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Q8JPY1

- NCAP_EBORR

UniProt

Q8JPY1 - NCAP_EBORR

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Protein
Nucleoprotein
Gene
NP
Organism
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. viral RNA genome packaging Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:NP
OrganismiReston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Taxonomic identifieri386032 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000007207: Genome

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
  2. host cell cytoplasm Source: UniProtKB-SubCell
  3. ribonucleoprotein complex Source: UniProtKB-KW
  4. viral nucleocapsid Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Nucleoprotein
PRO_0000245052Add
BLAST

Post-translational modificationi

Phosphorylated and O-glycosylated by host By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili334 – 36330 Reviewed prediction
Add
BLAST

Domaini

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR008609. Ebola_NP.
[Graphical view]
PfamiPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFiPIRSF003900. N_FiloV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8JPY1-1 [UniParc]FASTAAdd to Basket

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MDRGTRRIWV SQNQGDTDLD YHKILTAGLT VQQGIVRQKI ISVYLVDNLE    50
AMCQLVIQAF EAGIDFQENA DSFLLMLCLH HAYQGDYKLF LESNAVQYLE 100
GHGFKFELRK KDGVNRLEEL LPAATSGKNI RRTLAALPEE ETTEANAGQF 150
LSFASLFLPK LVVGEKACLE KVQRQIQVHA EQGLIQYPTA WQSVGHMMVI 200
FRLMRTNFLI KYLLIHQGMH MVAGHDANDA VIANSVAQAR FSGLLIVKTV 250
LDHILQKTDQ GVRLHPLART AKVRNEVNAF KAALSSLAKH GEYAPFARLL 300
NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA 350
EKQLQQYAES RELDSLGLDD QERRILMNFH QKKNEISFQQ TNAMVTLRKE 400
RLAKLTEAIT LASRPNLGSR QDDGNEIPFP GPISNNPDQD HLEDDPRDSR 450
DTIIPNGAID PEDGDFENYN GYHDDEVGTA GDLVLFDLDD HEDDNKAFEP 500
QDSSPQSQRE IERERLIHPP PGNNKDDNRA SDNNQQSADS EEQGGQYNWH 550
RGPERTTANR RLSPVHEEDT LMDQGDDDPS SLPPLESDDD DASSSQQDPD 600
YTAVAPPAPV YRSAEAHEPP HKSSNEPAET SQLNEDPDIG QSKSMQKLEE 650
TYHHLLRTQG PFEAINYYHM MKDEPVIFST DDGKEYTYPD SLEEAYPPWL 700
TEKERLDKEN RYIYINNQQF FWPVMSPRDK FLAILQHHQ 739
Length:739
Mass (Da):83,453
Last modified:October 1, 2002 - v1
Checksum:iAB1BFE0970BB2A86
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281G → V in strain: Isolate Pennsylvania-89.
Natural varianti67 – 671Q → R in strain: Isolate Pennsylvania-89.
Natural varianti373 – 3731R → G in strain: Isolate Pennsylvania-89.
Natural varianti483 – 4831L → W in strain: Isolate Pennsylvania-89.
Natural varianti517 – 5171I → T in strain: Isolate Pennsylvania-89.
Natural varianti721 – 7211F → S in strain: Isolate Pennsylvania-89.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF522874 Genomic RNA. Translation: AAN04448.1.
AY769362 Genomic RNA. Translation: AAV48574.1.
RefSeqiNP_690580.1. NC_004161.1.

Genome annotation databases

GeneIDi955194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF522874 Genomic RNA. Translation: AAN04448.1 .
AY769362 Genomic RNA. Translation: AAV48574.1 .
RefSeqi NP_690580.1. NC_004161.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 955194.

Family and domain databases

InterProi IPR008609. Ebola_NP.
[Graphical view ]
Pfami PF05505. Ebola_NP. 1 hit.
[Graphical view ]
PIRSFi PIRSF003900. N_FiloV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States."
    Groseth A., Stroeher U., Theriault S., Feldmann H.
    Virus Res. 87:155-163(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire."
    Boehmann Y., Enterlein S., Randolf A., Muehlberger E.I.
    Virology 332:406-417(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Pennsylvania-89.

Entry informationi

Entry nameiNCAP_EBORR
AccessioniPrimary (citable) accession number: Q8JPY1
Secondary accession number(s): Q5UAL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2002
Last modified: November 13, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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