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Q8JZM7

- CDC73_MOUSE

UniProt

Q8JZM7 - CDC73_MOUSE

Protein

Parafibromin

Gene

Cdc73

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. RNA polymerase II core binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cellular response to lipopolysaccharide Source: UniProtKB
    3. endodermal cell fate commitment Source: UniProtKB
    4. histone H2B ubiquitination Source: Ensembl
    5. histone monoubiquitination Source: Ensembl
    6. mRNA polyadenylation Source: UniProtKB
    7. negative regulation of cell proliferation Source: UniProtKB
    8. negative regulation of epithelial cell proliferation Source: Ensembl
    9. negative regulation of fibroblast proliferation Source: Ensembl
    10. negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
    11. negative regulation of myeloid cell differentiation Source: UniProtKB
    12. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    13. positive regulation of mRNA 3'-end processing Source: UniProtKB
    14. positive regulation of transcription elongation from RNA polymerase II promoter Source: UniProtKB
    15. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    16. positive regulation of Wnt signaling pathway Source: UniProtKB
    17. protein destabilization Source: Ensembl
    18. stem cell maintenance Source: UniProtKB
    19. transcription, DNA-templated Source: UniProtKB-KW
    20. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Transcription, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_216539. formation of the beta-catenin:TCF transactivating complex.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parafibromin
    Alternative name(s):
    Cell division cycle protein 73 homolog
    Hyperparathyroidism 2 protein homolog
    Gene namesi
    Name:Cdc73
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2384876. Cdc73.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. Cdc73/Paf1 complex Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 531530ParafibrominPRO_0000191804Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei212 – 2121PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8JZM7.
    PaxDbiQ8JZM7.
    PRIDEiQ8JZM7.

    PTM databases

    PhosphoSiteiQ8JZM7.

    Expressioni

    Tissue specificityi

    Found in the adrenal gland, kidney, heart, ovary and liver.1 Publication

    Gene expression databases

    BgeeiQ8JZM7.
    GenevestigatoriQ8JZM7.

    Interactioni

    Subunit structurei

    Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Interacts with POLR2A, CPSF1, CPSF4, CSTF2, KMT2A/MLL1 and CTNNB1. Interacts with a Set1-like complex that has histone methyltransferase activity and methylates histone H3. Found in a complex with BCL9L or BCL9, CDC73, CTNNB1 and PYGO1 indicative for the participation in a nuclear Wnt signaling complex By similarity.By similarity

    Protein-protein interaction databases

    BioGridi229532. 6 interactions.
    IntActiQ8JZM7. 7 interactions.
    MINTiMINT-4116595.
    STRINGi10090.ENSMUSP00000018337.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JZM7.
    SMRiQ8JZM7. Positions 358-523.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni200 – 531332Interaction with POLR2A and PAF1By similarityAdd
    BLAST
    Regioni200 – 25051Interaction with CTNNB1By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi125 – 13915Nuclear localization signalBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi361 – 3644Poly-Ile

    Sequence similaritiesi

    Belongs to the CDC73 family.Curated

    Phylogenomic databases

    eggNOGiCOG5157.
    GeneTreeiENSGT00390000001114.
    HOGENOMiHOG000007819.
    HOVERGENiHBG055033.
    InParanoidiQ8JZM7.
    KOiK15175.
    OMAiEYYTLEC.
    OrthoDBiEOG7KM5SP.
    PhylomeDBiQ8JZM7.
    TreeFamiTF313016.

