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Protein
Submitted name:

Prostaglandin G/H synthase 2

Gene

ptgs2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • heme binding Source: InterPro
  • peroxidase activity Source: ZFIN
  • prostaglandin-endoperoxide synthase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Protein family/group databases

PeroxiBasei3364. DrPGHS02.

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin G/H synthase 2Imported
Submitted name:
Prostaglandin-endoperoxide synthase 2aImported
Gene namesi
Name:ptgs2aImported
Synonyms:ptgs2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-020530-2. ptgs2a.

Structurei

3D structure databases

ProteinModelPortaliQ8JH43.
SMRiQ8JH43. Positions 23-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000366.
PhylomeDBiQ8JH43.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JH43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLVCLVLL SSIWIFPGEG YDPCCAQPCQ NQGVCLSKGA DAYECDCTRT
60 70 80 90 100
GYYGENCTTP ELLTRIKSAL KPRPNVVHHI LTHYKSIWDI INSISYLRDG
110 120 130 140 150
IMRYILLSRS HLVESPPTYN ADYGYKSWEA YSNLSYYTRT LAPLPQNCPT
160 170 180 190 200
PDLPNAKQVV EQVLLRKQFI PDPQRSSLMF AFFAQHFSHQ FFKSDFKKGP
210 220 230 240 250
AFTKALGHGV DLGHIYGETL EVQHKLRLFK DGKLKYQVVD GEVYPPLVKD
260 270 280 290 300
VQVEMHYPPH IPEEQKFAVG HEAFGLVPGL MMYATIWLRE HNRVCDIMKQ
310 320 330 340 350
EHPDWDDERI FQTTRLILIG ETIKIVIEDY VQHLSGYNFK LKFDPELIFS
360 370 380 390 400
ERFQYQNRIA AEFNTLYHWH PLLPDNFQIQ DQIYGYHQFV FNNSIVTTHG
410 420 430 440 450
IRNMVDSFTK QTAGRVSGGR NLPPAVQGVA VKVLEQTRQM RYQSFNAYRR
460 470 480 490 500
RFNMKPYSSF EEMTGDKDLA AQLKELYGHV DKVELYPGLL VEKSRPNSVF
510 520 530 540 550
GETMVEMGAP YSLKGLMGNA ICSPEYWKPS TFGGKVGFDI VNSASLKKLV
560 570 580 590 600
CLNISGPCPM VSFQVPDVKF QSSENVNSSS VHSTVNNINP TVVLNERSSE

L
Length:601
Mass (Da):68,673
Last modified:October 1, 2002 - v1
Checksum:iA5852C56521DD0C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056736 mRNA. Translation: AAH56736.1.
AY028585 mRNA. Translation: AAK33031.1.
RefSeqiNP_705943.1. NM_153657.1.
UniGeneiDr.113864.

Genome annotation databases

GeneIDi246227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056736 mRNA. Translation: AAH56736.1.
AY028585 mRNA. Translation: AAK33031.1.
RefSeqiNP_705943.1. NM_153657.1.
UniGeneiDr.113864.

3D structure databases

ProteinModelPortaliQ8JH43.
SMRiQ8JH43. Positions 23-565.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei3364. DrPGHS02.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246227.

Organism-specific databases

CTDi246227.
ZFINiZDB-GENE-020530-2. ptgs2a.

Phylogenomic databases

HOVERGENiHBG000366.
PhylomeDBiQ8JH43.

Miscellaneous databases

NextBioi20797214.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental expression of functional cyclooxygenases in zebrafish."
    Grosser T., Yusuff S., Cheskis E., Pack M.A., FitzGerald G.A.
    Proc. Natl. Acad. Sci. U.S.A. 99:8418-8423(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ8JH43_DANRE
AccessioniPrimary (citable) accession number: Q8JH43
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: May 27, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.