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Protein

Copine-5

Gene

Cpne5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-5Curated
Alternative name(s):
Copine VBy similarityImported
Gene namesi
Name:Cpne5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2385908 Cpne5

Subcellular locationi

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448441 – 593Copine-5Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1
Modified residuei103PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8JZW4
PaxDbiQ8JZW4
PeptideAtlasiQ8JZW4
PRIDEiQ8JZW4

PTM databases

iPTMnetiQ8JZW4
PhosphoSitePlusiQ8JZW4

Expressioni

Tissue specificityi

Expressed in the cerebra and cerebellum of newborn brain. Expressed in the eye, lung and muscles but weakly expressed in the adult brain (at protein level) (PubMed:18614158).1 Publication

Developmental stagei

Expressed at the ventricular zone and subventricular zone areas, in the tectum, frontal cortex, ganglionic eminence, dorsal thalamus, hippocampus and tegmentum of the embryonic brain from 12.5 to 14.5 dpc. Expressed in neural progenitor cells (at protein level). Expressed in the embryonic brain from 10.5 to 17.5 dpc. Expressed in the telencephalon, mesencephalon and rhombencephalon areas from 11.5 to 12.5 dpc. Expressed in the developing central nervous system (CNS), such as the frontal cortex, hypothalamus and ventricular zones along the IV ventricle and aquaeductus mesencephali at 13.5 dpc (PubMed:18614158).1 Publication

Gene expression databases

BgeeiENSMUSG00000024008
CleanExiMM_CPNE5
ExpressionAtlasiQ8JZW4 baseline and differential
GenevisibleiQ8JZW4 MM

Interactioni

Protein-protein interaction databases

IntActiQ8JZW4, 1 interactor
MINTiQ8JZW4
STRINGi10090.ENSMUSP00000024805

Structurei

3D structure databases

ProteinModelPortaliQ8JZW4
SMRiQ8JZW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 116C2 1PROSITE-ProRule annotationAdd BLAST108
Domaini147 – 268C2 2PROSITE-ProRule annotationAdd BLAST122
Domaini328 – 554VWFAPROSITE-ProRule annotationAdd BLAST227

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ8JZW4
OMAiHHSLRTV
OrthoDBiEOG091G05IT
PhylomeDBiQ8JZW4
TreeFamiTF316419

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8JZW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPEDMASL SEFDSLAGSI PATKVEITVS CRNLLDKDMF SKSDPLCVMY
60 70 80 90 100
TQGMENKQWR EFGRTEVIDN TLNPDFVRKF IVDYFFEEKQ NLRFDLYDVD
110 120 130 140 150
SKSPDLSKHD FLGQAFCTLG EIVGSSGSRL EKPLTIGTFS LNSRTGKPMP
160 170 180 190 200
AVSNGGVPGK KCGTIILSAE ELSNCRDVAT MQFCANKLDK KDFFGKSDPF
210 220 230 240 250
LVFYRSNEDG TFTICHKTEV MKNTLNPVWQ TFSIPVRALC NGDYDRTIKV
260 270 280 290 300
EVYDWDRDGS HDFIGEFTTS YRELARGQSQ FNIYEVINPK KKMKKKKYVN
310 320 330 340 350
SGTVTLLSFA VESESTFLDY IKGGTQINFT VAIDFTASNG NPSQSTSLHY
360 370 380 390 400
MSPYQLNAYA LALTAVGEII QHYDSDKMFP ALGFGAKLPP DGRVSHEFPL
410 420 430 440 450
NGNQENPSCC GIDGILEAYH SSLRTVQLYG PTNFAPVVTH VARNAAAVQD
460 470 480 490 500
GSQYSVLLII TDGVISDMAQ TKEAIVNAAK LPMSIIIVGV GQAEFDAMVE
510 520 530 540 550
LDGDDVRISS RGKLAERDIV QFVPFRDYVD RTGNHVLSMA RLARDVLAEI
560 570 580 590
PDQLVSYMKA QGIRPRPPPA APAQSPPQSP AHSPPGSPVH THI
Length:593
Mass (Da):65,592
Last modified:October 1, 2002 - v1
Checksum:i0B0BF66A852EACC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044042 mRNA Translation: BAC31750.1
BC036971 mRNA Translation: AAH36971.1
CCDSiCCDS28592.1
RefSeqiNP_694806.1, NM_153166.2
UniGeneiMm.39905

Genome annotation databases

EnsembliENSMUST00000024805; ENSMUSP00000024805; ENSMUSG00000024008
GeneIDi240058
KEGGimmu:240058
UCSCiuc008bsj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCPNE5_MOUSE
AccessioniPrimary (citable) accession number: Q8JZW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health