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Q8JU57 (VP4_AQRVC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Outer capsid protein VP4
Gene names
Name:S6
OrganismAquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) [Reference proteome]
Taxonomic identifier185783 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSpinareovirinaeAquareovirus

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interacts with VP7 to form the outer icosahedral capsid with an incomplete T=13 symmetry, about 80 nm in diameter, and consisting of 200 VP4-VP7 trimers. Myristoylated N-terminal peptide may be released in the endosome and involved in permeabilization and delivery of transcriptionally active viral particles into the host cell cytoplasm Potential.

Subunit structure

Interacts with VP6 and VP7 By similarity.

Subcellular location

Virion Potential.

Post-translational modification

Cleaved during the endosomal proteolytic disassembly of the outer capsid By similarity.

N-terminally myristoylated. This acylation is essential for the membrane fusion activity By similarity.

Sequence similarities

Belongs to the aquareoviridae outer capsid VP4 protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Potential
Chain2 – 648647Outer capsid protein VP4
PRO_0000404187

Regions

Compositional bias112 – 1154Poly-Thr

Sites

Site42 – 432Cleavage By similarity

Amino acid modifications

Lipidation21N-myristoyl glycine; by host By similarity
Glycosylation121N-linked (GlcNAc...); by host Potential
Glycosylation3111N-linked (GlcNAc...); by host Potential
Glycosylation3121N-linked (GlcNAc...); by host Potential
Glycosylation3901N-linked (GlcNAc...); by host Potential
Glycosylation4531N-linked (GlcNAc...); by host Potential
Glycosylation4921N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
Q8JU57 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: A6FA4DA4164826D2

FASTA64868,555
        10         20         30         40         50         60 
MGNVQTSVNT YNITGDGNSF TPTSDMTSTA APAIDLKPGV LNPTGKLWRP VGTSVATIDS 

        70         80         90        100        110        120 
LAIVSDRFGQ YSFVNEGMRE TFSKALFDIN MWQPLFQATK TGCGPIVLSS FTTTTSGYVG 

       130        140        150        160        170        180 
ATAGDALDNP VTNGVFISTV QVMNLQRTIA ARMRDVALWQ QHLDTAMTML TPDISAGSAS 

       190        200        210        220        230        240 
CNWKSLLAFA KDILPLDNLC LTYPNEFYNV AIHRYPALKP GNPDTKLPDA QAHPLGEVAG 

       250        260        270        280        290        300 
AFNAATSEVG SLVGSSSTLS QAISTMAGKD LDLIEADTPL PVSVFTPSLA PRSYRPAFIK 

       310        320        330        340        350        360 
PEDAKWIAEF NNSSLIRKTL TYSGATYAVQ LGPGPTRVID MNAMIDSVLT LDVSGTILPY 

       370        380        390        400        410        420 
DTNPDLSTSV PAFVLIQTSV PIQQVTTAAN ITAITVVSAA GASAINLAIN VRGQPRFNML 

       430        440        450        460        470        480 
HLQATFERET ITGIPYIYGL GTFLIPSPTS SSNFSNPTLM DGLLTVTPVL LRETTYKGEV 

       490        500        510        520        530        540 
VDAIVPATVM ANQTSEEVAS ALANDAIVLV SNHLNKLANV VGDAIPVASK TDDSATSAIV 

       550        560        570        580        590        600 
SRLAVQHKLS QVGQTSPTPP DYPLLWRRAK RAASMFVSNP SLALQVGIPV LTQSGMLSAL 

       610        620        630        640 
TSGVGTALRT GSLGKGVTDA SEKLRARQSL TVAKQAFFDQ IGSLWPGK 

« Hide

References

[1]"Common evolutionary origin of aquareoviruses and orthoreoviruses revealed by genome characterization of Golden shiner reovirus, Grass carp reovirus, Striped bass reovirus and golden ide reovirus (genus Aquareovirus, family Reoviridae)."
Attoui H., Fang Q., Mohd Jaafar F., Cantaloube J.F., Biagini P., de Micco P., de Lamballerie X.
J. Gen. Virol. 83:1941-1951(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF403403 Genomic RNA. Translation: AAM92749.1.
RefSeqNP_938065.1. NC_005171.1.

3D structure databases

ProteinModelPortalQ8JU57.
SMRQ8JU57. Positions 10-42.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2648334.

Family and domain databases

Gene3D1.10.2040.10. 2 hits.
2.60.120.420. 1 hit.
InterProIPR009113. Mu1/VP4.
IPR015962. Mu1_membr_pen_a-bundle_sub2.
IPR015960. Mu1_membr_pen_b-sand_sub.
[Graphical view]
PfamPF05993. Reovirus_M2. 1 hit.
[Graphical view]
SUPFAMSSF69908. SSF69908. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVP4_AQRVC
AccessionPrimary (citable) accession number: Q8JU57
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families