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Protein

Acyl-CoA dehydrogenase family member 9, mitochondrial

Gene

Acad9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for mitochondrial complex I assembly (By similarity). Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA then on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation (By similarity). Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0) (By similarity).By similarity

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei430Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA dehydrogenase family member 9, mitochondrial (EC:1.3.99.-)
Short name:
ACAD-9
Gene namesi
Name:Acad9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914272. Acad9.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

  • dendrite Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000000525? – 625Acyl-CoA dehydrogenase family member 9, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45N6-acetyllysineBy similarity1
Modified residuei96N6-succinyllysineCombined sources1
Modified residuei242N6-succinyllysineCombined sources1
Modified residuei482PhosphothreonineCombined sources1
Modified residuei525N6-acetyllysine; alternateCombined sources1
Modified residuei525N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8JZN5.
MaxQBiQ8JZN5.
PaxDbiQ8JZN5.
PeptideAtlasiQ8JZN5.
PRIDEiQ8JZN5.

PTM databases

iPTMnetiQ8JZN5.
PhosphoSitePlusiQ8JZN5.
SwissPalmiQ8JZN5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027710.
CleanExiMM_ACAD9.
ExpressionAtlasiQ8JZN5. baseline and differential.
GenevisibleiQ8JZN5. MM.

Interactioni

Subunit structurei

Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9 (By similarity). Interacts with NDUFAF1 and ECSIT (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-59192N.
IntActiQ8JZN5. 2 interactors.
MINTiMINT-4086603.
STRINGi10090.ENSMUSP00000011492.

Structurei

3D structure databases

ProteinModelPortaliQ8JZN5.
SMRiQ8JZN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0137. Eukaryota.
COG1960. LUCA.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131665.
HOVERGENiHBG050448.
InParanoidiQ8JZN5.
KOiK15980.
OMAiPQNTLAS.
OrthoDBiEOG091G04BS.
TreeFamiTF105053.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGCVLLSRG ATAAAAAARA SRVLREFTAR RRPLHTSLQS CSFAKELFLG
60 70 80 90 100
NIEQKGVFPF PEVSQHELSE INQFVGPLEK FFTEEVDSRK IDQEGKIPVD
110 120 130 140 150
TLEKLKSLGL FGIQVPEEYG GLGLSNTMYA RLGEIISLDA SITVTLAAHQ
160 170 180 190 200
AIGLKGIILV GNEEQKAKYL PKLSSGEHIA AFCLTEPASG SDAASIQTRA
210 220 230 240 250
TLSEDKKYFI LNGSKVWITN GGLANIFTVF AKTEVVDSDG SKTDKMTAFI
260 270 280 290 300
VERDFGGITN GKPEDKLGIR GSNTCEVHFE NTRVPVENVL GEVGGGFKVA
310 320 330 340 350
MNILNSGRFS MGSAVAGMLK KLIELTAEYA CTRKQFNRNL SEFGLIQEKF
360 370 380 390 400
ALMAQKAYVM ESMAYLTSGM LDQPGFPDCS IEAAMVKVFS SEAAWQCVSE
410 420 430 440 450
ALQILGGSGY MKDYPYERML RDARILLIFE GTNEILRLFI ALTGLQHAGR
460 470 480 490 500
ILTSRIKELK SGNVTTVMET IGRKLRDSLG RTVDLGLTGD LGVVHPSLGD
510 520 530 540 550
SANKLEENVH YFGRTVETLL LRFGKNIVEE QLVLKRVANI LINLYGMTAV
560 570 580 590 600
LSRASRSIRI GLRNHDHEVL LANMFCVEAY FQNLFSLSQL DKNAPENLDE
610 620
QIKKVSRQIL EKRAYICAHP LDRAS
Length:625
Mass (Da):68,722
Last modified:July 27, 2011 - v2
Checksum:i29567F60B52E6FEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15A → G in BAC27565 (PubMed:16141072).Curated1
Sequence conflicti53E → K in AAH31137 (PubMed:15489334).Curated1
Sequence conflicti53E → K in AAH32213 (PubMed:15489334).Curated1
Sequence conflicti53E → K in AAH33277 (PubMed:15489334).Curated1
Sequence conflicti163E → D in AAH31137 (PubMed:15489334).Curated1
Sequence conflicti163E → D in AAH32213 (PubMed:15489334).Curated1
Sequence conflicti163E → D in AAH33277 (PubMed:15489334).Curated1
Sequence conflicti540I → V in BAC27565 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031820 mRNA. Translation: BAC27565.1.
AK075984 mRNA. Translation: BAC36096.1.
AK145423 mRNA. Translation: BAE26429.1.
BC031137 mRNA. Translation: AAH31137.1.
BC032213 mRNA. Translation: AAH32213.1.
BC033277 mRNA. Translation: AAH33277.1.
CCDSiCCDS17310.1.
RefSeqiNP_766266.3. NM_172678.3.
UniGeneiMm.260997.

Genome annotation databases

EnsembliENSMUST00000011492; ENSMUSP00000011492; ENSMUSG00000027710.
GeneIDi229211.
KEGGimmu:229211.
UCSCiuc008oze.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031820 mRNA. Translation: BAC27565.1.
AK075984 mRNA. Translation: BAC36096.1.
AK145423 mRNA. Translation: BAE26429.1.
BC031137 mRNA. Translation: AAH31137.1.
BC032213 mRNA. Translation: AAH32213.1.
BC033277 mRNA. Translation: AAH33277.1.
CCDSiCCDS17310.1.
RefSeqiNP_766266.3. NM_172678.3.
UniGeneiMm.260997.

3D structure databases

ProteinModelPortaliQ8JZN5.
SMRiQ8JZN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59192N.
IntActiQ8JZN5. 2 interactors.
MINTiMINT-4086603.
STRINGi10090.ENSMUSP00000011492.

PTM databases

iPTMnetiQ8JZN5.
PhosphoSitePlusiQ8JZN5.
SwissPalmiQ8JZN5.

Proteomic databases

EPDiQ8JZN5.
MaxQBiQ8JZN5.
PaxDbiQ8JZN5.
PeptideAtlasiQ8JZN5.
PRIDEiQ8JZN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000011492; ENSMUSP00000011492; ENSMUSG00000027710.
GeneIDi229211.
KEGGimmu:229211.
UCSCiuc008oze.1. mouse.

Organism-specific databases

CTDi28976.
MGIiMGI:1914272. Acad9.

Phylogenomic databases

eggNOGiKOG0137. Eukaryota.
COG1960. LUCA.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131665.
HOVERGENiHBG050448.
InParanoidiQ8JZN5.
KOiK15980.
OMAiPQNTLAS.
OrthoDBiEOG091G04BS.
TreeFamiTF105053.

Enzyme and pathway databases

ReactomeiR-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ8JZN5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027710.
CleanExiMM_ACAD9.
ExpressionAtlasiQ8JZN5. baseline and differential.
GenevisibleiQ8JZN5. MM.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACAD9_MOUSE
AccessioniPrimary (citable) accession number: Q8JZN5
Secondary accession number(s): Q3ULL9, Q8BK76, Q8C0B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.