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Q8JU57

- VP4_AQRVC

UniProt

Q8JU57 - VP4_AQRVC

Protein

Outer capsid protein VP4

Gene

S6

Organism
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Interacts with VP7 to form the outer icosahedral capsid with an incomplete T=13 symmetry, about 80 nm in diameter, and consisting of 200 VP4-VP7 trimers. Myristoylated N-terminal peptide may be released in the endosome and involved in permeabilization and delivery of transcriptionally active viral particles into the host cell cytoplasm Potential.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei42 – 432CleavageBy similarity

    GO - Molecular functioni

    1. host cell surface binding Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: InterPro
    2. permeabilization of host organelle membrane involved in viral entry into host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Viral penetration into host cytoplasm, Viral penetration via permeabilization of host membrane, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer capsid protein VP4
    Gene namesi
    Name:S6
    OrganismiAquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C)
    Taxonomic identifieri185783 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeAquareovirus
    ProteomesiUP000006713: Genome

    Subcellular locationi

    Virion Curated

    GO - Cellular componenti

    1. T=13 icosahedral viral capsid Source: UniProtKB-KW
    2. viral outer capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Outer capsid protein, T=13 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedSequence Analysis
    Chaini2 – 648647Outer capsid protein VP4PRO_0000404187Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine; by hostBy similarity
    Glycosylationi12 – 121N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi453 – 4531N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi492 – 4921N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Cleaved during the endosomal proteolytic disassembly of the outer capsid.By similarity
    N-terminally myristoylated. This acylation is essential for the membrane fusion activity By similarity.By similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Myristate

    Interactioni

    Subunit structurei

    Interacts with VP6 and VP7.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JU57.
    SMRiQ8JU57. Positions 10-42.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi112 – 1154Poly-Thr

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.2040.10. 2 hits.
    2.60.120.420. 1 hit.
    InterProiIPR009113. Mu1/VP4.
    IPR015962. Mu1_membr_pen_a-bundle_sub2.
    IPR015960. Mu1_membr_pen_b-sand_sub.
    [Graphical view]
    PfamiPF05993. Reovirus_M2. 1 hit.
    [Graphical view]
    SUPFAMiSSF69908. SSF69908. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8JU57-1 [UniParc]FASTAAdd to Basket

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    MGNVQTSVNT YNITGDGNSF TPTSDMTSTA APAIDLKPGV LNPTGKLWRP    50
    VGTSVATIDS LAIVSDRFGQ YSFVNEGMRE TFSKALFDIN MWQPLFQATK 100
    TGCGPIVLSS FTTTTSGYVG ATAGDALDNP VTNGVFISTV QVMNLQRTIA 150
    ARMRDVALWQ QHLDTAMTML TPDISAGSAS CNWKSLLAFA KDILPLDNLC 200
    LTYPNEFYNV AIHRYPALKP GNPDTKLPDA QAHPLGEVAG AFNAATSEVG 250
    SLVGSSSTLS QAISTMAGKD LDLIEADTPL PVSVFTPSLA PRSYRPAFIK 300
    PEDAKWIAEF NNSSLIRKTL TYSGATYAVQ LGPGPTRVID MNAMIDSVLT 350
    LDVSGTILPY DTNPDLSTSV PAFVLIQTSV PIQQVTTAAN ITAITVVSAA 400
    GASAINLAIN VRGQPRFNML HLQATFERET ITGIPYIYGL GTFLIPSPTS 450
    SSNFSNPTLM DGLLTVTPVL LRETTYKGEV VDAIVPATVM ANQTSEEVAS 500
    ALANDAIVLV SNHLNKLANV VGDAIPVASK TDDSATSAIV SRLAVQHKLS 550
    QVGQTSPTPP DYPLLWRRAK RAASMFVSNP SLALQVGIPV LTQSGMLSAL 600
    TSGVGTALRT GSLGKGVTDA SEKLRARQSL TVAKQAFFDQ IGSLWPGK 648
    Length:648
    Mass (Da):68,555
    Last modified:October 1, 2002 - v1
    Checksum:iA6FA4DA4164826D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF403403 Genomic RNA. Translation: AAM92749.1.
    RefSeqiNP_938065.1. NC_005171.1.

    Genome annotation databases

    GeneIDi2648334.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF403403 Genomic RNA. Translation: AAM92749.1 .
    RefSeqi NP_938065.1. NC_005171.1.

    3D structure databases

    ProteinModelPortali Q8JU57.
    SMRi Q8JU57. Positions 10-42.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2648334.

    Family and domain databases

    Gene3Di 1.10.2040.10. 2 hits.
    2.60.120.420. 1 hit.
    InterProi IPR009113. Mu1/VP4.
    IPR015962. Mu1_membr_pen_a-bundle_sub2.
    IPR015960. Mu1_membr_pen_b-sand_sub.
    [Graphical view ]
    Pfami PF05993. Reovirus_M2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69908. SSF69908. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Common evolutionary origin of aquareoviruses and orthoreoviruses revealed by genome characterization of Golden shiner reovirus, Grass carp reovirus, Striped bass reovirus and golden ide reovirus (genus Aquareovirus, family Reoviridae)."
      Attoui H., Fang Q., Mohd Jaafar F., Cantaloube J.F., Biagini P., de Micco P., de Lamballerie X.
      J. Gen. Virol. 83:1941-1951(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP4_AQRVC
    AccessioniPrimary (citable) accession number: Q8JU57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3