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Protein

GAS2-like protein 1

Gene

Gas2l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be involved in the cross-linking of microtubules and microfilaments.By similarity

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

  • cell cycle arrest Source: UniProtKB
  • cellular response to starvation Source: UniProtKB
  • cellular response to thyroid hormone stimulus Source: UniProtKB
  • microtubule bundle formation Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of erythrocyte differentiation Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of microtubule depolymerization Source: UniProtKB
  • regulation of cell cycle Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
GAS2-like protein 1
Alternative name(s):
Growth arrest-specific protein 2-like 1
Gene namesi
Name:Gas2l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1926176. Gas2l1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 678677GAS2-like protein 1PRO_0000190443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei306 – 3061PhosphoserineCombined sources
Modified residuei352 – 3521PhosphoserineCombined sources
Modified residuei355 – 3551PhosphoserineCombined sources
Modified residuei394 – 3941PhosphoserineBy similarity
Modified residuei493 – 4931PhosphoserineCombined sources
Modified residuei501 – 5011PhosphothreonineBy similarity
Modified residuei654 – 6541PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8JZP9.
PaxDbiQ8JZP9.
PRIDEiQ8JZP9.

PTM databases

iPTMnetiQ8JZP9.
PhosphoSiteiQ8JZP9.

Expressioni

Gene expression databases

BgeeiQ8JZP9.
CleanExiMM_GAS2L1.
ExpressionAtlasiQ8JZP9. baseline and differential.
GenevisibleiQ8JZP9. MM.

Interactioni

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050275.

Structurei

3D structure databases

ProteinModelPortaliQ8JZP9.
SMRiQ8JZP9. Positions 219-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 147121CHPROSITE-ProRule annotationAdd
BLAST
Domaini203 – 27573GARPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi379 – 46284Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the GAS2 family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 GAR domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQBU. Eukaryota.
ENOG410XQ3S. LUCA.
GeneTreeiENSGT00390000002205.
HOGENOMiHOG000007404.
HOVERGENiHBG079404.
InParanoidiQ8JZP9.
OMAiDGQHSWV.
OrthoDBiEOG7VTDR1.
PhylomeDBiQ8JZP9.
TreeFamiTF323754.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
3.30.920.20. 1 hit.
InterProiIPR001715. CH-domain.
IPR029931. GAS2L1.
IPR003108. GAS_dom.
[Graphical view]
PANTHERiPTHR11915:SF296. PTHR11915:SF296. 1 hit.
PfamiPF00307. CH. 1 hit.
PF02187. GAS2. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00243. GAS2. 1 hit.
[Graphical view]
SUPFAMiSSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51460. GAR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8JZP9-1) [UniParc]FASTAAdd to basket

Also known as: Beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANPVAGIAG SAAKSVRPFR SSEAYVEAMK EDLADWLNAL YSLGLPGSGD
60 70 80 90 100
GFLTGLATGT TLCQHANAVT EAARALAAAR PTRGVAFQAH SVAPGSFMAR
110 120 130 140 150
DNVASFIGWC RAELGVPEVL MFETEDLVLR KNEKSVVLCL LEVARRGARL
160 170 180 190 200
GLLAPRLVQF EQEIERELRA TPQVSSVPAA EEDVTEIATV PGVPTRTPRM
210 220 230 240 250
TPNDLRNLDE LVREILGRCT CPDQFPMIKV SEGKYRVGDS SLLIFVRVLR
260 270 280 290 300
SHVMVRVGGG WDTLEHYLDK HDPCRCSSST HRLPQQRTGT FSPQRGSPTP
310 320 330 340 350
SPRPGSPVPG SERRSSRPEV TPISLRGTKE GPETPLRPRD QLPPLPRSRR
360 370 380 390 400
YSGDSDSSAS SAQSGPMGAR SDDSATGSRR ERPSHRPTSC LPASPRRPTA
410 420 430 440 450
PRSQSRDRLD RGRPRVAPGG RGAQLSTSSP ARRTRSQSRE EQAVLMVRRD
460 470 480 490 500
RDGQHSWVAR GRGGGGSGGS GRSTPQTPRA LSPAAPRPSR GPSPGPELAA
510 520 530 540 550
TPASIFRTPL QLDPQQEQQL FRRLEEEFLA NARALEAAAS HTPMGSAPDP
560 570 580 590 600
PAPDSAYCSS SSSSSSLSVL GGKCGQPGES GRTANGLPGP RSQALSSSSD
610 620 630 640 650
EGSPYLAVGG ALDATRSSLA GPEPSLTWAR GRMDTQPDRK PSRIPTPRGP
660 670
RRPSGPIELG AWHAQHSVTP RTEPDSSM
Length:678
Mass (Da):72,411
Last modified:October 1, 2002 - v1
Checksum:i067DCB47F5F1A3A7
GO
Isoform 2 (identifier: Q8JZP9-2) [UniParc]FASTAAdd to basket

Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     338-678: Missing.

