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Q8JPR1

- GP_BUNL8

UniProt

Q8JPR1 - GP_BUNL8

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Protein
Envelope glycoprotein
Gene
GP
Organism
Bunyavirus La Crosse (isolate Human/United States/L78/1978)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

GO - Biological processi

  1. modulation by virus of host morphology or physiology Source: InterPro
  2. viral entry into host cell Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiBunyavirus La Crosse (isolate Human/United States/L78/1978)
Taxonomic identifieri796210 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]
ProteomesiUP000008768: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: G1 alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of G1 and G2 results in efficient transport of G1 to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs By similarity.
Chain Glycoprotein G2 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction
Note: G2 is retained in the Golgi complex through a Golgi retention signal, which resides in the G2 transmembrane region By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini14 – 200187Lumenal Reviewed prediction
Add
BLAST
Transmembranei201 – 22121 Reviewed prediction
Add
BLAST
Topological domaini222 – 30584Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei306 – 32621 Reviewed prediction
Add
BLAST
Topological domaini327 – 36135Lumenal Reviewed prediction
Add
BLAST
Transmembranei362 – 38221 Reviewed prediction
Add
BLAST
Topological domaini383 – 45068Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei451 – 47121 Reviewed prediction
Add
BLAST
Topological domaini472 – 1395924Lumenal Reviewed prediction
Add
BLAST
Transmembranei1396 – 141621 Reviewed prediction
Add
BLAST
Topological domaini1417 – 143317Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1066 – 10661W → A: Complete loss of viral fusion and entry. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1313 Reviewed prediction
Add
BLAST
Chaini14 – 14411428Envelope glycoprotein
PRO_0000397205Add
BLAST
Chaini14 – 299286Glycoprotein G2 By similarity
PRO_0000397184Add
BLAST
Chaini300 – 473174Non-structural protein NSm By similarity
PRO_0000397185Add
BLAST
Chaini474 – 1441968Glycoprotein G1 By similarity
PRO_0000397186Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi490 – 4901N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1177 – 11771N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1066 – 108722Fusion peptide Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JPR1-1 [UniParc]FASTAAdd to Basket

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MICILVLITV AAASPVYQRC FQDGAIVKQN PSKEAVTEVC LKDDVSMIKT     50
EARYVRNATG VFSNNVAIRK WLVSDWHDCR PKKIVGGHIN VIEVGDDLSL 100
HTESYVCSAD CTIGVDKETA QVRLQTDTTN HFEIAGTTVK SGWFKSTTYI 150
TLDQTCEHLK VSCGPKSVQF HACFNQHMSC VRFLHRTILP GSIANSICQN 200
IEIIILVTLT LLIFILLSIL SKTYICYLLM PIFIPIAYIY GIIYNKSCKK 250
CKLCGLVYHP FTECGTHCVC GARYDTSDRM KLHRASGLCP GYKSLRAARV 300
MCKSKGPASI LSIITAVLVL TFVTPINSMV LGESKETFEL EDLPDDMLEM 350
ASRINSYYLT CILNYAVSWG LVIIGLLIGL LFKKYQHRFL NVYAMYCEEC 400
DMYHDKSGLK RHGDFTNKCR QCTCGQYEDA AGLMAHRKTY NCLVQYKAKW 450
MMNFLIIYIF LILIKDSAIV VQAAGTDFTT CLETESINWN CTGPFLNLGN 500
CQKQQKKEPY TNIATQLKGL KAISVLDVPI ITGIPDDIAG ALRYIEEKED 550
FHVQLTIEYA MLSKYCDYYT QFSDNSGYSQ TTWRVYLRSH DFEACILYPN 600
QHFCRCVKNG EKCSSSNWDF ANEMKDYYSG KQTKFDKDLN LALTALHHAF 650
RGTSSAYIAT MLSKKSNDDL IAYTNKIKTK FPGNALLKAI IDYIAYMKSL 700
PGMANFKYDE FWDELLYKPN PAKASNLARG KESSYNFKLA ISSKSIKTCK 750
NVKDVACLSP RSGAIYASII ACGEPNGPSV YRKPSGGVFQ SSTDRSIYCL 800
LDSHCLEEFE AIGQEELDAV KKSKCWEIEY PDVKLIQEGD GTKSCRMKDS 850
GNCNVATNRW PVIQCENDKF YYSELQKDYD KAQDIGHYCL SPGCTTVRYP 900
INPKHISNCN WQVSRSSIAK IDVHNIEDIE QYKKAITQKL QTSLSLFKYA 950
KTKNLPHIKP IYKYITIEGT ETAEGIESAY IESEVPALAG TSIGFKINSK 1000
EGKHLLDVIA YVKSASYSSV YTKLYSTGPT SGINTKHDEL CTGPCPANIN 1050
HQVGWLTFAR ERTSSWGCEE FGCLAVSDGC VFGSCQDIIK EELSVYRKET 1100
EEVTDVELCL TFSDKTYCTN LNPVTPIITD LFEVQFKTVE TYSLPRIVAV 1150
QNHEIKIGQI NDLGVYSKGC GNVQKVNGTI YGNGVPRFDY LCHLASRKEV 1200
IVRKCFDNDY QACKFLQSPA SYRLEEDSGT VTIIDYKKIL GTIKMKAILG 1250
DVKYKTFADS VDITAEGSCT GCINCFENIH CELTLHTTIE ASCPIKSSCT 1300
VFHDRILVTP NEHKYALKMV CTEKPGNTLT IKVCNTKVEA SMALVDAKPI 1350
IELAPVDQTA YIREKDERCK TWMCRVRDEG LQVILEPFKN LFGSYIGIFY 1400
TFIISIVVLL VIIYVLLPIC FKLRDTLRKH EDAYKREMKI R 1441
Length:1,441
Mass (Da):162,364
Last modified:October 1, 2002 - v1
Checksum:iD9A2BECC01821D1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF528166 Genomic RNA. Translation: AAM94388.1.
EF485034 Viral cRNA. Translation: ABQ12634.1.
RefSeqiNP_671969.1. NC_004109.1.

Genome annotation databases

GeneIDi956555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF528166 Genomic RNA. Translation: AAM94388.1 .
EF485034 Viral cRNA. Translation: ABQ12634.1 .
RefSeqi NP_671969.1. NC_004109.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956555.

Family and domain databases

InterProi IPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view ]
Pfami PF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view ]
PIRSFi PIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsi TIGR04210. bunya_NSm. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the Bunyavirus, La Crosse virus, Human/78 strain."
    Hughes M.T., Kempf B.J., Blair C.D., Beaty B.J.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes."
    Bennett R.S., Ton D.R., Hanson C.T., Murphy B.R., Whitehead S.S.
    Virol. J. 4:41-41(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Mutagenesis of the La Crosse Virus glycoprotein supports a role for Gc (1066-1087) as the fusion peptide."
    Plassmeyer M.L., Soldan S.S., Stachelek K.M., Roth S.M., Martin-Garcia J., Gonzalez-Scarano F.
    Virology 358:273-282(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF TRP-1066.

Entry informationi

Entry nameiGP_BUNL8
AccessioniPrimary (citable) accession number: Q8JPR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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