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Q8JSZ3

- GP_CCHFI

UniProt

Q8JSZ3 - GP_CCHFI

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Protein

Envelope glycoprotein

Gene

GP

Organism
Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei516 – 5172Cleavage; by hostBy similarity
Sitei1037 – 10382Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Clathrin-mediated endocytosis of virus by host, Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiCrimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV)
Taxonomic identifieri652961 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeNairovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Hyalomma [TaxID: 34625]
Ovis aries (Sheep) [TaxID: 9940]
Rhipicephalus microplus (Cattle tick) (Boophilus microplus) [TaxID: 6941]
ProteomesiUP000008767: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 16841666Envelope glycoproteinBy similarityPRO_0000406564Add
BLAST
Chaini19 – 515497Mucin-like variable regionBy similarityPRO_0000406565Add
BLAST
Chaini516 – 1037522Glycoprotein G2Sequence AnalysisPRO_0000406566Add
BLAST
Chaini1038 – 1684647Glycoprotein G1Sequence AnalysisPRO_0000406567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi30 – 301N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi196 – 1961N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi376 – 3761N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi426 – 4261N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi557 – 5571N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi755 – 7551N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi1054 – 10541N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi1345 – 13451N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi1563 – 15631N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei699 – 71921HelicalSequence AnalysisAdd
BLAST
Transmembranei822 – 84221HelicalSequence AnalysisAdd
BLAST
Transmembranei860 – 88021HelicalSequence AnalysisAdd
BLAST
Transmembranei973 – 99321HelicalSequence AnalysisAdd
BLAST
Transmembranei1595 – 161521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 242216Thr-richAdd
BLAST
Compositional biasi1165 – 120844Cys-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR012487. Nairovirus_M.
[Graphical view]
PfamiPF07948. Nairovirus_M. 1 hit.
[Graphical view]
PIRSFiPIRSF003962. M_poly_NairoV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JSZ3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MHISLMYAIL CLQLCGLGET HGSHNETRHN KTDTMTTPGD NPSSEPPVST
60 70 80 90 100
ALSITLDPST VTPTTPASGL EGSGEVYTSP PITTGSLPLS ETTPELPVTT
110 120 130 140 150
GTDTLSAGDV DPSTQTAGGT SAPTVRTSLP NSPSTPSTPQ DTHHPVRNLL
160 170 180 190 200
SVTSPGPDET STPSGTGKES SATSSPHPVS NRPPTPPATA QGPTENDSHN
210 220 230 240 250
ATEHPESLTQ SATPGLMTSP TQIVHPQSAT PITVQDTHPS PTNRSKRNLK
260 270 280 290 300
MEIILTLSQG LKKYYGKILR LLQLTLEEDT EGLLEWCKRN LGLDCDDTFF
310 320 330 340 350
QKRIEEFFIT GEGHFNEVLQ FRTPGTLSTT ESTPAGLPTA EPFKSYFAKG
360 370 380 390 400
FLSIDSGYYS AKCYSGTSNS GLQLINITRH STRIVDTPGP KITNLKTINC
410 420 430 440 450
INLKASIFKE HREVEINVLL PQVAVNLSNC HVVIKSHVCD YSLDIDGAVR
460 470 480 490 500
LPHIYHEGVF IPGTYKIVID KKNKLNDRCT LFTDCVIKGR EVRKGQSVLR
