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Q8JSZ3 (GP_CCHFI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein
Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 3 chains:

  1. Mucin-like variable region
  2. Glycoprotein G2
  3. Glycoprotein G1
Gene names
Name:GP
OrganismCrimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV) [Reference proteome]
Taxonomic identifier652961 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Bunyaviridae › Nairovirus ›
Virus hostBoophilus microplus (Cattle tick) [TaxID: 6941]
Bos taurus (Bovine) [TaxID: 9913]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Hyalomma [TaxID: 34625]
Ovis aries (Sheep) [TaxID: 9940]

Protein attributes

Sequence length1684 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion By similarity. Ref.3

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Multi-pass membrane protein Potential. Host Golgi apparatus membrane; Multi-pass membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Sequence similarities

Belongs to the nairovirus envelope glycoprotein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 16841666Envelope glycoprotein By similarity
PRO_0000406564
Chain19 – 515497Mucin-like variable region By similarity
PRO_0000406565
Chain516 – 1037522Glycoprotein G2 Potential
PRO_0000406566
Chain1038 – 1684647Glycoprotein G1 Potential
PRO_0000406567

Regions

Transmembrane699 – 71921Helical; Potential
Transmembrane822 – 84221Helical; Potential
Transmembrane860 – 88021Helical; Potential
Transmembrane973 – 99321Helical; Potential
Transmembrane1595 – 161521Helical; Potential
Compositional bias27 – 242216Thr-rich
Compositional bias1165 – 120844Cys-rich

Sites

Site516 – 5172Cleavage; by host By similarity
Site1037 – 10382Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation251N-linked (GlcNAc...); by host Potential
Glycosylation301N-linked (GlcNAc...); by host Potential
Glycosylation1961N-linked (GlcNAc...); by host Potential
Glycosylation2001N-linked (GlcNAc...); by host Potential
Glycosylation2431N-linked (GlcNAc...); by host Potential
Glycosylation3761N-linked (GlcNAc...); by host Potential
Glycosylation4261N-linked (GlcNAc...); by host Potential
Glycosylation5571N-linked (GlcNAc...); by host Potential
Glycosylation7551N-linked (GlcNAc...); by host Potential
Glycosylation10541N-linked (GlcNAc...); by host Potential
Glycosylation13451N-linked (GlcNAc...); by host Potential
Glycosylation15631N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
Q8JSZ3 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 7CEAB4B46F74F578

FASTA1,684186,589
        10         20         30         40         50         60 
MHISLMYAIL CLQLCGLGET HGSHNETRHN KTDTMTTPGD NPSSEPPVST ALSITLDPST 

        70         80         90        100        110        120 
VTPTTPASGL EGSGEVYTSP PITTGSLPLS ETTPELPVTT GTDTLSAGDV DPSTQTAGGT 

       130        140        150        160        170        180 
SAPTVRTSLP NSPSTPSTPQ DTHHPVRNLL SVTSPGPDET STPSGTGKES SATSSPHPVS 

       190        200        210        220        230        240 
NRPPTPPATA QGPTENDSHN ATEHPESLTQ SATPGLMTSP TQIVHPQSAT PITVQDTHPS 

       250        260        270        280        290        300 
PTNRSKRNLK MEIILTLSQG LKKYYGKILR LLQLTLEEDT EGLLEWCKRN LGLDCDDTFF 

       310        320        330        340        350        360 
QKRIEEFFIT GEGHFNEVLQ FRTPGTLSTT ESTPAGLPTA EPFKSYFAKG FLSIDSGYYS 

       370        380        390        400        410        420 
AKCYSGTSNS GLQLINITRH STRIVDTPGP KITNLKTINC INLKASIFKE HREVEINVLL 

       430        440        450        460        470        480 
PQVAVNLSNC HVVIKSHVCD YSLDIDGAVR LPHIYHEGVF IPGTYKIVID KKNKLNDRCT 

       490        500        510        520        530        540 
LFTDCVIKGR EVRKGQSVLR QYKTEIRIGK ASTGSRRLLS EEPSDDCISR TQLLRTETAE 

       550        560        570        580        590        600 
IHGDNYGGPG DKITICNGST IVDQRLGSEL GCYTINRVRS FKLCENSATG KNCEIDSVPV 

       610        620        630        640        650        660 
KCRQGYCLRI TQEGRGHVKL SRGSEVVLDA CDTSCEIMIP KGTGDILVDC SGGQQHFLKD 