    Family and domain databases

    InterProiIPR007852. RNA_pol_access_fac_Cdc73.
    [Graphical view]
    PANTHERiPTHR12466. PTHR12466. 1 hit.
    PfamiPF05179. CDC73. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8JZM7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADVLSVLRQ YNIQKKEIVV KGDEVIFGEF SWPKNVKTNY VVWGTGKEGQ    50
    PREYYTLDSI LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLGYLNG 100
    EASTSASIDR SAPLEIGLQR STQVKRAADE VLAEAKKPRI EDEECVRLDK 150
    ERLAARLEGH KEGIVQTEQI RSLSEAMSVE KIAAIKAKIM AKKRSTIKTD 200
    LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS TGKNFSKNIF 250
    AILQSVKARE EGRAPEQRPA PNAAPVDPTL RTKQPIPAAY NRYDQERFKG 300
    KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP 350
    PNQKKGSRTP IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE 400
    NETLIQRRKD QMQPGGTAIS VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP 450
    AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY DEVRLDPNVQ KWDVTVLELS 500
    YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F 531
    Length:531
    Mass (Da):60,577
    Last modified:October 1, 2002 - v1
    Checksum:i894A7448DBC0E793
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK080861 mRNA. Translation: BAC38048.1.
    BC027756 mRNA. Translation: AAH27756.1.
    BC031127 mRNA. Translation: AAH31127.1.
    CCDSiCCDS15341.1.
    RefSeqiNP_666103.1. NM_145991.1.
    UniGeneiMm.156727.
    Mm.393505.
    Mm.398849.

    Genome annotation databases

    EnsembliENSMUST00000018337; ENSMUSP00000018337; ENSMUSG00000026361.
    GeneIDi214498.
    KEGGimmu:214498.
    UCSCiuc007cwx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK080861 mRNA. Translation: BAC38048.1 .
    BC027756 mRNA. Translation: AAH27756.1 .
    BC031127 mRNA. Translation: AAH31127.1 .
    CCDSi CCDS15341.1.
    RefSeqi NP_666103.1. NM_145991.1.
    UniGenei Mm.156727.
    Mm.393505.
    Mm.398849.

    3D structure databases

    ProteinModelPortali Q8JZM7.
    SMRi Q8JZM7. Positions 358-523.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229532. 6 interactions.
    IntActi Q8JZM7. 7 interactions.
    MINTi MINT-4116595.
    STRINGi 10090.ENSMUSP00000018337.

    PTM databases

    PhosphoSitei Q8JZM7.

    Proteomic databases

    MaxQBi Q8JZM7.
    PaxDbi Q8JZM7.
    PRIDEi Q8JZM7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018337 ; ENSMUSP00000018337 ; ENSMUSG00000026361 .
    GeneIDi 214498.
    KEGGi mmu:214498.
    UCSCi uc007cwx.1. mouse.

    Organism-specific databases

    CTDi 79577.
    MGIi MGI:2384876. Cdc73.

    Phylogenomic databases

    eggNOGi COG5157.
    GeneTreei ENSGT00390000001114.
    HOGENOMi HOG000007819.
    HOVERGENi HBG055033.
    InParanoidi Q8JZM7.
    KOi K15175.
    OMAi EYYTLEC.
    OrthoDBi EOG7KM5SP.
    PhylomeDBi Q8JZM7.
    TreeFami TF313016.

    Enzyme and pathway databases

    Reactomei REACT_216539. formation of the beta-catenin:TCF transactivating complex.

    Miscellaneous databases

    NextBioi 374332.
    PROi Q8JZM7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8JZM7.
    Genevestigatori Q8JZM7.

    Family and domain databases

    InterProi IPR007852. RNA_pol_access_fac_Cdc73.
    [Graphical view ]
    PANTHERi PTHR12466. PTHR12466. 1 hit.
    Pfami PF05179. CDC73. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Adrenal gland.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and FVB/N.
      Tissue: Kidney and Mammary tumor.
    3. "Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression."
      Woodard G.E., Lin L., Zhang J.-H., Agarwal S.K., Marx S.J., Simonds W.F.
      Oncogene 24:1272-1276(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. Cited for: FUNCTION.

    Entry informationi

    Entry nameiCDC73_MOUSE
    AccessioniPrimary (citable) accession number: Q8JZM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3