Reviewed,
UniProtKB/Swiss-Prot Q8JZR0 (ACSL5_MOUSE)
Last modified
June 16, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Long-chain-fatty-acid--CoA ligase 5 EC=6.2.1.3 Alternative name(s): Long-chain acyl-CoA synthetase 5 Short name=LACS 5 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 683 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids By similarity. |
| Catalytic activity | ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA. |
| Subcellular location | Mitochondrion outer membrane; Single-pass type III membrane protein By similarity. Peroxisome membrane; Single-pass type III membrane protein By similarity. Microsome membrane; Single-pass type III membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass type III membrane protein By similarity. |
| Sequence similarities | Belongs to the ATP-dependent AMP-binding enzyme family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| BC031544 mRNA. Translation: AAH31544.1. | |
| IPI | IPI00170363. |
| PIR | S49487. |
| RefSeq | NP_082252.1. |
| UniGene | Mm.292056 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1LCI based on UniProtKB P08659. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q8JZR0. |
Proteomic databases | |
| PRIDE | Q8JZR0. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000024981. Mus musculus. [Contig view] |
| GeneID | 433256. |
| KEGG | mmu:433256. |
| NMPDR | fig|10090.3.peg.5260. |
Organism-specific databases | |
| MGI | MGI:1919129. Acsl5. |
Phylogenomic databases | |
| HOGENOM | Q8JZR0. |
| HOVERGEN | Q8JZR0. |
| OMA | Q8JZR0. XWVISEL. |
Enzyme and pathway databases | |
| BRENDA | 6.2.1.3. 244. |
Gene expression databases | |
| ArrayExpress | Q8JZR0. |
| Bgee | Q8JZR0. |
| CleanEx | MM_ACSL5. |
| GermOnline | ENSMUSG00000024981. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000873. AMP-dep_Synth/Lig. [Graphical view] |
| Pfam | PF00501. AMP-binding. 2 hits. [Graphical view] |
| PROSITE | PS00455. AMP_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 408505. |
| SOURCE | Search... |
Entry information
| Entry name | ACSL5_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8JZR0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


