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Q8JH71 (ALDOB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase B

EC=4.1.2.13
Alternative name(s):
Liver-type aldolase
Gene names
Name:aldob
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriolar satellite By similarity.

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
Cytoskeleton
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 364363Fructose-bisphosphate aldolase B
PRO_0000291611

Sites

Active site1881Proton acceptor By similarity
Active site2301Schiff-base intermediate with dihydroxyacetone-P By similarity
Binding site561Substrate By similarity
Binding site1471Substrate By similarity
Site3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8JH71 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: FB2DD9CDDCF4DB9E

FASTA36439,288
        10         20         30         40         50         60 
MTHQFPALST EQKKELATIA ERIVAPGKGI LAADESTGTM AKRFQKINVE NTEENRRSFR 

        70         80         90        100        110        120 
DLLFSVDDSI SESIGGVILF HETLYQKSDK GVLFPKVIKD KGIVVGIKVD KGTAGLAGTD 

       130        140        150        160        170        180 
GETTTQGLDG LSERCAQYKK DGCDFAKWRC VLKISDSCPS ALGIAENANV LARYASICQQ 

       190        200        210        220        230        240 
NGLVPIVEPE ILPDGDHDLK QCQYATEKVL AAVYKALSDH HVYLEGTLLK PNMVTAGHSC 

       250        260        270        280        290        300 
TKKYTPLEVA MATVTALRRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQL SLHRPWKLSF 

       310        320        330        340        350        360 
SYGRALQASA LSAWKGQAAN KKASQDAFVT RAKINSLASK GEYKPSGQAG QASTQSLFTA 


SYTY 

« Hide

References

« Hide 'large scale' references
[1]"Negative charge correlates with neural expression in vertebrate aldolase isozymes."
Merritt T.J.S., Quattro J.M.
J. Mol. Evol. 55:674-683(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Hematopoietic gene expression profile in zebrafish kidney marrow."
Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z.
Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney marrow.
[3]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF533646 mRNA. Translation: AAN04477.1.
AY394965 mRNA. Translation: AAQ94592.1.
BC062830 mRNA. Translation: AAH62830.1.
RefSeqNP_919348.3. NM_194367.3.
UniGeneDr.76309.

3D structure databases

ProteinModelPortalQ8JH71.
SMRQ8JH71. Positions 3-364.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8JH71.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000075744; ENSDARP00000070225; ENSDARG00000053684.
GeneID321664.
KEGGdre:321664.

Organism-specific databases

CTD229.
ZFINZDB-GENE-030131-383. aldob.

Phylogenomic databases

eggNOGCOG3588.
GeneTreeENSGT00390000010235.
HOGENOMHOG000220876.
HOVERGENHBG002386.
InParanoidQ8JH71.
KOK01623.
OMADMEHCQY.
OrthoDBEOG744T94.
PhylomeDBQ8JH71.
TreeFamTF314203.

Enzyme and pathway databases

UniPathwayUPA00109; UER00183.

Gene expression databases

BgeeQ8JH71.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20807478.
PROQ8JH71.

Entry information

Entry nameALDOB_DANRE
AccessionPrimary (citable) accession number: Q8JH71
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways