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Protein

3-hydroxybutyrate dehydrogenase type 2

Gene

Bdh2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase.1 Publication

Catalytic activityi

(R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH.

Pathwayi: Siderophore biosynthesis

This protein is involved in Siderophore biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Siderophore biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58NADBy similarity1
Binding sitei144SubstrateBy similarity1
Active sitei147Proton acceptor1
Binding sitei151NADBy similarity1
Binding sitei188SubstrateBy similarity1
Binding sitei205SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 37NADBy similarityAdd BLAST28
Nucleotide bindingi180 – 184NADBy similarity5

GO - Molecular functioni

GO - Biological processi

  • epithelial cell differentiation Source: MGI
  • fatty acid beta-oxidation Source: HGNC
  • heme metabolic process Source: UniProtKB
  • iron ion homeostasis Source: UniProtKB
  • siderophore biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-77111. Synthesis of Ketone Bodies.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxybutyrate dehydrogenase type 2 (EC:1.1.1.-, EC:1.1.1.30)
Alternative name(s):
Dehydrogenase/reductase SDR family member 6
R-beta-hydroxybutyrate dehydrogenase
Gene namesi
Name:Bdh2
Synonyms:Dhrs6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1917022. Bdh2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi147Y → F: Loss of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000425811 – 2453-hydroxybutyrate dehydrogenase type 2Add BLAST245

Proteomic databases

MaxQBiQ8JZV9.
PaxDbiQ8JZV9.
PRIDEiQ8JZV9.

PTM databases

iPTMnetiQ8JZV9.
PhosphoSitePlusiQ8JZV9.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000028167.
CleanExiMM_BDH2.
ExpressionAtlasiQ8JZV9. baseline and differential.
GenevisibleiQ8JZV9. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131111.

Structurei

3D structure databases

ProteinModelPortaliQ8JZV9.
SMRiQ8JZV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG002145.
InParanoidiQ8JZV9.
KOiK00019.
PhylomeDBiQ8JZV9.
TreeFamiTF328795.

Family and domain databases

InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8JZV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLDGKVIV LTAAAQGIGR ASALAFAREG AKVIATDINE SKLQELESYR
60 70 80 90 100
GIQTRVLDVT KKRQIDQFAS EIERIDVLFN VAGFVHHGTI LDCEEKDWDF
110 120 130 140 150
SMNLNVRSMF LMIKAFLPKM LAQKSGNIIN MSSVASSIKG VENRCVYSAT
160 170 180 190 200
KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARDNPKEALK
210 220 230 240
TFLNRQKTGR FASAEEVALL CVYLASDESA YVTGNPVIID GGWSL
Length:245
Mass (Da):26,753
Last modified:October 1, 2002 - v1
Checksum:i343A25B1F56B9CCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036998 mRNA. Translation: AAH36998.1.
CCDSiCCDS17853.1.
RefSeqiNP_081484.1. NM_027208.2.
UniGeneiMm.45121.

Genome annotation databases

EnsembliENSMUST00000029817; ENSMUSP00000029817; ENSMUSG00000028167.
GeneIDi69772.
KEGGimmu:69772.
UCSCiuc008rla.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBDH2_MOUSE
AccessioniPrimary (citable) accession number: Q8JZV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2002
Last modified: May 10, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families