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Protein

N-acetylglucosamine-6-phosphate deacetylase

Gene

Amdhd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.By similarity

Catalytic activityi

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi143 – 1431Divalent metal cationBy similarity
Metal bindingi211 – 2111Divalent metal cation; via tele nitrogenBy similarity
Metal bindingi232 – 2321Divalent metal cation; via tele nitrogenBy similarity
Binding sitei243 – 2431SubstrateBy similarity
Active sitei294 – 2941Proton donor/acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-446210. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00629.

Protein family/group databases

MEROPSiM38.979.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosamine-6-phosphate deacetylaseBy similarity (EC:3.5.1.25By similarity)
Short name:
GlcNAc 6-P deacetylaseBy similarity
Alternative name(s):
Amidohydrolase domain-containing protein 2By similarity
Gene namesi
Name:Amdhd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2443978. Amdhd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409N-acetylglucosamine-6-phosphate deacetylasePRO_0000315777Add
BLAST

Proteomic databases

EPDiQ8JZV7.
MaxQBiQ8JZV7.
PaxDbiQ8JZV7.
PeptideAtlasiQ8JZV7.
PRIDEiQ8JZV7.

2D gel databases

REPRODUCTION-2DPAGEQ8JZV7.

PTM databases

iPTMnetiQ8JZV7.
PhosphoSiteiQ8JZV7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036820.
CleanExiMM_AMDHD2.
ExpressionAtlasiQ8JZV7. baseline and differential.
GenevisibleiQ8JZV7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8JZV7. 3 interactions.
MINTiMINT-4116673.
STRINGi10090.ENSMUSP00000036141.

Structurei

3D structure databases

ProteinModelPortaliQ8JZV7.
SMRiQ8JZV7. Positions 15-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni154 – 1552Substrate bindingBy similarity
Regioni235 – 2362Substrate bindingBy similarity
Regioni269 – 2724Substrate bindingBy similarity
Regioni328 – 3303Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the NagA family.Curated

Phylogenomic databases

eggNOGiKOG3892. Eukaryota.
COG1820. LUCA.
GeneTreeiENSGT00390000012605.
HOGENOMiHOG000275010.
HOVERGENiHBG108170.
InParanoidiQ8JZV7.
KOiK01443.
OMAiGRHIFYG.
OrthoDBiEOG091G08JG.
PhylomeDBiQ8JZV7.
TreeFamiTF315036.

Family and domain databases

CDDicd00854. NagA. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR003764. GlcNAc_6-P_deAcase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038994. NagA. 1 hit.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR00221. nagA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8JZV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGQCAAGA PVLQFTNCRI LRGGTLLRED LWVRGGRILD PEKLFFEERR
60 70 80 90 100
VADEQRDCGG RILAPGFIDV QINGGFGVDF SKATEDVGSG VALVARRLLS
110 120 130 140 150
HGVTSFCPTL VTSPPEVYHK VLPQIPVKSG GPHGAGVLGV HLEGPFISRE
160 170 180 190 200
KRGAHPEAYL RSFEANAFHD VLATYGPLDN VCIVTLAPEL DRSHEVIQAL
210 220 230 240 250
TAQGIRVSLG HSVADLRAAE VAVQSGATFI THLFNAMLPF HHRDPGIVGL
260 270 280 290 300
LTSDQLPPGH CIFYGMIADG IHTNPAALRI AHRAHPQGLV LVTDAVPALG
310 320 330 340 350
LGNGRHTLGQ QEVEVDGLIA YIAGTKTLGG SIAPMDVCVR HFLQATGCSV
360 370 380 390 400
ESALEAASLH PAQMLGLEKT KGSLDFGADA DFVVLDDTLH VQATYISGEL

VWQAEEAGP
Length:409
Mass (Da):43,501
Last modified:October 1, 2002 - v1
Checksum:i914930464779CAC7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti354 – 3541L → M in BAC36877 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077584 mRNA. Translation: BAC36877.1.
AK090009 mRNA. Translation: BAC41042.1.
AK159860 mRNA. Translation: BAE35434.1.
AK168432 mRNA. Translation: BAE40339.1.
BC037005 mRNA. Translation: AAH37005.1.
CCDSiCCDS28475.1.
RefSeqiNP_766523.2. NM_172935.4.
UniGeneiMm.87319.

Genome annotation databases

EnsembliENSMUST00000040735; ENSMUSP00000036141; ENSMUSG00000036820.
GeneIDi245847.
KEGGimmu:245847.
UCSCiuc008aum.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077584 mRNA. Translation: BAC36877.1.
AK090009 mRNA. Translation: BAC41042.1.
AK159860 mRNA. Translation: BAE35434.1.
AK168432 mRNA. Translation: BAE40339.1.
BC037005 mRNA. Translation: AAH37005.1.
CCDSiCCDS28475.1.
RefSeqiNP_766523.2. NM_172935.4.
UniGeneiMm.87319.

3D structure databases

ProteinModelPortaliQ8JZV7.
SMRiQ8JZV7. Positions 15-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8JZV7. 3 interactions.
MINTiMINT-4116673.
STRINGi10090.ENSMUSP00000036141.

Protein family/group databases

MEROPSiM38.979.

PTM databases

iPTMnetiQ8JZV7.
PhosphoSiteiQ8JZV7.

2D gel databases

REPRODUCTION-2DPAGEQ8JZV7.

Proteomic databases

EPDiQ8JZV7.
MaxQBiQ8JZV7.
PaxDbiQ8JZV7.
PeptideAtlasiQ8JZV7.
PRIDEiQ8JZV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040735; ENSMUSP00000036141; ENSMUSG00000036820.
GeneIDi245847.
KEGGimmu:245847.
UCSCiuc008aum.1. mouse.

Organism-specific databases

CTDi51005.
MGIiMGI:2443978. Amdhd2.

Phylogenomic databases

eggNOGiKOG3892. Eukaryota.
COG1820. LUCA.
GeneTreeiENSGT00390000012605.
HOGENOMiHOG000275010.
HOVERGENiHBG108170.
InParanoidiQ8JZV7.
KOiK01443.
OMAiGRHIFYG.
OrthoDBiEOG091G08JG.
PhylomeDBiQ8JZV7.
TreeFamiTF315036.

Enzyme and pathway databases

UniPathwayiUPA00629.
ReactomeiR-MMU-446210. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

PROiQ8JZV7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036820.
CleanExiMM_AMDHD2.
ExpressionAtlasiQ8JZV7. baseline and differential.
GenevisibleiQ8JZV7. MM.

Family and domain databases

CDDicd00854. NagA. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR003764. GlcNAc_6-P_deAcase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038994. NagA. 1 hit.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR00221. nagA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNAGA_MOUSE
AccessioniPrimary (citable) accession number: Q8JZV7
Secondary accession number(s): Q8BK10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.