Q8JH70 (ALDCB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-bisphosphate aldolase C-B
EC=4.1.2.13

Alternative name(s):
Brain-type aldolase-B

Gene names

Name:	aldocb
Synonyms:	aldoc

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 363	362	Fructose-bisphosphate aldolase C-B		PRO_0000291612
Sites
	Active site	188	1	Proton acceptor By similarity
	Active site	230	1	Schiff-base intermediate with dihydroxyacetone-P By similarity
	Binding site	56	1	Substrate By similarity
	Binding site	147	1	Substrate By similarity
	Site	363	1	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8JH70 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 84D269B36579E6A0	FASTA	363	39,259
	10 20 30 40 50 60 MTHQYPALTA EQKKELQDIA QRIVAPGKGI LAADESTGSM AKRLNPIGVE NTEENRRLYR 70 80 90 100 110 120 QLLFSADERI DKCIGGVIFF HETLYQNTDD GTNFAQLIKD RGIVVGIKVD KGVVPLAGTN 130 140 150 160 170 180 GETTTQGLDG LSERCAQYKK DGADFAKWRS VLKISDTTPS ELAIMENANV LARYASICQQ 190 200 210 220 230 240 NGIVPIVEPE ILPDGEHDLK RCQYVTEKVL AACYKALSDH HVYLEGTLLK PNMVTAGHSC 250 260 270 280 290 300 PTKYSSEEIA MATVTALRRT VPPAVSGVTF LSGGQSEEEA SVNLNSINNC PLAKPWPLTF 310 320 330 340 350 360 SYGRALQASA LSAWRGAKSN EKAATEEFIK RAEANGLAAQ GKYVSSGTCG AAGQSLYVAN HAY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Negative charge correlates with neural expression in vertebrate aldolase isozymes." Merritt T.J.S., Quattro J.M. J. Mol. Evol. 55:674-683(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF533647 mRNA. Translation: AAN04478.1. BC053192 mRNA. Translation: AAH53192.1.
IPI	IPI00490850.
RefSeq	NP_919365.1. NM_194384.1.
UniGene	Dr.19223.
3D structure databases
HSSP	HSSP built from PDB template 1XDL based on UniProtKB P05062.
ProteinModelPortal	Q8JH70.
SMR	Q8JH70. Positions 3-343.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000024492.
Proteomic databases
PRIDE	Q8JH70.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000026766; ENSDARP00000024492; ENSDARG00000019702.
GeneID	369193.
KEGG	dre:369193.
Organism-specific databases
CTD	369193.
ZFIN	ZDB-GENE-030821-1. aldocb.
Phylogenomic databases
eggNOG	COG3588.
GeneTree	ENSGT00390000010235.
HOGENOM	HOG000220876.
HOVERGEN	HBG002386.
InParanoid	Q8JH70.
KO	K01623.
OMA	RGQQDNA.
OrthoDB	EOG4X3H1J.
Enzyme and pathway databases
UniPathway	UPA00109; UER00183.
Gene expression databases
Bgee	Q8JH70.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view]
PANTHER	PTHR11627. PTHR11627. 1 hit.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20813343.

Entry information

Entry name

ALDCB_DANRE

Accession

Primary (citable) accession number: Q8JH70

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program