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Q8JPR0

- NCAP_BUNL8

UniProt

Q8JPR0 - NCAP_BUNL8

Protein

Nucleoprotein

Gene

N

Organism
Bunyavirus La Crosse (isolate Human/United States/L78/1978)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. suppression by virus of host gene expression Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction

    Keywords - Ligandi

    RNA-binding, Viral nucleoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoprotein
    Alternative name(s):
    Nucleocapsid protein
    Short name:
    Protein N
    Gene namesi
    Name:N
    OrganismiBunyavirus La Crosse (isolate Human/United States/L78/1978)
    Taxonomic identifieri796210 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiCervidae (deer) [TaxID: 9850]
    Homo sapiens (Human) [TaxID: 9606]
    Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
    Tamias [TaxID: 13712]
    ProteomesiUP000008768: Genome

    Subcellular locationi

    Virion
    Note: Internal protein of virus particle.

    GO - Cellular componenti

    1. helical viral capsid Source: UniProtKB-KW
    2. ribonucleoprotein complex Source: UniProtKB-KW
    3. viral nucleocapsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Helical capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235NucleoproteinPRO_0000397188Add
    BLAST

    Interactioni

    Subunit structurei

    Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with host PABP1.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR001784. Bunya_nucleocap.
    [Graphical view]
    PfamiPF00952. Bunya_nucleocap. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
    ProDomiPD001909. Bunya_nucleocap. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q8JPR0-1 [UniParc]FASTAAdd to Basket

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    MSDLVFYDVA STGANGFDPD AGYMDFCVKN AELLNLAAVR IFFLNAAKAK    50
    AALSRKPERK ANPKFGEWQV EVINNHFPGN RNNPIGNNDL TIHRLSGYLA 100
    RWVLDQYNEN DDESQHELIR TTIINPIAES NGVGWDSGPE IYLSFFPGTE 150
    MFLETFKFYP LTIGIHRVKQ GMMDPQYLKK ALRQRYGTLT ADKWMSQKVA 200
    AIAKSLKDVE QLKWGKGGLS DTAKTFLQKF GIRLP 235
    Length:235
    Mass (Da):26,556
    Last modified:October 1, 2002 - v1
    Checksum:i152DD6D13709F891
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF528167 Genomic RNA. Translation: AAM94389.1.
    EF485033 Viral cRNA. Translation: ABQ12632.1.
    RefSeqiNP_671970.1. NC_004110.1.

    Genome annotation databases

    GeneIDi956556.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF528167 Genomic RNA. Translation: AAM94389.1 .
    EF485033 Viral cRNA. Translation: ABQ12632.1 .
    RefSeqi NP_671970.1. NC_004110.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 956556.

    Family and domain databases

    InterProi IPR001784. Bunya_nucleocap.
    [Graphical view ]
    Pfami PF00952. Bunya_nucleocap. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003947. N_OrthobunV. 1 hit.
    ProDomi PD001909. Bunya_nucleocap. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of the Bunyavirus, La Crosse virus, Human/78 strain."
      Hughes M.T., Kempf B.J., Blair C.D., Beaty B.J.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes."
      Bennett R.S., Ton D.R., Hanson C.T., Murphy B.R., Whitehead S.S.
      Virol. J. 4:41-41(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNCAP_BUNL8
    AccessioniPrimary (citable) accession number: Q8JPR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3