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Q8JZR4

- EAA5_MOUSE

UniProt

Q8JZR4 - EAA5_MOUSE

Protein

Excitatory amino acid transporter 5

Gene

Slc1a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing By similarity.By similarity

    GO - Molecular functioni

    1. sodium:dicarboxylate symporter activity Source: InterPro

    Keywords - Biological processi

    Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Excitatory amino acid transporter 5
    Alternative name(s):
    Solute carrier family 1 member 7
    Gene namesi
    Name:Slc1a7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2444087. Slc1a7.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Excitatory amino acid transporter 5PRO_0000284451Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8JZR4.

    PTM databases

    PhosphoSiteiQ8JZR4.

    Expressioni

    Gene expression databases

    BgeeiQ8JZR4.
    GenevestigatoriQ8JZR4.

    Interactioni

    Subunit structurei

    Interacts with the PDZ domains of DLG4.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JZR4.
    SMRiQ8JZR4. Positions 19-473.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini115 – 215101ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei329 – 34921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1301.
    HOGENOMiHOG000208776.
    HOVERGENiHBG000080.
    InParanoidiQ8JZR4.
    KOiK05618.
    PhylomeDBiQ8JZR4.
    TreeFamiTF315206.

    Family and domain databases

    Gene3Di1.10.3860.10. 2 hits.
    InterProiIPR001991. Na-dicarboxylate_symporter.
    IPR018107. Na-dicarboxylate_symporter_CS.
    [Graphical view]
    PANTHERiPTHR11958. PTHR11958. 1 hit.
    PfamiPF00375. SDF. 1 hit.
    [Graphical view]
    PRINTSiPR00173. EDTRNSPORT.
    SUPFAMiSSF118215. SSF118215. 2 hits.
    PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
    PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8JZR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLDAVLARG RTVCKHNGLL ILSVLSVIVG CLLGFFLRTQ RLSPQEISYF    50
    QFPGELLMRM LKMLILPLVV SSLMSGLASL DAKTSSRLGI LTVAYYLWTT 100
    FLAVVVGIIM VSIIHPGGAA QKETTEQSGK PVMSSADALL DLVRNMFPAN 150
    LVEATFKQYR TKTTPVIKSP RGAAEEAPRR IVIYGVQEDN GSRVQNFALD 200
    LTPPPEIVYK SEPGTSDGMN VLGIVIFSAT MGIMLGRMGD SGTPLVSFCQ 250
    CLNESVMKIV AVAGWYFPFG IVFLIAGKIL EMDDPKAVGK KLGFYAVTVV 300
    CGLVVHGLLI LPLLYFLITK KNPIVFIRGV LQALLIALAT SSSSATLPIT 350
    FKCLLENNHI DRRIARFVLP VGATINMDGT ALYEAVAAIF IAQVNNYELD 400
    FGQIITISIT ATAASIGAAG IPQAGLVTMV IVLTSVGLPT DDINLIIAVD 450
    WALDRFRTMI NVLGDALAAG IMAHICRKDF AQDMGTEKLL PCETKPVTLQ 500
    EIVAAQQNGC VKSVAEASEL TLGPTCPHHI PVQVEQDEDP AAASLDHCTI 550
    EISELETNV 559
    Length:559
    Mass (Da):60,106
    Last modified:October 1, 2002 - v1
    Checksum:iBEC713C884E27187
    GO

    Sequence cautioni

    The sequence CAM23593.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044586 mRNA. Translation: BAC31989.1.
    AK044671 mRNA. Translation: BAC32027.1.
    AL611936 Genomic DNA. Translation: CAM23593.1. Different initiation.
    BC030400 mRNA. Translation: AAH30400.1.
    RefSeqiNP_666367.2. NM_146255.2.
    UniGeneiMm.192040.

    Genome annotation databases

    GeneIDi242607.
    KEGGimmu:242607.
    UCSCiuc008uao.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK044586 mRNA. Translation: BAC31989.1 .
    AK044671 mRNA. Translation: BAC32027.1 .
    AL611936 Genomic DNA. Translation: CAM23593.1 . Different initiation.
    BC030400 mRNA. Translation: AAH30400.1 .
    RefSeqi NP_666367.2. NM_146255.2.
    UniGenei Mm.192040.

    3D structure databases

    ProteinModelPortali Q8JZR4.
    SMRi Q8JZR4. Positions 19-473.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8JZR4.

    Proteomic databases

    PRIDEi Q8JZR4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 242607.
    KEGGi mmu:242607.
    UCSCi uc008uao.2. mouse.

    Organism-specific databases

    CTDi 6512.
    MGIi MGI:2444087. Slc1a7.

    Phylogenomic databases

    eggNOGi COG1301.
    HOGENOMi HOG000208776.
    HOVERGENi HBG000080.
    InParanoidi Q8JZR4.
    KOi K05618.
    PhylomeDBi Q8JZR4.
    TreeFami TF315206.

    Miscellaneous databases

    NextBioi 385446.
    PROi Q8JZR4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8JZR4.
    Genevestigatori Q8JZR4.

    Family and domain databases

    Gene3Di 1.10.3860.10. 2 hits.
    InterProi IPR001991. Na-dicarboxylate_symporter.
    IPR018107. Na-dicarboxylate_symporter_CS.
    [Graphical view ]
    PANTHERi PTHR11958. PTHR11958. 1 hit.
    Pfami PF00375. SDF. 1 hit.
    [Graphical view ]
    PRINTSi PR00173. EDTRNSPORT.
    SUPFAMi SSF118215. SSF118215. 2 hits.
    PROSITEi PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
    PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Retina.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiEAA5_MOUSE
    AccessioniPrimary (citable) accession number: Q8JZR4
    Secondary accession number(s): A2A8F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3