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Q8JPR2

- L_BUNL8

UniProt

Q8JPR2 - L_BUNL8

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Protein

RNA-directed RNA polymerase L

Gene
L
Organism
Bunyavirus La Crosse (isolate Human/United States/L78/1978)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are not polyadenylated. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated By similarity.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiBunyavirus La Crosse (isolate Human/United States/L78/1978)
Taxonomic identifieri796210 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]
ProteomesiUP000008768: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22632263RNA-directed RNA polymerase LPRO_0000397189Add
BLAST

Interactioni

Subunit structurei

Homomultimerizes; the oligomeric structure is essential for the polymerase activity. Interacts with the nucleocapsid protein N By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1042 – 1230189RdRp catalyticAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1003 – 103331 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR026382. CapSnatchArena.
IPR029124. L_protein_N.
IPR007099. RNA-dir_pol_NSvirus.
IPR014384. RNA-dir_pol_orthobunyavirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF15518. L_protein_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000824. L_OrthobunV. 1 hit.
TIGRFAMsiTIGR04202. capSnatchArena. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JPR2-1 [UniParc]FASTAAdd to Basket

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MDYQEYQQFL ARINTARDAC VAKDIDVDLL MARHDYFGRE LCKSLNIEYR     50
NDVPFVDIIL DIRPEVDPLT IDAPHITPDN YLYINNVLYI IDYKVSVSNE 100
SSVITYDKYY ELTRDISDRL SIPIEIVIVR IDPVSKDLHI NSDRFKELYP 150
TIVVDINFNQ FFDLKQLLYE KFGDDEEFLL KVAHGDFTLT APWCKTGCPE 200
FWKHPIYKEF KMSMPVPERR LFEESVKFNA YESERWNTNL VKIREYTKKD 250
YSEHISKSAK NIFLASGFYK QPNKNEISEG WTLMVERVQD QREISKSLHD 300
QKPSIHFIWG AHNPGNSNNA TFKLILLSKS LQSIKGISTY TEAFKSLGKM 350
MDIGDKAIEY EEFCMSLKSK ARSSWKQIMN KKLEPKQINN ALVLWEQQFM 400
VNNDLIDKSE KLKLFKNFCG IGKHKQFKNK MLEDLEVSKP KILDFDDANM 450
YLASLTMMEQ SKKILSKSNG LKPDNFILNE FGSKIKDANK ETYDNMHKIF 500
ETRYWQCISD FSTLMKNILS VSQYNRHNTF RIAMCANNNV FAIVFPSADI 550
KTKKATVVYS IIVLHKEEEN IFNPGCLHGT FKCMNGYISI SRAIRLDKER 600
CQRIVSSPGL FLTTCLLFKH DNPTLVMSDI MNFSIYTSLS ITKSVLSLTE 650
PARYMIMNSL AISSNVKDYI AEKFSPYTKT LFSVYMTRLI KNACFDAYDQ 700
RQRVQLRDIY LSDYDITQKG IKDNRELTSI WFPGSVTLKE YLTQIYLPFY 750
FNAKGLHEKH HVMVDLAKTI LEIECEQREN IKEIWSTNCT KQTVNLKILI 800
HSLCKNLLAD TSRHNHLRNR IENRNNFRRS ITTISTFTSS KSCLKIGDFR 850
KEKELQSVKQ KKILEVQSRK MRLANPMFVT DEQVCLEVGH CNYEMLRNAM 900
PNYTDYISTK VFDRLYELLD KGVLTDKPVI EQIMDMMVDH KKFYFTFFNK 950
GQKTSKDREI FVGEYEAKMC MYAVERIAKE RCKLNPDEMI SEPGDGKLKV 1000
LEQKSEQEIR FLVETTRQKN REIDEAIEAL AAEGYESNLE KIEKLSLGKA 1050
KGLKMEINAD MSKWSAQDVF YKYFWLIALD PILYPQEKER ILYFMCNYMD 1100
