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Protein

Mitochondrial Rho GTPase 2

Gene

Rhot2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18GTP 1Sequence analysis8
Nucleotide bindingi57 – 61GTP 1Sequence analysis5
Nucleotide bindingi118 – 121GTP 1Sequence analysis4
Calcium bindingi197 – 2081PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi317 – 3282PROSITE-ProRule annotationAdd BLAST12
Nucleotide bindingi424 – 431GTP 2Sequence analysis8
Nucleotide bindingi461 – 465GTP 2Sequence analysis5
Nucleotide bindingi526 – 529GTP 2Sequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, GTP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial Rho GTPase 2 (EC:3.6.5.-)
Short name:
MIRO-2
Alternative name(s):
Ras homolog gene family member T2
Gene namesi
Name:Rhot2
Synonyms:Arht2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2384892. Rhot2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 594Mitochondrial intermembraneSequence analysisAdd BLAST594
Transmembranei595 – 617Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST23
Topological domaini618 – 620CytoplasmicSequence analysis3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393191 – 620Mitochondrial Rho GTPase 2Add BLAST620

Proteomic databases

EPDiQ8JZN7.
MaxQBiQ8JZN7.
PaxDbiQ8JZN7.
PeptideAtlasiQ8JZN7.
PRIDEiQ8JZN7.

PTM databases

iPTMnetiQ8JZN7.
PhosphoSitePlusiQ8JZN7.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000025733.
CleanExiMM_RHOT2.
ExpressionAtlasiQ8JZN7. baseline and differential.
GenevisibleiQ8JZN7. MM.

Interactioni

Subunit structurei

Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (By similarity). Interacts with Armcx3 (PubMed:22569362).By similarity1 Publication

Protein-protein interaction databases

BioGridi229580. 1 interactor.
STRINGi10090.ENSMUSP00000044639.

Structurei

3D structure databases

ProteinModelPortaliQ8JZN7.
SMRiQ8JZN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 177Miro 1Add BLAST177
Domaini184 – 219EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini304 – 339EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini411 – 620Miro 2Add BLAST210

Sequence similaritiesi

Belongs to the mitochondrial Rho GTPase family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1707. Eukaryota.
ENOG410XRHW. LUCA.
GeneTreeiENSGT00390000014374.
HOGENOMiHOG000215553.
HOVERGENiHBG079778.
InParanoidiQ8JZN7.
KOiK07871.
OMAiTELNHFG.
OrthoDBiEOG091G04UF.
PhylomeDBiQ8JZN7.
TreeFamiTF300814.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR013566. EF_hand_assoc_1.
IPR013567. EF_hand_assoc_2.
IPR002048. EF_hand_dom.
IPR021181. Miro.
IPR020860. MIRO_dom.
IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF08355. EF_assoc_1. 1 hit.
PF08356. EF_assoc_2. 1 hit.
PF00071. Ras. 1 hit.
PIRSFiPIRSF037488. Mt_Rho_GTPase. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS51423. MIRO. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8JZN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRDVRILLL GEAQVGKTSL ILSLVGEEFP EEVPARAEEI TIPADVTPEK
60 70 80 90 100
VPTHIVDYSE AEQTEEELQE EIHKANVVCV VYDVSEETTI EKIRTKWIPL
110 120 130 140 150
VNGRTATGPR LPIILVGNKS DLRPGSTMEA VLPIMSQFPE IETCVECSAK
160 170 180 190 200
HLRNISELFY YAQKAVLHPT APLYDPEAKQ LRPACAQALT RIFRLSDQDR
210 220 230 240 250
DHGLSDEELN AFQKSCFGHP LAPQALEDVK RVVCKNVSGG VQNDRLTLEG
260 270 280 290 300
FLFLNTLFIQ RGRHETTWTI LRRFGYSDSL ELTPDYLYPA LHVPPGCSTE
310 320 330 340 350
LNHRGYQFVQ RMFEKHDQDH DGVLSPTELQ NLFSVFSGAP WGPELLHTVP
360 370 380 390 400
TQAGCLPLHG YLCQWTLMTY LDVQQCLAHL GYLGYPTLCE QDSQAQAITV
410 420 430 440 450
TREKKLDQEK GQTQRSVLMC KVLGARGVGK SAFLQAFLGN SLGEARDPPE
460 470 480 490 500
KFPLHTINTV RVNGQEKYLI LCEVNADSLL DTSLDTTCDV ACLMFDSSDP
510 520 530 540 550
KTFVHCATIY KRYYMDGQTP CLFIASKADL PEGVAPPGLS PAEFCRRHRL
560 570 580 590 600
PAPASFSCLG PAMPSTDVFT QLATMATFPH LVHTELHPTS FWLRGVLVAV
610 620
GTAVAAVLSF SLYRVLVKSR
Length:620
Mass (Da):69,071
Last modified:October 1, 2002 - v1
Checksum:i439D7AA800730B53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY311390 mRNA. Translation: AAP78906.1.
BC029777 mRNA. Translation: AAH29777.1.
BC034062 mRNA. Translation: AAH34062.1.
CCDSiCCDS37505.1.
RefSeqiNP_666111.1. NM_145999.2.
UniGeneiMm.40907.
Mm.490420.

Genome annotation databases

EnsembliENSMUST00000043897; ENSMUSP00000044639; ENSMUSG00000025733.
GeneIDi214952.
KEGGimmu:214952.
UCSCiuc008bch.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMIRO2_MOUSE
AccessioniPrimary (citable) accession number: Q8JZN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome