Reviewed, UniProtKB/Swiss-Prot Q8JZV9 (BDH2_MOUSE)

Names and origin

Protein names

Recommended name:
    3-hydroxybutyrate dehydrogenase type 2
    EC=1.1.1.30
Alternative name(s):
    R-beta-hydroxybutyrate dehydrogenase
    Dehydrogenase/reductase SDR family member 6

Gene names

Name:	Bdh2
Synonyms:	Dhrs6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from sequence or structural similarity. Source: HGNC oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: HGNC
Molecular function	3-hydroxybutyrate dehydrogenase activity Inferred from sequence or structural similarity. Source: HGNC NAD or NADH binding Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	3-hydroxybutyrate dehydrogenase type 2		PRO_0000042581
Regions
	Nucleotide binding	10 – 37	28	NAD By similarity
	Nucleotide binding	180 – 184	5	NAD By similarity
Sites
	Active site	147	1	Proton acceptor By similarity
	Binding site	58	1	NAD By similarity
	Binding site	144	1	Substrate By similarity
	Binding site	151	1	NAD By similarity
	Binding site	188	1	Substrate By similarity
	Binding site	205	1	Substrate By similarity
Amino acid modifications
	Modified residue	132	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8JZV9-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 343A25B1F56B9CCF	FASTA	245	26,753
	10 20 30 40 50 60 MGRLDGKVIV LTAAAQGIGR ASALAFAREG AKVIATDINE SKLQELESYR GIQTRVLDVT 70 80 90 100 110 120 KKRQIDQFAS EIERIDVLFN VAGFVHHGTI LDCEEKDWDF SMNLNVRSMF LMIKAFLPKM 130 140 150 160 170 180 LAQKSGNIIN MSSVASSIKG VENRCVYSAT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV 190 200 210 220 230 240 DTPSLQERIQ ARDNPKEALK TFLNRQKTGR FASAEEVALL CVYLASDESA YVTGNPVIID GGWSL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC036998 mRNA. Translation: AAH36998.1.
IPI	IPI00172338.
RefSeq	NP_081484.1.
UniGene	Mm.45121
3D structure databases
HSSP	HSSP built from PDB template 1GZ6 based on UniProtKB P97852.
SMR	Q8JZV9. Positions 1-245.
ModBase	Search...
PTM databases
PhosphoSite	Q8JZV9.
Genome annotation databases
Ensembl	ENSMUSG00000028167. Mus musculus. [Contig view]
GeneID	69772.
KEGG	mmu:69772.
NMPDR	fig|10090.3.peg.9033.
Organism-specific databases
MGI	MGI:1917022. Bdh2.
Phylogenomic databases
HOVERGEN	Q8JZV9.
OMA	Q8JZV9. ERIDVLF.
Enzyme and pathway databases
BRENDA	1.1.1.30. 244.
Gene expression databases
ArrayExpress	Q8JZV9.
Bgee	Q8JZV9.
CleanEx	MM_BDH2.
GermOnline	ENSMUSG00000028167. Mus musculus.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	330302.
SOURCE	Search...

Entry information

Entry name

BDH2_MOUSE

Accession

Primary (citable) accession number: Q8JZV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)