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Protein

Fructose-bisphosphate aldolase C-B

Gene

aldocb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (gpib), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpib), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpib)
  3. ATP-dependent 6-phosphofructokinase (pfkla), ATP-dependent 6-phosphofructokinase (pfkmb), ATP-dependent 6-phosphofructokinase (pfklb), ATP-dependent 6-phosphofructokinase (pfkpa), ATP-dependent 6-phosphofructokinase (pfkpb), ATP-dependent 6-phosphofructokinase (pfkmb), ATP-dependent 6-phosphofructokinase (pfkla), ATP-dependent 6-phosphofructokinase (pfkma), ATP-dependent 6-phosphofructokinase (pfkpb), ATP-dependent 6-phosphofructokinase (pfklb), ATP-dependent 6-phosphofructokinase (pfkpa)
  4. Fructose-bisphosphate aldolase C-A (aldoca), Fructose-bisphosphate aldolase (aldob), Fructose-bisphosphate aldolase (aldoaa), Fructose-bisphosphate aldolase (aldoca), Fructose-bisphosphate aldolase (aldoca), Fructose-bisphosphate aldolase C-B (aldocb), Fructose-bisphosphate aldolase B (aldob), Fructose-bisphosphate aldolase (aldoab), Fructose-bisphosphate aldolase (aldoaa), Fructose-bisphosphate aldolase (aldob), Fructose-bisphosphate aldolase (aldocb)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei363Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase C-B (EC:4.1.2.13)
Alternative name(s):
Brain-type aldolase-B
Gene namesi
Name:aldocb
Synonyms:aldoc
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-030821-1. aldocb.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002916122 – 363Fructose-bisphosphate aldolase C-BAdd BLAST362

Proteomic databases

PaxDbiQ8JH70.
PRIDEiQ8JH70.

Expressioni

Gene expression databases

BgeeiENSDARG00000019702.
ExpressionAtlasiQ8JH70. differential.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024492.

Structurei

3D structure databases

ProteinModelPortaliQ8JH70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiQ8JH70.
KOiK01623.
OMAiLACQYKA.
OrthoDBiEOG091G0A9T.
PhylomeDBiQ8JH70.
TreeFamiTF314203.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JH70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQYPALTA EQKKELQDIA QRIVAPGKGI LAADESTGSM AKRLNPIGVE
60 70 80 90 100
NTEENRRLYR QLLFSADERI DKCIGGVIFF HETLYQNTDD GTNFAQLIKD
110 120 130 140 150
RGIVVGIKVD KGVVPLAGTN GETTTQGLDG LSERCAQYKK DGADFAKWRS
160 170 180 190 200
VLKISDTTPS ELAIMENANV LARYASICQQ NGIVPIVEPE ILPDGEHDLK
210 220 230 240 250
RCQYVTEKVL AACYKALSDH HVYLEGTLLK PNMVTAGHSC PTKYSSEEIA
260 270 280 290 300
MATVTALRRT VPPAVSGVTF LSGGQSEEEA SVNLNSINNC PLAKPWPLTF
310 320 330 340 350
SYGRALQASA LSAWRGAKSN EKAATEEFIK RAEANGLAAQ GKYVSSGTCG
360
AAGQSLYVAN HAY
Length:363
Mass (Da):39,259
Last modified:October 1, 2002 - v1
Checksum:i84D269B36579E6A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533647 mRNA. Translation: AAN04478.1.
BC053192 mRNA. Translation: AAH53192.1.
RefSeqiNP_919365.1. NM_194384.1.
UniGeneiDr.19223.

Genome annotation databases

EnsembliENSDART00000026766; ENSDARP00000024492; ENSDARG00000019702.
GeneIDi369193.
KEGGidre:369193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533647 mRNA. Translation: AAN04478.1.
BC053192 mRNA. Translation: AAH53192.1.
RefSeqiNP_919365.1. NM_194384.1.
UniGeneiDr.19223.

3D structure databases

ProteinModelPortaliQ8JH70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024492.

Proteomic databases

PaxDbiQ8JH70.
PRIDEiQ8JH70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000026766; ENSDARP00000024492; ENSDARG00000019702.
GeneIDi369193.
KEGGidre:369193.

Organism-specific databases

CTDi369193.
ZFINiZDB-GENE-030821-1. aldocb.

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiQ8JH70.
KOiK01623.
OMAiLACQYKA.
OrthoDBiEOG091G0A9T.
PhylomeDBiQ8JH70.
TreeFamiTF314203.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Miscellaneous databases

PROiQ8JH70.

Gene expression databases

BgeeiENSDARG00000019702.
ExpressionAtlasiQ8JH70. differential.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALDCB_DANRE
AccessioniPrimary (citable) accession number: Q8JH70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.