510 520 530 540 550
QYKTEIRIGK ASTGSRRLLS EEPSDDCISR TQLLRTETAE IHGDNYGGPG
560 570 580 590 600
DKITICNGST IVDQRLGSEL GCYTINRVRS FKLCENSATG KNCEIDSVPV
610 620 630 640 650
KCRQGYCLRI TQEGRGHVKL SRGSEVVLDA CDTSCEIMIP KGTGDILVDC
660 670 680 690 700
SGGQQHFLKD NLIDLGCPKI PLLGKMAIYI CRMSNHPKTT MAFLFWFSFG
710 720 730 740 750
YVITCILCKA IFYLLIIVGT LGKRLKQYRE LKPQTCTICE TTPVNAIDAE
760 770 780 790 800
MHDLNCSYNI CPYCASRLTS DGLARHVIQC PKRKEKVEET ELYLNLERIP
810 820 830 840 850
WVVRKLLQVS ESTGVALKRS SWLIVLLVLF TVSLSPVQSA PIGQGKTIEA
860 870 880 890 900
YRAREGYTSI CLFVLGSILF IVSCLMKGLV DSVGNSFFPG LSICKTCSIS
910 920 930 940 950
SINGFEIESH KCYCSLFCCP YCRHCSTDKE IHKLHLSICK KRKKGSNVML
960 970 980 990 1000
AVCKLMCFRA TMEVSNRALF IRSIINTTFV LCILILAVCV VSTSAVEMEN
1010 1020 1030 1040 1050
LPAGTWEREE DLTNFCHQEC QVTETECLCP YEALVLRKPL FLDSTAKGMK
1060 1070 1080 1090 1100
NLLNSTSLET SLSIEAPWGA INVQSTYKPT VSTANIALSW SSVEHRGNKI
1110 1120 1130 1140 1150
LVSGRSESIM KLEERTGISW DLGVEDASES KLLTVSVMDL SQMYSPVFEY
1160 1170 1180 1190 1200
LSGDRQVGEW PKATCTGDCP ERCGCTSSTC LHKEWPHSRN WRCNPTWCWG
1210 1220 1230 1240 1250
VGTGCTCCGL DVKDLFTDYM FVKWKVEYIK TEAIVCVELT SQERQCSLIE
1260 1270 1280 1290 1300
AGTRFNLGPV TITLSEPRNI QQKLPPEIIT LHPRIEEGFF DLMHVQKVLS
1310 1320 1330 1340 1350
ASTVCKLQSC THGVPGDLQV YHIGNLLKGD KVNGHLIHKI EPHFNTSWMS
1360 1370 1380 1390 1400
WDGCDLDYYC NMGDWPSCTY TGVTQHNHAS FVNLLNIETD YTKNFHFHSK
1410 1420 1430 1440 1450
RVTAHGDTPQ LDLKARPTYG AGEITVLVEV ADMELHTKKI EISGLKFASL
1460 1470 1480 1490 1500
ACTGCYACSS GISCKVRIHV DEPDELTVHV KSDDPDVVAA SSSLMARKLE
1510 1520 1530 1540 1550
FGTDSTFKAF SAMPKTSLCF YIVEREHCKS CSEEDTKKCV NTKLEQPQSI
1560 1570 1580 1590 1600
LIEHKGTIIG KQNSTCTAKA SCWLESVKSF FYGLKNMLSG IFGNVFMGIF
1610 1620 1630 1640 1650
LFLAPFILLI LFFMFGWRIL FCFKCCRRTR GLFKYRHLKD DEETGYRRII
1660 1670 1680
EKLNNKKGKN KLLDGERLAD RRIAELFSTK THIG
Length:1,684
Mass (Da):186,589
Last modified:October 1, 2002 - v1
Checksum:i7CEAB4B46F74F578
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF467768 Genomic RNA. Translation: AAM48106.1.
RefSeqiNP_950235.1. NC_005300.2.

Genome annotation databases

GeneIDi2943074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF467768 Genomic RNA. Translation: AAM48106.1 .
RefSeqi NP_950235.1. NC_005300.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2943074.

Family and domain databases

InterProi IPR012487. Nairovirus_M.
[Graphical view ]
Pfami PF07948. Nairovirus_M. 1 hit.
[Graphical view ]
PIRSFi PIRSF003962. M_poly_NairoV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of the glycoproteins of Crimean-Congo hemorrhagic fever virus."
    Sanchez A.J., Vincent M.J., Nichol S.T.
    J. Virol. 76:7263-7275(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Sanchez A.J., Vincent M.J., Deyde V.M., Khristova M.L., Nichol S.T.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Crimean-Congo hemorrhagic fever virus entry and replication is clathrin-, pH- and cholesterol-dependent."
    Simon M., Johansson C., Mirazimi A.
    J. Gen. Virol. 90:210-215(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGP_CCHFI
AccessioniPrimary (citable) accession number: Q8JSZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3