UniProtKB - Q8JP02 (ICP47_CHV1E)
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Protein
ICP47 protein
Gene
US12
Organism
Cercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus)
Status
Functioni
Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.By similarity
GO - Biological processi
- suppression by virus of host TAP complex Source: UniProtKB-KW
Keywordsi
| Biological process | Host-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host TAP by virus, Viral immunoevasion |
Names & Taxonomyi
| Protein namesi | Recommended name: ICP47 proteinAlternative name(s): Immediate-early protein IE12 Immediate-early-5 Infected cell protein 47 US12 protein Vmw12 |
| Gene namesi | Name:US12 |
| Organismi | Cercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus) |
| Taxonomic identifieri | 260965 [NCBI] |
| Taxonomic lineagei | Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
| Virus hosti | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541] Macaca mulatta (Rhesus macaque) [TaxID: 9544] Macaca nemestrina (Pig-tailed macaque) [TaxID: 9545] |
Subcellular locationi
- Host cytoplasm By similarity
- Host nucleus By similarity
GO - Cellular componenti
- host cell cytoplasm Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host cytoplasm, Host nucleusPTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000115812 | 1 – 81 | ICP47 proteinAdd BLAST | 81 |
Interactioni
Subunit structurei
Interacts with host TAP1 and TAP2; these interactions inhibit the loading of peptides onto MHC class I molecules.By similarity
Family & Domainsi
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 3 – 36 | Active domainBy similarityAdd BLAST | 34 |
Domaini
The N-terminal active domain blocks peptide binding to and peptide transport by TAP.By similarity
Sequence similaritiesi
Belongs to the herpesviridae US12 family.Curated
Family and domain databases
| InterProi | View protein in InterPro IPR008026. Herpes_ICP47. IPR020165. Herpes_US12_simplexvirus. |
| Pfami | View protein in Pfam PF05363. Herpes_US12. 1 hit. |
| ProDomi | View protein in ProDom or Entries sharing at least one domain PD751135. Herpes_US2_simplexvirus. 1 hit. |
Sequencei
Sequence statusi: Complete.
Q8JP02-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSRYLAAVD DYLHHPSPRY QAHVDLRREL RAYADEERRE AARAIAHPER
60 70 80
PLLPPPATQA APPQPSTREA AHPSAPTAAS S
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 4 – 7 | RYLA → GTWS in BAB83760 (PubMed:11773425).Curated | 4 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF533542 Genomic DNA. Translation: AAM97357.1. AF533768 Genomic DNA. Translation: AAP41490.1. AB074432 Genomic DNA. Translation: BAB83760.1. |
| RefSeqi | NP_851932.1. NC_004812.1. |
Genome annotation databases
| GeneIDi | 1487466. |
| KEGGi | vg:1487466. |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | ICP47_CHV1E | |
| Accessioni | Q8JP02Primary (citable) accession number: Q8JP02 Secondary accession number(s): Q8V717 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
| Last sequence update: | October 1, 2002 | |
| Last modified: | January 20, 2016 | |
| This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Viral Protein Annotation Program | |
