ID   ALDOB_DANRE             Reviewed;         364 AA.
AC   Q8JH71;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 47.
DE   RecName: Full=Fructose-bisphosphate aldolase B;
DE            EC=4.1.2.13;
DE   AltName: Full=Liver-type aldolase;
GN   Name=aldob;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12486526; DOI=10.1007/s00239-002-2363-8;
RA   Merritt T.J.S., Quattro J.M.;
RT   "Negative charge correlates with neural expression in vertebrate
RT   aldolase isozymes.";
RL   J. Mol. Evol. 55:674-683(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y.,
RA   Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I.,
RA   Kanki J.P., Liu T.X., Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-fructose 1,6-bisphosphate = glycerone
CC       phosphate + D-glyceraldehyde 3-phosphate.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 4/4.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the class I fructose-bisphosphate aldolase
CC       family.
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DR   EMBL; AF533646; AAN04477.1; -; mRNA.
DR   EMBL; AY394965; AAQ94592.1; -; mRNA.
DR   EMBL; BC062830; AAH62830.1; -; mRNA.
DR   IPI; IPI00505184; -.
DR   RefSeq; NP_919348.3; -.
DR   UniGene; Dr.76309; -.
DR   HSSP; P05062; 1QO5.
DR   SMR; Q8JH71; 3-364.
DR   Ensembl; ENSDARG00000053684; Danio rerio.
DR   GeneID; 321664; -.
DR   KEGG; dre:321664; -.
DR   ZFIN; ZDB-GENE-030131-383; aldob.
DR   HOVERGEN; Q8JH71; -.
DR   OMA; Q8JH71; INQVPLH.
DR   BRENDA; 4.1.2.13; 96826.
DR   ArrayExpress; Q8JH71; -.
DR   Bgee; Q8JH71; -.
DR   GO; GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:EC.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR000741; Aldolase_I.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR11627; Aldolase_I; 1.
DR   Pfam; PF00274; Glycolytic; 1.
DR   ProDom; PD001128; Aldolase_I; 1.
DR   PROSITE; PS00158; ALDOLASE_CLASS_I; 1.
PE   2: Evidence at transcript level;
KW   Glycolysis; Lyase; Schiff base.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    364       Fructose-bisphosphate aldolase B.
FT                                /FTId=PRO_0000291611.
FT   ACT_SITE    188    188       Proton acceptor (By similarity).
FT   ACT_SITE    230    230       Schiff-base intermediate with
FT                                dihydroxyacetone-P (By similarity).
FT   BINDING      56     56       Substrate (By similarity).
FT   BINDING     147    147       Substrate (By similarity).
FT   SITE        364    364       Necessary for preference for fructose
FT                                1,6-bisphosphate over fructose 1-
FT                                phosphate (By similarity).
SQ   SEQUENCE   364 AA;  39288 MW;  FB2DD9CDDCF4DB9E CRC64;
     MTHQFPALST EQKKELATIA ERIVAPGKGI LAADESTGTM AKRFQKINVE NTEENRRSFR
     DLLFSVDDSI SESIGGVILF HETLYQKSDK GVLFPKVIKD KGIVVGIKVD KGTAGLAGTD
     GETTTQGLDG LSERCAQYKK DGCDFAKWRC VLKISDSCPS ALGIAENANV LARYASICQQ
     NGLVPIVEPE ILPDGDHDLK QCQYATEKVL AAVYKALSDH HVYLEGTLLK PNMVTAGHSC
     TKKYTPLEVA MATVTALRRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQL SLHRPWKLSF
     SYGRALQASA LSAWKGQAAN KKASQDAFVT RAKINSLASK GEYKPSGQAG QASTQSLFTA
     SYTY
//