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Protein

GAS2-like protein 1

Gene

Gas2l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in the cross-linking of microtubules and microfilaments.By similarity

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB

GO - Biological processi

  • cell cycle arrest Source: UniProtKB
  • cellular response to starvation Source: UniProtKB
  • cellular response to thyroid hormone stimulus Source: UniProtKB
  • microtubule bundle formation Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of erythrocyte differentiation Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of microtubule depolymerization Source: UniProtKB
  • regulation of cell cycle Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
GAS2-like protein 1
Alternative name(s):
Growth arrest-specific protein 2-like 1
Gene namesi
Name:Gas2l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1926176 Gas2l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001904432 – 678GAS2-like protein 1Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei306PhosphoserineCombined sources1
Modified residuei316PhosphoserineBy similarity1
Modified residuei334PhosphothreonineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei394PhosphoserineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei489PhosphoserineBy similarity1
Modified residuei490Omega-N-methylarginineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei501PhosphothreonineBy similarity1
Modified residuei507Omega-N-methylarginineCombined sources1
Modified residuei630Omega-N-methylarginineCombined sources1
Modified residuei654PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ8JZP9
PeptideAtlasiQ8JZP9
PRIDEiQ8JZP9

PTM databases

iPTMnetiQ8JZP9
PhosphoSitePlusiQ8JZP9

Expressioni

Gene expression databases

BgeeiENSMUSG00000034201
CleanExiMM_GAS2L1
ExpressionAtlasiQ8JZP9 baseline and differential
GenevisibleiQ8JZP9 MM

Interactioni

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050275

Structurei

3D structure databases

ProteinModelPortaliQ8JZP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 148Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST122
Domaini203 – 275GARPROSITE-ProRule annotationAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi379 – 462Arg-richAdd BLAST84

Sequence similaritiesi

Belongs to the GAS2 family.Curated

Phylogenomic databases

eggNOGiENOG410IQBU Eukaryota
ENOG410XQ3S LUCA
GeneTreeiENSGT00390000002205
HOGENOMiHOG000007404
HOVERGENiHBG079404
InParanoidiQ8JZP9
OMAiDGQHSWV
OrthoDBiEOG091G0PJ6
PhylomeDBiQ8JZP9
TreeFamiTF323754

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR029931 GAS2L1
PANTHERiPTHR44878 PTHR44878, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF02187 GAS2, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00243 GAS2, 1 hit
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51460 GAR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8JZP9-1) [UniParc]FASTAAdd to basket
Also known as: Beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANPVAGIAG SAAKSVRPFR SSEAYVEAMK EDLADWLNAL YSLGLPGSGD
60 70 80 90 100
GFLTGLATGT TLCQHANAVT EAARALAAAR PTRGVAFQAH SVAPGSFMAR
110 120 130 140 150
DNVASFIGWC RAELGVPEVL MFETEDLVLR KNEKSVVLCL LEVARRGARL
160 170 180 190 200
GLLAPRLVQF EQEIERELRA TPQVSSVPAA EEDVTEIATV PGVPTRTPRM
210 220 230 240 250
TPNDLRNLDE LVREILGRCT CPDQFPMIKV SEGKYRVGDS SLLIFVRVLR
260 270 280 290 300
SHVMVRVGGG WDTLEHYLDK HDPCRCSSST HRLPQQRTGT FSPQRGSPTP
310 320 330 340 350
SPRPGSPVPG SERRSSRPEV TPISLRGTKE GPETPLRPRD QLPPLPRSRR
360 370 380 390 400
YSGDSDSSAS SAQSGPMGAR SDDSATGSRR ERPSHRPTSC LPASPRRPTA
410 420 430 440 450
PRSQSRDRLD RGRPRVAPGG RGAQLSTSSP ARRTRSQSRE EQAVLMVRRD
460 470 480 490 500
RDGQHSWVAR GRGGGGSGGS GRSTPQTPRA LSPAAPRPSR GPSPGPELAA
510 520 530 540 550
TPASIFRTPL QLDPQQEQQL FRRLEEEFLA NARALEAAAS HTPMGSAPDP
560 570 580 590 600
PAPDSAYCSS SSSSSSLSVL GGKCGQPGES GRTANGLPGP RSQALSSSSD
610 620 630 640 650
EGSPYLAVGG ALDATRSSLA GPEPSLTWAR GRMDTQPDRK PSRIPTPRGP
660 670
RRPSGPIELG AWHAQHSVTP RTEPDSSM
Length:678
Mass (Da):72,411
Last modified:October 1, 2002 - v1
Checksum:i067DCB47F5F1A3A7
GO
Isoform 2 (identifier: Q8JZP9-2) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     338-678: Missing.

Show »
Length:337
Mass (Da):36,573
Checksum:i59F279C447F0D26E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015496338 – 678Missing in isoform 2. 1 PublicationAdd BLAST341

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508323 mRNA Translation: AAM34262.1
AF508324 mRNA Translation: AAM34263.1
AL645522 Genomic DNA No translation available.
BC031785 mRNA Translation: AAH31785.1
CCDSiCCDS36101.1 [Q8JZP9-1]
RefSeqiNP_001177337.1, NM_001190408.1 [Q8JZP9-1]
NP_653146.1, NM_144560.3 [Q8JZP9-1]
UniGeneiMm.374836
Mm.44591

Genome annotation databases

EnsembliENSMUST00000056649; ENSMUSP00000050275; ENSMUSG00000034201 [Q8JZP9-1]
ENSMUST00000109895; ENSMUSP00000105521; ENSMUSG00000034201 [Q8JZP9-1]
GeneIDi78926
KEGGimmu:78926
UCSCiuc007hvr.2 mouse [Q8JZP9-2]
uc007hvu.2 mouse [Q8JZP9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGA2L1_MOUSE
AccessioniPrimary (citable) accession number: Q8JZP9
Secondary accession number(s): Q5SVG0, Q8K573
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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