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Q8JGW0

- TSP4B_DANRE

UniProt

Q8JGW0 - TSP4B_DANRE

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Protein

Thrombospondin-4-B

Gene

thbs4b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment. May play a role in ER stress response (By similarity).By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. positive regulation of cell division Source: UniProtKB-KW
  3. response to unfolded protein Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Biological processi

Cell adhesion, Unfolded protein response

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-4-B
Short name:
Thbs4-B
Gene namesi
Name:thbs4b
Synonyms:thbs4, tsp4
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-020708-4. thbs4b.

Subcellular locationi

Endoplasmic reticulum By similarity. Sarcoplasmic reticulum By similarity. Secreted By similarity. Secretedextracellular space By similarity. Secretedextracellular spaceextracellular matrix By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. extracellular matrix Source: UniProtKB
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: UniProtKB
  5. proteinaceous extracellular matrix Source: UniProtKB-KW
  6. sarcoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 949927Thrombospondin-4-BPRO_0000035855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi261 – 261InterchainBy similarityPROSITE-ProRule annotation
Disulfide bondi264 – 264InterchainBy similarityPROSITE-ProRule annotation
Disulfide bondi276 ↔ 287By similarityPROSITE-ProRule annotation
Disulfide bondi281 ↔ 296By similarityPROSITE-ProRule annotation
Disulfide bondi299 ↔ 310By similarityPROSITE-ProRule annotation
Disulfide bondi316 ↔ 327By similarityPROSITE-ProRule annotation
Disulfide bondi321 ↔ 336By similarityPROSITE-ProRule annotation
Disulfide bondi339 ↔ 363By similarityPROSITE-ProRule annotation
Disulfide bondi369 ↔ 383By similarityPROSITE-ProRule annotation
Disulfide bondi377 ↔ 392By similarityPROSITE-ProRule annotation
Disulfide bondi395 ↔ 407By similarityPROSITE-ProRule annotation
Disulfide bondi413 ↔ 427By similarityPROSITE-ProRule annotation
Disulfide bondi421 ↔ 437By similarityPROSITE-ProRule annotation
Disulfide bondi439 ↔ 450By similarityPROSITE-ProRule annotation
Disulfide bondi466 ↔ 471By similarityPROSITE-ProRule annotation
Disulfide bondi476 ↔ 496By similarityPROSITE-ProRule annotation
Disulfide bondi512 ↔ 532By similarityPROSITE-ProRule annotation
Disulfide bondi535 ↔ 555By similarityPROSITE-ProRule annotation
Disulfide bondi571 ↔ 591By similarityPROSITE-ProRule annotation
Disulfide bondi594 ↔ 614By similarityPROSITE-ProRule annotation
Glycosylationi601 – 6011N-linked (GlcNAc...)Curated
Disulfide bondi632 ↔ 652By similarityPROSITE-ProRule annotation
Glycosylationi637 – 6371N-linked (GlcNAc...)Curated
Disulfide bondi672 ↔ 692By similarityPROSITE-ProRule annotation
Disulfide bondi708 ↔ 929By similarityPROSITE-ProRule annotation
Glycosylationi930 – 9301N-linked (GlcNAc...)Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8JGW0.

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Present at the gastrulation and post-segmentation stages.1 Publication

