Reviewed, UniProtKB/Swiss-Prot Q8JP02 (ICP47_CHV1E)

Names and origin

Protein names

Recommended name:
    ICP47 protein
Alternative name(s):
    Infected cell protein 47
    Immediate-early protein IE12
    Immediate-early-5
    Vmw12
    US12 protein

Gene names

Name:

US12

Organism

Cercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus)

Taxonomic identifier

260965 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus

Virus host

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Macaca mulatta (Rhesus macaque) [TaxID: 9544]
Macaca nemestrina (Pig-tailed macaque) [TaxID: 9545]

Protein attributes

Sequence length	81 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules in the endoplasmic reticulum. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes By similarity.
Subcellular location	Host cytoplasm By similarity.
Domain	The N-terminal active domain blocks peptide binding to and peptide transport by TAP By similarity.
Sequence similarities	Belongs to the herpesviridae US12 family.

Ontologies

Keywords
Biological process	Viral immunoevasion
Cellular component	Host cytoplasm
Developmental stage	Early protein
Gene Ontology (GO)
Biological process	evasion by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 81	81	ICP47 protein		PRO_0000115812
Regions
	Region	3 – 36	34	Active domain
Experimental info
	Sequence conflict	4 – 7	4	RYLA → GTWS in BAB83760. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8JP02-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: CBD78EB9C31100D1	FASTA	81	8,946
	10 20 30 40 50 60 MSSRYLAAVD DYLHHPSPRY QAHVDLRREL RAYADEERRE AARAIAHPER PLLPPPATQA 70 80 APPQPSTREA AHPSAPTAAS S

References

[1]	"Comparison of ICP47 homologs from the primate simplexviruses." Bigger J.E., Martin D.W. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete Sequence and Comparative Analysis of the Genome of Herpes B Virus (Cercopithecine Herpesvirus 1) from a Rhesus Monkey." Perelygina L., Zhu L., Zurkuhlen H., Mills R., Borodovsky M., Hilliard J.K. J. Virol. 77:6167-6177(2003) [PubMed: 12743273] [Abstract] Cited for: COMPLETE GENOME.
[3]	"Sequence and genetic arrangement of the U(S) region of the monkey B virus (cercopithecine herpesvirus 1) genome and comparison with the U(S) regions of other primate herpesviruses." Ohsawa K., Black D.H., Sato H., Eberle R. J. Virol. 76:1516-1520(2002) [PubMed: 11773425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-81.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF533542 Genomic DNA. Translation: AAM97357.1. AF533768 Genomic DNA. Translation: AAP41490.1. AB074432 Genomic DNA. Translation: BAB83760.1.
RefSeq	NP_851932.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1487466.
Family and domain databases
InterPro	IPR020165. Herpes_US12_simplexvirus. [Graphical view]
ProDom	PD751135. Herpes_US2_simplexvirus. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ICP47_CHV1E

Accession

Primary (citable) accession number: Q8JP02
Secondary accession number(s): Q8V717

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	October 1, 2002
Last modified:	November 24, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)