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Q8JH70

- ALDCB_DANRE

UniProt

Q8JH70 - ALDCB_DANRE

Protein

Fructose-bisphosphate aldolase C-B

Gene

aldocb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Active sitei188 – 1881Proton acceptorBy similarity
    Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase C-B (EC:4.1.2.13)
    Alternative name(s):
    Brain-type aldolase-B
    Gene namesi
    Name:aldocb
    Synonyms:aldoc
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 21

    Organism-specific databases

    ZFINiZDB-GENE-030821-1. aldocb.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 363362Fructose-bisphosphate aldolase C-BPRO_0000291612Add
    BLAST

    Proteomic databases

    PRIDEiQ8JH70.

    Expressioni

    Gene expression databases

    BgeeiQ8JH70.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000024492.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JH70.
    SMRiQ8JH70. Positions 3-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3588.
    GeneTreeiENSGT00390000010235.
    HOGENOMiHOG000220876.
    HOVERGENiHBG002386.
    InParanoidiQ8JH70.
    KOiK01623.
    OMAiRGQQDNA.
    OrthoDBiEOG744T94.
    PhylomeDBiQ8JH70.
    TreeFamiTF314203.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8JH70-1 [UniParc]FASTAAdd to Basket

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    MTHQYPALTA EQKKELQDIA QRIVAPGKGI LAADESTGSM AKRLNPIGVE    50
    NTEENRRLYR QLLFSADERI DKCIGGVIFF HETLYQNTDD GTNFAQLIKD 100
    RGIVVGIKVD KGVVPLAGTN GETTTQGLDG LSERCAQYKK DGADFAKWRS 150
    VLKISDTTPS ELAIMENANV LARYASICQQ NGIVPIVEPE ILPDGEHDLK 200
    RCQYVTEKVL AACYKALSDH HVYLEGTLLK PNMVTAGHSC PTKYSSEEIA 250
    MATVTALRRT VPPAVSGVTF LSGGQSEEEA SVNLNSINNC PLAKPWPLTF 300
    SYGRALQASA LSAWRGAKSN EKAATEEFIK RAEANGLAAQ GKYVSSGTCG 350
    AAGQSLYVAN HAY 363
    Length:363
    Mass (Da):39,259
    Last modified:October 1, 2002 - v1
    Checksum:i84D269B36579E6A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF533647 mRNA. Translation: AAN04478.1.
    BC053192 mRNA. Translation: AAH53192.1.
    RefSeqiNP_919365.1. NM_194384.1.
    UniGeneiDr.19223.

    Genome annotation databases

    EnsembliENSDART00000026766; ENSDARP00000024492; ENSDARG00000019702.
    GeneIDi369193.
    KEGGidre:369193.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF533647 mRNA. Translation: AAN04478.1 .
    BC053192 mRNA. Translation: AAH53192.1 .
    RefSeqi NP_919365.1. NM_194384.1.
    UniGenei Dr.19223.

    3D structure databases

    ProteinModelPortali Q8JH70.
    SMRi Q8JH70. Positions 3-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000024492.

    Proteomic databases

    PRIDEi Q8JH70.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000026766 ; ENSDARP00000024492 ; ENSDARG00000019702 .
    GeneIDi 369193.
    KEGGi dre:369193.

    Organism-specific databases

    CTDi 369193.
    ZFINi ZDB-GENE-030821-1. aldocb.

    Phylogenomic databases

    eggNOGi COG3588.
    GeneTreei ENSGT00390000010235.
    HOGENOMi HOG000220876.
    HOVERGENi HBG002386.
    InParanoidi Q8JH70.
    KOi K01623.
    OMAi RGQQDNA.
    OrthoDBi EOG744T94.
    PhylomeDBi Q8JH70.
    TreeFami TF314203.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Miscellaneous databases

    NextBioi 20813343.
    PROi Q8JH70.

    Gene expression databases

    Bgeei Q8JH70.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Negative charge correlates with neural expression in vertebrate aldolase isozymes."
      Merritt T.J.S., Quattro J.M.
      J. Mol. Evol. 55:674-683(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiALDCB_DANRE
    AccessioniPrimary (citable) accession number: Q8JH70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3