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Protein

Excitatory amino acid transporter 5

Gene

Slc1a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing (By similarity).By similarity

GO - Molecular functioni

  • anion transmembrane transporter activity Source: MGI
  • L-glutamate transmembrane transporter activity Source: MGI
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • anion transmembrane transport Source: MGI
  • L-glutamate transmembrane transport Source: MGI

Keywordsi

Biological processSymport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 5
Alternative name(s):
Solute carrier family 1 member 7
Gene namesi
Name:Slc1a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2444087 Slc1a7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 215ExtracellularSequence analysisAdd BLAST101
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002844511 – 559Excitatory amino acid transporter 5Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8JZR4
PRIDEiQ8JZR4

PTM databases

iPTMnetiQ8JZR4
PhosphoSitePlusiQ8JZR4

Interactioni

Subunit structurei

Interacts with the PDZ domains of DLG4.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102324

Structurei

3D structure databases

ProteinModelPortaliQ8JZR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
HOGENOMiHOG000208776
HOVERGENiHBG000080
InParanoidiQ8JZR4
KOiK05618
PhylomeDBiQ8JZR4
TreeFamiTF315206

Family and domain databases

Gene3Di1.10.3860.10, 2 hits
InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 2 hits
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8JZR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLDAVLARG RTVCKHNGLL ILSVLSVIVG CLLGFFLRTQ RLSPQEISYF
60 70 80 90 100
QFPGELLMRM LKMLILPLVV SSLMSGLASL DAKTSSRLGI LTVAYYLWTT
110 120 130 140 150
FLAVVVGIIM VSIIHPGGAA QKETTEQSGK PVMSSADALL DLVRNMFPAN
160 170 180 190 200
LVEATFKQYR TKTTPVIKSP RGAAEEAPRR IVIYGVQEDN GSRVQNFALD
210 220 230 240 250
LTPPPEIVYK SEPGTSDGMN VLGIVIFSAT MGIMLGRMGD SGTPLVSFCQ
260 270 280 290 300
CLNESVMKIV AVAGWYFPFG IVFLIAGKIL EMDDPKAVGK KLGFYAVTVV
310 320 330 340 350
CGLVVHGLLI LPLLYFLITK KNPIVFIRGV LQALLIALAT SSSSATLPIT
360 370 380 390 400
FKCLLENNHI DRRIARFVLP VGATINMDGT ALYEAVAAIF IAQVNNYELD
410 420 430 440 450
FGQIITISIT ATAASIGAAG IPQAGLVTMV IVLTSVGLPT DDINLIIAVD
460 470 480 490 500
WALDRFRTMI NVLGDALAAG IMAHICRKDF AQDMGTEKLL PCETKPVTLQ
510 520 530 540 550
EIVAAQQNGC VKSVAEASEL TLGPTCPHHI PVQVEQDEDP AAASLDHCTI

EISELETNV
Length:559
Mass (Da):60,106
Last modified:October 1, 2002 - v1
Checksum:iBEC713C884E27187
GO

Sequence cautioni

The sequence CAM23593 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044586 mRNA Translation: BAC31989.1
AK044671 mRNA Translation: BAC32027.1
AL611936 Genomic DNA Translation: CAM23593.1 Different initiation.
BC030400 mRNA Translation: AAH30400.1
RefSeqiNP_666367.2, NM_146255.2
UniGeneiMm.192040

Genome annotation databases

GeneIDi242607
KEGGimmu:242607

Similar proteinsi

Entry informationi

Entry nameiEAA5_MOUSE
AccessioniPrimary (citable) accession number: Q8JZR4
Secondary accession number(s): A2A8F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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