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Protein

Cdc42 effector protein 2

Gene

Cdc42ep2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: MGI
  • GTP-Rho binding Source: MGI
  • opioid peptide activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell shape

Enzyme and pathway databases

ReactomeiR-MMU-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 2
Alternative name(s):
Binder of Rho GTPases 1
Gene namesi
Name:Cdc42ep2
Synonyms:Borg1, Cep2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1929744. Cdc42ep2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 214213Cdc42 effector protein 2PRO_0000212649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei101 – 1011PhosphoserineBy similarity
Modified residuei137 – 1371PhosphoserineCombined sources
Modified residuei141 – 1411PhosphoserineCombined sources
Modified residuei145 – 1451PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8JZX9.
PaxDbiQ8JZX9.
PRIDEiQ8JZX9.

PTM databases

iPTMnetiQ8JZX9.
PhosphoSiteiQ8JZX9.

Expressioni

Gene expression databases

BgeeiQ8JZX9.
CleanExiMM_CDC42EP2.
GenevisibleiQ8JZX9. MM.

Interactioni

Subunit structurei

Interacts with CDC42 and RHOQ in a GTP-dependent manner, and with SEPT7.By similarity

GO - Molecular functioni

  • GTP-Rho binding Source: MGI
  • opioid peptide activity Source: MGI

Protein-protein interaction databases

BioGridi222493. 1 interaction.
STRINGi10090.ENSMUSP00000059883.

Structurei

3D structure databases

ProteinModelPortaliQ8JZX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 4415CRIBPROSITE-ProRule annotationAdd
BLAST

Domaini

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated
Contains 1 CRIB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IZS0. Eukaryota.
ENOG4111X3X. LUCA.
GeneTreeiENSGT00730000110928.
HOGENOMiHOG000233908.
HOVERGENiHBG052803.
InParanoidiQ8JZX9.
OMAiIMDQDLG.
OrthoDBiEOG7V1FSH.
PhylomeDBiQ8JZX9.
TreeFamiTF331725.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR017363. Cdc42_effector_prot_2.
IPR000095. CRIB_dom.
[Graphical view]
PANTHERiPTHR15344:SF4. PTHR15344:SF4. 1 hit.
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
PIRSFiPIRSF038036. Cdc42_effector_p2. 1 hit.
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGDD
60 70 80 90 100
MFGDISFLQG KFHLLPGTAV EEAEEDGSFD LPFQFTRTTT VCGRELPDGL
110 120 130 140 150
SPLLKNAISL PVIGGPQALT LPTAQAPPKP PRLHLESPQP SPQPSPQGAG
160 170 180 190 200
NVDVWRIPEA GSPHNGMSPE PEAEEPFLSH ASSLLSLHVD LGPSILDDVL
210
QIMDHDLGRV QIPT
Length:214
Mass (Da):22,997
Last modified:October 1, 2002 - v1
Checksum:i24AD498747C2A6D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034884 mRNA. Translation: AAH34884.1.
CCDSiCCDS29484.1.
RefSeqiNP_081048.1. NM_026772.2.
UniGeneiMm.491103.

Genome annotation databases

EnsembliENSMUST00000055458; ENSMUSP00000059883; ENSMUSG00000045664.
GeneIDi104252.
KEGGimmu:104252.
UCSCiuc008gfz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034884 mRNA. Translation: AAH34884.1.
CCDSiCCDS29484.1.
RefSeqiNP_081048.1. NM_026772.2.
UniGeneiMm.491103.

3D structure databases

ProteinModelPortaliQ8JZX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222493. 1 interaction.
STRINGi10090.ENSMUSP00000059883.

PTM databases

iPTMnetiQ8JZX9.
PhosphoSiteiQ8JZX9.

Proteomic databases

MaxQBiQ8JZX9.
PaxDbiQ8JZX9.
PRIDEiQ8JZX9.

Protocols and materials databases

DNASUi104252.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055458; ENSMUSP00000059883; ENSMUSG00000045664.
GeneIDi104252.
KEGGimmu:104252.
UCSCiuc008gfz.2. mouse.

Organism-specific databases

CTDi10435.
MGIiMGI:1929744. Cdc42ep2.

Phylogenomic databases

eggNOGiENOG410IZS0. Eukaryota.
ENOG4111X3X. LUCA.
GeneTreeiENSGT00730000110928.
HOGENOMiHOG000233908.
HOVERGENiHBG052803.
InParanoidiQ8JZX9.
OMAiIMDQDLG.
OrthoDBiEOG7V1FSH.
PhylomeDBiQ8JZX9.
TreeFamiTF331725.

Enzyme and pathway databases

ReactomeiR-MMU-5687128. MAPK6/MAPK4 signaling.

Miscellaneous databases

ChiTaRSiCdc42ep2. mouse.
PROiQ8JZX9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8JZX9.
CleanExiMM_CDC42EP2.
GenevisibleiQ8JZX9. MM.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR017363. Cdc42_effector_prot_2.
IPR000095. CRIB_dom.
[Graphical view]
PANTHERiPTHR15344:SF4. PTHR15344:SF4. 1 hit.
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
PIRSFiPIRSF038036. Cdc42_effector_p2. 1 hit.
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Lung.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-141 AND SER-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiBORG1_MOUSE
AccessioniPrimary (citable) accession number: Q8JZX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.