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Q8JGW0

- TSP4B_DANRE

UniProt

Q8JGW0 - TSP4B_DANRE

Protein

Thrombospondin-4-B

Gene

thbs4b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment. May play a role in ER stress response By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. positive regulation of cell division Source: UniProtKB-KW
    3. response to unfolded protein Source: UniProtKB-KW

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Keywords - Biological processi

    Cell adhesion, Unfolded protein response

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thrombospondin-4-B
    Short name:
    Thbs4-B
    Gene namesi
    Name:thbs4b
    Synonyms:thbs4, tsp4
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-020708-4. thbs4b.

    Subcellular locationi

    Endoplasmic reticulum By similarity. Sarcoplasmic reticulum By similarity. Secreted By similarity. Secretedextracellular space By similarity. Secretedextracellular spaceextracellular matrix By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. extracellular matrix Source: UniProtKB
    3. extracellular region Source: UniProtKB
    4. extracellular space Source: UniProtKB
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
    6. sarcoplasmic reticulum Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 949927Thrombospondin-4-BPRO_0000035855Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi261 – 261InterchainBy similarityPROSITE-ProRule annotation
    Disulfide bondi264 – 264InterchainBy similarityPROSITE-ProRule annotation
    Disulfide bondi276 ↔ 287By similarityPROSITE-ProRule annotation
    Disulfide bondi281 ↔ 296By similarityPROSITE-ProRule annotation
    Disulfide bondi299 ↔ 310By similarityPROSITE-ProRule annotation
    Disulfide bondi316 ↔ 327By similarityPROSITE-ProRule annotation
    Disulfide bondi321 ↔ 336By similarityPROSITE-ProRule annotation
    Disulfide bondi339 ↔ 363By similarityPROSITE-ProRule annotation
    Disulfide bondi369 ↔ 383By similarityPROSITE-ProRule annotation
    Disulfide bondi377 ↔ 392By similarityPROSITE-ProRule annotation
    Disulfide bondi395 ↔ 407By similarityPROSITE-ProRule annotation
    Disulfide bondi413 ↔ 427By similarityPROSITE-ProRule annotation
    Disulfide bondi421 ↔ 437By similarityPROSITE-ProRule annotation
    Disulfide bondi439 ↔ 450By similarityPROSITE-ProRule annotation
    Disulfide bondi466 ↔ 471By similarityPROSITE-ProRule annotation
    Disulfide bondi476 ↔ 496By similarityPROSITE-ProRule annotation
    Disulfide bondi512 ↔ 532By similarityPROSITE-ProRule annotation
    Disulfide bondi535 ↔ 555By similarityPROSITE-ProRule annotation
    Disulfide bondi571 ↔ 591By similarityPROSITE-ProRule annotation
    Disulfide bondi594 ↔ 614By similarityPROSITE-ProRule annotation
    Glycosylationi601 – 6011N-linked (GlcNAc...)Curated
    Disulfide bondi632 ↔ 652By similarityPROSITE-ProRule annotation
    Glycosylationi637 – 6371N-linked (GlcNAc...)Curated
    Disulfide bondi672 ↔ 692By similarityPROSITE-ProRule annotation
    Disulfide bondi708 ↔ 929By similarityPROSITE-ProRule annotation
    Glycosylationi930 – 9301N-linked (GlcNAc...)Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8JGW0.

    Expressioni

    Developmental stagei

    Expressed both maternally and zygotically. Present at the gastrulation and post-segmentation stages.1 Publication

    Interactioni

    Subunit structurei

    Homotrimer; disulfide-linked.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8JGW0.
    SMRiQ8JGW0. Positions 592-931.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 198176Laminin G-likeAdd
    BLAST
    Domaini312 – 34938EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini365 – 40844EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini409 – 45143EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Repeati452 – 48433TSP type-3 1Add
    BLAST
    Repeati485 – 52036TSP type-3 2Add
    BLAST
    Repeati521 – 54323TSP type-3 3Add
    BLAST
    Repeati544 – 57936TSP type-3 4Add
    BLAST
    Repeati580 – 60223TSP type-3 5Add
    BLAST
    Repeati603 – 64038TSP type-3 6Add
    BLAST
    Repeati641 – 68040TSP type-3 7Add
    BLAST
    Repeati681 – 71636TSP type-3 8Add
    BLAST
    Domaini720 – 934215TSP C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 3 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
    Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000007542.
    HOVERGENiHBG000636.
    KOiK04659.
    PhylomeDBiQ8JGW0.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    4.10.1080.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    IPR024665. Thbs/COMP_coiled-coil.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    [Graphical view]
    PfamiPF11598. COMP. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02412. TSP_3. 6 hits.
    PF05735. TSP_C. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00179. EGF_CA. 2 hits.
    SM00210. TSPN. 1 hit.
    [Graphical view]
    SUPFAMiSSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEiPS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 3 hits.
    PS01187. EGF_CA. 2 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8JGW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGTMHLLTA VSLILMLSSA NAESTVYNLL TSPDCLPDLL HGGLAEQGVT    50
    ELYILTTFRI QPGTGNTIFS LYNPRDNSKY FEFSVFGKAN KAILRYLRRD 100
    GRMSAVTFNK LNLADGEKHR LLFHLKGLEV GHPGGFPHSQ GALPVPGVEL 150
    HLDCRLVETL RDLPAVFNGL NNHQAVELKT MQGKAQEGLE ELKLAYGDSV 200
    ENVASLQDCH TQSDSVQALG LNTKQLTTQM LELTKVINEL KDVLIQQVKE 250
    TSFLRNTISE CQACGLSGAE VVKPKCAPGV CFRDDMCIET AEGVECGPCP 300
    DGYTGDGYSC DDVDECQFNP CFPGVRCVNM APGFRCEACP LGFTGKPLEG 350
    VGVAYAQTHK QVCDDIDECK GPDNGGCTAN SICVNSVGSY QCGRCKTGFT 400
    GDQIRGCKPE KSCGNRLQNP CDPNAQCTEE RDGTITCQCG IGWAGNGYLC 450
    GKDTDIDGYP DERLRCRDPT CRKDNCVTVP NSGQEDADGD GKGDACDPDA 500
    DGDGILNEQD NCWLTPNINQ QNSDKDSHGD ACDNCVRVDN PDQRDTDSDG 550
    LGDACDDDMD GDGLKNFLDN CQRVKNRDQL DRDGDGVGDA CDSCPDIPNP 600
    NQSDIDNDLV GDSCDTNQDS DGDGHQDSKD NCPMVINSSQ LDTDKDGIGD 650
    ECDDDDDNDG IPDSLPPGPD NCRLVPNPEQ IDDNNDGVGD ICESDFDQDK 700
    VIDRIDNCPE NAEITLTDFR AYQTVVLDPE GDAQIDPNWV VLNQGMEIVQ 750
    TMNSDPGLAV GYTAFSGVDF EGTFHVNTVT DDDYAGFIFG YQDSSSFYVV 800
    MWKQTEQTYW QATPFRAVAE PGIQLKAVKS KTGPGEHLRN SLWHTGDTND 850
    QVRLLWKDPR NVGWKDKVSY RWYLQHRPQV GYIRVRFYEG TELVADSGVT 900
    IDTTMRGGRL GVFCFSQENI IWSNLKYRCN DTIPEDFQEF STQHGMDPL 949
    Length:949
    Mass (Da):103,991
    Last modified:October 1, 2002 - v1
    Checksum:iBBC9203814CA99CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY081009 mRNA. Translation: AAL82733.1.
    RefSeqiNP_775333.1. NM_173226.1.
    UniGeneiDr.76718.

    Genome annotation databases

    GeneIDi252850.
    KEGGidre:252850.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY081009 mRNA. Translation: AAL82733.1 .
    RefSeqi NP_775333.1. NM_173226.1.
    UniGenei Dr.76718.

    3D structure databases

    ProteinModelPortali Q8JGW0.
    SMRi Q8JGW0. Positions 592-931.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8JGW0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 252850.
    KEGGi dre:252850.

    Organism-specific databases

    CTDi 252850.
    ZFINi ZDB-GENE-020708-4. thbs4b.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000007542.
    HOVERGENi HBG000636.
    KOi K04659.
    PhylomeDBi Q8JGW0.

    Miscellaneous databases

    NextBioi 20799872.
    PROi Q8JGW0.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    4.10.1080.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR018097. EGF_Ca-bd_CS.
    IPR001791. Laminin_G.
    IPR024665. Thbs/COMP_coiled-coil.
    IPR003367. Thrombospondin_3-like_rpt.
    IPR017897. Thrombospondin_3_rpt.
    IPR008859. Thrombospondin_C.
    IPR028974. TSP_type-3_rpt.
    [Graphical view ]
    Pfami PF11598. COMP. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF02412. TSP_3. 6 hits.
    PF05735. TSP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 2 hits.
    SM00210. TSPN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103647. SSF103647. 3 hits.
    SSF49899. SSF49899. 2 hits.
    PROSITEi PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 3 hits.
    PS01187. EGF_CA. 2 hits.
    PS51234. TSP3. 8 hits.
    PS51236. TSP_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish thrombospondin 3 and 4 genes (thbs3 and thbs4): cDNA and protein structure."
      Adolph K.W.
      DNA Seq. 13:277-285(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTSP4B_DANRE
    AccessioniPrimary (citable) accession number: Q8JGW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3