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Protein

ICP47 protein

Gene

US12

Organism
Cercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host TAP by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
ICP47 protein
Alternative name(s):
Immediate-early protein IE12
Immediate-early-5
Infected cell protein 47
US12 protein
Vmw12
Gene namesi
Name:US12
OrganismiCercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus)
Taxonomic identifieri260965 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Macaca mulatta (Rhesus macaque) [TaxID: 9544]
Macaca nemestrina (Pig-tailed macaque) [TaxID: 9545]

Subcellular locationi

  • Host cytoplasm By similarity
  • Host nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001158121 – 81ICP47 proteinAdd BLAST81

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with host TAP1 and TAP2; these interactions inhibit the loading of peptides onto MHC class I molecules.By similarity

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 36Active domainBy similarityAdd BLAST34

Domaini

The N-terminal active domain blocks peptide binding to and peptide transport by TAP.By similarity

Sequence similaritiesi

Belongs to the herpesviridae US12 family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR008026. Herpes_ICP47.
IPR020165. Herpes_US12_simplexvirus.
PfamiView protein in Pfam
PF05363. Herpes_US12. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD751135. Herpes_US2_simplexvirus. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8JP02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRYLAAVD DYLHHPSPRY QAHVDLRREL RAYADEERRE AARAIAHPER
60 70 80
PLLPPPATQA APPQPSTREA AHPSAPTAAS S
Length:81
Mass (Da):8,946
Last modified:October 1, 2002 - v1
Checksum:iCBD78EB9C31100D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 7RYLA → GTWS in BAB83760 (PubMed:11773425).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533542 Genomic DNA. Translation: AAM97357.1.
AF533768 Genomic DNA. Translation: AAP41490.1.
AB074432 Genomic DNA. Translation: BAB83760.1.
RefSeqiNP_851932.1. NC_004812.1.

Genome annotation databases

GeneIDi1487466.
KEGGivg:1487466.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiICP47_CHV1E
AccessioniPrimary (citable) accession number: Q8JP02
Secondary accession number(s): Q8V717
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: October 1, 2002
Last modified: January 20, 2016
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families