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Q8JPQ9

- NSS_BUNL8

UniProt

Q8JPQ9 - NSS_BUNL8

Protein

Non-structural protein NS-S

Gene

N

Organism
Bunyavirus La Crosse (isolate Human/United States/L78/1978)
Status
Reviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
  1. Functioni

    Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 By similarity.By similarity

    GO - Biological processi

    1. suppression by virus of host gene expression Source: UniProtKB-KW

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of eukaryotic host transcription initiation by virus

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein NS-S
    Gene namesi
    Name:N
    OrganismiBunyavirus La Crosse (isolate Human/United States/L78/1978)
    Taxonomic identifieri796210 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeOrthobunyavirus
    Virus hostiCervidae (deer) [TaxID: 9850]
    Homo sapiens (Human) [TaxID: 9606]
    Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus) [TaxID: 7162]
    Tamias [TaxID: 13712]
    ProteomesiUP000008768: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9292Non-structural protein NS-SPRO_0000397187Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiQ8JPQ9. 83 interactions.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi35 – 384Poly-Ser

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR000797. Bunya_NSs.
    [Graphical view]
    PfamiPF01104. Bunya_NS-S. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003954. NS-S_OrthobunV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8JPQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSHQQVQMD LILMQGIWTS VLKMQNYSTL LQLGSSSSMP QRPRLLSRVS   50
    QRGRLTLNLE SGRWRLSIII FLETGTTQLV TTILPSTDYL GI 92
    Length:92
    Mass (Da):10,467
    Last modified:October 1, 2002 - v1
    Checksum:i034D8B31E8C6D348
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF528167 Genomic RNA. Translation: AAM94390.1.
    EF485033 Viral cRNA. Translation: ABQ12633.1.
    RefSeqiNP_671971.1. NC_004110.1.

    Genome annotation databases

    GeneIDi956557.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF528167 Genomic RNA. Translation: AAM94390.1 .
    EF485033 Viral cRNA. Translation: ABQ12633.1 .
    RefSeqi NP_671971.1. NC_004110.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8JPQ9. 83 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 956557.

    Family and domain databases

    InterProi IPR000797. Bunya_NSs.
    [Graphical view ]
    Pfami PF01104. Bunya_NS-S. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003954. NS-S_OrthobunV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of the Bunyavirus, La Crosse virus, Human/78 strain."
      Hughes M.T., Kempf B.J., Blair C.D., Beaty B.J.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes."
      Bennett R.S., Ton D.R., Hanson C.T., Murphy B.R., Whitehead S.S.
      Virol. J. 4:41-41(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts."
      Blakqori G., Delhaye S., Habjan M., Blair C.D., Sanchez-Vargas I., Olson K.E., Attarzadeh-Yazdi G., Fragkoudis R., Kohl A., Kalinke U., Weiss S., Michiels T., Staeheli P., Weber F.
      J. Virol. 81:4991-4999(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNSS_BUNL8
    AccessioniPrimary (citable) accession number: Q8JPQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3