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Q8JH71

- ALDOB_DANRE

UniProt

Q8JH71 - ALDOB_DANRE

Protein

Fructose-bisphosphate aldolase B

Gene

aldob

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Active sitei188 – 1881Proton acceptorBy similarity
    Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase B (EC:4.1.2.13)
    Alternative name(s):
    Liver-type aldolase
    Gene namesi
    Name:aldob
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 14

    Organism-specific databases

    ZFINiZDB-GENE-030131-383. aldob.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. microtubule organizing center Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 364363Fructose-bisphosphate aldolase BPRO_0000291611Add
    BLAST

    Proteomic databases

    PRIDEiQ8JH71.

    Expressioni

    Gene expression databases

    BgeeiQ8JH71.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JH71.
    SMRiQ8JH71. Positions 3-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3588.
    GeneTreeiENSGT00390000010235.
    HOGENOMiHOG000220876.
    HOVERGENiHBG002386.
    InParanoidiQ8JH71.
    KOiK01623.
    OMAiDMEHCQY.
    OrthoDBiEOG744T94.
    PhylomeDBiQ8JH71.
    TreeFamiTF314203.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8JH71-1 [UniParc]FASTAAdd to Basket

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    MTHQFPALST EQKKELATIA ERIVAPGKGI LAADESTGTM AKRFQKINVE    50
    NTEENRRSFR DLLFSVDDSI SESIGGVILF HETLYQKSDK GVLFPKVIKD 100
    KGIVVGIKVD KGTAGLAGTD GETTTQGLDG LSERCAQYKK DGCDFAKWRC 150
    VLKISDSCPS ALGIAENANV LARYASICQQ NGLVPIVEPE ILPDGDHDLK 200
    QCQYATEKVL AAVYKALSDH HVYLEGTLLK PNMVTAGHSC TKKYTPLEVA 250
    MATVTALRRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQL SLHRPWKLSF 300
    SYGRALQASA LSAWKGQAAN KKASQDAFVT RAKINSLASK GEYKPSGQAG 350
    QASTQSLFTA SYTY 364
    Length:364
    Mass (Da):39,288
    Last modified:October 1, 2002 - v1
    Checksum:iFB2DD9CDDCF4DB9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF533646 mRNA. Translation: AAN04477.1.
    AY394965 mRNA. Translation: AAQ94592.1.
    BC062830 mRNA. Translation: AAH62830.1.
    RefSeqiNP_919348.3. NM_194367.3.
    UniGeneiDr.76309.

    Genome annotation databases

    EnsembliENSDART00000075744; ENSDARP00000070225; ENSDARG00000053684.
    GeneIDi321664.
    KEGGidre:321664.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF533646 mRNA. Translation: AAN04477.1 .
    AY394965 mRNA. Translation: AAQ94592.1 .
    BC062830 mRNA. Translation: AAH62830.1 .
    RefSeqi NP_919348.3. NM_194367.3.
    UniGenei Dr.76309.

    3D structure databases

    ProteinModelPortali Q8JH71.
    SMRi Q8JH71. Positions 3-364.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8JH71.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000075744 ; ENSDARP00000070225 ; ENSDARG00000053684 .
    GeneIDi 321664.
    KEGGi dre:321664.

    Organism-specific databases

    CTDi 229.
    ZFINi ZDB-GENE-030131-383. aldob.

    Phylogenomic databases

    eggNOGi COG3588.
    GeneTreei ENSGT00390000010235.
    HOGENOMi HOG000220876.
    HOVERGENi HBG002386.
    InParanoidi Q8JH71.
    KOi K01623.
    OMAi DMEHCQY.
    OrthoDBi EOG744T94.
    PhylomeDBi Q8JH71.
    TreeFami TF314203.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Miscellaneous databases

    NextBioi 20807478.
    PROi Q8JH71.

    Gene expression databases

    Bgeei Q8JH71.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Negative charge correlates with neural expression in vertebrate aldolase isozymes."
      Merritt T.J.S., Quattro J.M.
      J. Mol. Evol. 55:674-683(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney marrow.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiALDOB_DANRE
    AccessioniPrimary (citable) accession number: Q8JH71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3