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Q8JPQ9 (NSS_BUNL8) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Inhibits host transcriptional machinery, by producing modifications to the phosphorylation state of the C-terminal domain (CTD) of RNA polymerase II. Inhibits phosphorylation at serine 2 in the heptapeptide repeat (YSPTSPS) of the CTD of RNA polymerase II, suggesting that the elongation step of transcription and/or 3'-end processing is prevented. Inhibition of host transcription machinery leads to shut off of host cell protein synthesis and inhibition of the host innate immune response. NSs also seems to be involved in the nuclear relocalization of host PABP1 By similarity. Ref.3

Sequence similarities

Belongs to the orthobunyaviruses NS-S protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9292Non-structural protein NS-S
PRO_0000397187

Regions

Compositional bias35 – 384Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
Q8JPQ9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 034D8B31E8C6D348

FASTA9210,467
        10         20         30         40         50         60 
MMSHQQVQMD LILMQGIWTS VLKMQNYSTL LQLGSSSSMP QRPRLLSRVS QRGRLTLNLE 

        70         80         90 
SGRWRLSIII FLETGTTQLV TTILPSTDYL GI 

« Hide

References

[1]"Complete sequence of the Bunyavirus, La Crosse virus, Human/78 strain."
Hughes M.T., Kempf B.J., Blair C.D., Beaty B.J.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes."
Bennett R.S., Ton D.R., Hanson C.T., Murphy B.R., Whitehead S.S.
Virol. J. 4:41-41(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts."
Blakqori G., Delhaye S., Habjan M., Blair C.D., Sanchez-Vargas I., Olson K.E., Attarzadeh-Yazdi G., Fragkoudis R., Kohl A., Kalinke U., Weiss S., Michiels T., Staeheli P., Weber F.
J. Virol. 81:4991-4999(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF528167 Genomic RNA. Translation: AAM94390.1.
EF485033 Viral cRNA. Translation: ABQ12633.1.
RefSeqNP_671971.1. NC_004110.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8JPQ9. 83 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID956557.

Family and domain databases

InterProIPR000797. Bunya_NSs.
[Graphical view]
PfamPF01104. Bunya_NS-S. 1 hit.
[Graphical view]
PIRSFPIRSF003954. NS-S_OrthobunV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNSS_BUNL8
AccessionPrimary (citable) accession number: Q8JPQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 1, 2002
Last modified: December 11, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families