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Protein

Melanin-concentrating hormone receptor 1

Gene

Mchr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • regulation of feeding behavior Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
SLC-1
Somatostatin receptor-like protein
Gene namesi
Name:Mchr1
Synonyms:Gpr24, Slc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2180756. Mchr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 114114ExtracellularSequence analysisAdd
BLAST
Transmembranei115 – 13723Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini138 – 14912CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17223Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini173 – 18614ExtracellularSequence analysisAdd
BLAST
Transmembranei187 – 20923Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini210 – 22920CytoplasmicSequence analysisAdd
BLAST
Transmembranei230 – 25223Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini253 – 27927ExtracellularSequence analysisAdd
BLAST
Transmembranei280 – 30223Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini303 – 32220CytoplasmicSequence analysisAdd
BLAST
Transmembranei323 – 34523Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini346 – 35914ExtracellularSequence analysisAdd
BLAST
Transmembranei360 – 38223Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini383 – 42341CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • ciliary membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • nonmotile primary cilium Source: BHF-UCL
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Melanin-concentrating hormone receptor 1PRO_0000069736Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8JZL2.
PRIDEiQ8JZL2.

PTM databases

iPTMnetiQ8JZL2.
PhosphoSiteiQ8JZL2.

Expressioni

Gene expression databases

BgeeiQ8JZL2.
CleanExiMM_MCHR1.

Interactioni

Subunit structurei

Interacts with NCDN.By similarity

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126191.

Chemistry

BindingDBiQ8JZL2.

Structurei

3D structure databases

ProteinModelPortaliQ8JZL2.
SMRiQ8JZL2. Positions 96-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ8JZL2.
KOiK04320.
PhylomeDBiQ8JZL2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JZL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGAGKEGV GRAVGLRGSR GCQAVEEDPF LDCGAQAPGQ GGGGRWRLPQ
60 70 80 90 100
PAWVDGRALH SREQATCTGC MDLQASLLST GPNASNISDG QDNFTLAGPP
110 120 130 140 150
PRTRSVSYIN IIMPSVFGTI CLLGIVGNST VIFAVVKKSK LHWCSNVPDI
160 170 180 190 200
FIINLSVVDL LFLLGMPFMI HQLMGNGVWH FGETMCTLIT AMDANSQFTS
210 220 230 240 250
TYILTAMAID RYLATVHPIS STKFRKPSMA TLVICLLWAL SFISITPVWL
260 270 280 290 300
YARLIPFPGG AVGCGIRLPN PDTDLYWFTL YQFFLAFALP FVVITAAYVK
310 320 330 340 350
ILQRMTSSVA PASQRSIRLR TKRVTRTAIA ICLVFFVCWA PYYVLQLTQL
360 370 380 390 400
SISRPTLTFV YLYNAAISLG YANSCLNPFV YIVLCETFRK RLVLSVKPAA
410 420
QGQLRTVSNA QTADEERTES KGT
Length:423
Mass (Da):46,269
Last modified:August 15, 2003 - v2
Checksum:i9E26A7DB9D494569
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01177985 Genomic DNA. No translation available.
AY049011 Genomic DNA. Translation: AAL06069.1.
AF498247 mRNA. Translation: AAM22964.1.
AF498248 mRNA. Translation: AAM22965.1.
BY276741 mRNA. No translation available.
RefSeqiNP_660114.1. NM_145132.2.
UniGeneiMm.323523.

Genome annotation databases

GeneIDi207911.
KEGGimmu:207911.
UCSCiuc007wwh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01177985 Genomic DNA. No translation available.
AY049011 Genomic DNA. Translation: AAL06069.1.
AF498247 mRNA. Translation: AAM22964.1.
AF498248 mRNA. Translation: AAM22965.1.
BY276741 mRNA. No translation available.
RefSeqiNP_660114.1. NM_145132.2.
UniGeneiMm.323523.

3D structure databases

ProteinModelPortaliQ8JZL2.
SMRiQ8JZL2. Positions 96-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126191.

Chemistry

BindingDBiQ8JZL2.
ChEMBLiCHEMBL4730.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8JZL2.
PhosphoSiteiQ8JZL2.

Proteomic databases

PaxDbiQ8JZL2.
PRIDEiQ8JZL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi207911.
KEGGimmu:207911.
UCSCiuc007wwh.2. mouse.

Organism-specific databases

CTDi2847.
MGIiMGI:2180756. Mchr1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ8JZL2.
KOiK04320.
PhylomeDBiQ8JZL2.

Miscellaneous databases

PROiQ8JZL2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8JZL2.
CleanExiMM_MCHR1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-129.
  3. "Cloning of the mouse melanin-concentrating hormone receptor 1 gene and promoter characterization."
    Lakaye B., Adamantidis A., Coumans B., Zorzi W., Parmentier M., Grisar T.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 71-423.
    Strain: 129/SvJ.
  4. "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
    Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J., Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.
    Mamm. Genome 12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-423.
    Strain: ILS and ISS.

Entry informationi

Entry nameiMCHR1_MOUSE
AccessioniPrimary (citable) accession number: Q8JZL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: July 6, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-71 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.