Q8JZP2 (SYN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synapsin-3

Alternative name(s):
Synapsin III

Gene names

Name:

Syn3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed By similarity.
Subunit structure	Interacts with CAPON By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles By similarity.
Miscellaneous	Regulated by calcium. Calcium inhibits ATP binding to the C-domain By similarity.
Sequence similarities	Belongs to the synapsin family.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Ligand	ATP-binding Calcium Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	neurotransmitter secretion Inferred from electronic annotation. Source: InterPro
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle membrane Inferred from direct assay. Source: MGI
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 579	579	Synapsin-3		PRO_0000183025
Regions
	Region	1 – 28	28	A
	Region	28 – 90	63	B; linker
	Region	91 – 398	308	C; actin-binding and synaptic-vesicle binding
	Region	399 – 530	132	J; Pro-rich linker
	Region	531 – 579	49	E
Amino acid modifications
	Modified residue	461	1	Phosphoserine Ref.4
	Modified residue	469	1	Phosphoserine Ref.4
	Modified residue	483	1	Phosphoserine Ref.3
Experimental info
	Sequence conflict	65	1	G → S in AAM22969. Ref.1
	Sequence conflict	65	1	G → S in AAM22970. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8JZP2 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 2B84E36A1663D50F	FASTA	579	63,315
	10 20 30 40 50 60 MNFLRRRLSD SSFVANLPNG YMPDLQRPES SSSSPASPAT ERRHPQPLAA SFSSPGSSLF 70 80 90 100 110 120 SSFSGAMKQT PQAPSGLMEP PTPVTPVVQR PRILLVIDDA HTDWSKYFHG KKVNGDIEIR 130 140 150 160 170 180 VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KIVRSFKPDF ILVRQHAYSM ALAEDYRSLV 190 200 210 220 230 240 IGLQYGGLPA VNSLYSVYNF CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP 250 260 270 280 290 300 NFPVVIKLGH AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN 310 320 330 340 350 360 YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV KAVHSKDGRD 370 380 390 400 410 420 YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQLLVPGA TVPSPLRPWG PQTKPAKSPG 430 440 450 460 470 480 QGQLGPLLGQ PQPRPPPQGG PRQAQSPQPP RSRSPSQQRL SPQGQQPVSP QSGSPQQQRS 490 500 510 520 530 540 PGSPQLSRAS GGSSPNQASK PSASLSSHNR PPVQGRSTSQ QGEEPQKSAS PHPHLNKSQS 550 560 570 LTNSLSTSDT SHRGTPSEDE AKAETIRNLR KSFASLFSD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"High-throughput sequence identification of gene coding variants within alcohol-related QTLs." Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M. Mamm. Genome 12:657-663(2001) [PubMed: 11471062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ILS and ISS.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6.
[3]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed: 16452087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, MASS SPECTROMETRY. Tissue: Brain.
[4]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461 AND SER-469, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF498252 mRNA. Translation: AAM22969.1. AF498253 mRNA. Translation: AAM22970.1. AC122919 Genomic DNA. No translation available. AC124614 Genomic DNA. No translation available. AC125060 Genomic DNA. No translation available. AC145076 Genomic DNA. No translation available. AC150899 Genomic DNA. No translation available.
IPI	IPI00463761.
RefSeq	NP_038750.2. NM_013722.3.
UniGene	Mm.394931. Mm.444790.
3D structure databases
ProteinModelPortal	Q8JZP2.
SMR	Q8JZP2. Positions 90-395.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8JZP2. 1 interaction.
STRING	Q8JZP2.
Proteomic databases
PRIDE	Q8JZP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000120638; ENSMUSP00000113720; ENSMUSG00000059602.
GeneID	27204.
KEGG	mmu:27204.
UCSC	uc007gnn.2. mouse.
Organism-specific databases
CTD	8224.
MGI	MGI:1351334. Syn3.
Phylogenomic databases
HOGENOM	HBG445598.
HOVERGEN	HBG016354.
InParanoid	Q8JZP2.
OrthoDB	EOG4KPTB4.
Gene expression databases
ArrayExpress	Q8JZP2.
Bgee	Q8JZP2.
CleanEx	MM_SYN3.
Genevestigator	Q8JZP2.
GermOnline	ENSMUSG00000059602. Mus musculus.
Family and domain databases
InterPro	IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR013817. Pre-ATP_grasp. IPR016185. PreATP-grasp-like. IPR001359. Synapsin. IPR020898. Synapsin_ATP-bd_dom. IPR019735. Synapsin_CS. IPR019736. Synapsin_P_site. IPR020897. Synapsin_pre-ATP-grasp_dom. [Graphical view]
Gene3D	G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit. G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 2 hits. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
Pfam	PF02078. Synapsin. 1 hit. PF02750. Synapsin_C. 1 hit. PF10581. Synapsin_N. 1 hit. [Graphical view]
PRINTS	PR01368. SYNAPSIN.
SUPFAM	SSF52440. PreATP-grasp-like. 1 hit.
PROSITE	PS00415. SYNAPSIN_1. 1 hit. PS00416. SYNAPSIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

SYN3_MOUSE

Accession

Primary (citable) accession number: Q8JZP2
Secondary accession number(s): E9QNQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program