KELILPDELL FNLLDQKVAY QNDIIATMTN QLNSNTVLIK RNWLQGNFNY 1150
TSSYVHSCAM SVYKEILKEA ITLLDGSILV NSLVHSDDNQ TSITIVQDKM 1200
ENDKIIDFAM KEFERACLTF GCQANMKKTY VTNCIKEFVS LFNLYGEPFS 1250
IYGRFLLTSV GDCAYIGPYE DLASRISSAQ TAIKHGCPPS LAWVSIAISH 1300
WMTSLTYNML PGQSNDPIDY FPAENRKDIP IELNGVLDAP LSMISTVGLE 1350
SGNLYFLIKL LSKYTPVMQK RESVVNQIAE VKNWKVEDLT DNEIFRLKIL 1400
RYLVLDAEMD PSDIMGETSD MRGRSILTPR KFTTAGSLRK LYSFSKYQDR 1450
LSSPGGMVEL FTYLLEKPEL LVTKGEDMKD YMESVIFRYN SKRFKESLSI 1500
QNPAQLFIEQ ILFSHKPIID FSGIRDKYIN LHDSRALEKE PDILGKVTFT 1550
EAYRLLMRDL SSLELTNDDI QVIYSYIILN DPMMITIANT HILSIYGSPQ 1600
RRMGMSCSTM PEFRNLKLIH HSPALVLRAY SKNNPDIQGA DPTEMARDLV 1650
HLKEFVENTN LEEKMKVRIA INEAEKGQRD IVFELKEMTR FYQVCYEYVK 1700
STEHKIKVFI LPTKSYTTTD FCSLMQGNLI KDKEWYTVHY LKQILSGGHK 1750
AIMQHNATSE QNIAFECFKL ITHFADSFID SLSRSAFLQL IIDEFSYKDV 1800
KVSKLYDIIK NGYNRTDFIP LLFRTGDLRQ ADLDKYDAMK SHERVTWNDW 1850
QTSRHLDMGS INLTITGYNR SITIIGEDNK LTYAELCLTR KTPENITISG 1900
RKLLGARHGL KFENMSKIQT YPGNYYITYR KKDRHQFVYQ IHSHESITRR 1950
NEEHMAIRTR IYNEITPVCV VNVAEVDGDQ RILIRSLDYL NNDIFSLSRI 2000
KVGLDEFATI KKAHFSKMVS FEGPPIKTGL LDLTELMKSQ DLLNLNYDNI 2050
RNSNLISFSK LICCEGSDNI NDGLEFLSDD PMNFTEGEAI HSTPIFNIYY 2100
SKRGERHMTY RNAIKLLIER ETKIFEEAFT FSENGFISPE NLGCLEAVVS 2150
LIKLLKTNEW STVIDKCIHI CLIKNGMDHM YHSFDVPKCF MGNPITRDMN 2200
WMMFREFINS LPGTDIPPWN VMTENFKKKC IALINSKLET QRDFSEFTKL 2250
MKKEGGRSNI EFD 2263
Length:2,263
Mass (Da):263,013
Last modified:October 1, 2002 - v1
Checksum:iA612682C8495E627
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF528165 Genomic RNA. Translation: AAM94387.1.
EF485035 Viral cRNA. Translation: ABQ12635.1.
RefSeqiNP_671968.1. NC_004108.1.

Genome annotation databases

GeneIDi956554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF528165 Genomic RNA. Translation: AAM94387.1 .
EF485035 Viral cRNA. Translation: ABQ12635.1 .
RefSeqi NP_671968.1. NC_004108.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956554.

Family and domain databases

InterProi IPR026382. CapSnatchArena.
IPR029124. L_protein_N.
IPR007099. RNA-dir_pol_NSvirus.
IPR014384. RNA-dir_pol_orthobunyavirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF15518. L_protein_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000824. L_OrthobunV. 1 hit.
TIGRFAMsi TIGR04202. capSnatchArena. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the Bunyavirus, La Crosse virus, Human/78 strain."
    Hughes M.T., Kempf B.J., Blair C.D., Beaty B.J.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes."
    Bennett R.S., Ton D.R., Hanson C.T., Murphy B.R., Whitehead S.S.
    Virol. J. 4:41-41(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_BUNL8
AccessioniPrimary (citable) accession number: Q8JPR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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