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Q8JZV7 (NAGA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative N-acetylglucosamine-6-phosphate deacetylase
EC=3.5.1.25
Alternative name(s):
Amidohydrolase domain-containing protein 2
GlcNAc 6-P deacetylase
Gene names
Name:Amdhd2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.

Sequence similarities

Belongs to the nagA family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processN-acetylglucosamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionN-acetylglucosamine-6-phosphate deacetylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 409409Putative N-acetylglucosamine-6-phosphate deacetylase
PRO_0000315777

Experimental info

Sequence conflict3541L → M in BAC36877. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8JZV7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 914930464779CAC7

FASTA40943,501
        10         20         30         40         50         60 
MRSGQCAAGA PVLQFTNCRI LRGGTLLRED LWVRGGRILD PEKLFFEERR VADEQRDCGG 

        70         80         90        100        110        120 
RILAPGFIDV QINGGFGVDF SKATEDVGSG VALVARRLLS HGVTSFCPTL VTSPPEVYHK 

       130        140        150        160        170        180 
VLPQIPVKSG GPHGAGVLGV HLEGPFISRE KRGAHPEAYL RSFEANAFHD VLATYGPLDN 

       190        200        210        220        230        240 
VCIVTLAPEL DRSHEVIQAL TAQGIRVSLG HSVADLRAAE VAVQSGATFI THLFNAMLPF 

       250        260        270        280        290        300 
HHRDPGIVGL LTSDQLPPGH CIFYGMIADG IHTNPAALRI AHRAHPQGLV LVTDAVPALG 

       310        320        330        340        350        360 
LGNGRHTLGQ QEVEVDGLIA YIAGTKTLGG SIAPMDVCVR HFLQATGCSV ESALEAASLH 

       370        380        390        400 
PAQMLGLEKT KGSLDFGADA DFVVLDDTLH VQATYISGEL VWQAEEAGP

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Amnion.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK077584 mRNA. Translation: BAC36877.1.
AK090009 mRNA. Translation: BAC41042.1.
AK159860 mRNA. Translation: BAE35434.1.
AK168432 mRNA. Translation: BAE40339.1.
BC037005 mRNA. Translation: AAH37005.1.
IPIIPI00323465.
RefSeqNP_766523.2. NM_172935.4.
UniGeneMm.87319.

3D structure databases

HSSPHSSP built from PDB template 1UN7 based on UniProtKB O34450.
ProteinModelPortalQ8JZV7.
SMRQ8JZV7. Positions 6-404.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8JZV7.

Protein family/group databases

MEROPSM38.979.

2D gel databases

REPRODUCTION-2DPAGEQ8JZV7.

Proteomic databases

PRIDEQ8JZV7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040735; ENSMUSP00000036141; ENSMUSG00000036820.
GeneID245847.
KEGGmmu:245847.
NMPDRfig|10090.3.peg.2296.
UCSCuc008aum.1. mouse.

Organism-specific databases

CTD51005.
MGIMGI:2443978. Amdhd2.

Phylogenomic databases

eggNOGroNOG07552.
GeneTreeENSGT00390000012605.
HOGENOMHBG464950.
HOVERGENHBG108170.
InParanoidQ8JZV7.
OMADGVHTHP.
OrthoDBEOG45HRXK.
PhylomeDBQ8JZV7.

Gene expression databases

ArrayExpressQ8JZV7.
BgeeQ8JZV7.
CleanExMM_AMDHD2.
GenevestigatorQ8JZV7.

Family and domain databases

InterProIPR006680. Amidohydro_1.
IPR003764. GlcNAc_6-P_deAcase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01443.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00221. NagA. 1 hit.
ProtoNetSearch...

Other

NextBio386954.
SOURCESearch...

Entry information

Entry nameNAGA_MOUSE
AccessionPrimary (citable) accession number: Q8JZV7
Secondary accession number(s): Q8BK10
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents