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Q8JZU2

- TXTP_MOUSE

UniProt

Q8JZU2 - TXTP_MOUSE

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Protein

Tricarboxylate transport protein, mitochondrial

Gene

Slc25a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in citrate-H+/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD+ for the glycolytic pathway.By similarity

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Tricarboxylate transport protein, mitochondrialBy similarity
Alternative name(s):
Citrate transport proteinBy similarity
Short name:
CTPBy similarity
Solute carrier family 25 member 1Imported
Tricarboxylate carrier proteinBy similarity
Gene namesi
Name:Slc25a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1345283. Slc25a1.

Subcellular locationi

Mitochondrion inner membrane By similarity1 Publication; Multi-pass membrane protein Sequence Analysis

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial inner membrane Source: MGI
  4. mitochondrion Source: MGI
  5. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313MitochondrionBy similarityAdd
BLAST
Chaini14 – 311298Tricarboxylate transport protein, mitochondrialPRO_0000430571Add
BLAST

Proteomic databases

MaxQBiQ8JZU2.
PaxDbiQ3TDH6.
PRIDEiQ3TDH6.

PTM databases

PhosphoSiteiQ3TDH6.

Expressioni

Tissue specificityi

Expressed minimally but ubiquitously throughout the adult brain. Detected at higher levels in the olfactory bulb, neocortex and cerebellum. Also expressed in a subset of large cells in the globus pallidus.1 Publication

Developmental stagei

Expression reaches a maximum between E16 and P0 and then declines in adulthood.1 Publication

Gene expression databases

GenevestigatoriQ8JZU2.

Interactioni

Protein-protein interaction databases

IntActiQ8JZU2. 2 interactions.
MINTiMINT-1860897.

Structurei

3D structure databases

ProteinModelPortaliQ8JZU2.
SMRiQ8JZU2. Positions 27-304.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4618Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei86 – 10520Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei129 – 14315Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei183 – 20220Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei224 – 24118Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei278 – 29720Helical; Name=6Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 11189Solcar 1PROSITE-ProRule annotationAdd
BLAST
Repeati122 – 20887Solcar 2PROSITE-ProRule annotationAdd
BLAST
Repeati218 – 30386Solcar 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]UniRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG306627.
GeneTreeiENSGT00550000074856.
HOGENOMiHOG000168307.
HOVERGENiHBG103009.
InParanoidiQ8JZU2.
KOiK15100.
OMAiFMIYDSI.
OrthoDBiEOG779NZP.
PhylomeDBiQ8JZU2.
TreeFamiTF105786.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZU2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPRGPRAL SAAAPGSGKP KLTHPGKAIL AGGLAGGIEI CITFPTEYVK
60 70 80 90 100
TQLQLDERAN PPRYRGIGDC VRQTVRSHGV LGLYRGLSSL LYGSIPKAAV
110 120 130 140 150
RFGMFEFLSN HMRDAQGRLD SRRGLLCGLG AGVAEAVVVV CPMETIKVKF
160 170 180 190 200
IHDQTSSNPK YRGFFHGVRE IIREQGLKGT YQGLTATVLK QGSNQAIRFF
210 220 230 240 250
VMTSLRNWYQ GDNHNKPMNP LITGVFGATA GAASVFGNTP LDVIKTRMQG
260 270 280 290 300
LEAHKYRNTL DCGLKILKNE GPKAFYKGTV PRLGRVCLDV AIVFIIYDEV
310
VKLLNKVWKT D
Length:311
Mass (Da):33,931
Last modified:October 1, 2002 - v1
Checksum:iE7910B52F006991D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781H → Y in BAE41625. (PubMed:16141072)Curated
Sequence conflicti115 – 1151A → D in BAE41625. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK159289 mRNA. Translation: BAE34965.1.
AK170191 mRNA. Translation: BAE41625.1.
AC078895 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97495.1.
BC037087 mRNA. Translation: AAH37087.1.
RefSeqiNP_694790.1. NM_153150.2.
UniGeneiMm.229291.

Genome annotation databases

EnsembliENSMUST00000003622; ENSMUSP00000003622; ENSMUSG00000003528.
GeneIDi13358.
KEGGimmu:13358.
UCSCiuc007ymp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK159289 mRNA. Translation: BAE34965.1 .
AK170191 mRNA. Translation: BAE41625.1 .
AC078895 Genomic DNA. No translation available.
CH466521 Genomic DNA. Translation: EDK97495.1 .
BC037087 mRNA. Translation: AAH37087.1 .
RefSeqi NP_694790.1. NM_153150.2.
UniGenei Mm.229291.

3D structure databases

ProteinModelPortali Q8JZU2.
SMRi Q8JZU2. Positions 27-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8JZU2. 2 interactions.
MINTi MINT-1860897.

PTM databases

PhosphoSitei Q3TDH6.

Proteomic databases

MaxQBi Q8JZU2.
PaxDbi Q3TDH6.
PRIDEi Q3TDH6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003622 ; ENSMUSP00000003622 ; ENSMUSG00000003528 .
GeneIDi 13358.
KEGGi mmu:13358.
UCSCi uc007ymp.2. mouse.

Organism-specific databases

CTDi 6576.
MGIi MGI:1345283. Slc25a1.

Phylogenomic databases

eggNOGi NOG306627.
GeneTreei ENSGT00550000074856.
HOGENOMi HOG000168307.
HOVERGENi HBG103009.
InParanoidi Q8JZU2.
KOi K15100.
OMAi FMIYDSI.
OrthoDBi EOG779NZP.
PhylomeDBi Q8JZU2.
TreeFami TF105786.

Miscellaneous databases

NextBioi 283688.
PROi Q8JZU2.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8JZU2.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: LiverImported.
  5. "Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes."
    Maynard T.M., Meechan D.W., Dudevoir M.L., Gopalakrishna D., Peters A.Z., Heindel C.C., Sugimoto T.J., Wu Y., Lieberman J.A., Lamantia A.S.
    Mol. Cell. Neurosci. 39:439-451(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTXTP_MOUSE
AccessioniPrimary (citable) accession number: Q8JZU2
Secondary accession number(s): Q3TDH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3