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Reviewed, UniProtKB/Swiss-Prot Q8JH64 (BTK_CHICK)

Last modified February 9, 2010. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tyrosine-protein kinase BTK
    EC=2.7.10.2
Alternative name(s):
    Bruton tyrosine kinase
Gene names
Name: BTK
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Plays a crucial role in B-cell ontogeny By similarity. UniProtKB Q06187

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity. UniProtKB Q06187

Enzyme regulation

Activated by phosphorylation By similarity.

Subunit structure

Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain By similarity.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.

Post-translational modification

Autophosphorylated on Tyr-220 and Tyr-549. The tyrosine phosphorylation of Tyr-220 may create a docking site for a SH2 containing protein By similarity. UniProtKB P35991

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

Contains 1 Btk-type zinc finger.

Contains 1 PH domain.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 657657Tyrosine-protein kinase BTK
PRO_0000088067

Regions

Domain3 – 132130PH
Domain214 – 27057SH3
Domain276 – 36691SH2
Domain400 – 653254Protein kinase
Zinc finger134 – 17037Btk-type
Nucleotide binding406 – 4149ATP By similarity UniProtKB P08631

Sites

Active site5191Proton acceptor By similarity UniProtKB P08631
Metal binding1421Zinc By similarity UniProtKB Q06187
Metal binding1531Zinc By similarity UniProtKB Q06187
Metal binding1541Zinc By similarity UniProtKB Q06187
Metal binding1641Zinc By similarity UniProtKB Q06187
Binding site4281ATP By similarity UniProtKB P08631

Amino acid modifications

Modified residue2201Phosphotyrosine; by autocatalysis By similarity UniProtKB P35991
Modified residue5491Phosphotyrosine; by autocatalysis By similarity UniProtKB P35991

Sequences

Sequence LengthMass (Da)Tools
Q8JH64-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: FE5217E8E6195F6A

FASTA65775,879
        10         20         30         40         50         60 
MASIILESIF LKRSQQKKKT SPLNFKKRLF LLTESKLSYY EYDFERGRRG SKKGSVDIEK 

        70         80         90        100        110        120 
ITCVETVVPE NNPPPERQVP KKGEDYNMEQ ISIIERFPYP FQVVYDEGPL YVFSPTEELR 

       130        140        150        160        170        180 
KRWIHQLKSV IRYNSDLVQK YHPCFWIDGQ YLCCSQTAKN AMGCKILESR NGSLKAGRSH 

       190        200        210        220        230        240 
RKTKKPLPPT PEEDTMVMKP LPPEPAPSAA GEMKKVVALY NYVPMNVQDL QLQKGEDYLI 

       250        260        270        280        290        300 
LEESHLPWWK ARDKNGREGY IPSNYVTATS NSLEIYEWYS KNITRSQAEQ LLKQEGKEGG 

       310        320        330        340        350        360 
FIVRDSTSKT GKYTVSVYAK SAVDPQGMIR HYVVCCTPQN QYYLAEKHLF NTIPELITYH 

       370        380        390        400        410        420 
QHNSAGLISR LKYPVSRHQK SAPSTAGLGY GSWEIDPKDL TFLKELGTGQ FGVVKYGKWR 

       430        440        450        460        470        480 
GQYNVAIKMI REGSMSEDEF IDEAKVMMNL SHEKLVQLYG VCTKQRPIFI ITEYMANGCL 

       490        500        510        520        530        540 
LNFLRETQRR FQPAELLEMC KDVCEAMEYL ESKQFLHRDL AARNCLVNDQ GIVKVSDFGL 

       550        560        570        580        590        600 
SRYVLDDEYT SSMGSKFPVR WSPPEVLLYS KFSSKSDVWS FGVLMWEVYS LGKMPYERFN 

       610        620        630        640        650 
NSETTEHVIQ GLRLYRPQQA SERVYAIMYS CWHEKAEERP TFSALLGSIV DITDEEP 

« Hide

References

[1]"Btk expressed in primary chicken erythroblasts."
Schmidt U., Haubenwallner S., Beug H., Nimpf J.
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF535118 mRNA. Translation: AAN04043.2.
IPIIPI00595247.
UniGeneGga.1305

3D structure databases

SMRQ8JH64. Positions 2-169, 128-201, 209-272, 267-385, 395-652.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8JH64.

Genome annotation databases

EnsemblENSGALT00000007950; ENSGALP00000007936; ENSGALG00000004958; Gallus gallus. [Genome view]

Phylogenomic databases

HOGENOMHBG755340.
HOVERGENQ8JH64.
InParanoidQ8JH64.

Enzyme and pathway databases

BRENDA2.7.10.2. 4.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR011993. PH_type.
IPR001849. Pleckstrin_homology.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR020473. SH3_region.
IPR020635. Tyr_Pkinase_cat_dom.
IPR020685. Tyr_prot_kinase.
IPR008266. Tyr_prot_kinase_AS.
IPR001562. Znf_Btk_motif.
[Graphical view]
Gene3DG3DSA:2.30.29.30. PH_type. 1 hit.
G3DSA:3.30.505.10. SH2. 1 hit.
PANTHERPTHR23256. Tyr_prot_kinase. 1 hit.
PfamPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00402. TECBTKDOMAIN.
SMARTSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBTK_CHICK
AccessionPrimary (citable) accession number: Q8JH64
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2002
Last modified: February 9, 2010
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents