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Q8JZK9

- HMCS1_MOUSE

UniProt

Q8JZK9 - HMCS1_MOUSE

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Protein

Hydroxymethylglutaryl-CoA synthase, cytoplasmic

Gene

Hmgcs1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.By similarity

Catalytic activityi

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton donor/acceptorPROSITE-ProRule annotation
Active sitei129 – 1291Acyl-thioester intermediatePROSITE-ProRule annotation
Active sitei264 – 2641Proton donor/acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. drug binding Source: Ensembl
  2. hydroxymethylglutaryl-CoA synthase activity Source: UniProtKB-EC
  3. isomerase activity Source: Ensembl
  4. organic acid binding Source: Ensembl

GO - Biological processi

  1. brain development Source: Ensembl
  2. cellular response to cholesterol Source: Ensembl
  3. cellular response to follicle-stimulating hormone stimulus Source: Ensembl
  4. cholesterol biosynthetic process Source: UniProtKB-KW
  5. isoprenoid biosynthetic process Source: InterPro
  6. liver development Source: Ensembl
  7. male gonad development Source: Ensembl
  8. response to acid chemical Source: Ensembl
  9. response to drug Source: Ensembl
  10. response to lipoprotein particle Source: Ensembl
  11. response to low light intensity stimulus Source: Ensembl
  12. response to purine-containing compound Source: Ensembl
  13. response to tellurium ion Source: Ensembl
  14. response to vitamin E Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.
REACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_208531. Cholesterol biosynthesis.
UniPathwayiUPA00058; UER00102.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (EC:2.3.3.10)
Short name:
HMG-CoA synthase
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene namesi
Name:Hmgcs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:107592. Hmgcs1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleus Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Hydroxymethylglutaryl-CoA synthase, cytoplasmicPRO_0000213748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei46 – 461N6-acetyllysineBy similarity
Modified residuei273 – 2731N6-acetyllysineBy similarity
Modified residuei495 – 4951Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8JZK9.
PaxDbiQ8JZK9.
PRIDEiQ8JZK9.

2D gel databases

REPRODUCTION-2DPAGEQ8JZK9.

PTM databases

PhosphoSiteiQ8JZK9.

Expressioni

Gene expression databases

BgeeiQ8JZK9.
CleanExiMM_HMGCS1.
GenevestigatoriQ8JZK9.

Interactioni

Protein-protein interaction databases

IntActiQ8JZK9. 2 interactions.
MINTiMINT-1869354.
STRINGi10090.ENSMUSP00000097858.

Structurei

3D structure databases

ProteinModelPortaliQ8JZK9.
SMRiQ8JZK9. Positions 16-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA synthase family.Curated

Phylogenomic databases

eggNOGiCOG3425.
GeneTreeiENSGT00390000006096.
HOGENOMiHOG000012351.
HOVERGENiHBG051912.
InParanoidiQ8JZK9.
KOiK01641.
OMAiRDFTLND.
OrthoDBiEOG741Z1W.
PhylomeDBiQ8JZK9.
TreeFamiTF105361.