       670        680        690        700        710        720 
NLIDLGCPKI PLLGKMAIYI CRMSNHPKTT MAFLFWFSFG YVITCILCKA IFYLLIIVGT 

       730        740        750        760        770        780 
LGKRLKQYRE LKPQTCTICE TTPVNAIDAE MHDLNCSYNI CPYCASRLTS DGLARHVIQC 

       790        800        810        820        830        840 
PKRKEKVEET ELYLNLERIP WVVRKLLQVS ESTGVALKRS SWLIVLLVLF TVSLSPVQSA 

       850        860        870        880        890        900 
PIGQGKTIEA YRAREGYTSI CLFVLGSILF IVSCLMKGLV DSVGNSFFPG LSICKTCSIS 

       910        920        930        940        950        960 
SINGFEIESH KCYCSLFCCP YCRHCSTDKE IHKLHLSICK KRKKGSNVML AVCKLMCFRA 

       970        980        990       1000       1010       1020 
TMEVSNRALF IRSIINTTFV LCILILAVCV VSTSAVEMEN LPAGTWEREE DLTNFCHQEC 

      1030       1040       1050       1060       1070       1080 
QVTETECLCP YEALVLRKPL FLDSTAKGMK NLLNSTSLET SLSIEAPWGA INVQSTYKPT 

      1090       1100       1110       1120       1130       1140 
VSTANIALSW SSVEHRGNKI LVSGRSESIM KLEERTGISW DLGVEDASES KLLTVSVMDL 

      1150       1160       1170       1180       1190       1200 
SQMYSPVFEY LSGDRQVGEW PKATCTGDCP ERCGCTSSTC LHKEWPHSRN WRCNPTWCWG 

      1210       1220       1230       1240       1250       1260 
VGTGCTCCGL DVKDLFTDYM FVKWKVEYIK TEAIVCVELT SQERQCSLIE AGTRFNLGPV 

      1270       1280       1290       1300       1310       1320 
TITLSEPRNI QQKLPPEIIT LHPRIEEGFF DLMHVQKVLS ASTVCKLQSC THGVPGDLQV 

      1330       1340       1350       1360       1370       1380 
YHIGNLLKGD KVNGHLIHKI EPHFNTSWMS WDGCDLDYYC NMGDWPSCTY TGVTQHNHAS 

      1390       1400       1410       1420       1430       1440 
FVNLLNIETD YTKNFHFHSK RVTAHGDTPQ LDLKARPTYG AGEITVLVEV ADMELHTKKI 

      1450       1460       1470       1480       1490       1500 
EISGLKFASL ACTGCYACSS GISCKVRIHV DEPDELTVHV KSDDPDVVAA SSSLMARKLE 

      1510       1520       1530       1540       1550       1560 
FGTDSTFKAF SAMPKTSLCF YIVEREHCKS CSEEDTKKCV NTKLEQPQSI LIEHKGTIIG 

      1570       1580       1590       1600       1610       1620 
KQNSTCTAKA SCWLESVKSF FYGLKNMLSG IFGNVFMGIF LFLAPFILLI LFFMFGWRIL 

      1630       1640       1650       1660       1670       1680 
FCFKCCRRTR GLFKYRHLKD DEETGYRRII EKLNNKKGKN KLLDGERLAD RRIAELFSTK 


THIG

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References

[1]"Characterization of the glycoproteins of Crimean-Congo hemorrhagic fever virus."
Sanchez A.J., Vincent M.J., Nichol S.T.
J. Virol. 76:7263-7275(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]Sanchez A.J., Vincent M.J., Deyde V.M., Khristova M.L., Nichol S.T.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"Crimean-Congo hemorrhagic fever virus entry and replication is clathrin-, pH- and cholesterol-dependent."
Simon M., Johansson C., Mirazimi A.
J. Gen. Virol. 90:210-215(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF467768 Genomic RNA. Translation: AAM48106.1.
RefSeqNP_950235.1. NC_005300.2.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2943074.

Family and domain databases

InterProIPR012487. Nairovirus_M.
[Graphical view]
PfamPF07948. Nairovirus_M. 1 hit.
[Graphical view]
PIRSFPIRSF003962. M_poly_NairoV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGP_CCHFI
AccessionPrimary (citable) accession number: Q8JSZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2002
Last modified: April 3, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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