGQCSGCGR
360 370 380 390 400
TIEPIHLSPE EYEFLKEKIM RDVIDGGDQY KKTTPQELKR FESFVNSCPP
410 420 430 440 450
FDIVIDGLNV AKMFPKGRES QNLLGVVSQL AQQNLQLLVL GRKHMLRPSS
460 470 480 490 500
QWRKEEMEQV RKQAHCFFAD NISEDDPFLL YATLNSGNHC KFITKDLLRD
510 520 530 540 550
HKACLPDART QRLFFKWQQG HQLAIMKGFQ KSKLTFQHIL SYDTVVQRTG
560 570 580
DSWHIPYDED LVQRSSCEVP TKWLCLQRKT PDPC
Length:584
Mass (Da):66,857
Last modified:October 1, 2002 - v1
Checksum:iBB68EF585649A3BD
GO

Sequence cautioni

The sequence BAB25874 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD32220 differs from that shown.Partial sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti430 – 4301L → V in BAC27278 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003589 mRNA. Translation: BAB22879.1.
AK008749 mRNA. Translation: BAB25874.1. Different initiation.
AK031144 mRNA. Translation: BAC27278.1.
AK151976 mRNA. Translation: BAE30844.1.
AK152028 mRNA. Translation: BAE30887.1.
CH466526 Genomic DNA. Translation: EDL36732.1.
BC034876 mRNA. Translation: AAH34876.1.
AK172942 mRNA. Translation: BAD32220.1. Sequence problems.
CCDSiCCDS49068.1.
RefSeqiNP_079649.1. NM_025373.1.
UniGeneiMm.383213.

Genome annotation databases

EnsembliENSMUST00000021411; ENSMUSP00000021411; ENSMUSG00000021023.
ENSMUST00000184766; ENSMUSP00000139204; ENSMUSG00000021023.
GeneIDi66132.
KEGGimmu:66132.
UCSCiuc007noo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003589 mRNA. Translation: BAB22879.1.
AK008749 mRNA. Translation: BAB25874.1. Different initiation.
AK031144 mRNA. Translation: BAC27278.1.
AK151976 mRNA. Translation: BAE30844.1.
AK152028 mRNA. Translation: BAE30887.1.
CH466526 Genomic DNA. Translation: EDL36732.1.
BC034876 mRNA. Translation: AAH34876.1.
AK172942 mRNA. Translation: BAD32220.1. Sequence problems.
CCDSiCCDS49068.1.
RefSeqiNP_079649.1. NM_025373.1.
UniGeneiMm.383213.

3D structure databases

ProteinModelPortaliQ8JZY4.
SMRiQ8JZY4. Positions 153-579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021411.

PTM databases

PhosphoSiteiQ8JZY4.

Proteomic databases

EPDiQ8JZY4.
MaxQBiQ8JZY4.
PaxDbiQ8JZY4.
PeptideAtlasiQ8JZY4.
PRIDEiQ8JZY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021411; ENSMUSP00000021411; ENSMUSG00000021023.
ENSMUST00000184766; ENSMUSP00000139204; ENSMUSG00000021023.
GeneIDi66132.
KEGGimmu:66132.
UCSCiuc007noo.2. mouse.

Organism-specific databases

MGIiMGI:1913382. 1110008L16Rik.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IE4T. Eukaryota.
ENOG4111GT9. LUCA.
GeneTreeiENSGT00390000002201.
HOGENOMiHOG000294131.
HOVERGENiHBG099441.
InParanoidiQ8JZY4.
KOiK17655.
OMAiCVIDGLN.
OrthoDBiEOG091G0JTR.
PhylomeDBiQ8JZY4.
TreeFamiTF324726.

Miscellaneous databases

PROiQ8JZY4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021023.
ExpressionAtlasiQ8JZY4. baseline and differential.
GenevisibleiQ8JZY4. MM.

Family and domain databases

InterProiIPR033495. MRPP3.
IPR031595. PRORP_C.
[Graphical view]
PANTHERiPTHR13547:SF1. PTHR13547:SF1. 1 hit.
PfamiPF16953. PRORP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRRP3_MOUSE
AccessioniPrimary (citable) accession number: Q8JZY4
Secondary accession number(s): Q6A076
, Q8BSN8, Q9CTH1, Q9D7W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.