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Q8JPR0

- NCAP_BUNL8

UniProt

Q8JPR0 - NCAP_BUNL8

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Protein

Nucleoprotein

Gene

N

Organism
Bunyavirus La Crosse (isolate Human/United States/L78/1978)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Encapsidates the genome protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication. Seems to participate in the nuclear relocalization of host PABP1, thereby inhibiting host cellular translation (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. suppression by virus of host gene expression Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:N
OrganismiBunyavirus La Crosse (isolate Human/United States/L78/1978)
Taxonomic identifieri796210 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]
ProteomesiUP000008768: Genome

Subcellular locationi

Virion
Note: Internal protein of virus particle.

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
  2. ribonucleoprotein complex Source: UniProtKB-KW
  3. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235NucleoproteinPRO_0000397188Add
BLAST

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with host PABP1.By similarity

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001784. Bunya_nucleocap.
[Graphical view]
PfamiPF00952. Bunya_nucleocap. 1 hit.
[Graphical view]
PIRSFiPIRSF003947. N_OrthobunV. 1 hit.
ProDomiPD001909. Bunya_nucleocap. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q8JPR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDLVFYDVA STGANGFDPD AGYMDFCVKN AELLNLAAVR IFFLNAAKAK
60 70 80 90 100
AALSRKPERK ANPKFGEWQV EVINNHFPGN RNNPIGNNDL TIHRLSGYLA
110 120 130 140 150
RWVLDQYNEN DDESQHELIR TTIINPIAES NGVGWDSGPE IYLSFFPGTE
160 170 180 190 200
MFLETFKFYP LTIGIHRVKQ GMMDPQYLKK ALRQRYGTLT ADKWMSQKVA
210 220 230
AIAKSLKDVE QLKWGKGGLS DTAKTFLQKF GIRLP
Length:235
Mass (Da):26,556
Last modified:October 1, 2002 - v1
Checksum:i152DD6D13709F891
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF528167 Genomic RNA. Translation: AAM94389.1.
EF485033 Viral cRNA. Translation: ABQ12632.1.
RefSeqiNP_671970.1. NC_004110.1.

Genome annotation databases

GeneIDi956556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF528167 Genomic RNA. Translation: AAM94389.1 .
EF485033 Viral cRNA. Translation: ABQ12632.1 .
RefSeqi NP_671970.1. NC_004110.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956556.

Family and domain databases

InterProi IPR001784. Bunya_nucleocap.
[Graphical view ]
Pfami PF00952. Bunya_nucleocap. 1 hit.
[Graphical view ]
PIRSFi PIRSF003947. N_OrthobunV. 1 hit.
ProDomi PD001909. Bunya_nucleocap. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the Bunyavirus, La Crosse virus, Human/78 strain."
    Hughes M.T., Kempf B.J., Blair C.D., Beaty B.J.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes."
    Bennett R.S., Ton D.R., Hanson C.T., Murphy B.R., Whitehead S.S.
    Virol. J. 4:41-41(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNCAP_BUNL8
AccessioniPrimary (citable) accession number: Q8JPR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3