Reviewed, UniProtKB/Swiss-Prot Q8JLF5 (GLRX1_ECTVM)

Names and origin

Protein names

Recommended name:
    Glutaredoxin-1

Gene names

Ordered Locus Names:

EVM053

Organism

Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)

Taxonomic identifier

265874 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus

Virus host

Mus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has thioltransferase and dehydroascorbate reductase activities By similarity.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Redox-active center
PTM	Disulfide bond
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 108

108

Glutaredoxin-1

PRO_0000141624

Regions

Domain

3 – 106

104

Glutaredoxin

Amino acid modifications

Disulfide bond

23 ↔ 26

Redox-active By similarity

Secondary structure

1

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108

Helix Strand Turn

Details...

Helix

2 – 7

6

Beta strand

15 – 19

5

Helix

24 – 33

10

Beta strand

42 – 47

6

Helix

48 – 50

3

Beta strand

51 – 53

3

Helix

54 – 65

12

Beta strand

72 – 75

4

Beta strand

78 – 82

5

Helix

83 – 91

9

Helix

95 – 101

7

Sequences

	Sequence		Length	Mass (Da)
	Q8JLF5-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 92BA76087D7F54D4	FASTA	108	12,327
	10 20 30 40 50 60 MAEEFVQQRL ANNKVTIFVK YTCPFCRNAL DILNKFSFKR GAYEIVDIKE FKPENELRDY 70 80 90 100 FEQITGGKTV PRIFFGKTSI GGYSDLLEID NMDALGDILS SIGVLRTC

References

[1]	"The genomic sequence of ectromelia virus, the causative agent of mousepox." Chen N., Danila M.I., Feng Z., Buller R.M., Wang C., Han X., Lefkowitz E.J., Upton C. Virology 317:165-186(2003) [PubMed: 14675635] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF012825 Genomic DNA. Translation: AAM92357.1.

RefSeq

NP_671571.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HZE	X-ray	1.80	A	1-108	[»]
			B	1-108	[»]
2HZF	X-ray	1.80	A/B	1-108	[»]

ModBase

Search...

Genome annotation databases

GeneID

951620.

Family and domain databases

InterPro

IPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR014025. Glutaredoxin_sub.
IPR011899. GRX_euk.
IPR012335. Thioredoxin_fold.
[Graphical view]

Gene3D

G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.

Pfam

PF00462. Glutaredoxin. 1 hit.
[Graphical view]

PRINTS

PR00160. GLUTAREDOXIN.

TIGRFAMs

TIGR02180. GRX_euk. 1 hit.

PROSITE

PS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

GLRX1_ECTVM

Accession

Primary (citable) accession number: Q8JLF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	October 1, 2002
Last modified:	May 26, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)