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Q8JH71

- ALDOB_DANRE

UniProt

Q8JH71 - ALDOB_DANRE

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Protein

Fructose-bisphosphate aldolase B

Gene

aldob

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561SubstrateBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Active sitei188 – 1881Proton acceptorBy similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Liver-type aldolase
Gene namesi
Name:aldob
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-030131-383. aldob.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 364363Fructose-bisphosphate aldolase BPRO_0000291611Add
BLAST

Proteomic databases

PRIDEiQ8JH71.

Expressioni

Gene expression databases

BgeeiQ8JH71.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8JH71.
SMRiQ8JH71. Positions 3-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiQ8JH71.
KOiK01623.
OMAiDMEHCQY.
OrthoDBiEOG744T94.
PhylomeDBiQ8JH71.
TreeFamiTF314203.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JH71-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHQFPALST EQKKELATIA ERIVAPGKGI LAADESTGTM AKRFQKINVE
60 70 80 90 100
NTEENRRSFR DLLFSVDDSI SESIGGVILF HETLYQKSDK GVLFPKVIKD
110 120 130 140 150
KGIVVGIKVD KGTAGLAGTD GETTTQGLDG LSERCAQYKK DGCDFAKWRC
160 170 180 190 200
VLKISDSCPS ALGIAENANV LARYASICQQ NGLVPIVEPE ILPDGDHDLK
210 220 230 240 250
QCQYATEKVL AAVYKALSDH HVYLEGTLLK PNMVTAGHSC TKKYTPLEVA
260 270 280 290 300
MATVTALRRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQL SLHRPWKLSF
310 320 330 340 350
SYGRALQASA LSAWKGQAAN KKASQDAFVT RAKINSLASK GEYKPSGQAG
360
QASTQSLFTA SYTY
Length:364
Mass (Da):39,288
Last modified:October 1, 2002 - v1
Checksum:iFB2DD9CDDCF4DB9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF533646 mRNA. Translation: AAN04477.1.
AY394965 mRNA. Translation: AAQ94592.1.
BC062830 mRNA. Translation: AAH62830.1.
RefSeqiNP_919348.3. NM_194367.3.
UniGeneiDr.76309.

Genome annotation databases

EnsembliENSDART00000075744; ENSDARP00000070225; ENSDARG00000053684.
GeneIDi321664.
KEGGidre:321664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF533646 mRNA. Translation: AAN04477.1 .
AY394965 mRNA. Translation: AAQ94592.1 .
BC062830 mRNA. Translation: AAH62830.1 .
RefSeqi NP_919348.3. NM_194367.3.
UniGenei Dr.76309.

3D structure databases

ProteinModelPortali Q8JH71.
SMRi Q8JH71. Positions 3-364.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8JH71.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000075744 ; ENSDARP00000070225 ; ENSDARG00000053684 .
GeneIDi 321664.
KEGGi dre:321664.

Organism-specific databases

CTDi 229.
ZFINi ZDB-GENE-030131-383. aldob.

Phylogenomic databases

eggNOGi COG3588.
GeneTreei ENSGT00390000010235.
HOGENOMi HOG000220876.
HOVERGENi HBG002386.
InParanoidi Q8JH71.
KOi K01623.
OMAi DMEHCQY.
OrthoDBi EOG744T94.
PhylomeDBi Q8JH71.
TreeFami TF314203.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Miscellaneous databases

NextBioi 20807478.
PROi Q8JH71.

Gene expression databases

Bgeei Q8JH71.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Negative charge correlates with neural expression in vertebrate aldolase isozymes."
    Merritt T.J.S., Quattro J.M.
    J. Mol. Evol. 55:674-683(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney marrow.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiALDOB_DANRE
AccessioniPrimary (citable) accession number: Q8JH71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3