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Protein

Thrombospondin-3a

Gene

thbs3a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • heparin binding Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • extracellular matrix organization Source: InterPro
  • mesenchymal to epithelial transition Source: ZFIN
  • somite development Source: ZFIN

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-3a
Short name:
Thbs3a
Gene namesi
Name:thbs3a
Synonyms:thbs3, tsp3
ORF Names:zgc:103461
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-020708-3 thbs3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003585124 – 962Thrombospondin-3aAdd BLAST939

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi269InterchainPROSITE-ProRule annotationBy similarity
Disulfide bondi272InterchainPROSITE-ProRule annotationBy similarity
Disulfide bondi281 ↔ 292PROSITE-ProRule annotationBy similarity
Disulfide bondi286 ↔ 303PROSITE-ProRule annotationBy similarity
Disulfide bondi306 ↔ 317PROSITE-ProRule annotationBy similarity
Glycosylationi313N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi323 ↔ 335PROSITE-ProRule annotationBy similarity
Disulfide bondi329 ↔ 344PROSITE-ProRule annotationBy similarity
Disulfide bondi347 ↔ 371PROSITE-ProRule annotationBy similarity
Disulfide bondi377 ↔ 390PROSITE-ProRule annotationBy similarity
Disulfide bondi384 ↔ 399PROSITE-ProRule annotationBy similarity
Disulfide bondi402 ↔ 414PROSITE-ProRule annotationBy similarity
Glycosylationi409N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi420 ↔ 434PROSITE-ProRule annotationBy similarity
Disulfide bondi428 ↔ 444PROSITE-ProRule annotationBy similarity
Disulfide bondi446 ↔ 457PROSITE-ProRule annotationBy similarity
Disulfide bondi473 ↔ 480PROSITE-ProRule annotationBy similarity
Disulfide bondi485 ↔ 505PROSITE-ProRule annotationBy similarity
Disulfide bondi521 ↔ 541PROSITE-ProRule annotationBy similarity
Disulfide bondi544 ↔ 564PROSITE-ProRule annotationBy similarity
Disulfide bondi580 ↔ 600PROSITE-ProRule annotationBy similarity
Disulfide bondi603 ↔ 623PROSITE-ProRule annotationBy similarity
Disulfide bondi641 ↔ 661PROSITE-ProRule annotationBy similarity
Glycosylationi646N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi684 ↔ 704PROSITE-ProRule annotationBy similarity
Glycosylationi710N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi720 ↔ 941PROSITE-ProRule annotationBy similarity
Glycosylationi942N-linked (GlcNAc...) asparagineCurated1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8JHW2
PRIDEiQ8JHW2

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Present at the gastrulation and post-segmentation stages.1 Publication

Interactioni

Subunit structurei

Oligomer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000057304

Structurei

3D structure databases

ProteinModelPortaliQ8JHW2
SMRiQ8JHW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 196Laminin G-likeAdd BLAST173
Domaini277 – 318EGF-like 1PROSITE-ProRule annotationCuratedAdd BLAST42
Domaini319 – 358EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini373 – 412EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini416 – 458EGF-like 4PROSITE-ProRule annotationCuratedAdd BLAST43
Repeati459 – 493TSP type-3 1Add BLAST35
Repeati494 – 529TSP type-3 2Add BLAST36
Repeati530 – 552TSP type-3 3Add BLAST23
Repeati553 – 588TSP type-3 4Add BLAST36
Repeati589 – 611TSP type-3 5Add BLAST23
Repeati612 – 649TSP type-3 6Add BLAST38
Repeati650 – 692TSP type-3 7Add BLAST43
Repeati693 – 728TSP type-3 8Add BLAST36
Domaini732 – 946TSP C-terminalPROSITE-ProRule annotationAdd BLAST215

Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
HOGENOMiHOG000007542
HOVERGENiHBG000636
InParanoidiQ8JHW2
KOiK04659
PhylomeDBiQ8JHW2

