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Q8JSZ3

- GP_CCHFI

UniProt

Q8JSZ3 - GP_CCHFI

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Protein
Envelope glycoprotein
Gene
GP
Organism
Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei516 – 5172Cleavage; by host By similarity
Sitei1037 – 10382Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Clathrin-mediated endocytosis of virus by host, Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiCrimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV)
Taxonomic identifieri652961 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeNairovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Hyalomma [TaxID: 34625]
Ovis aries (Sheep) [TaxID: 9940]
Rhipicephalus microplus (Cattle tick) (Boophilus microplus) [TaxID: 6941]
ProteomesiUP000008767: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei699 – 71921Helical; Reviewed prediction
Add
BLAST
Transmembranei822 – 84221Helical; Reviewed prediction
Add
BLAST
Transmembranei860 – 88021Helical; Reviewed prediction
Add
BLAST
Transmembranei973 – 99321Helical; Reviewed prediction
Add
BLAST
Transmembranei1595 – 161521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 16841666Envelope glycoprotein By similarity
PRO_0000406564Add
BLAST
Chaini19 – 515497Mucin-like variable region By similarity
PRO_0000406565Add
BLAST
Chaini516 – 1037522Glycoprotein G2 Reviewed prediction
PRO_0000406566Add
BLAST
Chaini1038 – 1684647Glycoprotein G1 Reviewed prediction
PRO_0000406567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi30 – 301N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi196 – 1961N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi243 – 2431N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi376 – 3761N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi426 – 4261N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi557 – 5571N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi755 – 7551N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1054 – 10541N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1345 – 13451N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1563 – 15631N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 242216Thr-rich
Add
BLAST
Compositional biasi1165 – 120844Cys-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR012487. Nairovirus_M.
[Graphical view]
PfamiPF07948. Nairovirus_M. 1 hit.
[Graphical view]
PIRSFiPIRSF003962. M_poly_NairoV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JSZ3-1 [UniParc]FASTAAdd to Basket

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MHISLMYAIL CLQLCGLGET HGSHNETRHN KTDTMTTPGD NPSSEPPVST     50
ALSITLDPST VTPTTPASGL EGSGEVYTSP PITTGSLPLS ETTPELPVTT 100
GTDTLSAGDV DPSTQTAGGT SAPTVRTSLP NSPSTPSTPQ DTHHPVRNLL 150
SVTSPGPDET STPSGTGKES SATSSPHPVS NRPPTPPATA QGPTENDSHN 200
ATEHPESLTQ SATPGLMTSP TQIVHPQSAT PITVQDTHPS PTNRSKRNLK 250
MEIILTLSQG LKKYYGKILR LLQLTLEEDT EGLLEWCKRN LGLDCDDTFF 300
QKRIEEFFIT GEGHFNEVLQ FRTPGTLSTT ESTPAGLPTA EPFKSYFAKG 350
FLSIDSGYYS AKCYSGTSNS GLQLINITRH STRIVDTPGP KITNLKTINC 400
INLKASIFKE HREVEINVLL PQVAVNLSNC HVVIKSHVCD YSLDIDGAVR 450
LPHIYHEGVF IPGTYKIVID KKNKLNDRCT LFTDCVIKGR EVRKGQSVLR 500
QYKTEIRIGK ASTGSRRLLS EEPSDDCISR TQLLRTETAE IHGDNYGGPG 550
DKITICNGST IVDQRLGSEL GCYTINRVRS FKLCENSATG KNCEIDSVPV 600
KCRQGYCLRI TQEGRGHVKL SRGSEVVLDA CDTSCEIMIP KGTGDILVDC 650
SGGQQHFLKD NLIDLGCPKI PLLGKMAIYI CRMSNHPKTT MAFLFWFSFG 700
YVITCILCKA IFYLLIIVGT LGKRLKQYRE LKPQTCTICE TTPVNAIDAE 750
MHDLNCSYNI CPYCASRLTS DGLARHVIQC PKRKEKVEET ELYLNLERIP 800
WVVRKLLQVS ESTGVALKRS SWLIVLLVLF TVSLSPVQSA PIGQGKTIEA 850
YRAREGYTSI CLFVLGSILF IVSCLMKGLV DSVGNSFFPG LSICKTCSIS 900
SINGFEIESH KCYCSLFCCP YCRHCSTDKE IHKLHLSICK KRKKGSNVML 950
AVCKLMCFRA TMEVSNRALF IRSIINTTFV LCILILAVCV VSTSAVEMEN 1000
LPAGTWEREE DLTNFCHQEC QVTETECLCP YEALVLRKPL FLDSTAKGMK 1050
NLLNSTSLET SLSIEAPWGA INVQSTYKPT VSTANIALSW SSVEHRGNKI 1100
LVSGRSESIM KLEERTGISW DLGVEDASES KLLTVSVMDL SQMYSPVFEY 1150
LSGDRQVGEW PKATCTGDCP ERCGCTSSTC LHKEWPHSRN WRCNPTWCWG 1200
VGTGCTCCGL DVKDLFTDYM FVKWKVEYIK TEAIVCVELT SQERQCSLIE 1250
AGTRFNLGPV TITLSEPRNI QQKLPPEIIT LHPRIEEGFF DLMHVQKVLS 1300
ASTVCKLQSC THGVPGDLQV YHIGNLLKGD KVNGHLIHKI EPHFNTSWMS 1350
WDGCDLDYYC NMGDWPSCTY TGVTQHNHAS FVNLLNIETD YTKNFHFHSK 1400
RVTAHGDTPQ LDLKARPTYG AGEITVLVEV ADMELHTKKI EISGLKFASL 1450
ACTGCYACSS GISCKVRIHV DEPDELTVHV KSDDPDVVAA SSSLMARKLE 1500
FGTDSTFKAF SAMPKTSLCF YIVEREHCKS CSEEDTKKCV NTKLEQPQSI 1550
LIEHKGTIIG KQNSTCTAKA SCWLESVKSF FYGLKNMLSG IFGNVFMGIF 1600
LFLAPFILLI LFFMFGWRIL FCFKCCRRTR GLFKYRHLKD DEETGYRRII 1650
EKLNNKKGKN KLLDGERLAD RRIAELFSTK THIG 1684
Length:1,684
Mass (Da):186,589
Last modified:October 1, 2002 - v1
Checksum:i7CEAB4B46F74F578
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF467768 Genomic RNA. Translation: AAM48106.1.
RefSeqiNP_950235.1. NC_005300.2.

Genome annotation databases

GeneIDi2943074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF467768 Genomic RNA. Translation: AAM48106.1 .
RefSeqi NP_950235.1. NC_005300.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2943074.

Family and domain databases

InterProi IPR012487. Nairovirus_M.
[Graphical view ]
Pfami PF07948. Nairovirus_M. 1 hit.
[Graphical view ]
PIRSFi PIRSF003962. M_poly_NairoV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of the glycoproteins of Crimean-Congo hemorrhagic fever virus."
    Sanchez A.J., Vincent M.J., Nichol S.T.
    J. Virol. 76:7263-7275(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Sanchez A.J., Vincent M.J., Deyde V.M., Khristova M.L., Nichol S.T.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Crimean-Congo hemorrhagic fever virus entry and replication is clathrin-, pH- and cholesterol-dependent."
    Simon M., Johansson C., Mirazimi A.
    J. Gen. Virol. 90:210-215(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGP_CCHFI
AccessioniPrimary (citable) accession number: Q8JSZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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