Synapsin-3 - Mus musculus (Mouse)

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Q8JZP2 (SYN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Synapsin-3

Alternative name(s):
Synapsin III

Gene names

Name:

Syn3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed By similarity.
Subunit structure	Interacts with CAPON By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles By similarity.
Domain	The A region binds phospholipids with a preference for negatively charged species By similarity.
Post-translational modification	Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles By similarity.
Miscellaneous	Regulated by calcium. Calcium inhibits ATP binding to the C-domain By similarity.
Sequence similarities	Belongs to the synapsin family.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Ligand	ATP-binding Calcium Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC neurotransmitter secretion Inferred from electronic annotation. Source: InterPro
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle membrane Inferred from direct assay PubMed 15071120. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 579

579

Synapsin-3

PRO_0000183025

Regions

Region

1 – 28

Region

28 – 90

B; linker

Region

91 – 398

308

C; actin-binding and synaptic-vesicle binding

Region

399 – 530

132

J; Pro-rich linker

Region

531 – 579

Amino acid modifications

Modified residue

Phosphoserine; by PKA and CaMK1 By similarity

Modified residue

461

Phosphoserine Ref.4

Modified residue

469

Phosphoserine; by CDK1 and MAPK Ref.4

Modified residue

483

Phosphoserine Ref.3

Experimental info

Sequence conflict

G → S in AAM22969. Ref.1

Sequence conflict

G → S in AAM22970. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q8JZP2 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 2B84E36A1663D50F
Show »

FASTA

579

63,315

        10         20         30         40         50         60 
MNFLRRRLSD SSFVANLPNG YMPDLQRPES SSSSPASPAT ERRHPQPLAA SFSSPGSSLF 

        70         80         90        100        110        120 
SSFSGAMKQT PQAPSGLMEP PTPVTPVVQR PRILLVIDDA HTDWSKYFHG KKVNGDIEIR 

       130        140        150        160        170        180 
VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KIVRSFKPDF ILVRQHAYSM ALAEDYRSLV 

       190        200        210        220        230        240 
IGLQYGGLPA VNSLYSVYNF CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP 

       250        260        270        280        290        300 
NFPVVIKLGH AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN 

       310        320        330        340        350        360 
YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV KAVHSKDGRD 

       370        380        390        400        410        420 
YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQLLVPGA TVPSPLRPWG PQTKPAKSPG 

       430        440        450        460        470        480 
QGQLGPLLGQ PQPRPPPQGG PRQAQSPQPP RSRSPSQQRL SPQGQQPVSP QSGSPQQQRS 

       490        500        510        520        530        540 
PGSPQLSRAS GGSSPNQASK PSASLSSHNR PPVQGRSTSQ QGEEPQKSAS PHPHLNKSQS 

       550        560        570 
LTNSLSTSDT SHRGTPSEDE AKAETIRNLR KSFASLFSD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"High-throughput sequence identification of gene coding variants within alcohol-related QTLs." Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M. Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ILS and ISS.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, MASS SPECTROMETRY. Tissue: Brain.
[4]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461 AND SER-469, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF498252 mRNA. Translation: AAM22969.1. AF498253 mRNA. Translation: AAM22970.1. AC122919 Genomic DNA. No translation available. AC124614 Genomic DNA. No translation available. AC125060 Genomic DNA. No translation available. AC145076 Genomic DNA. No translation available. AC150899 Genomic DNA. No translation available.
IPI	IPI00463761.
RefSeq	NP_038750.2. NM_013722.3.
UniGene	Mm.394931. Mm.444790.
3D structure databases
ProteinModelPortal	Q8JZP2.
SMR	Q8JZP2. Positions 90-395.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8JZP2. 1 interaction.
PTM databases
PhosphoSite	Q8JZP2.
Proteomic databases
PaxDb	Q8JZP2.
PRIDE	Q8JZP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000120638; ENSMUSP00000113720; ENSMUSG00000059602.
GeneID	27204.
KEGG	mmu:27204.
UCSC	uc007gnn.2. mouse.
Organism-specific databases
CTD	8224.
MGI	MGI:1351334. Syn3.
Phylogenomic databases
eggNOG	NOG284201.
GeneTree	ENSGT00530000063319.
HOGENOM	HOG000231323.
HOVERGEN	HBG016354.
InParanoid	Q8JZP2.
OMA	DDAHTDX.
OrthoDB	EOG4KPTB4.
Gene expression databases
ArrayExpress	Q8JZP2.
Bgee	Q8JZP2.
CleanEx	MM_SYN3.
Genevestigator	Q8JZP2.
GermOnline	ENSMUSG00000059602. Mus musculus.
Family and domain databases
Gene3D	3.30.1490.20. 1 hit. 3.30.470.20. 2 hits. 3.40.50.20. 1 hit.
InterPro	IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR016185. PreATP-grasp_dom. IPR001359. Synapsin. IPR020898. Synapsin_ATP-bd_dom. IPR019735. Synapsin_CS. IPR019736. Synapsin_P_site. IPR020897. Synapsin_pre-ATP-grasp_dom. [Graphical view]
Pfam	PF02078. Synapsin. 1 hit. PF02750. Synapsin_C. 1 hit. PF10581. Synapsin_N. 1 hit. [Graphical view]
PRINTS	PR01368. SYNAPSIN.
SUPFAM	SSF52440. PreATP-grasp-like. 1 hit.
PROSITE	PS00415. SYNAPSIN_1. 1 hit. PS00416. SYNAPSIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SYN3. mouse.
NextBio	305067.
SOURCE	Search...

Entry information

Entry name

SYN3_MOUSE

Accession

Primary (citable) accession number: Q8JZP2
Secondary accession number(s): E9QNQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents