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Q8JLG4

- PAP1_ECTVM

UniProt

Q8JLG4 - PAP1_ECTVM

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Protein
Poly(A) polymerase catalytic subunit
Gene
PAPL, EVM041
Organism
Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei202 – 2021 By similarity
Active sitei204 – 2041 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:EVM041
OrganismiEctromelia virus (strain Moscow) (ECTV) (Mousepox virus)
Taxonomic identifieri265874 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Poly(A) polymerase catalytic subunit
PRO_0000308932Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8JLG4.
SMRiQ8JLG4. Positions 12-479.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8JLG4-1 [UniParc]FASTAAdd to Basket

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MNRNPDQNTL PNITLKIIET YLGRLPSVNE YHMLKLQTRN IQKITVFNKD    50
IFVSLVKKNK KRFFSDVDTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL 100
QSVLVTTYTD ILGVLTIKAP NVISSKISYN VTSMEELARD MLNSMNVAVI 150
DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN KSCICYGSYS LYLINPNIRY 200
GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY MVIKDENDNH 250
IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK 300
DPEKFNARMA TMLEYVRYTH GIVFDGTRNN MPMKCIIDEN TRIVTVTTKD 350
YFSFKKCLVY LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF 400
SNTILLSDKG TVHEISARGL CAHILLYQML TSGEYKQCLS DLLNSMMNRD 450
KIPIYSHTER DKKPGRHGFI NIEKDIIVF 479
Length:479
Mass (Da):55,509
Last modified:October 1, 2002 - v1
Checksum:i78C31F515367CE03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012825 Genomic DNA. Translation: AAM92345.1.
RefSeqiNP_671559.1. NC_004105.1.

Genome annotation databases

GeneIDi951503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF012825 Genomic DNA. Translation: AAM92345.1 .
RefSeqi NP_671559.1. NC_004105.1.

3D structure databases

ProteinModelPortali Q8JLG4.
SMRi Q8JLG4. Positions 12-479.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 951503.

Family and domain databases

InterProi IPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view ]
Pfami PF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genomic sequence of Ectromelia virus, the causative agent of mousepox."
    Chen N., Danila M.I., Feng Z., Buller R.M., Wang C., Han X., Lefkowitz E.J., Upton C.
    Virology 317:165-186(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPAP1_ECTVM
AccessioniPrimary (citable) accession number: Q8JLG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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