Reviewed,
UniProtKB/Swiss-Prot Q8JH70 (ALDOC_DANRE)
Last modified
June 16, 2009.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Fructose-bisphosphate aldolase C EC=4.1.2.13 Alternative name(s): Brain-type aldolase | ||
| Gene names |
| ||
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) | ||
| Taxonomic identifier | 7955 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Protein attributes
| Sequence length | 363 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. |
| Pathway | |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the class I fructose-bisphosphate aldolase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Ligand | Schiff base |
| Molecular function | Lyase |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 363 | 362 | Fructose-bisphosphate aldolase C | PRO_0000291612 | |||||
Sites | |||||||||
| Active site | 230 | 1 | Schiff-base intermediate with dihydroxyacetone-P By similarity | ||||||
| Binding site | 56 | 1 | Substrate By similarity | ||||||
| Binding site | 147 | 1 | Substrate By similarity | ||||||
| Site | 363 | 1 | Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Negative charge correlates with neural expression in vertebrate aldolase isozymes." Merritt T.J.S., Quattro J.M. J. Mol. Evol. 55:674-683(2002) [PubMed: 12486526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
Cross-references
Sequence databases | |
|---|---|
| AF533647 mRNA. Translation: AAN04478.1. BC053192 mRNA. Translation: AAH53192.1. | |
| IPI | IPI00490850. |
| RefSeq | NP_919365.1. |
| UniGene | Dr.19223 |
3D structure databases | |
| HSSP | HSSP built from PDB template 6ALD based on UniProtKB P00883. |
| SMR | Q8JH70. Positions 3-363. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q8JH70. |
Genome annotation databases | |
| Ensembl | ENSDARG00000019702. Danio rerio. [Contig view] |
| GeneID | 369193. |
| KEGG | dre:369193. |
Organism-specific databases | |
| ZFIN | ZDB-GENE-030821-1. aldoc. |
Phylogenomic databases | |
| HOGENOM | Q8JH70. |
| HOVERGEN | Q8JH70. |
| OMA | Q8JH70. ACPIKYT. |
Enzyme and pathway databases | |
| BRENDA | 4.1.2.13. 96826. |
Gene expression databases | |
| ArrayExpress | Q8JH70. |
| Bgee | Q8JH70. |
Family and domain databases | |
| InterPro | IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR11627. Aldolase_I. 1 hit. |
| Pfam | PF00274. Glycolytic. 1 hit. [Graphical view] |
| ProDom | PD001128. Aldolase_I. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ALDOC_DANRE | ||||||||
| Accession | Primary (citable) accession number: Q8JH70 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Zebrafish annotation project | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


