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Q8JZN3

- KCJ14_MOUSE

UniProt

Q8JZN3 - KCJ14_MOUSE

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Protein

ATP-sensitive inward rectifier potassium channel 14

Gene

Kcnj14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).By similarity

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199076. Classical Kir channels.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 14
Alternative name(s):
Inward rectifier K(+) channel Kir2.4
Short name:
IRK-4
Potassium channel, inwardly rectifying subfamily J member 14
Gene namesi
Name:Kcnj14
Synonyms:Irk4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2384820. Kcnj14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8484CytoplasmicBy similarityAdd
BLAST
Transmembranei85 – 10925Helical; Name=M1By similarityAdd
BLAST
Topological domaini110 – 13122ExtracellularBy similarityAdd
BLAST
Intramembranei132 – 14312Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei144 – 1507Pore-formingBy similarity
Topological domaini151 – 1599ExtracellularBy similarity
Transmembranei160 – 18122Helical; Name=M2By similarityAdd
BLAST
Topological domaini182 – 434253CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. dendrite Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434ATP-sensitive inward rectifier potassium channel 14PRO_0000154969Add
BLAST

Proteomic databases

PRIDEiQ8JZN3.

Expressioni

Gene expression databases

BgeeiQ8JZN3.
ExpressionAtlasiQ8JZN3. baseline and differential.
GenevestigatoriQ8JZN3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071829.

Structurei

3D structure databases

ProteinModelPortaliQ8JZN3.
SMRiQ8JZN3. Positions 47-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi145 – 1506Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251076.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiQ8JZN3.
KOiK05007.
OMAiPCFSQVA.
OrthoDBiEOG7XPZ5K.
PhylomeDBiQ8JZN3.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8JZN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLARALRRL SGALEPGNSR AGDEEEAGAG LCRNGWAPGP VAGSRRRGRF
60 70 80 90 100
VKKDGHCNVR FVNLGGQGAR YLSDLFTTCV DVRWRWMCLL FSCSFLASWL
110 120 130 140 150
LFGLTFWLIA SLHGDLAAPP PPAPCFSQVA SFLAAFLFAL ETQTSIGYGV
160 170 180 190 200
RSVTEECPAA VAAVVLQCIA GCVLDAFVVG AVMAKMAKPK KRNETLVFSE
210 220 230 240 250
NAVVALRDHR LCLMWRVGNL RRSHLVEAHV RAQLLQPRVT PEGEYIPLDH
260 270 280 290 300
QDVDVGFDGG TDRIFLVSPI TIVHEIDSAS PLYELGRAEL ARADFELVVI
310 320 330 340 350
LEGMVEATAM TTQCRSSYLP GELLWGHRFE PVLFQRGSQY EVDYRHFHRT
360 370 380 390 400
YEVPGTPVCS AKELDERAEQ ASHSPKSSFP GSLTAFCYEN ELALSCCQEE
410 420 430
DEEEDTKEGT SAETPERAAS PQALTPTLAL TLPP
Length:434
Mass (Da):47,607
Last modified:October 1, 2002 - v1
Checksum:i67DC26097BD75BED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321C → F in BAC32051. (PubMed:16141072)Curated
Sequence conflicti297 – 2971L → M in BAC27093. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030711 mRNA. Translation: BAC27093.1.
AK044725 mRNA. Translation: BAC32051.1.
AK080732 mRNA. Translation: BAC38000.1.
BC029692 mRNA. Translation: AAH29692.1.
BC031753 mRNA. Translation: AAH31753.1.
CCDSiCCDS21265.1.
RefSeqiNP_666075.1. NM_145963.2.
UniGeneiMm.68170.

Genome annotation databases

EnsembliENSMUST00000071937; ENSMUSP00000071829; ENSMUSG00000058743.
GeneIDi211480.
KEGGimmu:211480.
UCSCiuc009gxi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030711 mRNA. Translation: BAC27093.1 .
AK044725 mRNA. Translation: BAC32051.1 .
AK080732 mRNA. Translation: BAC38000.1 .
BC029692 mRNA. Translation: AAH29692.1 .
BC031753 mRNA. Translation: AAH31753.1 .
CCDSi CCDS21265.1.
RefSeqi NP_666075.1. NM_145963.2.
UniGenei Mm.68170.

3D structure databases

ProteinModelPortali Q8JZN3.
SMRi Q8JZN3. Positions 47-374.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000071829.

Proteomic databases

PRIDEi Q8JZN3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071937 ; ENSMUSP00000071829 ; ENSMUSG00000058743 .
GeneIDi 211480.
KEGGi mmu:211480.
UCSCi uc009gxi.1. mouse.

Organism-specific databases

CTDi 3770.
MGIi MGI:2384820. Kcnj14.

Phylogenomic databases

eggNOGi NOG251076.
GeneTreei ENSGT00760000118842.
HOGENOMi HOG000237325.
HOVERGENi HBG006178.
InParanoidi Q8JZN3.
KOi K05007.
OMAi PCFSQVA.
OrthoDBi EOG7XPZ5K.
PhylomeDBi Q8JZN3.
TreeFami TF313676.

Enzyme and pathway databases

Reactomei REACT_199076. Classical Kir channels.

Miscellaneous databases

NextBioi 373248.
PROi Q8JZN3.
SOURCEi Search...

Gene expression databases

Bgeei Q8JZN3.
ExpressionAtlasi Q8JZN3. baseline and differential.
Genevestigatori Q8JZN3.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKCJ14_MOUSE
AccessioniPrimary (citable) accession number: Q8JZN3
Secondary accession number(s): Q8BMK3, Q8BXM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3