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Protein

Zinc finger protein 467

Gene

Znf467

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 182C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri188 – 210C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-381340. Transcriptional regulation of white adipocyte differentiation.
R-MMU-442533. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 467
Alternative name(s):
Endothelial cell-derived zinc finger protein
Short name:
EZI
Gene namesi
Name:Znf467
Synonyms:Ezi, Zfp467
ORF Names:MNCb-3350
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916160. Zfp467.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475181 – 594Zinc finger protein 467Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki368Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8JZL0.
PaxDbiQ8JZL0.
PRIDEiQ8JZL0.

PTM databases

iPTMnetiQ8JZL0.
PhosphoSitePlusiQ8JZL0.

Expressioni

Inductioni

Down-regulated by CTF1, PTH and OSM.1 Publication

Gene expression databases

BgeeiENSMUSG00000068551.
CleanExiMM_ZFP467.
ExpressionAtlasiQ8JZL0. baseline and differential.
GenevisibleiQ8JZL0. MM.

Interactioni

Subunit structurei

Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus.1 Publication

Protein-protein interaction databases

BioGridi213109. 4 interactors.
STRINGi10090.ENSMUSP00000110207.

Structurei

3D structure databases

ProteinModelPortaliQ8JZL0.
SMRiQ8JZL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 183Interaction with STAT31 PublicationAdd BLAST183

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri160 – 182C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri188 – 210C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00870000136592.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8JZL0.
OMAiGFAHGQH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8JZL0.
TreeFamiTF326846.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 12 hits.
SUPFAMiSSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.

Sequencei

Sequence statusi: Complete.

Q8JZL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRETLEALNS LGFSVGQPEM APQSEPRDGF SNAQEKMSSR GESTLHSCSG
60 70 80 90 100
HETPGQKEGI HTEQAEAPCM GSQASTPQKA EPAGSVPGEE WMIRKVKVED
110 120 130 140 150
EDQEAEEEVE WPQHLSFLPS PFPTPDLGQL AVTYKLEPGT PGALGGIALS
160 170 180 190 200
GWAPIPEKPY GCEECERRFR DQLTLRLHQR LHRGEGPCAC PDCGRSFTQR
210 220 230 240 250
AHMLLHQRSH RGERPFPCSE CDKRFSKKAH LTRHLRTHTG ERPYPCAECG
260 270 280 290 300
KRFSQKIHLG SHQKTHTGER PFPCTECEKR FRKKTHLIRH QRIHTGERPY
310 320 330 340 350
QCTQCTRSFT HKQHLVRHQR VHDAASRTRS SPDIPVAPHS PTASLTPSPP
360 370 380 390 400
GPKPFACSHC GQSFGWKKNL ATHQSLHLTE GRPFGCDECA LGTNVDPAAE
410 420 430 440 450
PSACTPHAPD CGPGSGPAAP QRTTSSERSF FCPDCGRGFA HGQHLARHRR
460 470 480 490 500
VHTGERPFAC AQCGRRFGSR PNLVAHSRAH SGARPFACAQ CGRRFSRKSH
510 520 530 540 550
LGRHQAVHTG SRPHACAVCA RCFSSKTNLV RHQAIHTGSR PFSCPQCAKS
560 570 580 590
FSRKTHLVRH QRIHGDAALP APASNLSAPA WSNPSEVVPP PIFF
Length:594
Mass (Da):65,633
Last modified:October 1, 2002 - v1
Checksum:iE11EA6416C4A5C6C
GO

Sequence cautioni

The sequence BAA95099 differs from that shown. Reason: Frameshift at positions 503 and 532.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti511S → G in BAA95099 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076746 mRNA. Translation: BAC00997.1.
AB041616 mRNA. Translation: BAA95099.1. Frameshift.
AK033146 mRNA. Translation: BAC28171.1.
BC029859 mRNA. Translation: AAH29859.1.
CCDSiCCDS51764.1.
RefSeqiNP_001078884.1. NM_001085415.1.
NP_001078885.1. NM_001085416.1.
NP_065614.2. NM_020589.2.
UniGeneiMm.2464.

Genome annotation databases

EnsembliENSMUST00000114560; ENSMUSP00000110207; ENSMUSG00000068551.
ENSMUST00000114561; ENSMUSP00000110208; ENSMUSG00000068551.
GeneIDi68910.
KEGGimmu:68910.
UCSCiuc009buf.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiZN467_MOUSE
AccessioniPrimary (citable) accession number: Q8JZL0
Secondary accession number(s): Q9JJ98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families