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Protein

Interleukin-17 receptor D

Gene

Il17rd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK (By similarity). Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons.By similarity2 Publications

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-5674135. MAP2K and MAPK activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor D
Short name:
IL-17 receptor D
Short name:
IL-17RD
Alternative name(s):
Interleukin-17 receptor-like protein
Sef homolog
Short name:
mSef
Gene namesi
Name:Il17rd
Synonyms:Il17rlm, Sef
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2159727. Il17rd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 299283ExtracellularSequence analysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence analysisAdd
BLAST
Topological domaini321 – 738418CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 738722Interleukin-17 receptor DPRO_0000041872Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence analysis
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8JZL1.
PRIDEiQ8JZL1.

PTM databases

PhosphoSiteiQ8JZL1.

Expressioni

Developmental stagei

During early embryogenesis, predominantly expressed at E6.5 and E9.5 in the forebrain, mid-hindbrain boundary, branchial arches, somites, limb bud and tailbud. At E12.5 additionally expressed in the diencephalon, optic stalk, pituitary, olfactory and oral epithelium, tooth primordia, somites, developing metanephric kidney and stomach. Expressed in the neopallial cortex, rhombic lip and dorsal regions of the myelencephalon and in the frontal nasal process. Expressed in the commissural plate and septal area of the forebrain and in the hippocampus, lens and optic cup. In the oral region, expressed in the tongue and in the mesenchyme of the first branchial arch. Also expressed in the developing inner ear. Expression patterns remain essentially unchanged at E15.5, with the addition of a strong expression in the submandibular gland.1 Publication

Gene expression databases

BgeeiQ8JZL1.
CleanExiMM_IL17RD.
GenevisibleiQ8JZL1. MM.

Interactioni

Subunit structurei

Self-associates. Interacts with FGFR2 and phosphorylated MAP2K1 or MAP2K2. Associates with a MAP2K1/2-MAPK1/3 complex (By similarity). Interacts with FGFR1 and MAP3K7.By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036076.

Structurei

3D structure databases

ProteinModelPortaliQ8JZL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini355 – 509155SEFIRPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi695 – 7006Poly-Ser

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEYK. Eukaryota.
ENOG4110CUP. LUCA.
GeneTreeiENSGT00840000129816.
HOGENOMiHOG000060160.
HOVERGENiHBG081777.
InParanoidiQ8JZL1.
KOiK05167.
OMAiSTKYKLM.
OrthoDBiEOG7P8P7V.
PhylomeDBiQ8JZL1.
TreeFamiTF329644.

Family and domain databases

InterProiIPR031951. IL17R_D_N.
IPR013568. SEFIR_dom.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF16742. IL17R_D_N. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8JZL1-1) [UniParc]FASTAAdd to basket

Also known as: "IL17RLM-L, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPWLQLCSF FFTVNACLNG SQLAVAAGGS GRARGADTCG WRGVGPASRN
60 70 80 90 100
SGLHNITFRY DNCTTYLNPG GKHAIADAQN ITISQYACHD QVAVTILWSP
110 120 130 140 150
GALGIEFLKG FRVILEELKS EGRQCQQLIL KDPKQLNSSF RRTGMESQPF
160 170 180 190 200
LNMKFETDYF VKIVPFPSIK NESNYHPFFF RTRACDLLLQ PDNLACKPFW
210 220 230 240 250
KPRNLNISQH GSDMHVSFDH APQNFGFRGF HVLYKLKHEG PFRRRTCRQD
260 270 280 290 300
QNTETTSCLL QNVSPGDYII ELVDDSNTTR KAAQYVVKSV QSPWAGPIRA
310 320 330 340 350
VAITVPLVVI SAFATLFTVM CRKKQQENIY SHLDEESPES STYAAALPRD
360 370 380 390 400
RLRPQPKVFL CYSNKDGQNH MNVVQCFAYF LQDFCGCEVA LDLWEDFSLC
410 420 430 440 450
REGQREWAIQ KIHESQFIIV VCSKGMKYFV DKKNFRHKGG SRGEAQGEFF
460 470 480 490 500
LVAVAAIAEK LRQAKQSSSA ALRKFIAVYF DYSCEGDVPC SLDLSTKYKL
510 520 530 540 550
MDHLPELCAH LHSGEQEVLG QHPGHSSRRN YFRSKSGRSL YVAICNMHQF
560 570 580 590 600
IDEEPDWFEK QFIPFQHPPV RYQEPVLEKF DSGLVLNDVI SKPGPESDFC
610 620 630 640 650
RKVEACVLGA AGPADSYSYL ESQHVGLDQD TEAQPSCDSA PALQPLLHAV
660 670 680 690 700
KAGSPSEMPR DSGIYDSSVP SSELSLPLME GLSPDQIETS SLTESVSSSS
710 720 730
GLGEEDPPTL PSKLLASGVS REHGCHSHTD ELQALAPL
Length:738
Mass (Da):82,348
Last modified:October 1, 2002 - v1
Checksum:iD8CE66230E3E8226
GO
Isoform 2 (identifier: Q8JZL1-2) [UniParc]FASTAAdd to basket

