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Q8JPY1

- NCAP_EBORR

UniProt

Q8JPY1 - NCAP_EBORR

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Protein

Nucleoprotein

Gene

NP

Organism
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome packaging Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:NP
OrganismiReston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Taxonomic identifieri386032 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
Sus scrofa (Pig) [TaxID: 9823]
ProteomesiUP000007207: Genome

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
  2. host cell cytoplasm Source: UniProtKB-KW
  3. ribonucleoprotein complex Source: UniProtKB-KW
  4. viral nucleocapsid Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739NucleoproteinPRO_0000245052Add
BLAST

Post-translational modificationi

Phosphorylated and O-glycosylated by host.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 (By similarity).By similarity

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili334 – 36330Sequence AnalysisAdd
BLAST

Domaini

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half.By similarity

Sequence similaritiesi

Belongs to the filoviruses nucleoprotein family.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR008609. Ebola_NP.
[Graphical view]
PfamiPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFiPIRSF003900. N_FiloV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8JPY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRGTRRIWV SQNQGDTDLD YHKILTAGLT VQQGIVRQKI ISVYLVDNLE
60 70 80 90 100
AMCQLVIQAF EAGIDFQENA DSFLLMLCLH HAYQGDYKLF LESNAVQYLE
110 120 130 140 150
GHGFKFELRK KDGVNRLEEL LPAATSGKNI RRTLAALPEE ETTEANAGQF
160 170 180 190 200
LSFASLFLPK LVVGEKACLE KVQRQIQVHA EQGLIQYPTA WQSVGHMMVI
210 220 230 240 250
FRLMRTNFLI KYLLIHQGMH MVAGHDANDA VIANSVAQAR FSGLLIVKTV
260 270 280 290 300
LDHILQKTDQ GVRLHPLART AKVRNEVNAF KAALSSLAKH GEYAPFARLL
310 320 330 340 350
NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA
360 370 380 390 400
EKQLQQYAES RELDSLGLDD QERRILMNFH QKKNEISFQQ TNAMVTLRKE
410 420 430 440 450
RLAKLTEAIT LASRPNLGSR QDDGNEIPFP GPISNNPDQD HLEDDPRDSR
460 470 480 490 500
DTIIPNGAID PEDGDFENYN GYHDDEVGTA GDLVLFDLDD HEDDNKAFEP
510 520 530 540 550
QDSSPQSQRE IERERLIHPP PGNNKDDNRA SDNNQQSADS EEQGGQYNWH
560 570 580 590 600
RGPERTTANR RLSPVHEEDT LMDQGDDDPS SLPPLESDDD DASSSQQDPD
610 620 630 640 650
YTAVAPPAPV YRSAEAHEPP HKSSNEPAET SQLNEDPDIG QSKSMQKLEE
660 670 680 690 700
TYHHLLRTQG PFEAINYYHM MKDEPVIFST DDGKEYTYPD SLEEAYPPWL
710 720 730
TEKERLDKEN RYIYINNQQF FWPVMSPRDK FLAILQHHQ
Length:739
Mass (Da):83,453
Last modified:October 1, 2002 - v1
Checksum:iAB1BFE0970BB2A86
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281G → V in strain: Isolate Pennsylvania-89.
Natural varianti67 – 671Q → R in strain: Isolate Pennsylvania-89.
Natural varianti373 – 3731R → G in strain: Isolate Pennsylvania-89.
Natural varianti483 – 4831L → W in strain: Isolate Pennsylvania-89.
Natural varianti517 – 5171I → T in strain: Isolate Pennsylvania-89.
Natural varianti721 – 7211F → S in strain: Isolate Pennsylvania-89.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522874 Genomic RNA. Translation: AAN04448.1.
AY769362 Genomic RNA. Translation: AAV48574.1.
RefSeqiNP_690580.1. NC_004161.1.

Genome annotation databases

GeneIDi955194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522874 Genomic RNA. Translation: AAN04448.1 .
AY769362 Genomic RNA. Translation: AAV48574.1 .
RefSeqi NP_690580.1. NC_004161.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 955194.

Family and domain databases

InterProi IPR008609. Ebola_NP.
[Graphical view ]
Pfami PF05505. Ebola_NP. 1 hit.
[Graphical view ]
PIRSFi PIRSF003900. N_FiloV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States."
    Groseth A., Stroeher U., Theriault S., Feldmann H.
    Virus Res. 87:155-163(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire."
    Boehmann Y., Enterlein S., Randolf A., Muehlberger E.I.
    Virology 332:406-417(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    Strain: Isolate Pennsylvania-89.

Entry informationi

Entry nameiNCAP_EBORR
AccessioniPrimary (citable) accession number: Q8JPY1
Secondary accession number(s): Q5UAL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3