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Protein

40S ribosomal protein S18

Gene

rps18

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA (By similarity). Plays an essential role in early embryonic development.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • regulation of cell cycle Source: ZFIN
  • ribosome biogenesis Source: GO_Central
  • translation Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein, Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-DRE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DRE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DRE-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DRE-72649. Translation initiation complex formation.
R-DRE-72689. Formation of a pool of free 40S subunits.
R-DRE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DRE-72702. Ribosomal scanning and start codon recognition.
R-DRE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DRE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DRE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S18
Gene namesi
Name:rps18
Synonyms:ke3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-020419-20. rps18.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Embryos have a reduced forebrain, kinked tail and inflated hindbrain ventricle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001322161 – 15240S ribosomal protein S18Add BLAST152

Proteomic databases

PaxDbiQ8JGS9.
PRIDEiQ8JGS9.

Expressioni

Gene expression databases

BgeeiENSDARG00000100392.
ExpressionAtlasiQ8JGS9. baseline.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000005719.

Structurei

3D structure databases

ProteinModelPortaliQ8JGS9.
SMRiQ8JGS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3311. Eukaryota.
COG0099. LUCA.
GeneTreeiENSGT00390000012691.
HOGENOMiHOG000039877.
HOVERGENiHBG000200.
InParanoidiQ8JGS9.
KOiK02964.
OMAiHKRGQKV.
OrthoDBiEOG091G0W4F.
PhylomeDBiQ8JGS9.
TreeFamiTF317649.

Family and domain databases

Gene3Di4.10.910.10. 1 hit.
HAMAPiMF_01315. Ribosomal_S13_S18. 1 hit.
InterProiView protein in InterPro
IPR027437. 30s_Rbsml_prot_S13_C.
IPR001892. Ribosomal_S13.
IPR010979. Ribosomal_S13-like_H2TH.
IPR018269. Ribosomal_S13_CS.
PfamiView protein in Pfam
PF00416. Ribosomal_S13. 1 hit.
PIRSFiPIRSF002134. Ribosomal_S13. 1 hit.
SUPFAMiSSF46946. SSF46946. 1 hit.
PROSITEiView protein in PROSITE
PS00646. RIBOSOMAL_S13_1. 1 hit.
PS50159. RIBOSOMAL_S13_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8JGS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI
60 70 80 90 100
DLNKRAGELT EDEVERVVTI MQNPRQYKIP DWFLNRQKDI KDGKYSQVLA
110 120 130 140 150
NGLDNKLRED LERLKKIRAH RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK

KK
Length:152
Mass (Da):17,732
Last modified:October 1, 2002 - v1
Checksum:i9D82B9E67E7D63B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY099517 mRNA. Translation: AAM28205.1.
BC062289 mRNA. Translation: AAH62289.1.
AF210641 mRNA. Translation: AAF70446.1.
RefSeqiNP_775341.1. NM_173234.1.
UniGeneiDr.76001.

Genome annotation databases

EnsembliENSDART00000167971; ENSDARP00000133054; ENSDARG00000100392.
GeneIDi192300.
KEGGidre:192300.

Similar proteinsi

Entry informationi

Entry nameiRS18_DANRE
AccessioniPrimary (citable) accession number: Q8JGS9
Secondary accession number(s): Q9IAC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2002
Last modified: August 30, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families