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Q8JTI5 (VP6_ROTW3) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.

Subunit structure

Homotrimer. Interacts with VP2 By similarity.

Subcellular location

Virion. Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

Post-translational modification

The N-terminus is blocked By similarity.

Miscellaneous

The zinc ion is not essential for either trimerization or transcription activity of the DLP. Zinc-depleted VP6 has an increased sensitivity to proteases By similarity.

Sequence similarities

Belongs to the rotavirus VP6 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Intermediate capsid protein VP6
PRO_0000368174

Sites

Metal binding1531Zinc; shared with all trimeric partners By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8JTI5 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 0241843253B49F25

FASTA39744,871
        10         20         30         40         50         60 
MDVLYSLSKT LKDARDKIVE GTLYSNVSDL IQQFNQMIIT MNGNEFQTGG IGNLPIRNWN 

        70         80         90        100        110        120 
FDFGLLGTTL LNLDANYVET ARNTIDYFVD FVDNVCMDEM VRESQRNGIA PQSDSLRKLS 

       130        140        150        160        170        180 
GIKFKRINFD NSSEYIENWN LQNRRQRTGF TFHKPNIFPY SASFTLNRSQ PAHDNLMGTM 

       190        200        210        220        230        240 
WLNAGSEIQV AGFDYSCAIN APANTQQFEH VVQLRRVLTT ATITLLPDAE RFSFPRVINS 

       250        260        270        280        290        300 
ADGATTWYFN PVILRPNNVE VEFLLNGQII NTYQARFGTI IARNFDTIRL SFQLMRPPNM 

       310        320        330        340        350        360 
TPAVAALFPN AQPFEHHATV GLTLRIESAV CESVLADASE TMLANVTSVR QEYAIPVGPV 

       370        380        390 
FPPGMNWTDL ITNYSPSRED NLQRVFTVAS IRSMLVK 

« Hide

References

[1]"Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3."
Ciarlet M., Hyser J.M., Estes M.K.
Virus Genes 24:107-118(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Ciarlet M., Hyser J.M., Estes M.K.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF411322 mRNA. Translation: AAM73767.2.

3D structure databases

ProteinModelPortalQ8JTI5.
SMRQ8JTI5. Positions 1-397.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008980. Capsid_hemagglutn.
IPR001385. Rotavirus_A/C_VP6.
IPR008935. Virus_capsid_a-hlx_vir.
[Graphical view]
PfamPF00980. Rota_Capsid_VP6. 1 hit.
[Graphical view]
ProDomPD001812. Rota_Capsid_VP6. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF48345. SSF48345. 2 hits.
SSF49818. SSF49818. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVP6_ROTW3
AccessionPrimary (citable) accession number: Q8JTI5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: December 11, 2013
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families