ID   NSS_BUNL8               Reviewed;          92 AA.
AC   Q8JPQ9;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   08-NOV-2023, entry version 53.
DE   RecName: Full=Non-structural protein NS-S;
GN   Name=N;
OS   Bunyavirus La Crosse (isolate Human/United States/L78/1978).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Peribunyaviridae; Orthobunyavirus;
OC   Orthobunyavirus lacrosseense.
OX   NCBI_TaxID=796210;
OH   NCBI_TaxID=9850; Cervidae (Deer).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=7162; Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus).
OH   NCBI_TaxID=13712; Tamias.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Hughes M.T., Kempf B.J., Blair C.D., Beaty B.J.;
RT   "Complete sequence of the Bunyavirus, La Crosse virus, Human/78 strain.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=17488515; DOI=10.1186/1743-422x-4-41;
RA   Bennett R.S., Ton D.R., Hanson C.T., Murphy B.R., Whitehead S.S.;
RT   "Genome sequence analysis of La Crosse virus and in vitro and in vivo
RT   phenotypes.";
RL   Virol. J. 4:41-41(2007).
RN   [3]
RP   FUNCTION.
RX   PubMed=17344298; DOI=10.1128/jvi.01933-06;
RA   Blakqori G., Delhaye S., Habjan M., Blair C.D., Sanchez-Vargas I.,
RA   Olson K.E., Attarzadeh-Yazdi G., Fragkoudis R., Kohl A., Kalinke U.,
RA   Weiss S., Michiels T., Staeheli P., Weber F.;
RT   "La Crosse bunyavirus nonstructural protein NSs serves to suppress the type
RT   I interferon system of mammalian hosts.";
RL   J. Virol. 81:4991-4999(2007).
CC   -!- FUNCTION: Inhibits host transcriptional machinery, by producing
CC       modifications to the phosphorylation state of the C-terminal domain
CC       (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the
CC       heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II,
CC       suggesting that the elongation step of transcription and/or 3'-end
CC       processing is prevented. Inhibition of host transcription machinery
CC       leads to shut off of host cell protein synthesis and inhibition of the
CC       host innate immune response. NSs also seems to be involved in the
CC       nuclear relocalization of host PABP1 (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:17344298}.
CC   -!- SIMILARITY: Belongs to the orthobunyaviruses NS-S protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF528167; AAM94390.1; -; Genomic_RNA.
DR   EMBL; EF485033; ABQ12633.1; -; Viral_cRNA.
DR   RefSeq; NP_671971.1; NC_004110.1.
DR   IntAct; Q8JPQ9; 83.
DR   GeneID; 956557; -.
DR   KEGG; vg:956557; -.
DR   Proteomes; UP000008768; Genome.
DR   Proteomes; UP000121242; Genome.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   InterPro; IPR000797; Bunya_NSs.
DR   Pfam; PF01104; Bunya_NS-S; 1.
DR   PIRSF; PIRSF003954; NS-S_OrthobunV; 1.
PE   3: Inferred from homology;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Eukaryotic host transcription shutoff by virus;
KW   Host gene expression shutoff by virus; Host-virus interaction;
KW   Inhibition of eukaryotic host transcription initiation by virus;
KW   Reference proteome.
FT   CHAIN           1..92
FT                   /note="Non-structural protein NS-S"
FT                   /id="PRO_0000397187"
SQ   SEQUENCE   92 AA;  10467 MW;  034D8B31E8C6D348 CRC64;
     MMSHQQVQMD LILMQGIWTS VLKMQNYSTL LQLGSSSSMP QRPRLLSRVS QRGRLTLNLE
     SGRWRLSIII FLETGTTQLV TTILPSTDYL GI
//