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Q8JZR0

- ACSL5_MOUSE

UniProt

Q8JZR0 - ACSL5_MOUSE

Protein

Long-chain-fatty-acid--CoA ligase 5

Gene

Acsl5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage By similarity. It was suggested that it may also stimulate fatty acid oxidation By similarity. At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL By similarity. May have a role in the survival of glioma cells By similarity. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids By similarity.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of extrinsic apoptotic signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi6.2.1.3. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 5 (EC:6.2.1.3)
    Alternative name(s):
    Long-chain acyl-CoA synthetase 5
    Short name:
    LACS 5
    Gene namesi
    Name:Acsl5
    Synonyms:Facl5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1919129. Acsl5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: MGI
    4. mitochondrial outer membrane Source: UniProtKB-SubCell
    5. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 683683Long-chain-fatty-acid--CoA ligase 5PRO_0000193113Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei361 – 3611N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8JZR0.
    PaxDbiQ8JZR0.
    PRIDEiQ8JZR0.

    PTM databases

    PhosphoSiteiQ8JZR0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8JZR0.
    BgeeiQ8JZR0.
    CleanExiMM_ACSL5.
    GenevestigatoriQ8JZR0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8JZR0. 2 interactions.
    MINTiMINT-1862123.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JZR0.
    SMRiQ8JZR0. Positions 106-620.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 683651CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221Helical; Signal-anchor for type III membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1022.
    GeneTreeiENSGT00690000101725.
    HOGENOMiHOG000159459.
    HOVERGENiHBG050452.
    InParanoidiQ8JZR0.
    KOiK01897.
    OMAiIFVHPEP.
    OrthoDBiEOG71CFKN.
    PhylomeDBiQ8JZR0.
    TreeFamiTF313877.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8JZR0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFIFNFLFS PLPTPALICL LTFGTAIFLW LINRPQPVLP LIDLDNQSVG    50
    IEGGARRGAF QKNNDLILYY FSDAKTLYEN FQRGLAVSDN GPCLGYRKPN 100
    QPYKWISYKQ VSDRAEYLGS CLLHKGYKSS QDQFVGIFAQ NRPEWVISEL 150
    ACYTYSMVAV PLYDTLGTEA IIFVINRADI PVVICDTPQK ATMLVENVEK 200
    GLTPGLKTII LMDPFDDDLM KRGEKCGVEM LSLHDAENIG KENFKKPVPP 250
    KPEDLSVICF TSGTTGDPKG AMLTHENVVS NMAAFLKFLE PIFQPTSDDV 300
    TISYLPLAHM FERLVQGILF SCGGKIGFFQ GDIRLLPDDM KALKPTVFPT 350
    VPRLLNRVYD KVQNEAKTPL KKFLLNLAII SKFNEVKNGI IRRDSLWDKL 400
    VFSKIQGSLG GKVRLMITGA APISTPVLTF FRAAMGCWVF EAYGQTECTG 450
    GCSITSPGDW TAGHVGTPVA CNFVKLEDVA DMNYFSVNNE GEICIKGNNV 500
    FKGYLKDPEK TQEVLDKDGW LHTGDIGRWL PNGTLKIVDR KKNIFKLAQG 550
    EYIAPEKIEN VYSRSRPVLQ VFVHGESLRS FLIGVVVPDP DSLPSFAAKI 600
    GVKGSFEELC KNQCVKEAIL EDLQKIGKEG GLKSFEQVKS IFVHPEPFTI 650
    ENGLLTPTLK AKRVELAKFF QTQIKSLYES IEE 683
    Length:683
    Mass (Da):76,206
    Last modified:October 1, 2002 - v1
    Checksum:i734A1A5878741D70
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031544 mRNA. Translation: AAH31544.1.
    CCDSiCCDS29908.1.
    PIRiS49487.
    RefSeqiNP_082252.1. NM_027976.2.
    XP_006527241.1. XM_006527178.1.
    UniGeneiMm.292056.

    Genome annotation databases

    EnsembliENSMUST00000043150; ENSMUSP00000046585; ENSMUSG00000024981.
    GeneIDi433256.
    KEGGimmu:433256.
    UCSCiuc008hxp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031544 mRNA. Translation: AAH31544.1 .
    CCDSi CCDS29908.1.
    PIRi S49487.
    RefSeqi NP_082252.1. NM_027976.2.
    XP_006527241.1. XM_006527178.1.
    UniGenei Mm.292056.

    3D structure databases

    ProteinModelPortali Q8JZR0.
    SMRi Q8JZR0. Positions 106-620.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8JZR0. 2 interactions.
    MINTi MINT-1862123.

    PTM databases

    PhosphoSitei Q8JZR0.

    Proteomic databases

    MaxQBi Q8JZR0.
    PaxDbi Q8JZR0.
    PRIDEi Q8JZR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043150 ; ENSMUSP00000046585 ; ENSMUSG00000024981 .
    GeneIDi 433256.
    KEGGi mmu:433256.
    UCSCi uc008hxp.1. mouse.

    Organism-specific databases

    CTDi 51703.
    MGIi MGI:1919129. Acsl5.

    Phylogenomic databases

    eggNOGi COG1022.
    GeneTreei ENSGT00690000101725.
    HOGENOMi HOG000159459.
    HOVERGENi HBG050452.
    InParanoidi Q8JZR0.
    KOi K01897.
    OMAi IFVHPEP.
    OrthoDBi EOG71CFKN.
    PhylomeDBi Q8JZR0.
    TreeFami TF313877.

    Enzyme and pathway databases

    BRENDAi 6.2.1.3. 3474.

    Miscellaneous databases

    ChiTaRSi ACSL5. mouse.
    NextBioi 408505.
    PROi Q8JZR0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8JZR0.
    Bgeei Q8JZR0.
    CleanExi MM_ACSL5.
    Genevestigatori Q8JZR0.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    2. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiACSL5_MOUSE
    AccessioniPrimary (citable) accession number: Q8JZR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3