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Protein

Melanin-concentrating hormone receptor 1

Gene

Mchr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: GO_Central
  • neuropeptide signaling pathway Source: GO_Central
  • regulation of feeding behavior Source: BHF-UCL

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanin-concentrating hormone receptor 1
Short name:
MCH receptor 1
Short name:
MCH-R1
Short name:
MCHR-1
Alternative name(s):
G-protein coupled receptor 24
MCH-1R
Short name:
MCH1R
Short name:
MCHR
SLC-11 Publication
Somatostatin receptor-like protein
Gene namesi
Name:Mchr1
Synonyms:Gpr24, Slc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 15, Unplaced

Organism-specific databases

MGIiMGI:2180756. Mchr1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularCuratedAdd BLAST45
Transmembranei46 – 66Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini67 – 79CytoplasmicCuratedAdd BLAST13
Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini101 – 116ExtracellularCuratedAdd BLAST16
Transmembranei117 – 139Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini140 – 161CytoplasmicCuratedAdd BLAST22
Transmembranei162 – 182Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini183 – 204ExtracellularCuratedAdd BLAST22
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 256CytoplasmicCuratedAdd BLAST31
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 294ExtracellularCuratedAdd BLAST17
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 353CytoplasmicCuratedAdd BLAST38

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697361 – 353Melanin-concentrating hormone receptor 1Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8JZL2.
PRIDEiQ8JZL2.

PTM databases

iPTMnetiQ8JZL2.
PhosphoSitePlusiQ8JZL2.

Expressioni

Tissue specificityi

Expressed predominantly in the brain. Expression in brain is negatively regulated by leptin. Also found in the epithelium of the tongue and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000050164.
CleanExiMM_MCHR1.

Interactioni

Subunit structurei

Interacts with NCDN.By similarity

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126191.

Chemistry databases

BindingDBiQ8JZL2.

Structurei

3D structure databases

ProteinModelPortaliQ8JZL2.
SMRiQ8JZL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000000704.
HOVERGENiHBG105726.
InParanoidiQ8JZL2.
KOiK04320.
OMAiTSTYILT.
OrthoDBiEOG091G0HEN.
PhylomeDBiQ8JZL2.
TreeFamiTF315737.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004047. MCH1_rcpt.
IPR008361. MCH_rcpt.
PANTHERiPTHR44627. PTHR44627. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01507. MCH1RECEPTOR.
PR01783. MCHRECEPTOR.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform 1 (identifier: Q8JZL2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLQASLLST GPNASNISDG QDNFTLAGPP PRTRSVSYIN IIMPSVFGTI
60 70 80 90 100
CLLGIVGNST VIFAVVKKSK LHWCSNVPDI FIINLSVVDL LFLLGMPFMI
110 120 130 140 150
HQLMGNGVWH FGETMCTLIT AMDANSQFTS TYILTAMAID RYLATVHPIS
160 170 180 190 200
STKFRKPSMA TLVICLLWAL SFISITPVWL YARLIPFPGG AVGCGIRLPN
210 220 230 240 250
PDTDLYWFTL YQFFLAFALP FVVITAAYVK ILQRMTSSVA PASQRSIRLR
260 270 280 290 300
TKRVTRTAIA ICLVFFVCWA PYYVLQLTQL SISRPTLTFV YLYNAAISLG
310 320 330 340 350
YANSCLNPFV YIVLCETFRK RLVLSVKPAA QGQLRTVSNA QTADEERTES

KGT
Length:353
Mass (Da):39,120
Last modified:November 22, 2017 - v3
Checksum:iD85D186EB1A4AEF9
GO
Isoform 2 (identifier: Q8JZL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MDLQASLLSTGPNASNISDGQDNFTLA → MRGQQEGRHGRLSASRSEGGSHLLFLSS

Show »
Length:354
Mass (Da):39,380
Checksum:iC8088113F93619A5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0592221 – 27MDLQA…NFTLA → MRGQQEGRHGRLSASRSEGG SHLLFLSS in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498247 mRNA. Translation: AAM22964.1.
AF498248 mRNA. Translation: AAM22965.1.
AY049011 Genomic DNA. Translation: AAL06069.1.
AY049011 Genomic DNA. Translation: AAL06070.1.
AK134867 mRNA. Translation: BAE22319.1.
AC102334 Genomic DNA. No translation available.
BC128286 mRNA. Translation: AAI28287.1.
RefSeqiNP_660114.1. NM_145132.2.
UniGeneiMm.323523.

Genome annotation databases

EnsembliENSMUST00000166855; ENSMUSP00000126191; ENSMUSG00000050164.
GeneIDi207911.
KEGGimmu:207911.
UCSCiuc007wwh.2. mouse.

Keywords - Coding sequence diversityi

Alternative promoter usage

Similar proteinsi

Entry informationi

Entry nameiMCHR1_MOUSE
AccessioniPrimary (citable) accession number: Q8JZL2
Secondary accession number(s): Q3UY93, Q8K3M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 22, 2017
Last modified: November 22, 2017
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families