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Reviewed, UniProtKB/Swiss-Prot Q8JZQ5 (ABP1_MOUSE)

Last modified June 16, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Amiloride-sensitive amine oxidase [copper-containing]
      Short name=Diamine oxidase
      Short name=DAO
    EC=1.4.3.22
Alternative name(s):
    Amiloride-binding protein
      Short name=ABP
    Histaminase
Gene names
Name: Abp1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length751 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis By similarity.

Catalytic activity

Histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2.

Cofactor

Binds 1 copper ion per subunit By similarity.

Binds 2 calcium ions per subunit By similarity.

Contains 1 topaquinone per subunit By similarity.

Subcellular location

Secreted › extracellular space By similarity.

Post-translational modification

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

Miscellaneous

Inhibited by amiloride in a competitive manner By similarity.

Sequence similarities

Belongs to the copper/topaquinone oxidase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 751729Amiloride-sensitive amine oxidase [copper-containing] By similarity
PRO_0000035667

Regions

Region568 – 5758Heparin-binding By similarity

Sites

Active site3731Proton acceptor By similarity
Active site4611Schiff-base intermediate with substrate; via topaquinone By similarity
Metal binding5101Copper By similarity
Metal binding5121Copper By similarity
Metal binding5191Calcium 1 By similarity
Metal binding5201Calcium 1; via carbonyl oxygen By similarity
Metal binding5211Calcium 1 By similarity
Metal binding5621Calcium 2 By similarity
Metal binding6531Calcium 2; via carbonyl oxygen By similarity
Metal binding6561Calcium 2 By similarity
Metal binding6581Calcium 2 By similarity
Metal binding6641Calcium 1 By similarity
Metal binding6651Calcium 1; via carbonyl oxygen By similarity
Metal binding6751Copper By similarity

Amino acid modifications

Modified residue46112',4',5'-topaquinone By similarity
Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation5381N-linked (GlcNAc...) Potential
Glycosylation7451N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict201A → P in AAH21880. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q8JZQ5-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 4E9682DA7C967AC7

FASTA75185,424
        10         20         30         40         50         60 
MSLAFGWAAV ILLLQTADTA SAVTTPHDKA RIFADLSPQE IKAVHSFLMS RKELGLESSK 

        70         80         90        100        110        120 
NLTLAKNSVF LIEMLLPKKK NVLKFLDEGR KSPVREARAI IFFGAQDHPN VTEFAVGPLP 

       130        140        150        160        170        180 
RPCYVQALSP RPGHHLSWSS RPISTAEYDL LYHMLNRAIT PLHQFFLDTT GFSFLGCDDR 

       190        200        210        220        230        240 
FLTFTDVAPR GVESGQRRSW LIVQRYVEGY FLHPTGLEIL VDHSSTDVQD WRVEQLWYNG 

       250        260        270        280        290        300 
KFYNSPEELA QKYAVGEVEA VVLEEVVLED PLPGATEQPP LFSSYKPRGE FHTPVTVAGP 

       310        320        330        340        350        360 
HVVQPSGPRY KLEGNVVLYG DWSFSYRLRS SSGLQIFNVL FGGERVAYEV SVQEAVALYG 

       370        380        390        400        410        420 
GHTPAGMQTK YIDVGWGLGS VTHELAPGID CPETATFLDA FHYYDSDGPV LYPRALCLFE 

       430        440        450        460        470        480 
MPTGVPLRRH FDSNFKGGFN FYAGLKGYVL VLRTTSTVYN YDYIWDFIFY PNGVMETKMH 

       490        500        510        520        530        540 
ATGYVHATFY TPEGLRHGTR LQTHLLGNIH THLVHYRVDL DVAGTKNSFR TLKTKLENIT 

       550        560        570        580        590        600 
NPWSPSHSLV QPTLEQTQYS HEHQAAFRFG QTLPKYLLFS SPQKNRWGHR RSYRLQIHSM 

       610        620        630        640        650        660 
AEQVLPPGWQ EERAVTWARY PLAVTKYRES ERYSSSLYNQ NDPWDPPVVF EEFLRNNENI 

       670        680        690        700        710        720 
ENEDLVAWVT VGFLHIPHSE DVPNTATPGN CVGFLIRPFN FFEEDPSLAS RDTVIVWPQD 

       730        740        750 
NGLNHVQRWI PENRDCLVSP PFSYNGTYKP V

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
+Additional computationally mapped references.

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Cross-references

Sequence databases

BC021880 mRNA. Translation: AAH21880.1.
BC022627 mRNA. Translation: AAH22627.1.
BC034215 mRNA. Translation: AAH34215.1.
IPIIPI00323436.
RefSeqNP_083914.1.
UniGeneMm.213898

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000029811. Mus musculus. [Contig view]
GeneID76507.
KEGGmmu:76507.
NMPDRfig|10090.3.peg.14357.

Organism-specific databases

MGIMGI:1923757. Abp1.

Phylogenomic databases

HOVERGENQ8JZQ5.

Enzyme and pathway databases

BRENDA1.4.3.6. 244.

Gene expression databases

ArrayExpressQ8JZQ5.
BgeeQ8JZQ5.
GermOnlineENSMUSG00000029811. Mus musculus.

Family and domain databases

InterProIPR000269. Cu_amine_oxidase.
IPR015798. Cu_amine_oxidase_C.
IPR015800. Cu_amine_oxidase_N2.
IPR015801. Cu_amine_oxidase_N2/3.
IPR015802. Cu_amine_oxidase_N3.
[Graphical view]
Gene3DG3DSA:3.10.450.40. CuNH_oxidase. 2 hits.
G3DSA:2.70.98.20. Lyase_8_central. 1 hit.
PANTHERPTHR10638. CuNH_oxidase. 1 hit.
PfamPF01179. Cu_amine_oxid. 1 hit.
PF02727. Cu_amine_oxidN2. 1 hit.
PF02728. Cu_amine_oxidN3. 1 hit.
[Graphical view]
PRINTSPR00766. CUDAOXIDASE.
PROSITEPS01164. COPPER_AMINE_OXID_1. 1 hit.
PS01165. COPPER_AMINE_OXID_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio345286.
SOURCESearch...

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Entry information

Entry nameABP1_MOUSE
AccessionPrimary (citable) accession number: Q8JZQ5
Secondary accession number(s): Q8R229, Q8VC36
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents