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Q8JH43

- Q8JH43_DANRE

UniProt

Q8JH43 - Q8JH43_DANRE

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Protein
Submitted name:

Prostaglandin G/H synthase 2

Gene

ptgs2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. peroxidase activity Source: ZFIN
  3. prostaglandin-endoperoxide synthase activity Source: InterPro

GO - Biological processi

  1. cellular response to organic cyclic compound Source: ZFIN
  2. cyclooxygenase pathway Source: InterPro
  3. inflammatory response Source: InterPro
  4. regulation of blood pressure Source: InterPro
  5. response to oxidative stress Source: InterPro
Complete GO annotation...

Protein family/group databases

PeroxiBasei3364. DrPGHS02.

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin G/H synthase 2Imported
Submitted name:
Prostaglandin-endoperoxide synthase 2aImported
Gene namesi
Name:ptgs2aImported
Synonyms:ptgs2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-020530-2. ptgs2a.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000366.
KOiK11987.

Family and domain databases

Gene3Di1.10.640.10. 1 hit.
InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PfamiPF03098. An_peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JH43-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKLVCLVLL SSIWIFPGEG YDPCCAQPCQ NQGVCLSKGA DAYECDCTRT
60 70 80 90 100
GYYGENCTTP ELLTRIKSAL KPRPNVVHHI LTHYKSIWDI INSISYLRDG
110 120 130 140 150
IMRYILLSRS HLVESPPTYN ADYGYKSWEA YSNLSYYTRT LAPLPQNCPT
160 170 180 190 200
PDLPNAKQVV EQVLLRKQFI PDPQRSSLMF AFFAQHFSHQ FFKSDFKKGP
210 220 230 240 250
AFTKALGHGV DLGHIYGETL EVQHKLRLFK DGKLKYQVVD GEVYPPLVKD
260 270 280 290 300
VQVEMHYPPH IPEEQKFAVG HEAFGLVPGL MMYATIWLRE HNRVCDIMKQ
310 320 330 340 350
EHPDWDDERI FQTTRLILIG ETIKIVIEDY VQHLSGYNFK LKFDPELIFS
360 370 380 390 400
ERFQYQNRIA AEFNTLYHWH PLLPDNFQIQ DQIYGYHQFV FNNSIVTTHG
410 420 430 440 450
IRNMVDSFTK QTAGRVSGGR NLPPAVQGVA VKVLEQTRQM RYQSFNAYRR
460 470 480 490 500
RFNMKPYSSF EEMTGDKDLA AQLKELYGHV DKVELYPGLL VEKSRPNSVF
510 520 530 540 550
GETMVEMGAP YSLKGLMGNA ICSPEYWKPS TFGGKVGFDI VNSASLKKLV
560 570 580 590 600
CLNISGPCPM VSFQVPDVKF QSSENVNSSS VHSTVNNINP TVVLNERSSE

L
Length:601
Mass (Da):68,673
Last modified:October 1, 2002 - v1
Checksum:iA5852C56521DD0C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056736 mRNA. Translation: AAH56736.1.
AY028585 mRNA. Translation: AAK33031.1.
RefSeqiNP_705943.1. NM_153657.1.
UniGeneiDr.113864.

Genome annotation databases

GeneIDi246227.
KEGGidre:246227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056736 mRNA. Translation: AAH56736.1 .
AY028585 mRNA. Translation: AAK33031.1 .
RefSeqi NP_705943.1. NM_153657.1.
UniGenei Dr.113864.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

PeroxiBasei 3364. DrPGHS02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 246227.
KEGGi dre:246227.

Organism-specific databases

CTDi 246227.
ZFINi ZDB-GENE-020530-2. ptgs2a.

Phylogenomic databases

HOVERGENi HBG000366.
KOi K11987.

Miscellaneous databases

NextBioi 20797214.

Family and domain databases

Gene3Di 1.10.640.10. 1 hit.
InterProi IPR029576. COX-2.
IPR000742. EG-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
[Graphical view ]
PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
Pfami PF03098. An_peroxidase. 2 hits.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental expression of functional cyclooxygenases in zebrafish."
    Grosser T., Yusuff S., Cheskis E., Pack M.A., FitzGerald G.A.
    Proc. Natl. Acad. Sci. U.S.A. 99:8418-8423(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ8JH43_DANRE
AccessioniPrimary (citable) accession number: Q8JH43
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)