Family and domain databases

Gene3Di4.10.1080.10, 3 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR024665 Thbs/COMP_coiled-coil
IPR037349 Thrombospondin
IPR028507 Thrombospondin-3
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR028974 TSP_type-3_rpt
PANTHERiPTHR10199 PTHR10199, 1 hit
PTHR10199:SF89 PTHR10199:SF89, 1 hit
PfamiView protein in Pfam
PF11598 COMP, 1 hit
PF07645 EGF_CA, 2 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 2 hits
SM00210 TSPN, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 2 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JHW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQMFVHIWV SLVVLMSVWS AQSDKKQDVP VIDVLGLEDV KQTVAAVEKL
60 70 80 90 100
SLALKTLSDV YVMSTFRLPP KLGGVLLGLY NKQDNKKYLE VAIMSKINKV
110 120 130 140 150
LVRYVREDGK LHTVNMQSPN VADGRPQSLI LRVGGLRREY LSLELYVNCR
160 170 180 190 200
LADSAQRLPP LVDLPRDAEL VEIRNGHKAY ARMQGSMDTL KLALGGTVAQ
210 220 230 240 250
AGALTDCPFQ GDASSYNIVN GEVNSILGDH TKALIGQLII FNQILGELRE
260 270 280 290 300
DIREQVKEMS LVRNAILECQ MCGFHEPRSR CQPNPCFKGV SCMETFEYPG
310 320 330 340 350
YRCGPCPDGM TGNGTHCQDI DECSEAQPCY TPGACVNTAR GFTCESCPPG
360 370 380 390 400
MWGPPLSGVG VEYAKSHRQE CSDIDECVDL ANACTPNSVC INIIGSFRCG
410 420 430 440 450
QCKTGYVGNQ TAGCFPRKSC SSLSFNPCDA NAHCVMQRNG DVSCACNVGW
460 470 480 490 500
AGNGHTCGKD TDIDGYPDRS LPCMDNHKHC RQDNCVYTPN SGQEDADNDG
510 520 530 540 550
IGDQCDEDAD GDGIKNVEDN CRLVSNKDQQ NSDTDSFGDA CDNCPTVPNI
560 570 580 590 600
DQKDTDSNGE GDACDDDIDG DGIQNVLDNC PKVPNPMQTD RDRDGVGDAC
610 620 630 640 650
DSCPEISNPM QTDVDNDLVG DVCDTNQDTD GDGHQDTRDN CPDIPNSSQL
660 670 680 690 700
DSDNDGIGDD CDEDDDNDGI PDNHAINGIG PDNCRLISNP NQKDSDSNGV
710 720 730 740 750
GDVCENDFDN DSVMDLVDVC PESAEVTLTD FRAYQTVILD PEGDAQIDPN
760 770 780 790 800
WVVLNQGMEI VQTMNSDPGL AVGYTAFNGV DFEGTFHVNT VTDDDCAGSI
810 820 830 840 850
FGYQDSSSFY VVMWKQTEQT YWQSIPFRAM AEPGLQLKAV KSRTGPGEFL
860 870 880 890 900
RNALWHAGDT DGEVKLLWKD PRNVGWLDKT SYRWQLSHRP QVGYIRVKLY
910 920 930 940 950
EGSEMVADSD VVIDTSMRGG RLGVFCFSQE NIIWSNLRYR CNDTVPEDFS
960
SHRKQVLMHI KV
Length:962
Mass (Da):105,591
Last modified:July 25, 2006 - v2
Checksum:i15D18A2A4E67373E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2E → K in AAM88772 (PubMed:12592708).Curated1
Sequence conflicti17S → F in AAM88772 (PubMed:12592708).Curated1
Sequence conflicti393I → T in AAM88772 (PubMed:12592708).Curated1
Sequence conflicti430A → T in AAM88772 (PubMed:12592708).Curated1
Sequence conflicti796C → Y in AAM88772 (PubMed:12592708).Curated1
Sequence conflicti799S → F in AAM88772 (PubMed:12592708).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462310 mRNA Translation: AAM88772.1
BC085524 mRNA Translation: AAH85524.1
RefSeqiNP_775332.1, NM_173225.1
UniGeneiDr.76211

Genome annotation databases

GeneIDi252849
KEGGidre:252849

Similar proteinsi

Entry informationi

Entry nameiTSP3A_DANRE
AccessioniPrimary (citable) accession number: Q8JHW2
Secondary accession number(s): Q5U3J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 25, 2006
Last modified: March 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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