Reviewed, UniProtKB/Swiss-Prot Q8JH70 (ALDOC_DANRE)

Names and origin

Protein names

Recommended name:
    Fructose-bisphosphate aldolase C
    EC=4.1.2.13
Alternative name(s):
    Brain-type aldolase

Gene names

Name:

aldoc

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 363	362	Fructose-bisphosphate aldolase C		PRO_0000291612
Sites
	Active site	230	1	Schiff-base intermediate with dihydroxyacetone-P By similarity
	Binding site	56	1	Substrate By similarity
	Binding site	147	1	Substrate By similarity
	Site	363	1	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8JH70-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 84D269B36579E6A0	FASTA	363	39,259
	10 20 30 40 50 60 MTHQYPALTA EQKKELQDIA QRIVAPGKGI LAADESTGSM AKRLNPIGVE NTEENRRLYR 70 80 90 100 110 120 QLLFSADERI DKCIGGVIFF HETLYQNTDD GTNFAQLIKD RGIVVGIKVD KGVVPLAGTN 130 140 150 160 170 180 GETTTQGLDG LSERCAQYKK DGADFAKWRS VLKISDTTPS ELAIMENANV LARYASICQQ 190 200 210 220 230 240 NGIVPIVEPE ILPDGEHDLK RCQYVTEKVL AACYKALSDH HVYLEGTLLK PNMVTAGHSC 250 260 270 280 290 300 PTKYSSEEIA MATVTALRRT VPPAVSGVTF LSGGQSEEEA SVNLNSINNC PLAKPWPLTF 310 320 330 340 350 360 SYGRALQASA LSAWRGAKSN EKAATEEFIK RAEANGLAAQ GKYVSSGTCG AAGQSLYVAN HAY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Negative charge correlates with neural expression in vertebrate aldolase isozymes." Merritt T.J.S., Quattro J.M. J. Mol. Evol. 55:674-683(2002) [PubMed: 12486526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF533647 mRNA. Translation: AAN04478.1. BC053192 mRNA. Translation: AAH53192.1.
IPI	IPI00490850.
RefSeq	NP_919365.1.
UniGene	Dr.19223
3D structure databases
HSSP	HSSP built from PDB template 6ALD based on UniProtKB P00883.
SMR	Q8JH70. Positions 3-363.
ModBase	Search...
Proteomic databases
PRIDE	Q8JH70.
Genome annotation databases
Ensembl	ENSDARG00000019702. Danio rerio. [Contig view]
GeneID	369193.
KEGG	dre:369193.
Organism-specific databases
ZFIN	ZDB-GENE-030821-1. aldoc.
Phylogenomic databases
HOGENOM	Q8JH70.
HOVERGEN	Q8JH70.
OMA	Q8JH70. ACPIKYT.
Enzyme and pathway databases
BRENDA	4.1.2.13. 96826.
Gene expression databases
ArrayExpress	Q8JH70.
Bgee	Q8JH70.
Family and domain databases
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11627. Aldolase_I. 1 hit.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
ProDom	PD001128. Aldolase_I. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDOC_DANRE

Accession

Primary (citable) accession number: Q8JH70

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project