Family and domain databases

Gene3Di3.40.47.10. 1 hit.
InterProiIPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 3 hits.
TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEiPS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JZK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGSLPLNAE ACWPKDVGIV ALEIYFPSQY VDQAELEKYD GVDAGKYTIG
60 70 80 90 100
LGQARMGFCT DREDINSLCL TVVQKLMERH SLSYDCIGRL EVGTETIIDK
110 120 130 140 150
SKSVKSNLMQ LFEESGNTDI EGIDTTNACY GGTAAVFNAV NWVESSSWDG
160 170 180 190 200
RYALVVAGDI AIYATGNARP TGGVGAVALL IGPNAPLIFD RGLRGTHMQH
210 220 230 240 250
AYDFYKPDML SEYPVVDGKL SIQCYLSALD RCYSVYRKKI RAQWQKEGKD
260 270 280 290 300
KDFTLNDFGF MIFHSPYCKL VQKSLARMFL NDFLNDQNRD KNSIYSGLEA
310 320 330 340 350
FGDVKLEDTY FDRDVEKAFM KASSELFNQK TKASLLVSNQ NGNMYTSSVY
360 370 380 390 400
GSLASVLAQY SPQQLAGKRV GVFSYGSGLA ATLYSLKVTQ DATPGSALDK
410 420 430 440 450
ITASLCDLKS RLDSRTCVAP DVFAENMKLR EDTHHLANYI PQCSIDSLFE
460 470 480 490 500
GTWYLVRVDE KHRRTYARRP FTNDHSLDEG MGLVHSNTAT EHIPSPAKKV
510 520
PRLPATSAES ESAVISNGEH
Length:520
Mass (Da):57,569
Last modified:October 1, 2002 - v1
Checksum:iE28F8772CF64D85C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC023851 mRNA. Translation: AAH23851.1.
BC029693 mRNA. Translation: AAH29693.1.
BC034317 mRNA. Translation: AAH34317.1.
AK031297 mRNA. Translation: BAC27338.1.
AK044835 mRNA. Translation: BAC32112.1.
AK045094 mRNA. Translation: BAC32218.1.
AK135551 mRNA. Translation: BAE22579.1.
CCDSiCCDS56901.1.
RefSeqiNP_001278368.1. NM_001291439.1.
NP_666054.2. NM_145942.5.
XP_006517641.1. XM_006517578.1.
UniGeneiMm.61526.

Genome annotation databases

EnsembliENSMUST00000179869; ENSMUSP00000136944; ENSMUSG00000093930.
GeneIDi208715.
KEGGimmu:208715.
UCSCiuc007rzv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC023851 mRNA. Translation: AAH23851.1 .
BC029693 mRNA. Translation: AAH29693.1 .
BC034317 mRNA. Translation: AAH34317.1 .
AK031297 mRNA. Translation: BAC27338.1 .
AK044835 mRNA. Translation: BAC32112.1 .
AK045094 mRNA. Translation: BAC32218.1 .
AK135551 mRNA. Translation: BAE22579.1 .
CCDSi CCDS56901.1.
RefSeqi NP_001278368.1. NM_001291439.1.
NP_666054.2. NM_145942.5.
XP_006517641.1. XM_006517578.1.
UniGenei Mm.61526.

3D structure databases

ProteinModelPortali Q8JZK9.
SMRi Q8JZK9. Positions 16-470.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8JZK9. 2 interactions.
MINTi MINT-1869354.
STRINGi 10090.ENSMUSP00000097858.

PTM databases

PhosphoSitei Q8JZK9.

2D gel databases

REPRODUCTION-2DPAGE Q8JZK9.

Proteomic databases

MaxQBi Q8JZK9.
PaxDbi Q8JZK9.
PRIDEi Q8JZK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000179869 ; ENSMUSP00000136944 ; ENSMUSG00000093930 .
GeneIDi 208715.
KEGGi mmu:208715.
UCSCi uc007rzv.1. mouse.

Organism-specific databases

CTDi 3157.
MGIi MGI:107592. Hmgcs1.

Phylogenomic databases

eggNOGi COG3425.
GeneTreei ENSGT00390000006096.
HOGENOMi HOG000012351.
HOVERGENi HBG051912.
InParanoidi Q8JZK9.
KOi K01641.
OMAi RDFTLND.
OrthoDBi EOG741Z1W.
PhylomeDBi Q8JZK9.
TreeFami TF105361.

Enzyme and pathway databases

UniPathwayi UPA00058 ; UER00102 .
Reactomei REACT_198602. PPARA activates gene expression.
REACT_198969. Activation of gene expression by SREBF (SREBP).
REACT_208531. Cholesterol biosynthesis.

Miscellaneous databases

NextBioi 372391.
PROi Q8JZK9.
SOURCEi Search...

Gene expression databases

Bgeei Q8JZK9.
CleanExi MM_HMGCS1.
Genevestigatori Q8JZK9.

Family and domain databases

Gene3Di 3.40.47.10. 1 hit.
InterProi IPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 3 hits.
TIGRFAMsi TIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEi PS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Muellerian duct and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N and FVB/N-3.
    Tissue: Eye and Mammary tumor.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 47-75; 90-100; 220-231; 278-289; 292-313; 322-330; 370-409; 416-428 AND 469-498, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHMCS1_MOUSE
AccessioniPrimary (citable) accession number: Q8JZK9
Secondary accession number(s): Q3UXI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3