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Q8JPR0 (NCAP_BUNL8) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name=Protein N
Gene names
Name:N
OrganismBunyavirus La Crosse (isolate Human/United States/L78/1978) [Reference proteome]
Taxonomic identifier796210 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation By similarity.

Subunit structure

Homomultimerizes to form the nucleocapsid By similarity. Binds to viral genomic RNA By similarity. Interacts with host PABP1 By similarity.

Subcellular location

Virion. Note: Internal protein of virus particle.

Sequence similarities

Belongs to the orthobunyaviruses nucleocapsid protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Nucleoprotein
PRO_0000397188

Sequences

Sequence LengthMass (Da)Tools
Q8JPR0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 152DD6D13709F891

FASTA23526,556
        10         20         30         40         50         60 
MSDLVFYDVA STGANGFDPD AGYMDFCVKN AELLNLAAVR IFFLNAAKAK AALSRKPERK 

        70         80         90        100        110        120 
ANPKFGEWQV EVINNHFPGN RNNPIGNNDL TIHRLSGYLA RWVLDQYNEN DDESQHELIR 

       130        140        150        160        170        180 
TTIINPIAES NGVGWDSGPE IYLSFFPGTE MFLETFKFYP LTIGIHRVKQ GMMDPQYLKK 

       190        200        210        220        230 
ALRQRYGTLT ADKWMSQKVA AIAKSLKDVE QLKWGKGGLS DTAKTFLQKF GIRLP 

« Hide

References

[1]"Complete sequence of the Bunyavirus, La Crosse virus, Human/78 strain."
Hughes M.T., Kempf B.J., Blair C.D., Beaty B.J.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes."
Bennett R.S., Ton D.R., Hanson C.T., Murphy B.R., Whitehead S.S.
Virol. J. 4:41-41(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF528167 Genomic RNA. Translation: AAM94389.1.
EF485033 Viral cRNA. Translation: ABQ12632.1.
RefSeqNP_671970.1. NC_004110.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID956556.

Family and domain databases

InterProIPR001784. Bunya_nucleocap.
[Graphical view]
PfamPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFPIRSF003947. N_OrthobunV. 1 hit.
ProDomPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameNCAP_BUNL8
AccessionPrimary (citable) accession number: Q8JPR0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families