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Protein

Copine-5

Gene

Cpne5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-5Curated
Alternative name(s):
Copine VBy similarityImported
Gene namesi
Name:Cpne5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2385908. Cpne5.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • neuronal cell body Source: MGI
  • neuron projection Source: MGI
  • perikaryon Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Copine-5PRO_0000144844Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineBy similarity
Modified residuei103 – 1031PhosphoserineCombined sources
Modified residuei140 – 1401PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8JZW4.
MaxQBiQ8JZW4.
PaxDbiQ8JZW4.
PRIDEiQ8JZW4.

PTM databases

iPTMnetiQ8JZW4.
PhosphoSiteiQ8JZW4.

Expressioni

Tissue specificityi

Expressed in the cerebra and cerebellum of newborn brain. Expressed in the eye, lung and muscles but weakly expressed in the adult brain (at protein level) (PubMed:18614158).1 Publication

Developmental stagei

Expressed at the ventricular zone and subventricular zone areas, in the tectum, frontal cortex, ganglionic eminence, dorsal thalamus, hippocampus and tegmentum of the embryonic brain from 12.5 to 14.5 dpc. Expressed in neural progenitor cells (at protein level). Expressed in the embryonic brain from 10.5 to 17.5 dpc. Expressed in the telencephalon, mesencephalon and rhombencephalon areas from 11.5 to 12.5 dpc. Expressed in the developing central nervous system (CNS), such as the frontal cortex, hypothalamus and ventricular zones along the IV ventricle and aquaeductus mesencephali at 13.5 dpc (PubMed:18614158).1 Publication

Gene expression databases

BgeeiQ8JZW4.
CleanExiMM_CPNE5.
ExpressionAtlasiQ8JZW4. baseline and differential.
GenevisibleiQ8JZW4. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8JZW4. 1 interaction.
MINTiMINT-4997721.
STRINGi10090.ENSMUSP00000024805.

Structurei

3D structure databases

ProteinModelPortaliQ8JZW4.
SMRiQ8JZW4. Positions 185-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 116108C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini147 – 268122C2 2PROSITE-ProRule annotationAdd
BLAST
Domaini328 – 554227VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the copine family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ8JZW4.
OMAiNGNMENP.
OrthoDBiEOG77DJ57.
PhylomeDBiQ8JZW4.
TreeFamiTF316419.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JZW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPEDMASL SEFDSLAGSI PATKVEITVS CRNLLDKDMF SKSDPLCVMY
60 70 80 90 100
TQGMENKQWR EFGRTEVIDN TLNPDFVRKF IVDYFFEEKQ NLRFDLYDVD
110 120 130 140 150
SKSPDLSKHD FLGQAFCTLG EIVGSSGSRL EKPLTIGTFS LNSRTGKPMP
160 170 180 190 200
AVSNGGVPGK KCGTIILSAE ELSNCRDVAT MQFCANKLDK KDFFGKSDPF
210 220 230 240 250
LVFYRSNEDG TFTICHKTEV MKNTLNPVWQ TFSIPVRALC NGDYDRTIKV
260 270 280 290 300
EVYDWDRDGS HDFIGEFTTS YRELARGQSQ FNIYEVINPK KKMKKKKYVN
310 320 330 340 350
SGTVTLLSFA VESESTFLDY IKGGTQINFT VAIDFTASNG NPSQSTSLHY
360 370 380 390 400
MSPYQLNAYA LALTAVGEII QHYDSDKMFP ALGFGAKLPP DGRVSHEFPL
410 420 430 440 450
NGNQENPSCC GIDGILEAYH SSLRTVQLYG PTNFAPVVTH VARNAAAVQD
460 470 480 490 500
GSQYSVLLII TDGVISDMAQ TKEAIVNAAK LPMSIIIVGV GQAEFDAMVE
510 520 530 540 550
LDGDDVRISS RGKLAERDIV QFVPFRDYVD RTGNHVLSMA RLARDVLAEI
560 570 580 590
PDQLVSYMKA QGIRPRPPPA APAQSPPQSP AHSPPGSPVH THI
Length:593
Mass (Da):65,592
Last modified:October 1, 2002 - v1
Checksum:i0B0BF66A852EACC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044042 mRNA. Translation: BAC31750.1.
BC036971 mRNA. Translation: AAH36971.1.
CCDSiCCDS28592.1.
RefSeqiNP_694806.1. NM_153166.2.
UniGeneiMm.39905.

Genome annotation databases

EnsembliENSMUST00000024805; ENSMUSP00000024805; ENSMUSG00000024008.
GeneIDi240058.
KEGGimmu:240058.
UCSCiuc008bsj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044042 mRNA. Translation: BAC31750.1.
BC036971 mRNA. Translation: AAH36971.1.
CCDSiCCDS28592.1.
RefSeqiNP_694806.1. NM_153166.2.
UniGeneiMm.39905.

3D structure databases

ProteinModelPortaliQ8JZW4.
SMRiQ8JZW4. Positions 185-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8JZW4. 1 interaction.
MINTiMINT-4997721.
STRINGi10090.ENSMUSP00000024805.

PTM databases

iPTMnetiQ8JZW4.
PhosphoSiteiQ8JZW4.

Proteomic databases

EPDiQ8JZW4.
MaxQBiQ8JZW4.
PaxDbiQ8JZW4.
PRIDEiQ8JZW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024805; ENSMUSP00000024805; ENSMUSG00000024008.
GeneIDi240058.
KEGGimmu:240058.
UCSCiuc008bsj.2. mouse.

Organism-specific databases

CTDi57699.
MGIiMGI:2385908. Cpne5.

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ8JZW4.
OMAiNGNMENP.
OrthoDBiEOG77DJ57.
PhylomeDBiQ8JZW4.
TreeFamiTF316419.

Miscellaneous databases

PROiQ8JZW4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8JZW4.
CleanExiMM_CPNE5.
ExpressionAtlasiQ8JZW4. baseline and differential.
GenevisibleiQ8JZW4. MM.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  3. "Localization and cellular distribution of CPNE5 in embryonic mouse brain."
    Ding X., Jin Y., Wu Y., Wu Y., Wu H., Xiong L., Song X., Liu S., Fan W., Fan M.
    Brain Res. 1224:20-28(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103 AND SER-140, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCPNE5_MOUSE
AccessioniPrimary (citable) accession number: Q8JZW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.