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Q8JPQ9

- NSS_BUNL8

UniProt

Q8JPQ9 - NSS_BUNL8

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Protein
Non-structural protein NS-S
Gene
N
Organism
Bunyavirus La Crosse (isolate Human/United States/L78/1978)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 By similarity.1 Publication

GO - Biological processi

  1. suppression by virus of host transcription initiation from RNA polymerase II promoter Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of eukaryotic host transcription initiation by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein NS-S
Gene namesi
Name:N
OrganismiBunyavirus La Crosse (isolate Human/United States/L78/1978)
Taxonomic identifieri796210 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
Virus hostiCervidae (deer) [TaxID: 9850]
Homo sapiens (Human) [TaxID: 9606]
Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
Tamias [TaxID: 13712]
ProteomesiUP000008768: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Non-structural protein NS-S
PRO_0000397187Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ8JPQ9. 83 interactions.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 384Poly-Ser

Sequence similaritiesi

Family and domain databases

InterProiIPR000797. Bunya_NSs.
[Graphical view]
PfamiPF01104. Bunya_NS-S. 1 hit.
[Graphical view]
PIRSFiPIRSF003954. NS-S_OrthobunV. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8JPQ9-1 [UniParc]FASTAAdd to Basket

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MMSHQQVQMD LILMQGIWTS VLKMQNYSTL LQLGSSSSMP QRPRLLSRVS   50
QRGRLTLNLE SGRWRLSIII FLETGTTQLV TTILPSTDYL GI 92
Length:92
Mass (Da):10,467
Last modified:October 1, 2002 - v1
Checksum:i034D8B31E8C6D348
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF528167 Genomic RNA. Translation: AAM94390.1.
EF485033 Viral cRNA. Translation: ABQ12633.1.
RefSeqiNP_671971.1. NC_004110.1.

Genome annotation databases

GeneIDi956557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF528167 Genomic RNA. Translation: AAM94390.1 .
EF485033 Viral cRNA. Translation: ABQ12633.1 .
RefSeqi NP_671971.1. NC_004110.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8JPQ9. 83 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956557.

Family and domain databases

InterProi IPR000797. Bunya_NSs.
[Graphical view ]
Pfami PF01104. Bunya_NS-S. 1 hit.
[Graphical view ]
PIRSFi PIRSF003954. NS-S_OrthobunV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the Bunyavirus, La Crosse virus, Human/78 strain."
    Hughes M.T., Kempf B.J., Blair C.D., Beaty B.J.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes."
    Bennett R.S., Ton D.R., Hanson C.T., Murphy B.R., Whitehead S.S.
    Virol. J. 4:41-41(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts."
    Blakqori G., Delhaye S., Habjan M., Blair C.D., Sanchez-Vargas I., Olson K.E., Attarzadeh-Yazdi G., Fragkoudis R., Kohl A., Kalinke U., Weiss S., Michiels T., Staeheli P., Weber F.
    J. Virol. 81:4991-4999(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNSS_BUNL8
AccessioniPrimary (citable) accession number: Q8JPQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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