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Q8JH70

- ALDCB_DANRE

UniProt

Q8JH70 - ALDCB_DANRE

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Protein

Fructose-bisphosphate aldolase C-B

Gene

aldocb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561SubstrateBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Active sitei188 – 1881Proton acceptorBy similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiREACT_244478. Glycolysis.
REACT_250324. Gluconeogenesis.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase C-B (EC:4.1.2.13)
Alternative name(s):
Brain-type aldolase-B
Gene namesi
Name:aldocb
Synonyms:aldoc
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-030821-1. aldocb.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 363362Fructose-bisphosphate aldolase C-BPRO_0000291612Add
BLAST

Proteomic databases

PRIDEiQ8JH70.

Expressioni

Gene expression databases

BgeeiQ8JH70.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024492.

Structurei

3D structure databases

ProteinModelPortaliQ8JH70.
SMRiQ8JH70. Positions 3-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiQ8JH70.
KOiK01623.
OMAiRGQQDNA.
OrthoDBiEOG744T94.
PhylomeDBiQ8JH70.
TreeFamiTF314203.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JH70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHQYPALTA EQKKELQDIA QRIVAPGKGI LAADESTGSM AKRLNPIGVE
60 70 80 90 100
NTEENRRLYR QLLFSADERI DKCIGGVIFF HETLYQNTDD GTNFAQLIKD
110 120 130 140 150
RGIVVGIKVD KGVVPLAGTN GETTTQGLDG LSERCAQYKK DGADFAKWRS
160 170 180 190 200
VLKISDTTPS ELAIMENANV LARYASICQQ NGIVPIVEPE ILPDGEHDLK
210 220 230 240 250
RCQYVTEKVL AACYKALSDH HVYLEGTLLK PNMVTAGHSC PTKYSSEEIA
260 270 280 290 300
MATVTALRRT VPPAVSGVTF LSGGQSEEEA SVNLNSINNC PLAKPWPLTF
310 320 330 340 350
SYGRALQASA LSAWRGAKSN EKAATEEFIK RAEANGLAAQ GKYVSSGTCG
360
AAGQSLYVAN HAY
Length:363
Mass (Da):39,259
Last modified:October 1, 2002 - v1
Checksum:i84D269B36579E6A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533647 mRNA. Translation: AAN04478.1.
BC053192 mRNA. Translation: AAH53192.1.
RefSeqiNP_919365.1. NM_194384.1.
UniGeneiDr.19223.

Genome annotation databases

EnsembliENSDART00000026766; ENSDARP00000024492; ENSDARG00000019702.
GeneIDi369193.
KEGGidre:369193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533647 mRNA. Translation: AAN04478.1 .
BC053192 mRNA. Translation: AAH53192.1 .
RefSeqi NP_919365.1. NM_194384.1.
UniGenei Dr.19223.

3D structure databases

ProteinModelPortali Q8JH70.
SMRi Q8JH70. Positions 3-343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000024492.

Proteomic databases

PRIDEi Q8JH70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000026766 ; ENSDARP00000024492 ; ENSDARG00000019702 .
GeneIDi 369193.
KEGGi dre:369193.

Organism-specific databases

CTDi 369193.
ZFINi ZDB-GENE-030821-1. aldocb.

Phylogenomic databases

eggNOGi COG3588.
GeneTreei ENSGT00390000010235.
HOGENOMi HOG000220876.
HOVERGENi HBG002386.
InParanoidi Q8JH70.
KOi K01623.
OMAi RGQQDNA.
OrthoDBi EOG744T94.
PhylomeDBi Q8JH70.
TreeFami TF314203.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
Reactomei REACT_244478. Glycolysis.
REACT_250324. Gluconeogenesis.

Miscellaneous databases

NextBioi 20813343.
PROi Q8JH70.

Gene expression databases

Bgeei Q8JH70.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Negative charge correlates with neural expression in vertebrate aldolase isozymes."
    Merritt T.J.S., Quattro J.M.
    J. Mol. Evol. 55:674-683(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiALDCB_DANRE
AccessioniPrimary (citable) accession number: Q8JH70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3