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Protein

Zinc finger protein 467

Gene

Znf467

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 18223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri542 – 56423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 467
Alternative name(s):
Endothelial cell-derived zinc finger protein
Short name:
EZI
Gene namesi
Name:Znf467
Synonyms:Ezi, Zfp467
ORF Names:MNCb-3350
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916160. Zfp467.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Zinc finger protein 467PRO_0000247518Add
BLAST

Proteomic databases

MaxQBiQ8JZL0.
PaxDbiQ8JZL0.
PRIDEiQ8JZL0.

PTM databases

PhosphoSiteiQ8JZL0.

Expressioni

Inductioni

Down-regulated by CTF1, PTH and OSM.1 Publication

Gene expression databases

BgeeiQ8JZL0.
CleanExiMM_ZFP467.
ExpressionAtlasiQ8JZL0. baseline and differential.
GenevisibleiQ8JZL0. MM.

Interactioni

Subunit structurei

Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus.1 Publication

Protein-protein interaction databases

BioGridi213109. 4 interactions.
STRINGi10090.ENSMUSP00000110207.

Structurei

3D structure databases

ProteinModelPortaliQ8JZL0.
SMRiQ8JZL0. Positions 157-564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 183183Interacts with STAT3Add
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri160 – 18223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri542 – 56423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130023.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8JZL0.
OMAiERSFFCP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8JZL0.
TreeFamiTF326846.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JZL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRETLEALNS LGFSVGQPEM APQSEPRDGF SNAQEKMSSR GESTLHSCSG
60 70 80 90 100
HETPGQKEGI HTEQAEAPCM GSQASTPQKA EPAGSVPGEE WMIRKVKVED
110 120 130 140 150
EDQEAEEEVE WPQHLSFLPS PFPTPDLGQL AVTYKLEPGT PGALGGIALS
160 170 180 190 200
GWAPIPEKPY GCEECERRFR DQLTLRLHQR LHRGEGPCAC PDCGRSFTQR
210 220 230 240 250
AHMLLHQRSH RGERPFPCSE CDKRFSKKAH LTRHLRTHTG ERPYPCAECG
260 270 280 290 300
KRFSQKIHLG SHQKTHTGER PFPCTECEKR FRKKTHLIRH QRIHTGERPY
310 320 330 340 350
QCTQCTRSFT HKQHLVRHQR VHDAASRTRS SPDIPVAPHS PTASLTPSPP
360 370 380 390 400
GPKPFACSHC GQSFGWKKNL ATHQSLHLTE GRPFGCDECA LGTNVDPAAE
410 420 430 440 450
PSACTPHAPD CGPGSGPAAP QRTTSSERSF FCPDCGRGFA HGQHLARHRR
460 470 480 490 500
VHTGERPFAC AQCGRRFGSR PNLVAHSRAH SGARPFACAQ CGRRFSRKSH
510 520 530 540 550
LGRHQAVHTG SRPHACAVCA RCFSSKTNLV RHQAIHTGSR PFSCPQCAKS
560 570 580 590
FSRKTHLVRH QRIHGDAALP APASNLSAPA WSNPSEVVPP PIFF
Length:594
Mass (Da):65,633
Last modified:October 1, 2002 - v1
Checksum:iE11EA6416C4A5C6C
GO

Sequence cautioni

The sequence BAA95099.1 differs from that shown. Reason: Frameshift at positions 503 and 532. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti511 – 5111S → G in BAA95099 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076746 mRNA. Translation: BAC00997.1.
AB041616 mRNA. Translation: BAA95099.1. Frameshift.
AK033146 mRNA. Translation: BAC28171.1.
BC029859 mRNA. Translation: AAH29859.1.
CCDSiCCDS51764.1.
RefSeqiNP_001078884.1. NM_001085415.1.
NP_001078885.1. NM_001085416.1.
NP_065614.2. NM_020589.2.
XP_006506606.1. XM_006506543.2.
XP_011239753.1. XM_011241451.1.
UniGeneiMm.2464.

Genome annotation databases

EnsembliENSMUST00000114560; ENSMUSP00000110207; ENSMUSG00000068551.
ENSMUST00000114561; ENSMUSP00000110208; ENSMUSG00000068551.
GeneIDi68910.
KEGGimmu:68910.
UCSCiuc009buf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076746 mRNA. Translation: BAC00997.1.
AB041616 mRNA. Translation: BAA95099.1. Frameshift.
AK033146 mRNA. Translation: BAC28171.1.
BC029859 mRNA. Translation: AAH29859.1.
CCDSiCCDS51764.1.
RefSeqiNP_001078884.1. NM_001085415.1.
NP_001078885.1. NM_001085416.1.
NP_065614.2. NM_020589.2.
XP_006506606.1. XM_006506543.2.
XP_011239753.1. XM_011241451.1.
UniGeneiMm.2464.

3D structure databases

ProteinModelPortaliQ8JZL0.
SMRiQ8JZL0. Positions 157-564.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213109. 4 interactions.
STRINGi10090.ENSMUSP00000110207.

PTM databases

PhosphoSiteiQ8JZL0.

Proteomic databases

MaxQBiQ8JZL0.
PaxDbiQ8JZL0.
PRIDEiQ8JZL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114560; ENSMUSP00000110207; ENSMUSG00000068551.
ENSMUST00000114561; ENSMUSP00000110208; ENSMUSG00000068551.
GeneIDi68910.
KEGGimmu:68910.
UCSCiuc009buf.1. mouse.

Organism-specific databases

CTDi68910.
MGIiMGI:1916160. Zfp467.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130023.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8JZL0.
OMAiERSFFCP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8JZL0.
TreeFamiTF326846.

Miscellaneous databases

NextBioi328153.
PROiQ8JZL0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8JZL0.
CleanExiMM_ZFP467.
ExpressionAtlasiQ8JZL0. baseline and differential.
GenevisibleiQ8JZL0. MM.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3."
    Nakayama K., Kim K.-W., Miyajima A.
    EMBO J. 21:6174-6184(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STAT3.
  2. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment."
    Quach J.M., Walker E.C., Allan E., Solano M., Yokoyama A., Kato S., Sims N.A., Gillespie M.T., Martin T.J.
    J. Biol. Chem. 286:4186-4198(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiZN467_MOUSE
AccessioniPrimary (citable) accession number: Q8JZL0
Secondary accession number(s): Q9JJ98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.