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Protein
Submitted name:

Insulin-like growth factor 2

Gene

igf2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • insulin-like growth factor receptor binding Source: ZFIN

GO - Biological processi

  • fin regeneration Source: ZFIN
  • forebrain development Source: ZFIN
  • notochord development Source: ZFIN
  • pronephros development Source: ZFIN
  • somitogenesis Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-DRE-2428928. IRS-related events triggered by IGF1R.
R-DRE-2428933. SHC-related events triggered by IGF1R.
R-DRE-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor 2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:igf2bImported
Synonyms:igf2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 25

Organism-specific databases

ZFINiZDB-GENE-030131-2935. igf2b.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000033307.

Interactioni

GO - Molecular functioni

  • insulin-like growth factor receptor binding Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000047568.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 108IlGFInterPro annotationAdd BLAST58

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IY3P. Eukaryota.
ENOG4111KP2. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
KOiK13769.
OMAiALQFVCE.
OrthoDBiEOG091G0H56.
TreeFamiTF332820.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JIE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDQLKHHSV CHTCSRTDSF VNKVIKMFWS IRMPICILFL TLSAFEVASA
60 70 80 90 100
ETLCGGELVD ALQFVCEDRG FYFSRPTSRS NSRRSQNRGI VEECCFSSCN
110 120 130 140 150
LALLEQYCAK PAKSERDVSA TSLQVIPVMP ALKQEVPRKH VTVKYSKYDV
160 170 180 190 200
WQRKAAQRLR RGIPAILRAK KFRRQAERIK AQEQLLHHRP LITLPSKLPP
210
ILLPTENYVS HK
Length:212
Mass (Da):24,372
Last modified:October 1, 2002 - v1
Checksum:i77CBF5C0DE94DEB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954320 Genomic DNA. No translation available.
AF250289 mRNA. Translation: AAM75746.1.
RefSeqiNP_001001815.1. NM_001001815.1.
UniGeneiDr.78546.

Genome annotation databases

EnsembliENSDART00000047569; ENSDARP00000047568; ENSDARG00000033307.
GeneIDi324215.
KEGGidre:324215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954320 Genomic DNA. No translation available.
AF250289 mRNA. Translation: AAM75746.1.
RefSeqiNP_001001815.1. NM_001001815.1.
UniGeneiDr.78546.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000047568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000047569; ENSDARP00000047568; ENSDARG00000033307.
GeneIDi324215.
KEGGidre:324215.

Organism-specific databases

CTDi324215.
ZFINiZDB-GENE-030131-2935. igf2b.

Phylogenomic databases

eggNOGiENOG410IY3P. Eukaryota.
ENOG4111KP2. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
KOiK13769.
OMAiALQFVCE.
OrthoDBiEOG091G0H56.
TreeFamiTF332820.

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-DRE-2428928. IRS-related events triggered by IGF1R.
R-DRE-2428933. SHC-related events triggered by IGF1R.
R-DRE-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Gene expression databases

BgeeiENSDARG00000033307.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8JIE4_DANRE
AccessioniPrimary (citable) accession number: Q8JIE4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.