Also known as: "IL17RLM-S, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Show »
Length:594
Mass (Da):66,746
Checksum:iBA146B655DCF4ECE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti715 – 7151L → F in AAM74078 (PubMed:12958313).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 144144Missing in isoform 2. 1 PublicationVSP_015585Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459444 mRNA. Translation: AAM28441.1.
AF424804 mRNA. Translation: AAL79530.1.
AF494209 mRNA. Translation: AAM74078.1.
AF494210 mRNA. Translation: AAM74079.1.
BC138629 mRNA. Translation: AAI38630.1.
CCDSiCCDS26885.1. [Q8JZL1-1]
RefSeqiNP_602319.1. NM_134437.3. [Q8JZL1-1]
XP_006518731.1. XM_006518668.1. [Q8JZL1-2]
UniGeneiMm.206726.

Genome annotation databases

EnsembliENSMUST00000035336; ENSMUSP00000036076; ENSMUSG00000040717. [Q8JZL1-1]
GeneIDi171463.
KEGGimmu:171463.
UCSCiuc007stl.1. mouse. [Q8JZL1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459444 mRNA. Translation: AAM28441.1.
AF424804 mRNA. Translation: AAL79530.1.
AF494209 mRNA. Translation: AAM74078.1.
AF494210 mRNA. Translation: AAM74079.1.
BC138629 mRNA. Translation: AAI38630.1.
CCDSiCCDS26885.1. [Q8JZL1-1]
RefSeqiNP_602319.1. NM_134437.3. [Q8JZL1-1]
XP_006518731.1. XM_006518668.1. [Q8JZL1-2]
UniGeneiMm.206726.

3D structure databases

ProteinModelPortaliQ8JZL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036076.

PTM databases

PhosphoSiteiQ8JZL1.

Proteomic databases

PaxDbiQ8JZL1.
PRIDEiQ8JZL1.

Protocols and materials databases

DNASUi171463.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035336; ENSMUSP00000036076; ENSMUSG00000040717. [Q8JZL1-1]
GeneIDi171463.
KEGGimmu:171463.
UCSCiuc007stl.1. mouse. [Q8JZL1-1]

Organism-specific databases

CTDi54756.
MGIiMGI:2159727. Il17rd.

Phylogenomic databases

eggNOGiENOG410IEYK. Eukaryota.
ENOG4110CUP. LUCA.
GeneTreeiENSGT00840000129816.
HOGENOMiHOG000060160.
HOVERGENiHBG081777.
InParanoidiQ8JZL1.
KOiK05167.
OMAiSTKYKLM.
OrthoDBiEOG7P8P7V.
PhylomeDBiQ8JZL1.
TreeFamiTF329644.

Enzyme and pathway databases

ReactomeiR-MMU-5674135. MAP2K and MAPK activation.

Miscellaneous databases

PROiQ8JZL1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8JZL1.
CleanExiMM_IL17RD.
GenevisibleiQ8JZL1. MM.

Family and domain databases

InterProiIPR031951. IL17R_D_N.
IPR013568. SEFIR_dom.
IPR007087. Znf_C2H2.
[Graphical view]
PfamiPF16742. IL17R_D_N. 1 hit.
PF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis."
    Lin W., Fuerthauer M., Thisse B., Thisse C., Jing N., Ang S.-L.
    Mech. Dev. 113:163-168(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE.
  2. "hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling."
    Xiong S.Q., Zhao Q.H., Rong Z., Huang G.R., Huang Y., Chen P.L., Zhang S., Liu L., Chang Z.J.
    J. Biol. Chem. 278:50273-50282(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: BALB/cJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation."
    Kovalenko D., Yang X., Nadeau R.J., Harkins L.K., Friesel R.
    J. Biol. Chem. 278:14087-14091(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FGFR1.
  5. Cited for: FUNCTION, INTERACTION WITH MAP3K7.
  6. Cited for: POSSIBLE FUNCTION IN GNRH NEURON FATE SPECIFICATION.

Entry informationi

Entry nameiI17RD_MOUSE
AccessioniPrimary (citable) accession number: Q8JZL1
Secondary accession number(s): B2RRY7, Q8K447, Q8R5J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.