Q8JP02 (ICP47_CHV1E) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ICP47 protein

Alternative name(s):
Immediate-early protein IE12
Immediate-early-5
Infected cell protein 47
US12 protein
Vmw12

Gene names

Name:

US12

Organism

Cercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus)

Taxonomic identifier

260965 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Cercopithecine herpesvirus 1

Virus host

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Macaca mulatta (Rhesus macaque) [TaxID: 9544]
Macaca nemestrina (Pig-tailed macaque) [TaxID: 9545]

Protein attributes

Sequence length	81 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules in the endoplasmic reticulum. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes By similarity.
Subcellular location	Host cytoplasm By similarity.
Domain	The N-terminal active domain blocks peptide binding to and peptide transport by TAP By similarity.
Sequence similarities	Belongs to the herpesviridae US12 family.

Ontologies

Keywords
Biological process	Host-virus interaction Inhibition of host TAP by virus Inhibition of host adaptive immune response by virus Viral immunoevasion
Cellular component	Host cytoplasm
Developmental stage	Early protein
Gene Ontology (GO)
Biological_process	suppression by virus of host TAP complex Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 81	81	ICP47 protein		PRO_0000115812
Regions
	Region	3 – 36	34	Active domain
Experimental info
	Sequence conflict	4 – 7	4	RYLA → GTWS in BAB83760. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8JP02 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: CBD78EB9C31100D1	FASTA	81	8,946
	10 20 30 40 50 60 MSSRYLAAVD DYLHHPSPRY QAHVDLRREL RAYADEERRE AARAIAHPER PLLPPPATQA 70 80 APPQPSTREA AHPSAPTAAS S

References

[1]	"Comparison of ICP47 homologs from the primate simplexviruses." Bigger J.E., Martin D.W. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence and comparative analysis of the genome of herpes B virus (Cercopithecine herpesvirus 1) from a rhesus monkey." Perelygina L., Zhu L., Zurkuhlen H., Mills R., Borodovsky M., Hilliard J.K. J. Virol. 77:6167-6177(2003) [PubMed] [Europe PMC] [Abstract] Cited for: COMPLETE GENOME.
[3]	"Sequence and genetic arrangement of the U(S) region of the monkey B virus (cercopithecine herpesvirus 1) genome and comparison with the U(S) regions of other primate herpesviruses." Ohsawa K., Black D.H., Sato H., Eberle R. J. Virol. 76:1516-1520(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-81.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF533542 Genomic DNA. Translation: AAM97357.1. AF533768 Genomic DNA. Translation: AAP41490.1. AB074432 Genomic DNA. Translation: BAB83760.1.
RefSeq	NP_851932.1. NC_004812.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1487466.
Phylogenomic databases
ProtClustDB	CLSP2512680.
Family and domain databases
InterPro	IPR008026. Herpes_ICP47. IPR020165. Herpes_US12_simplexvirus. [Graphical view]
Pfam	PF05363. Herpes_US12. 1 hit. [Graphical view]
ProDom	PD751135. Herpes_US2_simplexvirus. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ICP47_CHV1E

Accession

Primary (citable) accession number: Q8JP02
Secondary accession number(s): Q8V717

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program