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Q8JH44

- Q8JH44_DANRE

UniProt

Q8JH44 - Q8JH44_DANRE

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Protein
Submitted name:

Prostaglandin G/H synthase 1

Gene

ptgs1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. peroxidase activity Source: ZFIN
  3. prostaglandin-endoperoxide synthase activity Source: ZFIN

GO - Biological processi

  1. cellular response to organic cyclic compound Source: ZFIN
  2. cyclooxygenase pathway Source: InterPro
  3. inflammatory response Source: InterPro
  4. kidney development Source: ZFIN
  5. regulation of blood pressure Source: InterPro
  6. response to oxidative stress Source: InterPro
  7. vasculogenesis Source: ZFIN
Complete GO annotation...

Protein family/group databases

PeroxiBasei3363. DrPGHS01.

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin G/H synthase 1Imported
Gene namesi
Name:ptgs1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-020530-1. ptgs1.

Structurei

3D structure databases

ProteinModelPortaliQ8JH44.
SMRiQ8JH44. Positions 34-583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000366.
KOiK00509.
PhylomeDBiQ8JH44.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029580. COX-1.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF6. PTHR11903:SF6. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JH44-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRECNFLLKW TVILLLSVSF CAGEESPTSS NTANPCCYYP CQNQGICVRY
60 70 80 90 100
GLERYECDCT RTGYYGENCT IPELWTRVYR LLKPSPNVVH YILTHFDWLW
110 120 130 140 150
DLINRSFLRD WLMRKVLTVR ANLIPSPPTY NSRYDYLNWE AYSNITYYTR
160 170 180 190 200
ILPPVPNDCP TPMGTKGKIK LPDPKLLVEK FMLRRNFRLD PQGTNLMFAF
210 220 230 240 250
FAQHFTHQFF KTHNRVGLGF TKGLGHGVDA GHIYGDSLDR QLELRLHKDG
260 270 280 290 300
KLKYQVLNGD IYPPTVLHAQ VKMSYPPSVP PEQQLAIGQE VFGLLPGLGM
310 320 330 340 350
YATLWLREHN RVCEILKQEH PTWGDEQLFQ TARLIIIGET IRIVIEEYVQ
360 370 380 390 400
HLSGYRLKLH FDPTLLFNSQ FQYQNRISVE FNQLYHWHPL MPDSFYIDGD
410 420 430 440 450
HIQYSKFIFN TSILTHYGLE KLVEAFSIQP AGQIGGGHNI HPVVSGVAER
460 470 480 490 500
VIVESRELRL QPFNEYRKRF NLKPYTSFAE LTGEQEMSKE LEELYGHIDA
510 520 530 540 550
MEFYPALLLE KTRPGAVFGE SMVEMGAPFS LKGLMGNPIC SPDYWKPSTF
560 570 580 590
GGKTGFDIVN SATLKKLVCL NTKWCPYVSF HTPPSDYKPQ RTSHGEL
Length:597
Mass (Da):68,963
Last modified:October 1, 2002 - v1
Checksum:iA13593679926F292
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY028584 mRNA. Translation: AAK33030.1.
RefSeqiNP_705942.1. NM_153656.1.
UniGeneiDr.18294.

Genome annotation databases

GeneIDi246226.
KEGGidre:246226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY028584 mRNA. Translation: AAK33030.1 .
RefSeqi NP_705942.1. NM_153656.1.
UniGenei Dr.18294.

3D structure databases

ProteinModelPortali Q8JH44.
SMRi Q8JH44. Positions 34-583.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

PeroxiBasei 3363. DrPGHS01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 246226.
KEGGi dre:246226.

Organism-specific databases

CTDi 5742.
ZFINi ZDB-GENE-020530-1. ptgs1.

Phylogenomic databases

HOVERGENi HBG000366.
KOi K00509.
PhylomeDBi Q8JH44.

Miscellaneous databases

NextBioi 20797213.

Family and domain databases

Gene3Di 1.10.640.10. 1 hit.
InterProi IPR029580. COX-1.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view ]
PANTHERi PTHR11903:SF6. PTHR11903:SF6. 1 hit.
Pfami PF03098. An_peroxidase. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Developmental expression of functional cyclooxygenases in zebrafish."
    Grosser T., Yusuff S., Cheskis E., Pack M.A., FitzGerald G.A.
    Proc. Natl. Acad. Sci. U.S.A. 99:8418-8423(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8JH44_DANRE
AccessioniPrimary (citable) accession number: Q8JH44
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)