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Q8JZN3

- KCJ14_MOUSE

UniProt

Q8JZN3 - KCJ14_MOUSE

Protein

ATP-sensitive inward rectifier potassium channel 14

Gene

Kcnj14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium By similarity.By similarity

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199076. Classical Kir channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 14
    Alternative name(s):
    Inward rectifier K(+) channel Kir2.4
    Short name:
    IRK-4
    Potassium channel, inwardly rectifying subfamily J member 14
    Gene namesi
    Name:Kcnj14
    Synonyms:Irk4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2384820. Kcnj14.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434ATP-sensitive inward rectifier potassium channel 14PRO_0000154969Add
    BLAST

    Proteomic databases

    PRIDEiQ8JZN3.

    Expressioni

    Gene expression databases

    BgeeiQ8JZN3.
    GenevestigatoriQ8JZN3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000071829.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JZN3.
    SMRiQ8JZN3. Positions 47-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8484CytoplasmicBy similarityAdd
    BLAST
    Topological domaini110 – 13122ExtracellularBy similarityAdd
    BLAST
    Topological domaini151 – 1599ExtracellularBy similarity
    Topological domaini182 – 434253CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei132 – 14312Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei144 – 1507Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei85 – 10925Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei160 – 18122Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi145 – 1506Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251076.
    GeneTreeiENSGT00650000093228.
    HOGENOMiHOG000237325.
    HOVERGENiHBG006178.
    InParanoidiQ8JZN3.
    KOiK05007.
    OMAiPCFSQVA.
    OrthoDBiEOG7XPZ5K.
    PhylomeDBiQ8JZN3.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8JZN3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLARALRRL SGALEPGNSR AGDEEEAGAG LCRNGWAPGP VAGSRRRGRF    50
    VKKDGHCNVR FVNLGGQGAR YLSDLFTTCV DVRWRWMCLL FSCSFLASWL 100
    LFGLTFWLIA SLHGDLAAPP PPAPCFSQVA SFLAAFLFAL ETQTSIGYGV 150
    RSVTEECPAA VAAVVLQCIA GCVLDAFVVG AVMAKMAKPK KRNETLVFSE 200
    NAVVALRDHR LCLMWRVGNL RRSHLVEAHV RAQLLQPRVT PEGEYIPLDH 250
    QDVDVGFDGG TDRIFLVSPI TIVHEIDSAS PLYELGRAEL ARADFELVVI 300
    LEGMVEATAM TTQCRSSYLP GELLWGHRFE PVLFQRGSQY EVDYRHFHRT 350
    YEVPGTPVCS AKELDERAEQ ASHSPKSSFP GSLTAFCYEN ELALSCCQEE 400
    DEEEDTKEGT SAETPERAAS PQALTPTLAL TLPP 434
    Length:434
    Mass (Da):47,607
    Last modified:October 1, 2002 - v1
    Checksum:i67DC26097BD75BED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321C → F in BAC32051. (PubMed:16141072)Curated
    Sequence conflicti297 – 2971L → M in BAC27093. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030711 mRNA. Translation: BAC27093.1.
    AK044725 mRNA. Translation: BAC32051.1.
    AK080732 mRNA. Translation: BAC38000.1.
    BC029692 mRNA. Translation: AAH29692.1.
    BC031753 mRNA. Translation: AAH31753.1.
    CCDSiCCDS21265.1.
    RefSeqiNP_666075.1. NM_145963.2.
    UniGeneiMm.68170.

    Genome annotation databases

    EnsembliENSMUST00000071937; ENSMUSP00000071829; ENSMUSG00000058743.
    GeneIDi211480.
    KEGGimmu:211480.
    UCSCiuc009gxi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK030711 mRNA. Translation: BAC27093.1 .
    AK044725 mRNA. Translation: BAC32051.1 .
    AK080732 mRNA. Translation: BAC38000.1 .
    BC029692 mRNA. Translation: AAH29692.1 .
    BC031753 mRNA. Translation: AAH31753.1 .
    CCDSi CCDS21265.1.
    RefSeqi NP_666075.1. NM_145963.2.
    UniGenei Mm.68170.

    3D structure databases

    ProteinModelPortali Q8JZN3.
    SMRi Q8JZN3. Positions 47-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000071829.

    Proteomic databases

    PRIDEi Q8JZN3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071937 ; ENSMUSP00000071829 ; ENSMUSG00000058743 .
    GeneIDi 211480.
    KEGGi mmu:211480.
    UCSCi uc009gxi.1. mouse.

    Organism-specific databases

    CTDi 3770.
    MGIi MGI:2384820. Kcnj14.

    Phylogenomic databases

    eggNOGi NOG251076.
    GeneTreei ENSGT00650000093228.
    HOGENOMi HOG000237325.
    HOVERGENi HBG006178.
    InParanoidi Q8JZN3.
    KOi K05007.
    OMAi PCFSQVA.
    OrthoDBi EOG7XPZ5K.
    PhylomeDBi Q8JZN3.
    TreeFami TF313676.

    Enzyme and pathway databases

    Reactomei REACT_199076. Classical Kir channels.

    Miscellaneous databases

    NextBioi 373248.
    PROi Q8JZN3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8JZN3.
    Genevestigatori Q8JZN3.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Retina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiKCJ14_MOUSE
    AccessioniPrimary (citable) accession number: Q8JZN3
    Secondary accession number(s): Q8BMK3, Q8BXM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3