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Q8JZP2

- SYN3_MOUSE

UniProt

Q8JZP2 - SYN3_MOUSE

Protein

Synapsin-3

Gene

Syn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. catalytic activity Source: InterPro

    GO - Biological processi

    1. neurotransmitter secretion Source: InterPro

    Keywords - Ligandi

    ATP-binding, Calcium, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synapsin-3
    Alternative name(s):
    Synapsin III
    Gene namesi
    Name:Syn3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1351334. Syn3.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. synapse Source: MGI
    3. synaptic vesicle membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 579579Synapsin-3PRO_0000183025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91Phosphoserine; by PKA and CaMK1By similarity
    Modified residuei469 – 4691Phosphoserine; by CDK1 and MAPKBy similarity
    Modified residuei483 – 4831Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8JZP2.
    PaxDbiQ8JZP2.
    PRIDEiQ8JZP2.

    PTM databases

    PhosphoSiteiQ8JZP2.

    Expressioni

    Gene expression databases

    BgeeiQ8JZP2.
    CleanExiMM_SYN3.
    GenevestigatoriQ8JZP2.

    Interactioni

    Subunit structurei

    Interacts with CAPON.By similarity

    Protein-protein interaction databases

    BioGridi205126. 1 interaction.
    IntActiQ8JZP2. 2 interactions.
    MINTiMINT-4136325.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JZP2.
    SMRiQ8JZP2. Positions 90-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828AAdd
    BLAST
    Regioni28 – 9063B; linkerAdd
    BLAST
    Regioni91 – 398308C; actin-binding and synaptic-vesicle bindingAdd
    BLAST
    Regioni399 – 530132J; Pro-rich linkerAdd
    BLAST
    Regioni531 – 57949EAdd
    BLAST

    Domaini

    The A region binds phospholipids with a preference for negatively charged species.By similarity

    Sequence similaritiesi

    Belongs to the synapsin family.Curated

    Phylogenomic databases

    eggNOGiNOG284201.
    GeneTreeiENSGT00530000063319.
    HOGENOMiHOG000231323.
    HOVERGENiHBG016354.
    InParanoidiQ8JZP2.
    OMAiNHKPMLT.
    OrthoDBiEOG793B7G.
    TreeFamiTF319919.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProiIPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR001359. Synapsin.
    IPR020898. Synapsin_ATP-bd_dom.
    IPR019735. Synapsin_CS.
    IPR019736. Synapsin_P_site.
    IPR020897. Synapsin_pre-ATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR10841. PTHR10841. 1 hit.
    PfamiPF02078. Synapsin. 1 hit.
    PF02750. Synapsin_C. 1 hit.
    PF10581. Synapsin_N. 1 hit.
    [Graphical view]
    PRINTSiPR01368. SYNAPSIN.
    SUPFAMiSSF52440. SSF52440. 1 hit.
    PROSITEiPS00415. SYNAPSIN_1. 1 hit.
    PS00416. SYNAPSIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8JZP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFLRRRLSD SSFVANLPNG YMPDLQRPES SSSSPASPAT ERRHPQPLAA    50
    SFSSPGSSLF SSFSGAMKQT PQAPSGLMEP PTPVTPVVQR PRILLVIDDA 100
    HTDWSKYFHG KKVNGDIEIR VEQAEFSELN LAAYVTGGCM VDMQVVRNGT 150
    KIVRSFKPDF ILVRQHAYSM ALAEDYRSLV IGLQYGGLPA VNSLYSVYNF 200
    CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP NFPVVIKLGH 250
    AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN 300
    YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV 350
    KAVHSKDGRD YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQLLVPGA 400
    TVPSPLRPWG PQTKPAKSPG QGQLGPLLGQ PQPRPPPQGG PRQAQSPQPP 450
    RSRSPSQQRL SPQGQQPVSP QSGSPQQQRS PGSPQLSRAS GGSSPNQASK 500
    PSASLSSHNR PPVQGRSTSQ QGEEPQKSAS PHPHLNKSQS LTNSLSTSDT 550
    SHRGTPSEDE AKAETIRNLR KSFASLFSD 579
    Length:579
    Mass (Da):63,315
    Last modified:July 27, 2011 - v2
    Checksum:i2B84E36A1663D50F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651G → S in AAM22969. (PubMed:11471062)Curated
    Sequence conflicti65 – 651G → S in AAM22970. (PubMed:11471062)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF498252 mRNA. Translation: AAM22969.1.
    AF498253 mRNA. Translation: AAM22970.1.
    AC122919 Genomic DNA. No translation available.
    AC124614 Genomic DNA. No translation available.
    AC125060 Genomic DNA. No translation available.
    AC145076 Genomic DNA. No translation available.
    AC150899 Genomic DNA. No translation available.
    CCDSiCCDS24096.1.
    RefSeqiNP_038750.2. NM_013722.3.
    XP_006513761.1. XM_006513698.1.
    XP_006513762.1. XM_006513699.1.
    XP_006513763.1. XM_006513700.1.
    UniGeneiMm.394931.
    Mm.444790.

    Genome annotation databases

    EnsembliENSMUST00000120638; ENSMUSP00000113720; ENSMUSG00000059602.
    GeneIDi27204.
    KEGGimmu:27204.
    UCSCiuc007gnn.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF498252 mRNA. Translation: AAM22969.1 .
    AF498253 mRNA. Translation: AAM22970.1 .
    AC122919 Genomic DNA. No translation available.
    AC124614 Genomic DNA. No translation available.
    AC125060 Genomic DNA. No translation available.
    AC145076 Genomic DNA. No translation available.
    AC150899 Genomic DNA. No translation available.
    CCDSi CCDS24096.1.
    RefSeqi NP_038750.2. NM_013722.3.
    XP_006513761.1. XM_006513698.1.
    XP_006513762.1. XM_006513699.1.
    XP_006513763.1. XM_006513700.1.
    UniGenei Mm.394931.
    Mm.444790.

    3D structure databases

    ProteinModelPortali Q8JZP2.
    SMRi Q8JZP2. Positions 90-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205126. 1 interaction.
    IntActi Q8JZP2. 2 interactions.
    MINTi MINT-4136325.

    PTM databases

    PhosphoSitei Q8JZP2.

    Proteomic databases

    MaxQBi Q8JZP2.
    PaxDbi Q8JZP2.
    PRIDEi Q8JZP2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000120638 ; ENSMUSP00000113720 ; ENSMUSG00000059602 .
    GeneIDi 27204.
    KEGGi mmu:27204.
    UCSCi uc007gnn.2. mouse.

    Organism-specific databases

    CTDi 8224.
    MGIi MGI:1351334. Syn3.

    Phylogenomic databases

    eggNOGi NOG284201.
    GeneTreei ENSGT00530000063319.
    HOGENOMi HOG000231323.
    HOVERGENi HBG016354.
    InParanoidi Q8JZP2.
    OMAi NHKPMLT.
    OrthoDBi EOG793B7G.
    TreeFami TF319919.

    Miscellaneous databases

    ChiTaRSi SYN3. mouse.
    NextBioi 305067.
    PROi Q8JZP2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8JZP2.
    CleanExi MM_SYN3.
    Genevestigatori Q8JZP2.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProi IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR001359. Synapsin.
    IPR020898. Synapsin_ATP-bd_dom.
    IPR019735. Synapsin_CS.
    IPR019736. Synapsin_P_site.
    IPR020897. Synapsin_pre-ATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR10841. PTHR10841. 1 hit.
    Pfami PF02078. Synapsin. 1 hit.
    PF02750. Synapsin_C. 1 hit.
    PF10581. Synapsin_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01368. SYNAPSIN.
    SUPFAMi SSF52440. SSF52440. 1 hit.
    PROSITEi PS00415. SYNAPSIN_1. 1 hit.
    PS00416. SYNAPSIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
      Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
      Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ILS and ISS.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiSYN3_MOUSE
    AccessioniPrimary (citable) accession number: Q8JZP2
    Secondary accession number(s): E9QNQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Regulated by calcium. Calcium inhibits ATP binding to the C-domain By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3