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Protein

Cysteine-rich venom protein triflin

Gene
N/A
Organism
Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Blocks contraction of smooth muscle elicited by high potassium-induced depolarization (PubMed:12047379). May target voltage-gated calcium channels (Cav) on smooth muscle.1 Publication

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Protein family/group databases

TCDBi8.B.9.1.1. the triflin toxin (triflin or crisp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich venom protein triflin
Short name:
CRVP
OrganismiProtobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Taxonomic identifieri88087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeProtobothrops

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000000628720 – 240Cysteine-rich venom protein triflinAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 153PROSITE-ProRule annotation1 Publication
Disulfide bondi92 ↔ 167PROSITE-ProRule annotation1 Publication
Disulfide bondi148 ↔ 164PROSITE-ProRule annotation1 Publication
Disulfide bondi186 ↔ 193PROSITE-ProRule annotation1 Publication
Disulfide bondi189 ↔ 198PROSITE-ProRule annotation1 Publication
Disulfide bondi202 ↔ 235PROSITE-ProRule annotation1 Publication
Disulfide bondi211 ↔ 229PROSITE-ProRule annotation1 Publication
Disulfide bondi220 ↔ 233PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Forms a stable, non-covalent complex with SSP-2.1 Publication

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 25Combined sources5
Helixi31 – 45Combined sources15
Beta strandi52 – 54Combined sources3
Helixi62 – 72Combined sources11
Helixi82 – 85Combined sources4
Beta strandi93 – 101Combined sources9
Helixi105 – 113Combined sources9
Helixi114 – 118Combined sources5
Turni121 – 123Combined sources3
Beta strandi124 – 127Combined sources4
Helixi133 – 138Combined sources6
Beta strandi145 – 152Combined sources8
Beta strandi156 – 168Combined sources13
Turni173 – 177Combined sources5
Beta strandi182 – 184Combined sources3
Turni185 – 188Combined sources4
Beta strandi192 – 194Combined sources3
Helixi211 – 217Combined sources7
Helixi223 – 228Combined sources6
Helixi230 – 234Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WVRX-ray2.40A20-240[»]
ProteinModelPortaliQ8JI39.
SMRiQ8JI39.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8JI39.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 166SCPAdd BLAST128
Domaini202 – 235ShKTPROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated
Contains 1 ShKT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004184.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JI39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAFIVLPIL AAVLQQSSGN VDFDSESPRK PEIQNEIIDL HNSLRRSVNP
60 70 80 90 100
TASNMLKMEW YPEAAANAER WAYRCIESHS SRDSRVIGGI KCGENIYMAT
110 120 130 140 150
YPAKWTDIIH AWHGEYKDFK YGVGAVPSDA VIGHYTQIVW YKSYRAGCAA
160 170 180 190 200
AYCPSSKYSY FYVCQYCPAG NIIGKTATPY KSGPPCGDCP SDCDNGLCTN
210 220 230 240
PCTRENEFTN CDSLVQKSSC QDNYMKSKCP ASCFCQNKII
Length:240
Mass (Da):26,752
Last modified:October 1, 2002 - v1
Checksum:i1EE3C9C426D974A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384219 mRNA. Translation: AAM45665.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384219 mRNA. Translation: AAM45665.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WVRX-ray2.40A20-240[»]
ProteinModelPortaliQ8JI39.
SMRiQ8JI39.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.9.1.1. the triflin toxin (triflin or crisp) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004184.

Miscellaneous databases

EvolutionaryTraceiQ8JI39.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRVP_PROFL
AccessioniPrimary (citable) accession number: Q8JI39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.