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Q8JU57

- VP4_AQRVC

UniProt

Q8JU57 - VP4_AQRVC

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Protein

Outer capsid protein VP4

Gene

S6

Organism
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Interacts with VP7 to form the outer icosahedral capsid with an incomplete T=13 symmetry, about 80 nm in diameter, and consisting of 200 VP4-VP7 trimers. Myristoylated N-terminal peptide may be released in the endosome and involved in permeabilization and delivery of transcriptionally active viral particles into the host cell cytoplasm (Potential).Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei42 – 432CleavageBy similarity

GO - Molecular functioni

  1. host cell surface binding Source: InterPro

GO - Biological processi

  1. pathogenesis Source: InterPro
  2. permeabilization of host organelle membrane involved in viral entry into host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Viral penetration into host cytoplasm, Viral penetration via permeabilization of host membrane, Virus entry into host cell

Protein family/group databases

MEROPSiN07.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer capsid protein VP4
Gene namesi
Name:S6
OrganismiAquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C)
Taxonomic identifieri185783 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeAquareovirus
ProteomesiUP000006713: Genome

Subcellular locationi

Virion Curated

GO - Cellular componenti

  1. T=13 icosahedral viral capsid Source: UniProtKB-KW
  2. viral outer capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Outer capsid protein, T=13 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedSequence Analysis
Chaini2 – 648647Outer capsid protein VP4PRO_0000404187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine; by hostBy similarity
Glycosylationi12 – 121N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi311 – 3111N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi390 – 3901N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi453 – 4531N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi492 – 4921N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Cleaved during the endosomal proteolytic disassembly of the outer capsid.By similarity
N-terminally myristoylated. This acylation is essential for the membrane fusion activity (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate

Interactioni

Subunit structurei

Interacts with VP6 and VP7.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8JU57.
SMRiQ8JU57. Positions 10-42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi112 – 1154Poly-Thr

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.2040.10. 2 hits.
2.60.120.420. 1 hit.
InterProiIPR009113. Mu1/VP4.
IPR015962. Mu1_membr_pen_a-bundle_sub2.
IPR015960. Mu1_membr_pen_b-sand_sub.
[Graphical view]
PfamiPF05993. Reovirus_M2. 1 hit.
[Graphical view]
SUPFAMiSSF69908. SSF69908. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JU57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNVQTSVNT YNITGDGNSF TPTSDMTSTA APAIDLKPGV LNPTGKLWRP
60 70 80 90 100
VGTSVATIDS LAIVSDRFGQ YSFVNEGMRE TFSKALFDIN MWQPLFQATK
110 120 130 140 150
TGCGPIVLSS FTTTTSGYVG ATAGDALDNP VTNGVFISTV QVMNLQRTIA
160 170 180 190 200
ARMRDVALWQ QHLDTAMTML TPDISAGSAS CNWKSLLAFA KDILPLDNLC
210 220 230 240 250
LTYPNEFYNV AIHRYPALKP GNPDTKLPDA QAHPLGEVAG AFNAATSEVG
260 270 280 290 300
SLVGSSSTLS QAISTMAGKD LDLIEADTPL PVSVFTPSLA PRSYRPAFIK
310 320 330 340 350
PEDAKWIAEF NNSSLIRKTL TYSGATYAVQ LGPGPTRVID MNAMIDSVLT
360 370 380 390 400
LDVSGTILPY DTNPDLSTSV PAFVLIQTSV PIQQVTTAAN ITAITVVSAA
410 420 430 440 450
GASAINLAIN VRGQPRFNML HLQATFERET ITGIPYIYGL GTFLIPSPTS
460 470 480 490 500
SSNFSNPTLM DGLLTVTPVL LRETTYKGEV VDAIVPATVM ANQTSEEVAS
510 520 530 540 550
ALANDAIVLV SNHLNKLANV VGDAIPVASK TDDSATSAIV SRLAVQHKLS
560 570 580 590 600
QVGQTSPTPP DYPLLWRRAK RAASMFVSNP SLALQVGIPV LTQSGMLSAL
610 620 630 640
TSGVGTALRT GSLGKGVTDA SEKLRARQSL TVAKQAFFDQ IGSLWPGK
Length:648
Mass (Da):68,555
Last modified:October 1, 2002 - v1
Checksum:iA6FA4DA4164826D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403403 Genomic RNA. Translation: AAM92749.1.
RefSeqiNP_938065.1. NC_005171.1.

Genome annotation databases

GeneIDi2648334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403403 Genomic RNA. Translation: AAM92749.1 .
RefSeqi NP_938065.1. NC_005171.1.

3D structure databases

ProteinModelPortali Q8JU57.
SMRi Q8JU57. Positions 10-42.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi N07.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2648334.

Family and domain databases

Gene3Di 1.10.2040.10. 2 hits.
2.60.120.420. 1 hit.
InterProi IPR009113. Mu1/VP4.
IPR015962. Mu1_membr_pen_a-bundle_sub2.
IPR015960. Mu1_membr_pen_b-sand_sub.
[Graphical view ]
Pfami PF05993. Reovirus_M2. 1 hit.
[Graphical view ]
SUPFAMi SSF69908. SSF69908. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Common evolutionary origin of aquareoviruses and orthoreoviruses revealed by genome characterization of Golden shiner reovirus, Grass carp reovirus, Striped bass reovirus and golden ide reovirus (genus Aquareovirus, family Reoviridae)."
    Attoui H., Fang Q., Mohd Jaafar F., Cantaloube J.F., Biagini P., de Micco P., de Lamballerie X.
    J. Gen. Virol. 83:1941-1951(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP4_AQRVC
AccessioniPrimary (citable) accession number: Q8JU57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3