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Protein

ATP-sensitive inward rectifier potassium channel 14

Gene

Kcnj14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296053 Classical Kir channels
R-MMU-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 14
Alternative name(s):
Inward rectifier K(+) channel Kir2.4
Short name:
IRK-4
Potassium channel, inwardly rectifying subfamily J member 14
Gene namesi
Name:Kcnj14
Synonyms:Irk4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2384820 Kcnj14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 84CytoplasmicBy similarityAdd BLAST84
Transmembranei85 – 109Helical; Name=M1By similarityAdd BLAST25
Topological domaini110 – 131ExtracellularBy similarityAdd BLAST22
Intramembranei132 – 143Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei144 – 150Pore-formingBy similarity7
Topological domaini151 – 159ExtracellularBy similarity9
Transmembranei160 – 181Helical; Name=M2By similarityAdd BLAST22
Topological domaini182 – 434CytoplasmicBy similarityAdd BLAST253

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549691 – 434ATP-sensitive inward rectifier potassium channel 14Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79S-nitrosocysteineBy similarity1

Keywords - PTMi

S-nitrosylation

Proteomic databases

PaxDbiQ8JZN3
PRIDEiQ8JZN3

Expressioni

Gene expression databases

BgeeiENSMUSG00000058743
ExpressionAtlasiQ8JZN3 baseline and differential
GenevisibleiQ8JZN3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071829

Structurei

3D structure databases

ProteinModelPortaliQ8JZN3
SMRiQ8JZN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi145 – 150Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827 Eukaryota
ENOG410XQ62 LUCA
GeneTreeiENSGT00760000118842
HOGENOMiHOG000237325
HOVERGENiHBG006178
InParanoidiQ8JZN3
KOiK05007
OMAiWLIASAH
OrthoDBiEOG091G08HC
PhylomeDBiQ8JZN3
TreeFamiTF313676

Family and domain databases

Gene3Di2.60.40.1400, 2 hits
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR016449 K_chnl_inward-rec_Kir
IPR013518 K_chnl_inward-rec_Kir_cyto
PANTHERiPTHR11767 PTHR11767, 1 hit
PfamiView protein in Pfam
PF01007 IRK, 1 hit
PIRSFiPIRSF005465 GIRK_kir, 1 hit
PRINTSiPR01320 KIRCHANNEL
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Q8JZN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLARALRRL SGALEPGNSR AGDEEEAGAG LCRNGWAPGP VAGSRRRGRF
60 70 80 90 100
VKKDGHCNVR FVNLGGQGAR YLSDLFTTCV DVRWRWMCLL FSCSFLASWL
110 120 130 140 150
LFGLTFWLIA SLHGDLAAPP PPAPCFSQVA SFLAAFLFAL ETQTSIGYGV
160 170 180 190 200
RSVTEECPAA VAAVVLQCIA GCVLDAFVVG AVMAKMAKPK KRNETLVFSE
210 220 230 240 250
NAVVALRDHR LCLMWRVGNL RRSHLVEAHV RAQLLQPRVT PEGEYIPLDH
260 270 280 290 300
QDVDVGFDGG TDRIFLVSPI TIVHEIDSAS PLYELGRAEL ARADFELVVI
310 320 330 340 350
LEGMVEATAM TTQCRSSYLP GELLWGHRFE PVLFQRGSQY EVDYRHFHRT
360 370 380 390 400
YEVPGTPVCS AKELDERAEQ ASHSPKSSFP GSLTAFCYEN ELALSCCQEE
410 420 430
DEEEDTKEGT SAETPERAAS PQALTPTLAL TLPP
Length:434
Mass (Da):47,607
Last modified:October 1, 2002 - v1
Checksum:i67DC26097BD75BED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32C → F in BAC32051 (PubMed:16141072).Curated1
Sequence conflicti297L → M in BAC27093 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030711 mRNA Translation: BAC27093.1
AK044725 mRNA Translation: BAC32051.1
AK080732 mRNA Translation: BAC38000.1
BC029692 mRNA Translation: AAH29692.1
BC031753 mRNA Translation: AAH31753.1
CCDSiCCDS21265.1
RefSeqiNP_666075.1, NM_145963.2
XP_017177583.1, XM_017322094.1
UniGeneiMm.68170

Genome annotation databases

EnsembliENSMUST00000071937; ENSMUSP00000071829; ENSMUSG00000058743
GeneIDi211480
KEGGimmu:211480
UCSCiuc009gxi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKCJ14_MOUSE
AccessioniPrimary (citable) accession number: Q8JZN3
Secondary accession number(s): Q8BMK3, Q8BXM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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