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Protein
Submitted name:

Prostaglandin G/H synthase 1

Gene

ptgs1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • heme binding Source: InterPro
  • peroxidase activity Source: ZFIN
  • prostaglandin-endoperoxide synthase activity Source: ZFIN

GO - Biological processi

  • cellular response to organic cyclic compound Source: ZFIN
  • cyclooxygenase pathway Source: InterPro
  • inflammatory response Source: InterPro
  • kidney development Source: ZFIN
  • regulation of blood pressure Source: InterPro
  • response to oxidative stress Source: InterPro
  • vasculogenesis Source: ZFIN
Complete GO annotation...

Protein family/group databases

PeroxiBasei3363. DrPGHS01.

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin G/H synthase 1Imported
Gene namesi
Name:ptgs1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-020530-1. ptgs1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104772.

Structurei

3D structure databases

ProteinModelPortaliQ8JH44.
SMRiQ8JH44. Positions 34-583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000366.
KOiK00509.
PhylomeDBiQ8JH44.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029580. COX-1.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF6. PTHR11903:SF6. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JH44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRECNFLLKW TVILLLSVSF CAGEESPTSS NTANPCCYYP CQNQGICVRY
60 70 80 90 100
GLERYECDCT RTGYYGENCT IPELWTRVYR LLKPSPNVVH YILTHFDWLW
110 120 130 140 150
DLINRSFLRD WLMRKVLTVR ANLIPSPPTY NSRYDYLNWE AYSNITYYTR
160 170 180 190 200
ILPPVPNDCP TPMGTKGKIK LPDPKLLVEK FMLRRNFRLD PQGTNLMFAF
210 220 230 240 250
FAQHFTHQFF KTHNRVGLGF TKGLGHGVDA GHIYGDSLDR QLELRLHKDG
260 270 280 290 300
KLKYQVLNGD IYPPTVLHAQ VKMSYPPSVP PEQQLAIGQE VFGLLPGLGM
310 320 330 340 350
YATLWLREHN RVCEILKQEH PTWGDEQLFQ TARLIIIGET IRIVIEEYVQ
360 370 380 390 400
HLSGYRLKLH FDPTLLFNSQ FQYQNRISVE FNQLYHWHPL MPDSFYIDGD
410 420 430 440 450
HIQYSKFIFN TSILTHYGLE KLVEAFSIQP AGQIGGGHNI HPVVSGVAER
460 470 480 490 500
VIVESRELRL QPFNEYRKRF NLKPYTSFAE LTGEQEMSKE LEELYGHIDA
510 520 530 540 550
MEFYPALLLE KTRPGAVFGE SMVEMGAPFS LKGLMGNPIC SPDYWKPSTF
560 570 580 590
GGKTGFDIVN SATLKKLVCL NTKWCPYVSF HTPPSDYKPQ RTSHGEL
Length:597
Mass (Da):68,963
Last modified:October 1, 2002 - v1
Checksum:iA13593679926F292
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028584 mRNA. Translation: AAK33030.1.
RefSeqiNP_705942.1. NM_153656.1.
UniGeneiDr.18294.

Genome annotation databases

GeneIDi246226.
KEGGidre:246226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028584 mRNA. Translation: AAK33030.1.
RefSeqiNP_705942.1. NM_153656.1.
UniGeneiDr.18294.

3D structure databases

ProteinModelPortaliQ8JH44.
SMRiQ8JH44. Positions 34-583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000104772.

Protein family/group databases

PeroxiBasei3363. DrPGHS01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246226.
KEGGidre:246226.

Organism-specific databases

CTDi5742.
ZFINiZDB-GENE-020530-1. ptgs1.

Phylogenomic databases

HOVERGENiHBG000366.
KOiK00509.
PhylomeDBiQ8JH44.

Miscellaneous databases

NextBioi20797213.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029580. COX-1.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF6. PTHR11903:SF6. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Developmental expression of functional cyclooxygenases in zebrafish."
    Grosser T., Yusuff S., Cheskis E., Pack M.A., FitzGerald G.A.
    Proc. Natl. Acad. Sci. U.S.A. 99:8418-8423(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8JH44_DANRE
AccessioniPrimary (citable) accession number: Q8JH44
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.