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Q8JZR4 (EAA5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Excitatory amino acid transporter 5
Alternative name(s):
Solute carrier family 1 member 7
Gene names
Name:Slc1a7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing By similarity.

Subunit structure

Interacts with the PDZ domains of DLG4 By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A7 subfamily. [View classification]

Sequence caution

The sequence CAM23593.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processSymport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsodium:dicarboxylate symporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Excitatory amino acid transporter 5
PRO_0000284451

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane94 – 11421Helical; Potential
Topological domain115 – 215101Extracellular Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane259 – 27921Helical; Potential
Transmembrane298 – 31821Helical; Potential
Transmembrane329 – 34921Helical; Potential
Transmembrane371 – 39121Helical; Potential
Transmembrane413 – 43321Helical; Potential
Transmembrane456 – 47621Helical; Potential

Amino acid modifications

Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation2531N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8JZR4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: BEC713C884E27187

FASTA55960,106
        10         20         30         40         50         60 
MVLDAVLARG RTVCKHNGLL ILSVLSVIVG CLLGFFLRTQ RLSPQEISYF QFPGELLMRM 

        70         80         90        100        110        120 
LKMLILPLVV SSLMSGLASL DAKTSSRLGI LTVAYYLWTT FLAVVVGIIM VSIIHPGGAA 

       130        140        150        160        170        180 
QKETTEQSGK PVMSSADALL DLVRNMFPAN LVEATFKQYR TKTTPVIKSP RGAAEEAPRR 

       190        200        210        220        230        240 
IVIYGVQEDN GSRVQNFALD LTPPPEIVYK SEPGTSDGMN VLGIVIFSAT MGIMLGRMGD 

       250        260        270        280        290        300 
SGTPLVSFCQ CLNESVMKIV AVAGWYFPFG IVFLIAGKIL EMDDPKAVGK KLGFYAVTVV 

       310        320        330        340        350        360 
CGLVVHGLLI LPLLYFLITK KNPIVFIRGV LQALLIALAT SSSSATLPIT FKCLLENNHI 

       370        380        390        400        410        420 
DRRIARFVLP VGATINMDGT ALYEAVAAIF IAQVNNYELD FGQIITISIT ATAASIGAAG 

       430        440        450        460        470        480 
IPQAGLVTMV IVLTSVGLPT DDINLIIAVD WALDRFRTMI NVLGDALAAG IMAHICRKDF 

       490        500        510        520        530        540 
AQDMGTEKLL PCETKPVTLQ EIVAAQQNGC VKSVAEASEL TLGPTCPHHI PVQVEQDEDP 

       550 
AAASLDHCTI EISELETNV 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Retina.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK044586 mRNA. Translation: BAC31989.1.
AK044671 mRNA. Translation: BAC32027.1.
AL611936 Genomic DNA. Translation: CAM23593.1. Different initiation.
BC030400 mRNA. Translation: AAH30400.1.
RefSeqNP_666367.2. NM_146255.2.
UniGeneMm.192040.

3D structure databases

ProteinModelPortalQ8JZR4.
SMRQ8JZR4. Positions 19-473.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8JZR4.

Proteomic databases

PRIDEQ8JZR4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID242607.
KEGGmmu:242607.
UCSCuc008uao.2. mouse.

Organism-specific databases

CTD6512.
MGIMGI:2444087. Slc1a7.

Phylogenomic databases

eggNOGCOG1301.
HOGENOMHOG000208776.
HOVERGENHBG000080.
InParanoidQ8JZR4.
KOK05618.
PhylomeDBQ8JZR4.
TreeFamTF315206.

Gene expression databases

BgeeQ8JZR4.
GenevestigatorQ8JZR4.

Family and domain databases

Gene3D1.10.3860.10. 2 hits.
InterProIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERPTHR11958. PTHR11958. 1 hit.
PfamPF00375. SDF. 1 hit.
[Graphical view]
PRINTSPR00173. EDTRNSPORT.
SUPFAMSSF118215. SSF118215. 2 hits.
PROSITEPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio385446.
PROQ8JZR4.
SOURCESearch...

Entry information

Entry nameEAA5_MOUSE
AccessionPrimary (citable) accession number: Q8JZR4
Secondary accession number(s): A2A8F0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot