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Q8JZP2

- SYN3_MOUSE

UniProt

Q8JZP2 - SYN3_MOUSE

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Protein

Synapsin-3

Gene

Syn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. catalytic activity Source: InterPro

GO - Biological processi

  1. neurotransmitter secretion Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-3
Alternative name(s):
Synapsin III
Gene namesi
Name:Syn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1351334. Syn3.

Subcellular locationi

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. synapse Source: MGI
  3. synaptic vesicle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Synapsin-3PRO_0000183025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Phosphoserine; by PKA and CaMK1By similarity
Modified residuei469 – 4691Phosphoserine; by CDK1 and MAPKBy similarity
Modified residuei483 – 4831Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8JZP2.
PaxDbiQ8JZP2.
PRIDEiQ8JZP2.

PTM databases

PhosphoSiteiQ8JZP2.

Expressioni

Gene expression databases

BgeeiQ8JZP2.
CleanExiMM_SYN3.
ExpressionAtlasiQ8JZP2. baseline.
GenevestigatoriQ8JZP2.

Interactioni

Subunit structurei

Interacts with CAPON.By similarity

Protein-protein interaction databases

BioGridi205126. 1 interaction.
IntActiQ8JZP2. 2 interactions.
MINTiMINT-4136325.

Structurei

3D structure databases

ProteinModelPortaliQ8JZP2.
SMRiQ8JZP2. Positions 90-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828AAdd
BLAST
Regioni28 – 9063B; linkerAdd
BLAST
Regioni91 – 398308C; actin-binding and synaptic-vesicle bindingAdd
BLAST
Regioni399 – 530132J; Pro-rich linkerAdd
BLAST
Regioni531 – 57949EAdd
BLAST

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

eggNOGiNOG284201.
GeneTreeiENSGT00530000063319.
HOGENOMiHOG000231323.
HOVERGENiHBG016354.
InParanoidiQ8JZP2.
OMAiNHKPMLT.
OrthoDBiEOG793B7G.
TreeFamiTF319919.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 1 hit.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JZP2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFLRRRLSD SSFVANLPNG YMPDLQRPES SSSSPASPAT ERRHPQPLAA
60 70 80 90 100
SFSSPGSSLF SSFSGAMKQT PQAPSGLMEP PTPVTPVVQR PRILLVIDDA
110 120 130 140 150
HTDWSKYFHG KKVNGDIEIR VEQAEFSELN LAAYVTGGCM VDMQVVRNGT
160 170 180 190 200
KIVRSFKPDF ILVRQHAYSM ALAEDYRSLV IGLQYGGLPA VNSLYSVYNF
210 220 230 240 250
CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP NFPVVIKLGH
260 270 280 290 300
AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN
310 320 330 340 350
YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV
360 370 380 390 400
KAVHSKDGRD YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQLLVPGA
410 420 430 440 450
TVPSPLRPWG PQTKPAKSPG QGQLGPLLGQ PQPRPPPQGG PRQAQSPQPP
460 470 480 490 500
RSRSPSQQRL SPQGQQPVSP QSGSPQQQRS PGSPQLSRAS GGSSPNQASK
510 520 530 540 550
PSASLSSHNR PPVQGRSTSQ QGEEPQKSAS PHPHLNKSQS LTNSLSTSDT
560 570
SHRGTPSEDE AKAETIRNLR KSFASLFSD
Length:579
Mass (Da):63,315
Last modified:July 27, 2011 - v2
Checksum:i2B84E36A1663D50F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651G → S in AAM22969. (PubMed:11471062)Curated
Sequence conflicti65 – 651G → S in AAM22970. (PubMed:11471062)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498252 mRNA. Translation: AAM22969.1.
AF498253 mRNA. Translation: AAM22970.1.
AC122919 Genomic DNA. No translation available.
AC124614 Genomic DNA. No translation available.
AC125060 Genomic DNA. No translation available.
AC145076 Genomic DNA. No translation available.
AC150899 Genomic DNA. No translation available.
CCDSiCCDS24096.1.
RefSeqiNP_038750.2. NM_013722.3.
XP_006513761.1. XM_006513698.1.
XP_006513762.1. XM_006513699.1.
XP_006513763.1. XM_006513700.1.
UniGeneiMm.394931.
Mm.444790.

Genome annotation databases

EnsembliENSMUST00000120638; ENSMUSP00000113720; ENSMUSG00000059602.
GeneIDi27204.
KEGGimmu:27204.
UCSCiuc007gnn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF498252 mRNA. Translation: AAM22969.1 .
AF498253 mRNA. Translation: AAM22970.1 .
AC122919 Genomic DNA. No translation available.
AC124614 Genomic DNA. No translation available.
AC125060 Genomic DNA. No translation available.
AC145076 Genomic DNA. No translation available.
AC150899 Genomic DNA. No translation available.
CCDSi CCDS24096.1.
RefSeqi NP_038750.2. NM_013722.3.
XP_006513761.1. XM_006513698.1.
XP_006513762.1. XM_006513699.1.
XP_006513763.1. XM_006513700.1.
UniGenei Mm.394931.
Mm.444790.

3D structure databases

ProteinModelPortali Q8JZP2.
SMRi Q8JZP2. Positions 90-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 205126. 1 interaction.
IntActi Q8JZP2. 2 interactions.
MINTi MINT-4136325.

PTM databases

PhosphoSitei Q8JZP2.

Proteomic databases

MaxQBi Q8JZP2.
PaxDbi Q8JZP2.
PRIDEi Q8JZP2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000120638 ; ENSMUSP00000113720 ; ENSMUSG00000059602 .
GeneIDi 27204.
KEGGi mmu:27204.
UCSCi uc007gnn.2. mouse.

Organism-specific databases

CTDi 8224.
MGIi MGI:1351334. Syn3.

Phylogenomic databases

eggNOGi NOG284201.
GeneTreei ENSGT00530000063319.
HOGENOMi HOG000231323.
HOVERGENi HBG016354.
InParanoidi Q8JZP2.
OMAi NHKPMLT.
OrthoDBi EOG793B7G.
TreeFami TF319919.

Miscellaneous databases

ChiTaRSi SYN3. mouse.
NextBioi 305067.
PROi Q8JZP2.
SOURCEi Search...

Gene expression databases

Bgeei Q8JZP2.
CleanExi MM_SYN3.
ExpressionAtlasi Q8JZP2. baseline.
Genevestigatori Q8JZP2.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProi IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR10841. PTHR10841. 1 hit.
Pfami PF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view ]
PRINTSi PR01368. SYNAPSIN.
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
    Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ILS and ISS.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiSYN3_MOUSE
AccessioniPrimary (citable) accession number: Q8JZP2
Secondary accession number(s): E9QNQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Regulated by calcium. Calcium inhibits ATP binding to the C-domain (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3