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Protein

T-complex protein 1 subunit gamma

Gene

cct3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • embryonic eye morphogenesis Source: ZFIN
  • negative regulation of retinal cell programmed cell death Source: ZFIN
  • protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit gammaUniRule annotation
Gene namesi
Name:cct3Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-020419-5. cct3.

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ8JHI7.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004738.

Structurei

3D structure databases

ProteinModelPortaliQ8JHI7.
SMRiQ8JHI7. Positions 210-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0364. Eukaryota.
COG0459. LUCA.
HOVERGENiHBG104982.
KOiK09495.
PhylomeDBiQ8JHI7.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012719. Chap_CCT_gamma.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF63. PTHR11353:SF63. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02344. chap_CCT_gamma. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JHI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGRPVLVLS QNIKRESGRK VQIGNISAAK TIADIIRTCL GPRAMMKMLL
60 70 80 90 100
DPMGGIVMTN DGNAILREIQ VQHPAAKSMI EISRTQDEEV GDGTTSVIIL
110 120 130 140 150
AGEMLSVAEQ FLEQQMHPTV VIGAYRQALD DMLNILKDIS TPVDVSNRDM
160 170 180 190 200
MLKIINSAIN TKALSRWSTL ACNIALDAVR TVELDENGRE EIDIKKYAKV
210 220 230 240 250
EKVPGGIIED SCVLRGVMVN KDVTHPRMRR LIKNPRIVLL DCSLEYKKGE
260 270 280 290 300
SQTDIEIARE EDFARILQME EEYVQQICED IIRLKPDLIF TEKGISDLAQ
310 320 330 340 350
HYLMKANITA IRRIRKTDNN RIARACGARI ASRTDELTEN DVGTGTGLFE
360 370 380 390 400
VKKIGDEYFT FVTECKDPKA CTILLRGASK EILAEVERNL QDAMQVCRNV
410 420 430 440 450
LLDPYLLPGG GAVEMEVSHR LTERSRAMTG VEQWPYRAVA QALEVVPRTL
460 470 480 490 500
IQNCGASAIR VLTSLRAKHT QEGNSSWGVN GETGTLADME QLGIWEPLAV
510 520 530 540
KAQTYKTAVE TAILLLRIDD IVSGHKKKGD GEQTGGAPME DRE
Length:543
Mass (Da):60,299
Last modified:October 1, 2002 - v1
Checksum:i9465E5BA46DFCF3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506209 mRNA. Translation: AAM34653.1.
RefSeqiNP_775357.1. NM_173250.1.
UniGeneiDr.26749.

Genome annotation databases

GeneIDi192327.
KEGGidre:192327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506209 mRNA. Translation: AAM34653.1.
RefSeqiNP_775357.1. NM_173250.1.
UniGeneiDr.26749.

3D structure databases

ProteinModelPortaliQ8JHI7.
SMRiQ8JHI7. Positions 210-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004738.

Proteomic databases

PaxDbiQ8JHI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi192327.
KEGGidre:192327.

Organism-specific databases

CTDi7203.
ZFINiZDB-GENE-020419-5. cct3.

Phylogenomic databases

eggNOGiKOG0364. Eukaryota.
COG0459. LUCA.
HOVERGENiHBG104982.
KOiK09495.
PhylomeDBiQ8JHI7.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012719. Chap_CCT_gamma.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF63. PTHR11353:SF63. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02344. chap_CCT_gamma. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development."
    Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W., Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M., Hopkins N.
    Nat. Genet. 31:135-140(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8JHI7_DANRE
AccessioniPrimary (citable) accession number: Q8JHI7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.