Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8JZR4

- EAA5_MOUSE

UniProt

Q8JZR4 - EAA5_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Excitatory amino acid transporter 5

Gene

Slc1a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing (By similarity).By similarity

GO - Molecular functioni

  1. sodium:dicarboxylate symporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_229514. Glutamate Neurotransmitter Release Cycle.
REACT_251788. Transport of inorganic cations/anions and amino acids/oligopeptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 5
Alternative name(s):
Solute carrier family 1 member 7
Gene namesi
Name:Slc1a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2444087. Slc1a7.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Topological domaini115 – 215101ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence AnalysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence AnalysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence AnalysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence AnalysisAdd
BLAST
Transmembranei371 – 39121HelicalSequence AnalysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence AnalysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Excitatory amino acid transporter 5PRO_0000284451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8JZR4.

PTM databases

PhosphoSiteiQ8JZR4.

Expressioni

Gene expression databases

BgeeiQ8JZR4.
ExpressionAtlasiQ8JZR4. baseline and differential.
GenevestigatoriQ8JZR4.

Interactioni

Subunit structurei

Interacts with the PDZ domains of DLG4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8JZR4.
SMRiQ8JZR4. Positions 19-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1301.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiQ8JZR4.
KOiK05618.
PhylomeDBiQ8JZR4.
TreeFamiTF315206.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JZR4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLDAVLARG RTVCKHNGLL ILSVLSVIVG CLLGFFLRTQ RLSPQEISYF
60 70 80 90 100
QFPGELLMRM LKMLILPLVV SSLMSGLASL DAKTSSRLGI LTVAYYLWTT
110 120 130 140 150
FLAVVVGIIM VSIIHPGGAA QKETTEQSGK PVMSSADALL DLVRNMFPAN
160 170 180 190 200
LVEATFKQYR TKTTPVIKSP RGAAEEAPRR IVIYGVQEDN GSRVQNFALD
210 220 230 240 250
LTPPPEIVYK SEPGTSDGMN VLGIVIFSAT MGIMLGRMGD SGTPLVSFCQ
260 270 280 290 300
CLNESVMKIV AVAGWYFPFG IVFLIAGKIL EMDDPKAVGK KLGFYAVTVV
310 320 330 340 350
CGLVVHGLLI LPLLYFLITK KNPIVFIRGV LQALLIALAT SSSSATLPIT
360 370 380 390 400
FKCLLENNHI DRRIARFVLP VGATINMDGT ALYEAVAAIF IAQVNNYELD
410 420 430 440 450
FGQIITISIT ATAASIGAAG IPQAGLVTMV IVLTSVGLPT DDINLIIAVD
460 470 480 490 500
WALDRFRTMI NVLGDALAAG IMAHICRKDF AQDMGTEKLL PCETKPVTLQ
510 520 530 540 550
EIVAAQQNGC VKSVAEASEL TLGPTCPHHI PVQVEQDEDP AAASLDHCTI

EISELETNV
Length:559
Mass (Da):60,106
Last modified:October 1, 2002 - v1
Checksum:iBEC713C884E27187
GO

Sequence cautioni

The sequence CAM23593.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044586 mRNA. Translation: BAC31989.1.
AK044671 mRNA. Translation: BAC32027.1.
AL611936 Genomic DNA. Translation: CAM23593.1. Different initiation.
BC030400 mRNA. Translation: AAH30400.1.
RefSeqiNP_666367.2. NM_146255.2.
UniGeneiMm.192040.

Genome annotation databases

GeneIDi242607.
KEGGimmu:242607.
UCSCiuc008uao.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044586 mRNA. Translation: BAC31989.1 .
AK044671 mRNA. Translation: BAC32027.1 .
AL611936 Genomic DNA. Translation: CAM23593.1 . Different initiation.
BC030400 mRNA. Translation: AAH30400.1 .
RefSeqi NP_666367.2. NM_146255.2.
UniGenei Mm.192040.

3D structure databases

ProteinModelPortali Q8JZR4.
SMRi Q8JZR4. Positions 19-473.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8JZR4.

Proteomic databases

PRIDEi Q8JZR4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 242607.
KEGGi mmu:242607.
UCSCi uc008uao.2. mouse.

Organism-specific databases

CTDi 6512.
MGIi MGI:2444087. Slc1a7.

Phylogenomic databases

eggNOGi COG1301.
HOGENOMi HOG000208776.
HOVERGENi HBG000080.
InParanoidi Q8JZR4.
KOi K05618.
PhylomeDBi Q8JZR4.
TreeFami TF315206.

Enzyme and pathway databases

Reactomei REACT_229514. Glutamate Neurotransmitter Release Cycle.
REACT_251788. Transport of inorganic cations/anions and amino acids/oligopeptides.

Miscellaneous databases

NextBioi 385446.
PROi Q8JZR4.
SOURCEi Search...

Gene expression databases

Bgeei Q8JZR4.
ExpressionAtlasi Q8JZR4. baseline and differential.
Genevestigatori Q8JZR4.

Family and domain databases

Gene3Di 1.10.3860.10. 2 hits.
InterProi IPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view ]
PANTHERi PTHR11958. PTHR11958. 1 hit.
Pfami PF00375. SDF. 1 hit.
[Graphical view ]
PRINTSi PR00173. EDTRNSPORT.
SUPFAMi SSF118215. SSF118215. 2 hits.
PROSITEi PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiEAA5_MOUSE
AccessioniPrimary (citable) accession number: Q8JZR4
Secondary accession number(s): A2A8F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3