Interactioni

Subunit structurei

Homotrimer; disulfide-linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8JGW0.
SMRiQ8JGW0. Positions 592-931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 198176Laminin G-likeAdd
BLAST
Domaini312 – 34938EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini365 – 40844EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini409 – 45143EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Repeati452 – 48433TSP type-3 1Add
BLAST
Repeati485 – 52036TSP type-3 2Add
BLAST
Repeati521 – 54323TSP type-3 3Add
BLAST
Repeati544 – 57936TSP type-3 4Add
BLAST
Repeati580 – 60223TSP type-3 5Add
BLAST
Repeati603 – 64038TSP type-3 6Add
BLAST
Repeati641 – 68040TSP type-3 7Add
BLAST
Repeati681 – 71636TSP type-3 8Add
BLAST
Domaini720 – 934215TSP C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thrombospondin family.Curated
Contains 3 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 1 TSP C-terminal (TSPC) domain.PROSITE-ProRule annotation
Contains 8 TSP type-3 repeats.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000007542.
HOVERGENiHBG000636.
InParanoidiQ8JGW0.
KOiK04659.
PhylomeDBiQ8JGW0.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PfamiPF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JGW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGTMHLLTA VSLILMLSSA NAESTVYNLL TSPDCLPDLL HGGLAEQGVT
60 70 80 90 100
ELYILTTFRI QPGTGNTIFS LYNPRDNSKY FEFSVFGKAN KAILRYLRRD
110 120 130 140 150
GRMSAVTFNK LNLADGEKHR LLFHLKGLEV GHPGGFPHSQ GALPVPGVEL
160 170 180 190 200
HLDCRLVETL RDLPAVFNGL NNHQAVELKT MQGKAQEGLE ELKLAYGDSV
210 220 230 240 250
ENVASLQDCH TQSDSVQALG LNTKQLTTQM LELTKVINEL KDVLIQQVKE
260 270 280 290 300
TSFLRNTISE CQACGLSGAE VVKPKCAPGV CFRDDMCIET AEGVECGPCP
310 320 330 340 350
DGYTGDGYSC DDVDECQFNP CFPGVRCVNM APGFRCEACP LGFTGKPLEG
360 370 380 390 400
VGVAYAQTHK QVCDDIDECK GPDNGGCTAN SICVNSVGSY QCGRCKTGFT
410 420 430 440 450
GDQIRGCKPE KSCGNRLQNP CDPNAQCTEE RDGTITCQCG IGWAGNGYLC
460 470 480 490 500
GKDTDIDGYP DERLRCRDPT CRKDNCVTVP NSGQEDADGD GKGDACDPDA
510 520 530 540 550
DGDGILNEQD NCWLTPNINQ QNSDKDSHGD ACDNCVRVDN PDQRDTDSDG
560 570 580 590 600
LGDACDDDMD GDGLKNFLDN CQRVKNRDQL DRDGDGVGDA CDSCPDIPNP
610 620 630 640 650
NQSDIDNDLV GDSCDTNQDS DGDGHQDSKD NCPMVINSSQ LDTDKDGIGD
660 670 680 690 700
ECDDDDDNDG IPDSLPPGPD NCRLVPNPEQ IDDNNDGVGD ICESDFDQDK
710 720 730 740 750
VIDRIDNCPE NAEITLTDFR AYQTVVLDPE GDAQIDPNWV VLNQGMEIVQ
760 770 780 790 800
TMNSDPGLAV GYTAFSGVDF EGTFHVNTVT DDDYAGFIFG YQDSSSFYVV
810 820 830 840 850
MWKQTEQTYW QATPFRAVAE PGIQLKAVKS KTGPGEHLRN SLWHTGDTND
860 870 880 890 900
QVRLLWKDPR NVGWKDKVSY RWYLQHRPQV GYIRVRFYEG TELVADSGVT
910 920 930 940
IDTTMRGGRL GVFCFSQENI IWSNLKYRCN DTIPEDFQEF STQHGMDPL
Length:949
Mass (Da):103,991
Last modified:October 1, 2002 - v1
Checksum:iBBC9203814CA99CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081009 mRNA. Translation: AAL82733.1.
RefSeqiNP_775333.1. NM_173226.1.
UniGeneiDr.76718.

Genome annotation databases

GeneIDi252850.
KEGGidre:252850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081009 mRNA. Translation: AAL82733.1 .
RefSeqi NP_775333.1. NM_173226.1.
UniGenei Dr.76718.

3D structure databases

ProteinModelPortali Q8JGW0.
SMRi Q8JGW0. Positions 592-931.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8JGW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 252850.
KEGGi dre:252850.

Organism-specific databases

CTDi 252850.
ZFINi ZDB-GENE-020708-4. thbs4b.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000007542.
HOVERGENi HBG000636.
InParanoidi Q8JGW0.
KOi K04659.
PhylomeDBi Q8JGW0.

Miscellaneous databases

NextBioi 20799872.
PROi Q8JGW0.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view ]
Pfami PF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
PROSITEi PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish thrombospondin 3 and 4 genes (thbs3 and thbs4): cDNA and protein structure."
    Adolph K.W.
    DNA Seq. 13:277-285(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTSP4B_DANRE
AccessioniPrimary (citable) accession number: Q8JGW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3