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Q8JGW0 (TSP4B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thrombospondin-4-B

Short name=Thbs4-B
Gene names
Name:thbs4b
Synonyms:thbs4, tsp4
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length949 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment. May play a role in ER stress response By similarity.

Subunit structure

Homotrimer; disulfide-linked By similarity. UniProtKB P35443

Subcellular location

Endoplasmic reticulum By similarity. Sarcoplasmic reticulum By similarity. Secreted By similarity. Secretedextracellular space By similarity. Secretedextracellular spaceextracellular matrix By similarity.

Developmental stage

Expressed both maternally and zygotically. Present at the gastrulation and post-segmentation stages. Ref.1

Sequence similarities

Belongs to the thrombospondin family.

Contains 3 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 1 TSP C-terminal (TSPC) domain.

Contains 8 TSP type-3 repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 949927Thrombospondin-4-B
PRO_0000035855

Regions

Domain23 – 198176Laminin G-like
Domain312 – 34938EGF-like 1; calcium-binding Potential
Domain365 – 40844EGF-like 2; calcium-binding Potential
Domain409 – 45143EGF-like 3
Repeat452 – 48433TSP type-3 1
Repeat485 – 52036TSP type-3 2
Repeat521 – 54323TSP type-3 3
Repeat544 – 57936TSP type-3 4
Repeat580 – 60223TSP type-3 5
Repeat603 – 64038TSP type-3 6
Repeat641 – 68040TSP type-3 7
Repeat681 – 71636TSP type-3 8
Domain720 – 934215TSP C-terminal

Amino acid modifications

Glycosylation6011N-linked (GlcNAc...) Potential
Glycosylation6371N-linked (GlcNAc...) Potential
Glycosylation9301N-linked (GlcNAc...) Potential
Disulfide bond261Interchain By similarity UniProtKB Q9R0G6
Disulfide bond264Interchain By similarity UniProtKB Q9R0G6
Disulfide bond276 ↔ 287 By similarity UniProtKB P35443
Disulfide bond281 ↔ 296 By similarity UniProtKB P35443
Disulfide bond299 ↔ 310 By similarity UniProtKB P35443
Disulfide bond316 ↔ 327 By similarity UniProtKB P35443
Disulfide bond321 ↔ 336 By similarity UniProtKB P35443
Disulfide bond339 ↔ 363 By similarity UniProtKB P35443
Disulfide bond369 ↔ 383 By similarity UniProtKB P35443
Disulfide bond377 ↔ 392 By similarity UniProtKB P35443
Disulfide bond395 ↔ 407 By similarity UniProtKB P35443
Disulfide bond413 ↔ 427 By similarity UniProtKB P35443
Disulfide bond421 ↔ 437 By similarity UniProtKB P35443
Disulfide bond439 ↔ 450 By similarity UniProtKB P35443
Disulfide bond466 ↔ 471 By similarity UniProtKB P35442
Disulfide bond476 ↔ 496 By similarity UniProtKB P35442
Disulfide bond512 ↔ 532 By similarity UniProtKB P35442
Disulfide bond535 ↔ 555 By similarity UniProtKB P35442
Disulfide bond571 ↔ 591 By similarity UniProtKB P35442
Disulfide bond594 ↔ 614 By similarity UniProtKB P35442
Disulfide bond632 ↔ 652 By similarity UniProtKB P35442
Disulfide bond672 ↔ 692 By similarity UniProtKB P35442
Disulfide bond708 ↔ 929 By similarity UniProtKB P35442

Sequences

Sequence LengthMass (Da)Tools
Q8JGW0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: BBC9203814CA99CB

FASTA949103,991
        10         20         30         40         50         60 
MAGTMHLLTA VSLILMLSSA NAESTVYNLL TSPDCLPDLL HGGLAEQGVT ELYILTTFRI 

        70         80         90        100        110        120 
QPGTGNTIFS LYNPRDNSKY FEFSVFGKAN KAILRYLRRD GRMSAVTFNK LNLADGEKHR 

       130        140        150        160        170        180 
LLFHLKGLEV GHPGGFPHSQ GALPVPGVEL HLDCRLVETL RDLPAVFNGL NNHQAVELKT 

       190        200        210        220        230        240 
MQGKAQEGLE ELKLAYGDSV ENVASLQDCH TQSDSVQALG LNTKQLTTQM LELTKVINEL 

       250        260        270        280        290        300 
KDVLIQQVKE TSFLRNTISE CQACGLSGAE VVKPKCAPGV CFRDDMCIET AEGVECGPCP 

       310        320        330        340        350        360 
DGYTGDGYSC DDVDECQFNP CFPGVRCVNM APGFRCEACP LGFTGKPLEG VGVAYAQTHK 

       370        380        390        400        410        420 
QVCDDIDECK GPDNGGCTAN SICVNSVGSY QCGRCKTGFT GDQIRGCKPE KSCGNRLQNP 

       430        440        450        460        470        480 
CDPNAQCTEE RDGTITCQCG IGWAGNGYLC GKDTDIDGYP DERLRCRDPT CRKDNCVTVP 

       490        500        510        520        530        540 
NSGQEDADGD GKGDACDPDA DGDGILNEQD NCWLTPNINQ QNSDKDSHGD ACDNCVRVDN 

       550        560        570        580        590        600 
PDQRDTDSDG LGDACDDDMD GDGLKNFLDN CQRVKNRDQL DRDGDGVGDA CDSCPDIPNP 

       610        620        630        640        650        660 
NQSDIDNDLV GDSCDTNQDS DGDGHQDSKD NCPMVINSSQ LDTDKDGIGD ECDDDDDNDG 

       670        680        690        700        710        720 
IPDSLPPGPD NCRLVPNPEQ IDDNNDGVGD ICESDFDQDK VIDRIDNCPE NAEITLTDFR 

       730        740        750        760        770        780 
AYQTVVLDPE GDAQIDPNWV VLNQGMEIVQ TMNSDPGLAV GYTAFSGVDF EGTFHVNTVT 

       790        800        810        820        830        840 
DDDYAGFIFG YQDSSSFYVV MWKQTEQTYW QATPFRAVAE PGIQLKAVKS KTGPGEHLRN 

       850        860        870        880        890        900 
SLWHTGDTND QVRLLWKDPR NVGWKDKVSY RWYLQHRPQV GYIRVRFYEG TELVADSGVT 

       910        920        930        940 
IDTTMRGGRL GVFCFSQENI IWSNLKYRCN DTIPEDFQEF STQHGMDPL 

« Hide

References

[1]"The zebrafish thrombospondin 3 and 4 genes (thbs3 and thbs4): cDNA and protein structure."
Adolph K.W.
DNA Seq. 13:277-285(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY081009 mRNA. Translation: AAL82733.1.
RefSeqNP_775333.1. NM_173226.1.
UniGeneDr.76718.

3D structure databases

ProteinModelPortalQ8JGW0.
SMRQ8JGW0. Positions 592-931.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8JGW0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID252850.
KEGGdre:252850.

Organism-specific databases

CTD252850.
ZFINZDB-GENE-020708-4. thbs4b.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000007542.
HOVERGENHBG000636.
KOK04659.
PhylomeDBQ8JGW0.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PfamPF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
PROSITEPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20799872.
PROQ8JGW0.

Entry information

Entry nameTSP4B_DANRE
AccessionPrimary (citable) accession number: Q8JGW0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families