Show »
Length:337
Mass (Da):36,573
Checksum:i59F279C447F0D26E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei338 – 678341Missing in isoform 2. 1 PublicationVSP_015496Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508323 mRNA. Translation: AAM34262.1.
AF508324 mRNA. Translation: AAM34263.1.
AL645522 Genomic DNA. Translation: CAI25940.1.
AL645522 Genomic DNA. Translation: CAI25941.1.
BC031785 mRNA. Translation: AAH31785.1.
CCDSiCCDS36101.1. [Q8JZP9-1]
RefSeqiNP_001177337.1. NM_001190408.1. [Q8JZP9-1]
NP_653146.1. NM_144560.3. [Q8JZP9-1]
UniGeneiMm.374836.
Mm.44591.

Genome annotation databases

EnsembliENSMUST00000056649; ENSMUSP00000050275; ENSMUSG00000034201. [Q8JZP9-1]
ENSMUST00000109895; ENSMUSP00000105521; ENSMUSG00000034201. [Q8JZP9-1]
GeneIDi78926.
KEGGimmu:78926.
UCSCiuc007hvr.2. mouse. [Q8JZP9-2]
uc007hvu.2. mouse. [Q8JZP9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508323 mRNA. Translation: AAM34262.1.
AF508324 mRNA. Translation: AAM34263.1.
AL645522 Genomic DNA. Translation: CAI25940.1.
AL645522 Genomic DNA. Translation: CAI25941.1.
BC031785 mRNA. Translation: AAH31785.1.
CCDSiCCDS36101.1. [Q8JZP9-1]
RefSeqiNP_001177337.1. NM_001190408.1. [Q8JZP9-1]
NP_653146.1. NM_144560.3. [Q8JZP9-1]
UniGeneiMm.374836.
Mm.44591.

3D structure databases

ProteinModelPortaliQ8JZP9.
SMRiQ8JZP9. Positions 219-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050275.

PTM databases

iPTMnetiQ8JZP9.
PhosphoSiteiQ8JZP9.

Proteomic databases

MaxQBiQ8JZP9.
PaxDbiQ8JZP9.
PRIDEiQ8JZP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056649; ENSMUSP00000050275; ENSMUSG00000034201. [Q8JZP9-1]
ENSMUST00000109895; ENSMUSP00000105521; ENSMUSG00000034201. [Q8JZP9-1]
GeneIDi78926.
KEGGimmu:78926.
UCSCiuc007hvr.2. mouse. [Q8JZP9-2]
uc007hvu.2. mouse. [Q8JZP9-1]

Organism-specific databases

CTDi10634.
MGIiMGI:1926176. Gas2l1.

Phylogenomic databases

eggNOGiENOG410IQBU. Eukaryota.
ENOG410XQ3S. LUCA.
GeneTreeiENSGT00390000002205.
HOGENOMiHOG000007404.
HOVERGENiHBG079404.
InParanoidiQ8JZP9.
OMAiDGQHSWV.
OrthoDBiEOG7VTDR1.
PhylomeDBiQ8JZP9.
TreeFamiTF323754.

Miscellaneous databases

ChiTaRSiGas2l1. mouse.
PROiQ8JZP9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8JZP9.
CleanExiMM_GAS2L1.
ExpressionAtlasiQ8JZP9. baseline and differential.
GenevisibleiQ8JZP9. MM.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
3.30.920.20. 1 hit.
InterProiIPR001715. CH-domain.
IPR029931. GAS2L1.
IPR003108. GAS_dom.
[Graphical view]
PANTHERiPTHR11915:SF296. PTHR11915:SF296. 1 hit.
PfamiPF00307. CH. 1 hit.
PF02187. GAS2. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00243. GAS2. 1 hit.
[Graphical view]
SUPFAMiSSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51460. GAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules."
    Goriounov D., Leung C.L., Liem R.K.
    J. Cell Sci. 116:1045-1058(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306; SER-352; SER-355; SER-493 AND SER-654, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Testis.

Entry informationi

Entry nameiGA2L1_MOUSE
AccessioniPrimary (citable) accession number: Q8JZP9
Secondary accession number(s): Q5SVG0, Q8K573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.