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Protein

Envelopment polyprotein

Gene

GP

Organism
Bunyavirus La Crosse (isolate Human/United States/L78/1978)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Glycoprotein C and glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelopment polyprotein
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Glycoprotein NBy similarity
Short name:
Gn
Alternative name(s):
Glycoprotein G2
Glycoprotein CBy similarity
Short name:
Gc
Alternative name(s):
Glycoprotein G1
Gene namesi
Name:GP
OrganismiBunyavirus La Crosse (isolate Human/United States/L78/1978)
Taxonomic identifieri796210 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]
Proteomesi
  • UP000008768 Componenti: Genome

Subcellular locationi

Glycoprotein C :
Glycoprotein N :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini14 – 200LumenalSequence analysisAdd BLAST187
Transmembranei201 – 221Sequence analysisAdd BLAST21
Topological domaini222 – 305CytoplasmicSequence analysisAdd BLAST84
Transmembranei306 – 326Sequence analysisAdd BLAST21
Topological domaini327 – 361LumenalSequence analysisAdd BLAST35
Transmembranei362 – 382Sequence analysisAdd BLAST21
Topological domaini383 – 450CytoplasmicSequence analysisAdd BLAST68
Transmembranei451 – 471Sequence analysisAdd BLAST21
Topological domaini472 – 1395LumenalSequence analysisAdd BLAST924
Transmembranei1396 – 1416Sequence analysisAdd BLAST21
Topological domaini1417 – 1433CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1066W → A: Complete loss of viral fusion and entry. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13Sequence analysisAdd BLAST13
ChainiPRO_000039720514 – 1441Envelopment polyproteinAdd BLAST1428
ChainiPRO_000039718414 – 299Glycoprotein NBy similarityAdd BLAST286
ChainiPRO_0000397185300 – 473Non-structural protein MBy similarityAdd BLAST174
ChainiPRO_0000397186474 – 1441Glycoprotein CBy similarityAdd BLAST968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi490N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi1177N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Glycoprotein C and Glycoprotein N interact with each other.By similarity

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1066 – 1087Fusion peptideSequence analysisAdd BLAST22

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JPR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICILVLITV AAASPVYQRC FQDGAIVKQN PSKEAVTEVC LKDDVSMIKT
60 70 80 90 100
EARYVRNATG VFSNNVAIRK WLVSDWHDCR PKKIVGGHIN VIEVGDDLSL
110 120 130 140 150
HTESYVCSAD CTIGVDKETA QVRLQTDTTN HFEIAGTTVK SGWFKSTTYI
160 170 180 190 200
TLDQTCEHLK VSCGPKSVQF HACFNQHMSC VRFLHRTILP GSIANSICQN
210 220 230 240 250
IEIIILVTLT LLIFILLSIL SKTYICYLLM PIFIPIAYIY GIIYNKSCKK
260 270 280 290 300
CKLCGLVYHP FTECGTHCVC GARYDTSDRM KLHRASGLCP GYKSLRAARV
310 320 330 340 350
MCKSKGPASI LSIITAVLVL TFVTPINSMV LGESKETFEL EDLPDDMLEM
360 370 380 390 400
ASRINSYYLT CILNYAVSWG LVIIGLLIGL LFKKYQHRFL NVYAMYCEEC
410 420 430 440 450
DMYHDKSGLK RHGDFTNKCR QCTCGQYEDA AGLMAHRKTY NCLVQYKAKW
460 470 480 490 500
MMNFLIIYIF LILIKDSAIV VQAAGTDFTT CLETESINWN CTGPFLNLGN
510 520 530 540 550
CQKQQKKEPY TNIATQLKGL KAISVLDVPI ITGIPDDIAG ALRYIEEKED
560 570 580 590 600
FHVQLTIEYA MLSKYCDYYT QFSDNSGYSQ TTWRVYLRSH DFEACILYPN
610 620 630 640 650
QHFCRCVKNG EKCSSSNWDF ANEMKDYYSG KQTKFDKDLN LALTALHHAF
660 670 680 690 700
RGTSSAYIAT MLSKKSNDDL IAYTNKIKTK FPGNALLKAI IDYIAYMKSL
710 720 730 740 750
PGMANFKYDE FWDELLYKPN PAKASNLARG KESSYNFKLA ISSKSIKTCK
760 770 780 790 800
NVKDVACLSP RSGAIYASII ACGEPNGPSV YRKPSGGVFQ SSTDRSIYCL
810 820 830 840 850
LDSHCLEEFE AIGQEELDAV KKSKCWEIEY PDVKLIQEGD GTKSCRMKDS
860 870 880 890 900
GNCNVATNRW PVIQCENDKF YYSELQKDYD KAQDIGHYCL SPGCTTVRYP
910 920 930 940 950
INPKHISNCN WQVSRSSIAK IDVHNIEDIE QYKKAITQKL QTSLSLFKYA
960 970 980 990 1000
KTKNLPHIKP IYKYITIEGT ETAEGIESAY IESEVPALAG TSIGFKINSK
1010 1020 1030 1040 1050
EGKHLLDVIA YVKSASYSSV YTKLYSTGPT SGINTKHDEL CTGPCPANIN
1060 1070 1080 1090 1100
HQVGWLTFAR ERTSSWGCEE FGCLAVSDGC VFGSCQDIIK EELSVYRKET
1110 1120 1130 1140 1150
EEVTDVELCL TFSDKTYCTN LNPVTPIITD LFEVQFKTVE TYSLPRIVAV
1160 1170 1180 1190 1200
QNHEIKIGQI NDLGVYSKGC GNVQKVNGTI YGNGVPRFDY LCHLASRKEV
1210 1220 1230 1240 1250
IVRKCFDNDY QACKFLQSPA SYRLEEDSGT VTIIDYKKIL GTIKMKAILG
1260 1270 1280 1290 1300
DVKYKTFADS VDITAEGSCT GCINCFENIH CELTLHTTIE ASCPIKSSCT
1310 1320 1330 1340 1350
VFHDRILVTP NEHKYALKMV CTEKPGNTLT IKVCNTKVEA SMALVDAKPI
1360 1370 1380 1390 1400
IELAPVDQTA YIREKDERCK TWMCRVRDEG LQVILEPFKN LFGSYIGIFY
1410 1420 1430 1440
TFIISIVVLL VIIYVLLPIC FKLRDTLRKH EDAYKREMKI R
Length:1,441
Mass (Da):162,364
Last modified:October 1, 2002 - v1
Checksum:iD9A2BECC01821D1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF528166 Genomic RNA. Translation: AAM94388.1.
EF485034 Viral cRNA. Translation: ABQ12634.1.
RefSeqiNP_671969.1. NC_004109.1.

Genome annotation databases

GeneIDi956555.
KEGGivg:956555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF528166 Genomic RNA. Translation: AAM94388.1.
EF485034 Viral cRNA. Translation: ABQ12634.1.
RefSeqiNP_671969.1. NC_004109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi956555.
KEGGivg:956555.

Family and domain databases

InterProiIPR005167. Bunya_G1.
IPR005168. Bunya_G2.
IPR026400. Bunya_nonstruc_pro_NSm.
IPR014413. M_poly_OrthobunV.
[Graphical view]
PfamiPF03557. Bunya_G1. 1 hit.
PF03563. Bunya_G2. 1 hit.
[Graphical view]
PIRSFiPIRSF003944. M_poly_OrthobunV. 1 hit.
TIGRFAMsiTIGR04210. bunya_NSm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGP_BUNL8
AccessioniPrimary (citable) accession number: Q8JPR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2002
Last modified: January 20, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.