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Protein

Interleukin-17 receptor D

Gene

Il17rd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK (By similarity). Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons.By similarity2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-5674135 MAP2K and MAPK activation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor D
Short name:
IL-17 receptor D
Short name:
IL-17RD
Alternative name(s):
Interleukin-17 receptor-like protein
Sef homolog
Short name:
mSef
Gene namesi
Name:Il17rd
Synonyms:Il17rlm, Sef
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2159727 Il17rd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 299ExtracellularSequence analysisAdd BLAST283
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Topological domaini321 – 738CytoplasmicSequence analysisAdd BLAST418

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000004187217 – 738Interleukin-17 receptor DAdd BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8JZL1
PeptideAtlasiQ8JZL1
PRIDEiQ8JZL1

PTM databases

PhosphoSitePlusiQ8JZL1

Expressioni

Developmental stagei

During early embryogenesis, predominantly expressed at E6.5 and E9.5 in the forebrain, mid-hindbrain boundary, branchial arches, somites, limb bud and tailbud. At E12.5 additionally expressed in the diencephalon, optic stalk, pituitary, olfactory and oral epithelium, tooth primordia, somites, developing metanephric kidney and stomach. Expressed in the neopallial cortex, rhombic lip and dorsal regions of the myelencephalon and in the frontal nasal process. Expressed in the commissural plate and septal area of the forebrain and in the hippocampus, lens and optic cup. In the oral region, expressed in the tongue and in the mesenchyme of the first branchial arch. Also expressed in the developing inner ear. Expression patterns remain essentially unchanged at E15.5, with the addition of a strong expression in the submandibular gland.1 Publication

Gene expression databases

BgeeiENSMUSG00000040717
CleanExiMM_IL17RD
ExpressionAtlasiQ8JZL1 baseline and differential
GenevisibleiQ8JZL1 MM

Interactioni

Subunit structurei

Self-associates. Interacts with FGFR2 and phosphorylated MAP2K1 or MAP2K2. Associates with a MAP2K1/2-MAPK1/3 complex (By similarity). Interacts with FGFR1 and MAP3K7.By similarity2 Publications

Protein-protein interaction databases

BioGridi2285961 interactor.
STRINGi10090.ENSMUSP00000036076

Structurei

3D structure databases

ProteinModelPortaliQ8JZL1
SMRiQ8JZL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 509SEFIRPROSITE-ProRule annotationAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi695 – 700Poly-Ser6

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEYK Eukaryota
ENOG4110CUP LUCA
GeneTreeiENSGT00880000137935
HOGENOMiHOG000060160
HOVERGENiHBG081777
InParanoidiQ8JZL1
KOiK05167
OMAiSTKYKLM
OrthoDBiEOG091G01XZ
PhylomeDBiQ8JZL1
TreeFamiTF329644

Family and domain databases

InterProiView protein in InterPro
IPR031951 IL17R_D_N
IPR013568 SEFIR_dom
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF16742 IL17R_D_N, 1 hit
PF08357 SEFIR, 1 hit
PROSITEiView protein in PROSITE
PS51534 SEFIR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8JZL1-1) [UniParc]FASTAAdd to basket
Also known as: "IL17RLM-L, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPWLQLCSF FFTVNACLNG SQLAVAAGGS GRARGADTCG WRGVGPASRN
60 70 80 90 100
SGLHNITFRY DNCTTYLNPG GKHAIADAQN ITISQYACHD QVAVTILWSP
110 120 130 140 150
GALGIEFLKG FRVILEELKS EGRQCQQLIL KDPKQLNSSF RRTGMESQPF
160 170 180 190 200
LNMKFETDYF VKIVPFPSIK NESNYHPFFF RTRACDLLLQ PDNLACKPFW
210 220 230 240 250
KPRNLNISQH GSDMHVSFDH APQNFGFRGF HVLYKLKHEG PFRRRTCRQD
260 270 280 290 300
QNTETTSCLL QNVSPGDYII ELVDDSNTTR KAAQYVVKSV QSPWAGPIRA
310 320 330 340 350
VAITVPLVVI SAFATLFTVM CRKKQQENIY SHLDEESPES STYAAALPRD
360 370 380 390 400
RLRPQPKVFL CYSNKDGQNH MNVVQCFAYF LQDFCGCEVA LDLWEDFSLC
410 420 430 440 450
REGQREWAIQ KIHESQFIIV VCSKGMKYFV DKKNFRHKGG SRGEAQGEFF
460 470 480 490 500
LVAVAAIAEK LRQAKQSSSA ALRKFIAVYF DYSCEGDVPC SLDLSTKYKL
510 520 530 540 550
MDHLPELCAH LHSGEQEVLG QHPGHSSRRN YFRSKSGRSL YVAICNMHQF
560 570 580 590 600
IDEEPDWFEK QFIPFQHPPV RYQEPVLEKF DSGLVLNDVI SKPGPESDFC
610 620 630 640 650
RKVEACVLGA AGPADSYSYL ESQHVGLDQD TEAQPSCDSA PALQPLLHAV
660 670 680 690 700
KAGSPSEMPR DSGIYDSSVP SSELSLPLME GLSPDQIETS SLTESVSSSS
710 720 730
GLGEEDPPTL PSKLLASGVS REHGCHSHTD ELQALAPL
Length:738
Mass (Da):82,348
Last modified:October 1, 2002 - v1
Checksum:iD8CE66230E3E8226
GO
Isoform 2 (identifier: Q8JZL1-2) [UniParc]FASTAAdd to basket
Also known as: "IL17RLM-S, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Show »
Length:594
Mass (Da):66,746
Checksum:iBA146B655DCF4ECE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti715L → F in AAM74078 (PubMed:12958313).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0155851 – 144Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF459444 mRNA Translation: AAM28441.1
AF424804 mRNA Translation: AAL79530.1
AF494209 mRNA Translation: AAM74078.1
AF494210 mRNA Translation: AAM74079.1
BC138629 mRNA Translation: AAI38630.1
CCDSiCCDS26885.1 [Q8JZL1-1]
RefSeqiNP_602319.1, NM_134437.3 [Q8JZL1-1]
XP_006518731.1, XM_006518668.2 [Q8JZL1-2]
UniGeneiMm.206726

Genome annotation databases

EnsembliENSMUST00000035336; ENSMUSP00000036076; ENSMUSG00000040717 [Q8JZL1-1]
ENSMUST00000225146; ENSMUSP00000153543; ENSMUSG00000040717 [Q8JZL1-2]
GeneIDi171463
KEGGimmu:171463
UCSCiuc007stl.1 mouse [Q8JZL1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiI17RD_MOUSE
AccessioniPrimary (citable) accession number: Q8JZL1
Secondary accession number(s): B2RRY7, Q8K447, Q8R5J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome