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Q8JGW0

- TSP4B_DANRE

UniProt

Q8JGW0 - TSP4B_DANRE

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Protein
Thrombospondin-4-B
Gene
thbs4b, thbs4, tsp4
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment. May play a role in ER stress response By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. positive regulation of cell division Source: UniProtKB-KW
  3. response to unfolded protein Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Biological processi

Cell adhesion, Unfolded protein response

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-4-B
Short name:
Thbs4-B
Gene namesi
Name:thbs4b
Synonyms:thbs4, tsp4
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-020708-4. thbs4b.

Subcellular locationi

Endoplasmic reticulum By similarity. Sarcoplasmic reticulum By similarity. Secreted By similarity. Secretedextracellular space By similarity. Secretedextracellular spaceextracellular matrix By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. extracellular matrix Source: UniProtKB
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: UniProtKB
  5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
  6. sarcoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 949927Thrombospondin-4-B
PRO_0000035855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi261 – 261Interchain By similarityBy similarity
Disulfide bondi264 – 264Interchain By similarityBy similarity
Disulfide bondi276 ↔ 287 By similarityBy similarity
Disulfide bondi281 ↔ 296 By similarityBy similarity
Disulfide bondi299 ↔ 310 By similarityBy similarity
Disulfide bondi316 ↔ 327 By similarityBy similarity
Disulfide bondi321 ↔ 336 By similarityBy similarity
Disulfide bondi339 ↔ 363 By similarityBy similarity
Disulfide bondi369 ↔ 383 By similarityBy similarity
Disulfide bondi377 ↔ 392 By similarityBy similarity
Disulfide bondi395 ↔ 407 By similarityBy similarity
Disulfide bondi413 ↔ 427 By similarityBy similarity
Disulfide bondi421 ↔ 437 By similarityBy similarity
Disulfide bondi439 ↔ 450 By similarityBy similarity
Disulfide bondi466 ↔ 471 By similarityBy similarity
Disulfide bondi476 ↔ 496 By similarityBy similarity
Disulfide bondi512 ↔ 532 By similarityBy similarity
Disulfide bondi535 ↔ 555 By similarityBy similarity
Disulfide bondi571 ↔ 591 By similarityBy similarity
Disulfide bondi594 ↔ 614 By similarityBy similarity
Glycosylationi601 – 6011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi632 ↔ 652 By similarityBy similarity
Glycosylationi637 – 6371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi672 ↔ 692 By similarityBy similarity
Disulfide bondi708 ↔ 929 By similarityBy similarity
Glycosylationi930 – 9301N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8JGW0.

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Present at the gastrulation and post-segmentation stages.1 Publication

Interactioni

Subunit structurei

Homotrimer; disulfide-linked By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8JGW0.
SMRiQ8JGW0. Positions 592-931.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 198176Laminin G-like
Add
BLAST
Domaini312 – 34938EGF-like 1; calcium-binding Reviewed prediction
Add
BLAST
Domaini365 – 40844EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini409 – 45143EGF-like 3
Add
BLAST
Repeati452 – 48433TSP type-3 1
Add
BLAST
Repeati485 – 52036TSP type-3 2
Add
BLAST
Repeati521 – 54323TSP type-3 3
Add
BLAST
Repeati544 – 57936TSP type-3 4
Add
BLAST
Repeati580 – 60223TSP type-3 5
Add
BLAST
Repeati603 – 64038TSP type-3 6
Add
BLAST
Repeati641 – 68040TSP type-3 7
Add
BLAST
Repeati681 – 71636TSP type-3 8
Add
BLAST
Domaini720 – 934215TSP C-terminal
Add
BLAST

Sequence similaritiesi

Belongs to the thrombospondin family.
Contains 3 EGF-like domains.
Contains 8 TSP type-3 repeats.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000007542.
HOVERGENiHBG000636.
KOiK04659.
PhylomeDBiQ8JGW0.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view]
PfamiPF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JGW0-1 [UniParc]FASTAAdd to Basket

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MAGTMHLLTA VSLILMLSSA NAESTVYNLL TSPDCLPDLL HGGLAEQGVT    50
ELYILTTFRI QPGTGNTIFS LYNPRDNSKY FEFSVFGKAN KAILRYLRRD 100
GRMSAVTFNK LNLADGEKHR LLFHLKGLEV GHPGGFPHSQ GALPVPGVEL 150
HLDCRLVETL RDLPAVFNGL NNHQAVELKT MQGKAQEGLE ELKLAYGDSV 200
ENVASLQDCH TQSDSVQALG LNTKQLTTQM LELTKVINEL KDVLIQQVKE 250
TSFLRNTISE CQACGLSGAE VVKPKCAPGV CFRDDMCIET AEGVECGPCP 300
DGYTGDGYSC DDVDECQFNP CFPGVRCVNM APGFRCEACP LGFTGKPLEG 350
VGVAYAQTHK QVCDDIDECK GPDNGGCTAN SICVNSVGSY QCGRCKTGFT 400
GDQIRGCKPE KSCGNRLQNP CDPNAQCTEE RDGTITCQCG IGWAGNGYLC 450
GKDTDIDGYP DERLRCRDPT CRKDNCVTVP NSGQEDADGD GKGDACDPDA 500
DGDGILNEQD NCWLTPNINQ QNSDKDSHGD ACDNCVRVDN PDQRDTDSDG 550
LGDACDDDMD GDGLKNFLDN CQRVKNRDQL DRDGDGVGDA CDSCPDIPNP 600
NQSDIDNDLV GDSCDTNQDS DGDGHQDSKD NCPMVINSSQ LDTDKDGIGD 650
ECDDDDDNDG IPDSLPPGPD NCRLVPNPEQ IDDNNDGVGD ICESDFDQDK 700
VIDRIDNCPE NAEITLTDFR AYQTVVLDPE GDAQIDPNWV VLNQGMEIVQ 750
TMNSDPGLAV GYTAFSGVDF EGTFHVNTVT DDDYAGFIFG YQDSSSFYVV 800
MWKQTEQTYW QATPFRAVAE PGIQLKAVKS KTGPGEHLRN SLWHTGDTND 850
QVRLLWKDPR NVGWKDKVSY RWYLQHRPQV GYIRVRFYEG TELVADSGVT 900
IDTTMRGGRL GVFCFSQENI IWSNLKYRCN DTIPEDFQEF STQHGMDPL 949
Length:949
Mass (Da):103,991
Last modified:October 1, 2002 - v1
Checksum:iBBC9203814CA99CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY081009 mRNA. Translation: AAL82733.1.
RefSeqiNP_775333.1. NM_173226.1.
UniGeneiDr.76718.

Genome annotation databases

GeneIDi252850.
KEGGidre:252850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY081009 mRNA. Translation: AAL82733.1 .
RefSeqi NP_775333.1. NM_173226.1.
UniGenei Dr.76718.

3D structure databases

ProteinModelPortali Q8JGW0.
SMRi Q8JGW0. Positions 592-931.
ModBasei Search...

Proteomic databases

PRIDEi Q8JGW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 252850.
KEGGi dre:252850.

Organism-specific databases

CTDi 252850.
ZFINi ZDB-GENE-020708-4. thbs4b.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000007542.
HOVERGENi HBG000636.
KOi K04659.
PhylomeDBi Q8JGW0.

Miscellaneous databases

NextBioi 20799872.
PROi Q8JGW0.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
4.10.1080.10. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
IPR024665. Thbs/COMP_coiled-coil.
IPR003367. Thrombospondin_3-like_rpt.
IPR017897. Thrombospondin_3_rpt.
IPR008859. Thrombospondin_C.
IPR028974. TSP_type-3_rpt.
[Graphical view ]
Pfami PF11598. COMP. 1 hit.
PF07645. EGF_CA. 2 hits.
PF02412. TSP_3. 6 hits.
PF05735. TSP_C. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF103647. SSF103647. 3 hits.
SSF49899. SSF49899. 2 hits.
PROSITEi PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.
PS51234. TSP3. 8 hits.
PS51236. TSP_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish thrombospondin 3 and 4 genes (thbs3 and thbs4): cDNA and protein structure."
    Adolph K.W.
    DNA Seq. 13:277-285(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTSP4B_DANRE
AccessioniPrimary (citable) accession number: Q8JGW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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