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Q8JSZ3

- GP_CCHFI

UniProt

Q8JSZ3 - GP_CCHFI

Protein

Envelope glycoprotein

Gene

GP

Organism
Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei516 – 5172Cleavage; by hostBy similarity
    Sitei1037 – 10382Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
    2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Clathrin-mediated endocytosis of virus by host, Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:GP
    OrganismiCrimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV)
    Taxonomic identifieri652961 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeNairovirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]
    Capra hircus (Goat) [TaxID: 9925]
    Homo sapiens (Human) [TaxID: 9606]
    Hyalomma [TaxID: 34625]
    Ovis aries (Sheep) [TaxID: 9940]
    Rhipicephalus microplus (Cattle tick) (Boophilus microplus) [TaxID: 6941]
    ProteomesiUP000008767: Genome

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 16841666Envelope glycoproteinBy similarityPRO_0000406564Add
    BLAST
    Chaini19 – 515497Mucin-like variable regionBy similarityPRO_0000406565Add
    BLAST
    Chaini516 – 1037522Glycoprotein G2Sequence AnalysisPRO_0000406566Add
    BLAST
    Chaini1038 – 1684647Glycoprotein G1Sequence AnalysisPRO_0000406567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi30 – 301N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi196 – 1961N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi243 – 2431N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi376 – 3761N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi426 – 4261N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi557 – 5571N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi755 – 7551N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1054 – 10541N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1345 – 13451N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1563 – 15631N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei699 – 71921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei822 – 84221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei860 – 88021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei973 – 99321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1595 – 161521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 242216Thr-richAdd
    BLAST
    Compositional biasi1165 – 120844Cys-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR012487. Nairovirus_M.
    [Graphical view]
    PfamiPF07948. Nairovirus_M. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003962. M_poly_NairoV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8JSZ3-1 [UniParc]FASTAAdd to Basket

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    MHISLMYAIL CLQLCGLGET HGSHNETRHN KTDTMTTPGD NPSSEPPVST     50
    ALSITLDPST VTPTTPASGL EGSGEVYTSP PITTGSLPLS ETTPELPVTT 100
    GTDTLSAGDV DPSTQTAGGT SAPTVRTSLP NSPSTPSTPQ DTHHPVRNLL 150
    SVTSPGPDET STPSGTGKES SATSSPHPVS NRPPTPPATA QGPTENDSHN 200
    ATEHPESLTQ SATPGLMTSP TQIVHPQSAT PITVQDTHPS PTNRSKRNLK 250
    MEIILTLSQG LKKYYGKILR LLQLTLEEDT EGLLEWCKRN LGLDCDDTFF 300
    QKRIEEFFIT GEGHFNEVLQ FRTPGTLSTT ESTPAGLPTA EPFKSYFAKG 350
    FLSIDSGYYS AKCYSGTSNS GLQLINITRH STRIVDTPGP KITNLKTINC 400
    INLKASIFKE HREVEINVLL PQVAVNLSNC HVVIKSHVCD YSLDIDGAVR 450
    LPHIYHEGVF IPGTYKIVID KKNKLNDRCT LFTDCVIKGR EVRKGQSVLR 500
    QYKTEIRIGK ASTGSRRLLS EEPSDDCISR TQLLRTETAE IHGDNYGGPG 550
    DKITICNGST IVDQRLGSEL GCYTINRVRS FKLCENSATG KNCEIDSVPV 600
    KCRQGYCLRI TQEGRGHVKL SRGSEVVLDA CDTSCEIMIP KGTGDILVDC 650
    SGGQQHFLKD NLIDLGCPKI PLLGKMAIYI CRMSNHPKTT MAFLFWFSFG 700
    YVITCILCKA IFYLLIIVGT LGKRLKQYRE LKPQTCTICE TTPVNAIDAE 750
    MHDLNCSYNI CPYCASRLTS DGLARHVIQC PKRKEKVEET ELYLNLERIP 800
    WVVRKLLQVS ESTGVALKRS SWLIVLLVLF TVSLSPVQSA PIGQGKTIEA 850
    YRAREGYTSI CLFVLGSILF IVSCLMKGLV DSVGNSFFPG LSICKTCSIS 900
    SINGFEIESH KCYCSLFCCP YCRHCSTDKE IHKLHLSICK KRKKGSNVML 950
    AVCKLMCFRA TMEVSNRALF IRSIINTTFV LCILILAVCV VSTSAVEMEN 1000
    LPAGTWEREE DLTNFCHQEC QVTETECLCP YEALVLRKPL FLDSTAKGMK 1050
    NLLNSTSLET SLSIEAPWGA INVQSTYKPT VSTANIALSW SSVEHRGNKI 1100
    LVSGRSESIM KLEERTGISW DLGVEDASES KLLTVSVMDL SQMYSPVFEY 1150
    LSGDRQVGEW PKATCTGDCP ERCGCTSSTC LHKEWPHSRN WRCNPTWCWG 1200
    VGTGCTCCGL DVKDLFTDYM FVKWKVEYIK TEAIVCVELT SQERQCSLIE 1250
    AGTRFNLGPV TITLSEPRNI QQKLPPEIIT LHPRIEEGFF DLMHVQKVLS 1300
    ASTVCKLQSC THGVPGDLQV YHIGNLLKGD KVNGHLIHKI EPHFNTSWMS 1350
    WDGCDLDYYC NMGDWPSCTY TGVTQHNHAS FVNLLNIETD YTKNFHFHSK 1400
    RVTAHGDTPQ LDLKARPTYG AGEITVLVEV ADMELHTKKI EISGLKFASL 1450
    ACTGCYACSS GISCKVRIHV DEPDELTVHV KSDDPDVVAA SSSLMARKLE 1500
    FGTDSTFKAF SAMPKTSLCF YIVEREHCKS CSEEDTKKCV NTKLEQPQSI 1550
    LIEHKGTIIG KQNSTCTAKA SCWLESVKSF FYGLKNMLSG IFGNVFMGIF 1600
    LFLAPFILLI LFFMFGWRIL FCFKCCRRTR GLFKYRHLKD DEETGYRRII 1650
    EKLNNKKGKN KLLDGERLAD RRIAELFSTK THIG 1684
    Length:1,684
    Mass (Da):186,589
    Last modified:October 1, 2002 - v1
    Checksum:i7CEAB4B46F74F578
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF467768 Genomic RNA. Translation: AAM48106.1.
    RefSeqiNP_950235.1. NC_005300.2.

    Genome annotation databases

    GeneIDi2943074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF467768 Genomic RNA. Translation: AAM48106.1 .
    RefSeqi NP_950235.1. NC_005300.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2943074.

    Family and domain databases

    InterProi IPR012487. Nairovirus_M.
    [Graphical view ]
    Pfami PF07948. Nairovirus_M. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003962. M_poly_NairoV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the glycoproteins of Crimean-Congo hemorrhagic fever virus."
      Sanchez A.J., Vincent M.J., Nichol S.T.
      J. Virol. 76:7263-7275(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Sanchez A.J., Vincent M.J., Deyde V.M., Khristova M.L., Nichol S.T.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Crimean-Congo hemorrhagic fever virus entry and replication is clathrin-, pH- and cholesterol-dependent."
      Simon M., Johansson C., Mirazimi A.
      J. Gen. Virol. 90:210-215(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiGP_CCHFI
    AccessioniPrimary (citable) accession number: Q8JSZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3