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Protein

40S ribosomal protein S18

Gene

rps18

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA (By similarity). Plays an essential role in early embryonic development.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • regulation of cell cycle Source: ZFIN
  • ribosome biogenesis Source: GO_Central
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-DRE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DRE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DRE-6791226. Major pathway of rRNA processing in the nucleolus.
R-DRE-72649. Translation initiation complex formation.
R-DRE-72689. Formation of a pool of free 40S subunits.
R-DRE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DRE-72702. Ribosomal scanning and start codon recognition.
R-DRE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DRE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DRE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S18
Gene namesi
Name:rps18
Synonyms:ke3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-020419-20. rps18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Embryos have a reduced forebrain, kinked tail and inflated hindbrain ventricle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15215240S ribosomal protein S18PRO_0000132216Add
BLAST

Proteomic databases

PaxDbiQ8JGS9.
PRIDEiQ8JGS9.

Expressioni

Gene expression databases

BgeeiQ8JGS9.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000005719.

Structurei

3D structure databases

ProteinModelPortaliQ8JGS9.
SMRiQ8JGS9. Positions 13-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S13P family.Curated

Phylogenomic databases

eggNOGiKOG3311. Eukaryota.
COG0099. LUCA.
GeneTreeiENSGT00390000012691.
HOGENOMiHOG000039877.
HOVERGENiHBG000200.
InParanoidiQ8JGS9.
KOiK02964.
OMAiRIMNTDL.
OrthoDBiEOG7Q5HG2.
PhylomeDBiQ8JGS9.
TreeFamiTF317649.

Family and domain databases

Gene3Di4.10.910.10. 1 hit.
HAMAPiMF_01315. Ribosomal_S13_S18.
InterProiIPR027437. 30s_Rbsml_prot_S13_C.
IPR001892. Ribosomal_S13.
IPR010979. Ribosomal_S13-like_H2TH.
IPR018269. Ribosomal_S13_CS.
[Graphical view]
PfamiPF00416. Ribosomal_S13. 1 hit.
[Graphical view]
PIRSFiPIRSF002134. Ribosomal_S13. 1 hit.
SUPFAMiSSF46946. SSF46946. 1 hit.
PROSITEiPS00646. RIBOSOMAL_S13_1. 1 hit.
PS50159. RIBOSOMAL_S13_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8JGS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI
60 70 80 90 100
DLNKRAGELT EDEVERVVTI MQNPRQYKIP DWFLNRQKDI KDGKYSQVLA
110 120 130 140 150
NGLDNKLRED LERLKKIRAH RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK

KK
Length:152
Mass (Da):17,732
Last modified:October 1, 2002 - v1
Checksum:i9D82B9E67E7D63B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY099517 mRNA. Translation: AAM28205.1.
BC062289 mRNA. Translation: AAH62289.1.
AF210641 mRNA. Translation: AAF70446.1.
RefSeqiNP_775341.1. NM_173234.1.
UniGeneiDr.76001.

Genome annotation databases

EnsembliENSDART00000167971; ENSDARP00000133054; ENSDARG00000100392.
GeneIDi192300.
KEGGidre:192300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY099517 mRNA. Translation: AAM28205.1.
BC062289 mRNA. Translation: AAH62289.1.
AF210641 mRNA. Translation: AAF70446.1.
RefSeqiNP_775341.1. NM_173234.1.
UniGeneiDr.76001.

3D structure databases

ProteinModelPortaliQ8JGS9.
SMRiQ8JGS9. Positions 13-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000005719.

Proteomic databases

PaxDbiQ8JGS9.
PRIDEiQ8JGS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000167971; ENSDARP00000133054; ENSDARG00000100392.
GeneIDi192300.
KEGGidre:192300.

Organism-specific databases

CTDi6222.
ZFINiZDB-GENE-020419-20. rps18.

Phylogenomic databases

eggNOGiKOG3311. Eukaryota.
COG0099. LUCA.
GeneTreeiENSGT00390000012691.
HOGENOMiHOG000039877.
HOVERGENiHBG000200.
InParanoidiQ8JGS9.
KOiK02964.
OMAiRIMNTDL.
OrthoDBiEOG7Q5HG2.
PhylomeDBiQ8JGS9.
TreeFamiTF317649.

Enzyme and pathway databases

ReactomeiR-DRE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DRE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DRE-6791226. Major pathway of rRNA processing in the nucleolus.
R-DRE-72649. Translation initiation complex formation.
R-DRE-72689. Formation of a pool of free 40S subunits.
R-DRE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DRE-72702. Ribosomal scanning and start codon recognition.
R-DRE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DRE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DRE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiQ8JGS9.

Gene expression databases

BgeeiQ8JGS9.

Family and domain databases

Gene3Di4.10.910.10. 1 hit.
HAMAPiMF_01315. Ribosomal_S13_S18.
InterProiIPR027437. 30s_Rbsml_prot_S13_C.
IPR001892. Ribosomal_S13.
IPR010979. Ribosomal_S13-like_H2TH.
IPR018269. Ribosomal_S13_CS.
[Graphical view]
PfamiPF00416. Ribosomal_S13. 1 hit.
[Graphical view]
PIRSFiPIRSF002134. Ribosomal_S13. 1 hit.
SUPFAMiSSF46946. SSF46946. 1 hit.
PROSITEiPS00646. RIBOSOMAL_S13_1. 1 hit.
PS50159. RIBOSOMAL_S13_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development."
    Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W., Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M., Hopkins N.
    Nat. Genet. 31:135-140(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION, DISRUPTION PHENOTYPE.
    Tissue: Embryo.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.
  3. "Conservation of Mhc class III region synteny between zebrafish and human as determined by radiation hybrid mapping."
    Sueltmann H., Sato A., Murray B.W., Takezaki N., Geisler R., Rauch G.-J., Klein J.
    J. Immunol. 165:6984-6993(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-148.

Entry informationi

Entry nameiRS18_DANRE
AccessioniPrimary (citable) accession number: Q8JGS9
Secondary accession number(s): Q9IAC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.