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Protein

3-hydroxybutyrate dehydrogenase type 2

Gene

Bdh2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase.1 Publication

Catalytic activityi

(R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH.

Pathwayi: Siderophore biosynthesis

This protein is involved in Siderophore biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Siderophore biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei58 – 581NADBy similarity
Binding sitei144 – 1441SubstrateBy similarity
Active sitei147 – 1471Proton acceptor
Binding sitei151 – 1511NADBy similarity
Binding sitei188 – 1881SubstrateBy similarity
Binding sitei205 – 2051SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 3728NADBy similarityAdd
BLAST
Nucleotide bindingi180 – 1845NADBy similarity

GO - Molecular functioni

GO - Biological processi

  • epithelial cell differentiation Source: MGI
  • fatty acid beta-oxidation Source: HGNC
  • heme metabolic process Source: UniProtKB
  • iron ion homeostasis Source: UniProtKB
  • siderophore biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-MMU-77111. Synthesis of Ketone Bodies.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxybutyrate dehydrogenase type 2 (EC:1.1.1.-, EC:1.1.1.30)
Alternative name(s):
Dehydrogenase/reductase SDR family member 6
R-beta-hydroxybutyrate dehydrogenase
Gene namesi
Name:Bdh2
Synonyms:Dhrs6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1917022. Bdh2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi147 – 1471Y → F: Loss of function. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2452453-hydroxybutyrate dehydrogenase type 2PRO_0000042581Add
BLAST

Proteomic databases

EPDiQ8JZV9.
MaxQBiQ8JZV9.
PaxDbiQ8JZV9.
PRIDEiQ8JZV9.

PTM databases

iPTMnetiQ8JZV9.
PhosphoSiteiQ8JZV9.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ8JZV9.
CleanExiMM_BDH2.
ExpressionAtlasiQ8JZV9. baseline and differential.
GenevisibleiQ8JZV9. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131111.

Structurei

3D structure databases

ProteinModelPortaliQ8JZV9.
SMRiQ8JZV9. Positions 1-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG002145.
InParanoidiQ8JZV9.
KOiK00019.
OrthoDBiEOG7W154W.
PhylomeDBiQ8JZV9.
TreeFamiTF328795.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JZV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLDGKVIV LTAAAQGIGR ASALAFAREG AKVIATDINE SKLQELESYR
60 70 80 90 100
GIQTRVLDVT KKRQIDQFAS EIERIDVLFN VAGFVHHGTI LDCEEKDWDF
110 120 130 140 150
SMNLNVRSMF LMIKAFLPKM LAQKSGNIIN MSSVASSIKG VENRCVYSAT
160 170 180 190 200
KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARDNPKEALK
210 220 230 240
TFLNRQKTGR FASAEEVALL CVYLASDESA YVTGNPVIID GGWSL
Length:245
Mass (Da):26,753
Last modified:October 1, 2002 - v1
Checksum:i343A25B1F56B9CCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036998 mRNA. Translation: AAH36998.1.
CCDSiCCDS17853.1.
RefSeqiNP_081484.1. NM_027208.2.
UniGeneiMm.45121.

Genome annotation databases

EnsembliENSMUST00000029817; ENSMUSP00000029817; ENSMUSG00000028167.
GeneIDi69772.
KEGGimmu:69772.
UCSCiuc008rla.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036998 mRNA. Translation: AAH36998.1.
CCDSiCCDS17853.1.
RefSeqiNP_081484.1. NM_027208.2.
UniGeneiMm.45121.

3D structure databases

ProteinModelPortaliQ8JZV9.
SMRiQ8JZV9. Positions 1-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131111.

PTM databases

iPTMnetiQ8JZV9.
PhosphoSiteiQ8JZV9.

Proteomic databases

EPDiQ8JZV9.
MaxQBiQ8JZV9.
PaxDbiQ8JZV9.
PRIDEiQ8JZV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029817; ENSMUSP00000029817; ENSMUSG00000028167.
GeneIDi69772.
KEGGimmu:69772.
UCSCiuc008rla.2. mouse.

Organism-specific databases

CTDi56898.
MGIiMGI:1917022. Bdh2.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG002145.
InParanoidiQ8JZV9.
KOiK00019.
OrthoDBiEOG7W154W.
PhylomeDBiQ8JZV9.
TreeFamiTF328795.

Enzyme and pathway databases

ReactomeiR-MMU-77111. Synthesis of Ketone Bodies.

Miscellaneous databases

PROiQ8JZV9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8JZV9.
CleanExiMM_BDH2.
ExpressionAtlasiQ8JZV9. baseline and differential.
GenevisibleiQ8JZV9. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  2. "A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production."
    Devireddy L.R., Hart D.O., Goetz D.H., Green M.R.
    Cell 141:1006-1017(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PATHWAY, TISSUE SPECIFICITY, MUTAGENESIS OF TYR-147.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiBDH2_MOUSE
AccessioniPrimary (citable) accession number: Q8JZV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.