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Protein

Kelch-like protein 2

Gene

Klhl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes growth of cell projections in oligodendrocyte precursors. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (By similarity). Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Plays a role in the reorganization of the actin cytoskeleton.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein ubiquitination Source: UniProtKB

Keywordsi

Molecular functionActin-binding
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 2
Gene namesi
Name:Klhl2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1924363 Klhl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191021 – 593Kelch-like protein 2Add BLAST593

Proteomic databases

MaxQBiQ8JZP3
PaxDbiQ8JZP3
PRIDEiQ8JZP3

PTM databases

PhosphoSitePlusiQ8JZP3

Expressioni

Gene expression databases

BgeeiENSMUSG00000031605
CleanExiMM_KLHL2
ExpressionAtlasiQ8JZP3 baseline and differential
GenevisibleiQ8JZP3 MM

Interactioni

Subunit structurei

Binds actin. Interacts with KLHL12. Interacts (via N-terminus) with FYN (via SH3 domain) (By similarity). Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Interacts with NPTXR and CUL3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218522, 4 interactors
STRINGi10090.ENSMUSP00000034017

Structurei

3D structure databases

ProteinModelPortaliQ8JZP3
SMRiQ8JZP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 123BTBPROSITE-ProRule annotationAdd BLAST68
Repeati308 – 353Kelch 1Sequence analysisAdd BLAST46
Repeati354 – 400Kelch 2Sequence analysisAdd BLAST47
Repeati402 – 447Kelch 3Sequence analysisAdd BLAST46
Repeati449 – 496Kelch 4Sequence analysisAdd BLAST48
Repeati497 – 543Kelch 5Sequence analysisAdd BLAST47
Repeati545 – 591Kelch 6Sequence analysisAdd BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118931
HOVERGENiHBG014286
InParanoidiQ8JZP3
KOiK10443
OrthoDBiEOG091G04QJ
PhylomeDBiQ8JZP3
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8JZP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPPLPPAC TKQGHQKPLD SKDENPEKHC PLTVNPWHMK KAFKVMNELR
60 70 80 90 100
SQNLLCDVTI VAEDMEIPAH RVVLAACSPY FHAMFTGEMS ESRAKRVRIK
110 120 130 140 150
EVDGWTLRML VDYVYTAEIQ VTEENVQVLL PAAGLLQLQD VKKTCCEFLE
160 170 180 190 200
SQLHPVNCLG IRAFADMHAC TDLLNKANTY AEQHFADVVL SEEFLNLGIE
210 220 230 240 250
QVCSLISSDK LTISSEEKVF EAVIAWVNHD KDVRQEFMAR LMEHVRLPLL
260 270 280 290 300
PREYLVQRVE EEALVKNSSA CKDYLIEAMK YHLLPTEQRM LMKSVRTRLR
310 320 330 340 350
TPMNLPKLMV VVGGQAPKAI RSVECYDFKE ERWHQVAELP SRRCRAGMVY
360 370 380 390 400
MAGLVFAVGG FNGSLRVRTV DSYDPVKDQW TSVANMRDRR STLGAAVLNG
410 420 430 440 450
LLYAVGGFDG STGLSSVEAY NIKSNEWFHV APMNTRRSSV GVGVVGGLLY
460 470 480 490 500
AVGGYDGASR QCLSTVECYN ATANEWTYIA EMSTRRSGAG VGVLNNLLYA
510 520 530 540 550
VGGHDGPLVR KSVEVYDPTT NAWRQVADMN MCRRNAGVCA VNGLLYVVGG
560 570 580 590
DDGSCNLASV EYYNPTTDKW TVVSSCMSTG RSYAGVTVID KPL
Length:593
Mass (Da):65,983
Last modified:October 1, 2002 - v1
Checksum:i15B3ADEB5DDD0144
GO

Sequence cautioni

The sequence BAC27712 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024572 mRNA Translation: AAH24572.1
BC031142 mRNA Translation: AAH31142.1
BC031144 mRNA Translation: AAH31144.1
AK032116 mRNA Translation: BAC27712.1 Different initiation.
CCDSiCCDS85544.1
RefSeqiNP_848748.2, NM_178633.3
UniGeneiMm.350347

Genome annotation databases

EnsembliENSMUST00000034017; ENSMUSP00000034017; ENSMUSG00000031605
GeneIDi77113
KEGGimmu:77113
UCSCiuc057alr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKLHL2_MOUSE
AccessioniPrimary (citable) accession number: Q8JZP3
Secondary accession number(s): Q8CCU0, Q8R3U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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